DAPAT
label: DHAPAT
label: GNPAT
label: UniProt:O15228 GNPAT

PLA2G6
label: PLPLA9
label: UniProt:O60733 PLA2G6

CDS2
label: UniProt:O95674 CDS2

CHAT
label: UniProt:P28329 CHAT

KIAA0024
label: PSSA
label: PTDSS1
label: UniProt:P48651 PTDSS1

EFE2
label: G4.5
label: TAZ
label: UniProt:Q16635 TAZ

PGS1
label: UniProt:Q32NB8 PGS1

PLB
label: PLB1
label: UniProt:Q6P1J6 PLB1

AGPAT8
label: ALCAT1
label: LCLAT1
label: LYCAT
label: UNQ1849/PRO3579
label: UniProt:Q6UWP7 LCLAT1

TPIP
label: TPTE2
label: UniProt:Q6XPS3 TPTE2

AGPAT6
label: GPAT4
label: UNQ551/PRO1108
label: UniProt:Q86UL3 AGPAT6

MOSP
label: PLIP
label: PNAS-129
label: PTPMT1
label: UniProt:Q8WUK0 PTPMT1

BB1
label: LENG4
label: MBOAT7
label: OACT7
label: UniProt:Q96N66 MBOAT7

PSS2
label: PTDSS2
label: UniProt:Q9BVG9 PTDSS2

GDE5
label: GPCPD1
label: KIAA1434
label: UniProt:Q9NPB8 GPCPD1

KIAA0851
label: SACM1L
label: UniProt:Q9NTJ5 SACM1L

AGPAT5
label: UniProt:Q9NUQ2 AGPAT5

PEMPT
label: PEMT
label: PNMT
label: UniProt:Q9UBM1 PEMT

C20orf155
label: CLS1
label: CRLS1
label: UniProt:Q9UJA2 CRLS1

PLA2G4C
label: UniProt:Q9UP65 PLA2G4C

CTL1-5 can mediate the uptake of choline
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015220
BFO_0000050: Synthesis of PC
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: Catalysis1652
directly activates: Catalysis2329
label: Cho transports from the extracellular space to the cytosol

Cho is acetylated to AcCho by CHAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: enabled by
  some values from: CHAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004102
BFO_0000050: Synthesis of PC
directly activates: BiochemicalReaction3698
directly activates: Catalysis1653
label: Synthesis of o-acetylcholine

AcCho is hydrolyzed to Cho and acetate by ACHE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003990
BFO_0000050: Synthesis of PC
directly activates: CTL1-5 can mediate the uptake of choline
directly activates: Catalysis694
label: Acetylcholine clearance from synaptic cleft

Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004367
BFO_0000050: Synthesis of PA
directly activates: Conversion of glycerol-3-phosphate to lysophosphatidic acid
directly activates: BiochemicalReaction4759
directly activates: G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
directly activates: Catalysis2114
directly activates: Catalysis2115
directly activates: Catalysis2301
label: DHAP is converted to G3P by GPD1/GPD1L

Conversion of glycerol-3-phosphate to lysophosphatidic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: Restriction
  on property: enabled by
  some values from: AGPAT6
type: GO_0004366
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116
label: G3P is acylated to 1-acyl LPA by AGPAT6
label: glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated]

1-acyl LPA is acylated to PA by AGPAT (LPAAT)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Synthesis of PA
directly activates: BiochemicalReaction4761
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2[1]
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2G2A
directly activates: PA is dephosphorylated to DAG by LPIN
directly activates: PA is converted to CDP-DAG by CDS1
directly activates: Catalysis2117
directly activates: Catalysis2299
directly activates: Catalysis2300
directly activates: Catalysis2315
directly activates: Catalysis2355
label: 1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH
label: lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)

DHAP is converted to 1-acyl GO3P by GNPAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: Restriction
  on property: enabled by
  some values from: DAPAT
type: GO_0016287
BFO_0000050: Synthesis of PA

PA is hydrolysed to 1-acyl LPA by PLA2[1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116

PA is hydrolysed to 1-acyl LPA by PLA2G2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
directly activates: Catalysis2116

G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004366
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT5 (OM)
directly activates: Catalysis2302

1-acyl LPA is acylated to PA by AGPAT5 (OM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: enabled by
  some values from: AGPAT5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0003841
BFO_0000050: Synthesis of PA
directly activates: PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
directly activates: PA transports from the outer to the inner mitochondrial membrane
directly activates: Catalysis2303

PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Synthesis of PA
directly activates: 1-acyl LPA is acylated to PA by AGPAT5 (OM)
directly activates: Catalysis2302

PC is hydrolyzed to PA and choline by PLD1/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004630
BFO_0000050: Synthesis of PA
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2[1]
directly activates: PA is hydrolysed to 1-acyl LPA by PLA2G2A
directly activates: PA is dephosphorylated to DAG by LPIN
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: PA is converted to CDP-DAG by CDS1
directly activates: Catalysis1652
directly activates: Catalysis2299
directly activates: Catalysis2300
directly activates: Catalysis2315
directly activates: Catalysis2329
directly activates: Catalysis2355

PA is hydrolyzed to 1-acyl LPA by PLA2[15]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Synthesis of PA

TAG is hydrolyzed to DAG by PNPLA2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004806
BFO_0000050: Acyl chain remodeling of DAG and TAG
directly activates: DAG is acylated to TAG by DGAT1/2
directly activates: DAG is hydrolyzed to 2-MAG by PNPLA2/3
directly activates: 2-MAG and DAG are transacylated to TAG by PNPLA2/3
directly activates: CDP-ETA and DAG are converted to PE by CEPT1/EPT1
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: Catalysis2307
directly activates: Catalysis2308
directly activates: Catalysis2310
directly activates: Catalysis2316
directly activates: Catalysis2332

DAG is acylated to TAG by DGAT1/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004144
BFO_0000050: Acyl chain remodeling of DAG and TAG
directly activates: TAG is hydrolyzed to DAG by PNPLA2/3
directly activates: Catalysis2306

DAG is hydrolyzed to 2-MAG by PNPLA2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004465
BFO_0000050: Acyl chain remodeling of DAG and TAG
directly activates: 2-MAG is transacylated to DAG by PNPLA2/3
directly activates: 2-MAG and DAG are transacylated to TAG by PNPLA2/3
directly activates: 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
directly activates: Catalysis2309
directly activates: Catalysis2310
directly activates: Catalysis2311

2-MAG is transacylated to DAG by PNPLA2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016411
BFO_0000050: Acyl chain remodeling of DAG and TAG
directly activates: DAG is acylated to TAG by DGAT1/2
directly activates: DAG is hydrolyzed to 2-MAG by PNPLA2/3
directly activates: 2-MAG and DAG are transacylated to TAG by PNPLA2/3
directly activates: CDP-ETA and DAG are converted to PE by CEPT1/EPT1
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: Catalysis2307
directly activates: Catalysis2308
directly activates: Catalysis2310
directly activates: Catalysis2316
directly activates: Catalysis2332

2-MAG and DAG are transacylated to TAG by PNPLA2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0016411
BFO_0000050: Acyl chain remodeling of DAG and TAG
directly activates: TAG is hydrolyzed to DAG by PNPLA2/3
directly activates: Catalysis2306

2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047372
BFO_0000050: Acyl chain remodeling of DAG and TAG

ETA is phosphorylated to PETA by CHK/ETNK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004305
BFO_0000050: Synthesis of PE
directly activates: PETA is dephosphorylated to ETA by PHOSPHO1
directly activates: PETA and CTP are condensed to CDP-ETA by PCY2
directly activates: Catalysis2313
directly activates: Catalysis2314

PETA is dephosphorylated to ETA by PHOSPHO1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052732
BFO_0000050: Synthesis of PE
directly activates: ETA is phosphorylated to PETA by CHK/ETNK
directly activates: Catalysis2312

PETA and CTP are condensed to CDP-ETA by PCY2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004306
BFO_0000050: Synthesis of PE
directly activates: CDP-ETA and DAG are converted to PE by CEPT1/EPT1
directly activates: Catalysis2316

PA is dephosphorylated to DAG by LPIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008195
BFO_0000050: Synthesis of PE
BFO_0000050: Synthesis of PC
directly activates: CDP-ETA and DAG are converted to PE by CEPT1/EPT1
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: Catalysis2316
directly activates: Catalysis2332

CDP-ETA and DAG are converted to PE by CEPT1/EPT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004307
BFO_0000050: Synthesis of PE
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2G4C
directly activates: PE is methylated to PC by PEMT
directly activates: PE is converted to PS by PTDSS2
directly activates: Catalysis2318
directly activates: Catalysis2319
directly activates: Catalysis2321
directly activates: Catalysis2322
directly activates: Catalysis2328
directly activates: Catalysis2348

PS transports from the ER membrane to the IM membrane
type: GO_0003674
BFO_0000050: Synthesis of PE
directly activates: PS is decarboxylated to PE by PISD
directly activates: Catalysis2317

PS is decarboxylated to PE by PISD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004609
BFO_0000050: Synthesis of PE
directly activates: PE transports from the mitochondrial membrane to the ER
directly activates: MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
directly activates: Catalysis2381

PE transports from the mitochondrial membrane to the ER
type: GO_0003674
BFO_0000050: Synthesis of PE
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2G4C
directly activates: PE is methylated to PC by PEMT
directly activates: PE is converted to PS by PTDSS2
directly activates: Catalysis2318
directly activates: Catalysis2319
directly activates: Catalysis2321
directly activates: Catalysis2322
directly activates: Catalysis2328
directly activates: Catalysis2348

PE is hydrolyzed to 1-acyl LPE by PLA2[2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PE
directly activates: 1-acyl LPE is acylated to PE by LPEAT
directly activates: 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
directly activates: Catalysis2320
directly activates: Catalysis2325

PE is hydrolyzed to 1-acyl LPE by PLA2[3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PE
directly activates: 1-acyl LPE is acylated to PE by LPEAT
directly activates: 1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
directly activates: Catalysis2320
directly activates: Catalysis2325

1-acyl LPE is acylated to PE by LPEAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Acyl chain remodelling of PE
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2G4C
directly activates: PE is methylated to PC by PEMT
directly activates: PE is converted to PS by PTDSS2
directly activates: Catalysis2318
directly activates: Catalysis2319
directly activates: Catalysis2321
directly activates: Catalysis2322
directly activates: Catalysis2328
directly activates: Catalysis2348

PE is hydrolyzed to 2-acyl LPE by PLA2[4]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008970
BFO_0000050: Acyl chain remodelling of PE
directly activates: 2-acyl LPE is acylated to PE by LPEAT
directly activates: 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
directly activates: Catalysis2323
directly activates: Catalysis2326

PE is hydrolyzed to 2-acyl LPE by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0008970
BFO_0000050: Acyl chain remodelling of PE
directly activates: 2-acyl LPE is acylated to PE by LPEAT
directly activates: 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
directly activates: Catalysis2323
directly activates: Catalysis2326

2-acyl LPE is acylated to PE by LPEAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047144
BFO_0000050: Acyl chain remodelling of PE
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
directly activates: PE is hydrolyzed to 1-acyl LPE by PLA2[3]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2[4]
directly activates: PE is hydrolyzed to 2-acyl LPE by PLA2G4C
directly activates: PE is methylated to PC by PEMT
directly activates: PE is converted to PS by PTDSS2
directly activates: Catalysis2318
directly activates: Catalysis2319
directly activates: Catalysis2321
directly activates: Catalysis2322
directly activates: Catalysis2328
directly activates: Catalysis2348

PE is hydrolyzed to 1-acyl LPE by PLA2[16]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PE

1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004622
BFO_0000050: Hydrolysis of LPE
directly activates: GPETA is hydrolyzed to ETA and G3P by GPCPD1
directly activates: Catalysis2327

2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004622
BFO_0000050: Hydrolysis of LPE
directly activates: GPETA is hydrolyzed to ETA and G3P by GPCPD1
directly activates: Catalysis2327

GPETA is hydrolyzed to ETA and G3P by GPCPD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008889
BFO_0000050: Hydrolysis of LPE
directly activates: Conversion of glycerol-3-phosphate to lysophosphatidic acid
directly activates: G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
directly activates: ETA is phosphorylated to PETA by CHK/ETNK
directly activates: Catalysis2114
directly activates: Catalysis2301
directly activates: Catalysis2312

PE is methylated to PC by PEMT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: enabled by
  some values from: PEMPT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004608
BFO_0000050: Synthesis of PC

Cho is phosphorylated to PCho by CHK dimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004103
BFO_0000050: Synthesis of PC
directly activates: PCho is dephosphorylated to Cho by PHOSPHO1
directly activates: PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
directly activates: Catalysis2330
directly activates: Catalysis2331

PCho is dephosphorylated to Cho by PHOSPHO1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052731
BFO_0000050: Synthesis of PC
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: Catalysis1652
directly activates: Catalysis2329

PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004105
BFO_0000050: Synthesis of PC
directly activates: CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
directly activates: CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
directly activates: Catalysis2332
directly activates: Catalysis2333

CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004142
BFO_0000050: Synthesis of PC
directly activates: PC is hydrolyzed to PA and choline by PLD1/2
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[6]
directly activates: PC is hydrolysed to 2-acyl LPC by PLA2[7]
directly activates: PC is hydrolyzed to 2-acyl LPC by PLA2G4C
directly activates: PC is converted to PS by PTDSS1
directly activates: PC is transphosphatidylated to PG by PLD1-4/6
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004142
BFO_0000050: Synthesis of PC
directly activates: PI is exchanged with PC by PITPNB

PI:PITPNB is transported from the ER membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: PI and PC transport between ER and Golgi membranes
directly activates: PI is exchanged with PC by PITPNB

PI is exchanged with PC by PITPNB
type: GO_0003674
BFO_0000050: PI and PC transport between ER and Golgi membranes
directly activates: PC:PITPNB is transported from the Golgi membrane to the ER membrane
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PC:PITPNB is transported from the Golgi membrane to the ER membrane
type: GO_0003674
BFO_0000050: PI and PC transport between ER and Golgi membranes
directly activates: PC is exchanged with PI by PITPNB

PC is exchanged with PI by PITPNB
type: GO_0003674
BFO_0000050: PI and PC transport between ER and Golgi membranes
directly activates: PC is hydrolyzed to PA and choline by PLD1/2
directly activates: PI:PITPNB is transported from the ER membrane to the Golgi membrane
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[6]
directly activates: PC is hydrolysed to 2-acyl LPC by PLA2[7]
directly activates: PC is hydrolyzed to 2-acyl LPC by PLA2G4C
directly activates: PC is converted to PS by PTDSS1
directly activates: PC is transphosphatidylated to PG by PLD1-4/6
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

PC is hydrolyzed to 1-acyl LPC by PLA2[5]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PC
directly activates: 1-acyl LPC is acylated to PC by LPCAT
directly activates: 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
directly activates: 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
directly activates: Catalysis2336
directly activates: Catalysis2342
directly activates: Catalysis2343

PC is hydrolyzed to 1-acyl LPC by PLA2[6]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PC
directly activates: 1-acyl LPC is acylated to PC by LPCAT
directly activates: 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
directly activates: 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
directly activates: Catalysis2336
directly activates: Catalysis2342
directly activates: Catalysis2343

1-acyl LPC is acylated to PC by LPCAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Acyl chain remodelling of PC
directly activates: PC is hydrolyzed to PA and choline by PLD1/2
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[6]
directly activates: PC is hydrolysed to 2-acyl LPC by PLA2[7]
directly activates: PC is hydrolyzed to 2-acyl LPC by PLA2G4C
directly activates: PC is converted to PS by PTDSS1
directly activates: PC is transphosphatidylated to PG by PLD1-4/6
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

PC is hydrolysed to 2-acyl LPC by PLA2[7]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008970
BFO_0000050: Acyl chain remodelling of PC
directly activates: 2-acyl LPC is acylated to PC by LPCAT
directly activates: 2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
directly activates: 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
directly activates: Catalysis2339
directly activates: Catalysis2344
directly activates: Catalysis2345

PC is hydrolyzed to 2-acyl LPC by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008970
BFO_0000050: Acyl chain remodelling of PC
directly activates: 2-acyl LPC is acylated to PC by LPCAT
directly activates: 2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
directly activates: 2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
directly activates: Catalysis2339
directly activates: Catalysis2344
directly activates: Catalysis2345

2-acyl LPC is acylated to PC by LPCAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047144
BFO_0000050: Acyl chain remodelling of PC
directly activates: PC is hydrolyzed to PA and choline by PLD1/2
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
directly activates: PC is hydrolyzed to 1-acyl LPC by PLA2[6]
directly activates: PC is hydrolysed to 2-acyl LPC by PLA2[7]
directly activates: PC is hydrolyzed to 2-acyl LPC by PLA2G4C
directly activates: PC is converted to PS by PTDSS1
directly activates: PC is transphosphatidylated to PG by PLD1-4/6
directly activates: Catalysis2304
directly activates: Catalysis2334
directly activates: Catalysis2335
directly activates: Catalysis2337
directly activates: Catalysis2338
directly activates: Catalysis2347
directly activates: Catalysis2363

PC is hydrolyzed to 1-acyl LPC by PLA2[16]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PC

PC is hydrolyzed to 1-acyl LPC by PLB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: enabled by
  some values from: PLB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PC

1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004622
BFO_0000050: Hydrolysis of LPC
directly activates: GPCho is hydrolyzed to Cho and G3P by GPCPD1
directly activates: Catalysis2346

1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0004622
BFO_0000050: Hydrolysis of LPC
directly activates: GPCho is hydrolyzed to Cho and G3P by GPCPD1
directly activates: Catalysis2346

2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004622
BFO_0000050: Hydrolysis of LPC
directly activates: GPCho is hydrolyzed to Cho and G3P by GPCPD1
directly activates: Catalysis2346

2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: Restriction
  on property: enabled by
  some values from: PLA2G4C
type: GO_0004622
BFO_0000050: Hydrolysis of LPC
directly activates: GPCho is hydrolyzed to Cho and G3P by GPCPD1
directly activates: Catalysis2346

GPCho is hydrolyzed to Cho and G3P by GPCPD1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: Restriction
  on property: enabled by
  some values from: GDE5
type: GO_0008889
BFO_0000050: Hydrolysis of LPC
directly activates: Cho is acetylated to AcCho by CHAT
directly activates: Conversion of glycerol-3-phosphate to lysophosphatidic acid
directly activates: G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
directly activates: Cho is phosphorylated to PCho by CHK dimer
directly activates: Catalysis1652
directly activates: Catalysis2114
directly activates: Catalysis2301
directly activates: Catalysis2329

PC is converted to PS by PTDSS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: Restriction
  on property: enabled by
  some values from: KIAA0024
type: GO_0016740
BFO_0000050: Synthesis of PS
directly activates: PS transports from the ER membrane to the IM membrane
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2G2A
directly activates: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
directly activates: Catalysis2349
directly activates: Catalysis2350
directly activates: Catalysis2352

PE is converted to PS by PTDSS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: Restriction
  on property: enabled by
  some values from: PSS2
type: GO_0016740
BFO_0000050: Synthesis of PS
directly activates: PS transports from the ER membrane to the IM membrane
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2G2A
directly activates: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
directly activates: Catalysis2349
directly activates: Catalysis2350
directly activates: Catalysis2352

PS is hydrolyzed to 1-acyl LPS by PLA2[9]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PS
directly activates: 1-acyl LPS is acylated to PS by LPSAT
directly activates: Catalysis2351

PS is hydrolyzed to 1-acyl LPS by PLA2G2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PS
directly activates: 1-acyl LPS is acylated to PS by LPSAT
directly activates: Catalysis2351

1-acyl LPS is acylated to PS by LPSAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Acyl chain remodelling of PS
directly activates: PS transports from the ER membrane to the IM membrane
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2G2A
directly activates: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
directly activates: Catalysis2349
directly activates: Catalysis2350
directly activates: Catalysis2352

PS is hydrolyzed to 2-acyl LPS by PLA2[10]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PS
directly activates: 2-acyl LPS is acylated to PS by LPSAT
directly activates: Catalysis2353

2-acyl LPS is acylated to PS by LPSAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047144
BFO_0000050: Acyl chain remodelling of PS
directly activates: PS transports from the ER membrane to the IM membrane
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2[9]
directly activates: PS is hydrolyzed to 1-acyl LPS by PLA2G2A
directly activates: PS is hydrolyzed to 2-acyl LPS by PLA2[10]
directly activates: Catalysis2349
directly activates: Catalysis2350
directly activates: Catalysis2352

PS is hydrolyzed to 1-acyl LPS by PLA2[15]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PS

PA is converted to CDP-DAG by CDS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004605
BFO_0000050: Synthesis of PI
directly activates: CDP-DAG is converted to PI by CDIPT
directly activates: Catalysis2356

CDP-DAG is converted to PI by CDIPT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003881
BFO_0000050: Synthesis of PI
directly activates: PC is exchanged with PI by PITPNB
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[12]
directly activates: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is hydrolyzed to 1-acyl LPI by PLA2[11]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PI
directly activates: 1-acyl LPI is acylated to PI by MBOAT7
directly activates: Catalysis2359

PI is hydrolyzed to 1-acyl LPI by PLA2[12]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PI
directly activates: 1-acyl LPI is acylated to PI by MBOAT7
directly activates: Catalysis2359

1-acyl LPI is acylated to PI by MBOAT7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: GO_0003841
BFO_0000050: Acyl chain remodelling of PI
directly activates: PC is exchanged with PI by PITPNB
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[12]
directly activates: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is hydrolyzed to 2-acyl LPI by PLA2[13]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008970
BFO_0000050: Acyl chain remodelling of PI
directly activates: 2-acyl LPI is acylated to PI by MBOAT7
directly activates: Catalysis2361

2-acyl LPI is acylated to PI by MBOAT7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: Restriction
  on property: enabled by
  some values from: BB1
type: GO_0047144
BFO_0000050: Acyl chain remodelling of PI
directly activates: PC is exchanged with PI by PITPNB
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[12]
directly activates: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is hydrolyzed to 1-acyl LPI by PLA2[15]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PI

PC is transphosphatidylated to PG by PLD1-4/6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004630
BFO_0000050: Synthesis of PG
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2[1]
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G2A
directly activates: PG is hydrolyzed to 2-acyl LPG by PLA2[14]
directly activates: PG transports from the ER membrane to the late endosome membrane
directly activates: Catalysis2367
directly activates: Catalysis2368
directly activates: Catalysis2370

PA transports from the outer to the inner mitochondrial membrane
type: GO_0003674
BFO_0000050: Synthesis of PG
directly activates: PA is converted to CDP-DAG by CDS2
directly activates: Catalysis2364

PA is converted to CDP-DAG by CDS2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: Restriction
  on property: enabled by
  some values from: CDS2
type: GO_0004605
BFO_0000050: Synthesis of PG
directly activates: CDP-DAG is converted to PGP by PGS1
directly activates: PG and CDP-DAG are converted to CL by CRLS1
directly activates: Catalysis2365
directly activates: Catalysis2377

CDP-DAG is converted to PGP by PGS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: Restriction
  on property: enabled by
  some values from: PGS1
type: GO_0008444
BFO_0000050: Synthesis of PG
directly activates: PTPMT1 dephosphorylates PGP to PG
directly activates: Catalysis2366

PTPMT1 dephosphorylates PGP to PG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: Restriction
  on property: enabled by
  some values from: MOSP
type: GO_0008962
BFO_0000050: Synthesis of PG
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
directly activates: PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
directly activates: PG and CDP-DAG are converted to CL by CRLS1
directly activates: Catalysis2372
directly activates: Catalysis2374
directly activates: Catalysis2377

PG is hydrolyzed to 1-acyl LPG by PLA2[1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PG
directly activates: 1-acyl LPG is acylated to PG by LPGAT
directly activates: Catalysis2369

PG is hydrolyzed to 1-acyl LPG by PLA2G2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PG
directly activates: 1-acyl LPG is acylated to PG by LPGAT
directly activates: Catalysis2369

1-acyl LPG is acylated to PG by LPGAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003841
BFO_0000050: Acyl chain remodelling of PG
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2[1]
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G2A
directly activates: PG is hydrolyzed to 2-acyl LPG by PLA2[14]
directly activates: PG transports from the ER membrane to the late endosome membrane
directly activates: Catalysis2367
directly activates: Catalysis2368
directly activates: Catalysis2370

PG is hydrolyzed to 2-acyl LPG by PLA2[14]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008970
BFO_0000050: Acyl chain remodelling of PG
directly activates: 2-acyl LPG is acylated to PG by LPGAT
directly activates: Catalysis2371

2-acyl LPG is acylated to PG by LPGAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0047144
BFO_0000050: Acyl chain remodelling of PG
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2[1]
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G2A
directly activates: PG is hydrolyzed to 2-acyl LPG by PLA2[14]
directly activates: PG transports from the ER membrane to the late endosome membrane
directly activates: Catalysis2367
directly activates: Catalysis2368
directly activates: Catalysis2370

PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PG
directly activates: 1-acyl LPG is acylated to PG by CRLS1 (IM)
directly activates: Catalysis2373

1-acyl LPG is acylated to PG by CRLS1 (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: GO_0003841
BFO_0000050: Acyl chain remodelling of PG
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
directly activates: PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
directly activates: Catalysis2372
directly activates: Catalysis2374

PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0008970
BFO_0000050: Acyl chain remodelling of PG
directly activates: 2-acyl LPG is acylated to PG by CRLS1 (IM)
directly activates: Catalysis2375

2-acyl LPG is acylated to PG by CRLS1 (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: GO_0047144
BFO_0000050: Acyl chain remodelling of PG
directly activates: PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
directly activates: PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
directly activates: Catalysis2372
directly activates: Catalysis2374

PG is hydrolyzed to 1-acyl LPG by PLA2[16]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004623
BFO_0000050: Acyl chain remodelling of PG

PG and CDP-DAG are converted to CL by CRLS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: Restriction
  on property: enabled by
  some values from: C20orf155
type: GO_0043337
BFO_0000050: Synthesis of CL
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

CL is hydrolyzed to MLCL by PLA2G6 (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: Restriction
  on property: enabled by
  some values from: PLA2G6
type: GO_0004623
BFO_0000050: Acyl chain remodeling of CL
directly activates: MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
directly activates: MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
directly activates: MLCL is acylated to CL by HADH (IM)
directly activates: MLCL transports from the IM to the ER
directly activates: MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
directly activates: Catalysis2379
directly activates: Catalysis2381
directly activates: Catalysis2383
directly activates: Catalysis2385

MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: GO_0008374
BFO_0000050: Acyl chain remodeling of CL
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: GO_0047184
BFO_0000050: Acyl chain remodeling of CL
directly activates: MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
directly activates: MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
directly activates: MLCL is acylated to CL by HADH (IM)
directly activates: MLCL transports from the IM to the ER
directly activates: MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
directly activates: Catalysis2379
directly activates: Catalysis2381
directly activates: Catalysis2383
directly activates: Catalysis2385

MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: GO_0008374
BFO_0000050: Acyl chain remodeling of CL
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: Restriction
  on property: enabled by
  some values from: EFE2
type: GO_0003841
BFO_0000050: Acyl chain remodeling of CL
directly activates: PE transports from the mitochondrial membrane to the ER
directly activates: MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
directly activates: MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
directly activates: MLCL is acylated to CL by HADH (IM)
directly activates: MLCL transports from the IM to the ER
directly activates: MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
directly activates: Catalysis2379
directly activates: Catalysis2381
directly activates: Catalysis2383
directly activates: Catalysis2385

MLCL is acylated to CL by HADH (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0008374
BFO_0000050: Acyl chain remodeling of CL
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

MLCL transports from the IM to the ER
type: GO_0003674
BFO_0000050: Acyl chain remodeling of CL
directly activates: MLCL is acylated to CL by LCLAT1 (ER)
directly activates: Catalysis2384

MLCL is acylated to CL by LCLAT1 (ER)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: GO_0008374
BFO_0000050: Acyl chain remodeling of CL
directly activates: CL transports from the ER to the IM

CL transports from the ER to the IM
type: GO_0003674
BFO_0000050: Acyl chain remodeling of CL
directly activates: CL is hydrolyzed to MLCL by PLA2G6 (IM)
directly activates: CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
directly activates: CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
directly activates: Catalysis2378
directly activates: Catalysis2380
directly activates: Catalysis2382

MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004623
BFO_0000050: Acyl chain remodeling of CL
directly activates: DLCL transports from the IM to the ER

DLCL transports from the IM to the ER
type: GO_0003674
BFO_0000050: Acyl chain remodeling of CL
directly activates: DLCL is acylated to MLCL by LCLAT1 (ER)
directly activates: Catalysis2386

DLCL is acylated to MLCL by LCLAT1 (ER)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: Restriction
  on property: enabled by
  some values from: AGPAT8
type: GO_0008374
BFO_0000050: Acyl chain remodeling of CL
directly activates: MLCL is acylated to CL by LCLAT1 (ER)
directly activates: Catalysis2384

PG transports from the ER membrane to the late endosome membrane
type: GO_0003674
BFO_0000050: Synthesis of BMP
directly activates: PG is converted to BMP

PG is converted to BMP
type: GO_0003674
BFO_0000050: Synthesis of BMP

PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the ER membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the ER membrane
directly activates: Catalysis2388

PI4P is dephosphorylated to PI by SACM1L at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0034596
BFO_0000050: Synthesis of PIPs at the ER membrane
directly activates: PC is exchanged with PI by PITPNB
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[11]
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[12]
directly activates: PI is hydrolyzed to 2-acyl LPI by PLA2[13]
directly activates: PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
directly activates: Catalysis2357
directly activates: Catalysis2358
directly activates: Catalysis2360
directly activates: Catalysis2387

PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4KB binds to ARF1/3:GTP at the Golgi membrane
type: GO_0003674
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: Catalysis2390

PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0034596
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
directly activates: Catalysis2393
directly activates: Catalysis2394

PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: Restriction
  on property: enabled by
  some values from: KIAA0851
type: GO_0004438
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
directly activates: PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
directly activates: Catalysis2389
directly activates: Catalysis2390
directly activates: Catalysis2392

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0000285
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Catalysis2395

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0043813
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
directly activates: Catalysis2393
directly activates: Catalysis2394

PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
directly activates: Catalysis2397

PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: Restriction
  on property: enabled by
  some values from: TPIP
type: GO_0051800
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004439
BFO_0000050: Synthesis of PIPs at the Golgi membrane
directly activates: PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
directly activates: PI4P transports from the Golgi membrane to the plasma membrane
directly activates: Catalysis2391
directly activates: Catalysis2396

PI4P transports from the Golgi membrane to the plasma membrane
type: GO_0003674
BFO_0000050: PIPs transport between Golgi and plasma membranes
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016308
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: BiochemicalReaction979
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004439
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0046934
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
directly activates: Catalysis2402
directly activates: Catalysis2404

PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052812
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
directly activates: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
directly activates: Catalysis2402
directly activates: Catalysis2404

PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0034485
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0051800
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052811
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
directly activates: PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
directly activates: Catalysis2403
directly activates: Catalysis2406
directly activates: Catalysis2408

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016316
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
directly activates: PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
directly activates: Catalysis2407
directly activates: Catalysis2409
directly activates: Catalysis2411

PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[15]
directly activates: PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
directly activates: Catalysis2362
directly activates: Catalysis2410
directly activates: Catalysis2415

PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052810
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
directly activates: Catalysis2414

PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000285
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane
directly activates: Catalysis2412
directly activates: Catalysis2413

PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0043813
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
directly activates: PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
directly activates: Catalysis2407
directly activates: Catalysis2409
directly activates: Catalysis2411

PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
directly activates: Catalysis2414

PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016309
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: BiochemicalReaction4609
directly activates: BiochemicalReaction4610
directly activates: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
directly activates: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
directly activates: Catalysis2022
directly activates: Catalysis2023
directly activates: Catalysis2400
directly activates: Catalysis2401

PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
directly activates: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
directly activates: Catalysis2399
directly activates: Catalysis2405
directly activates: Catalysis2416

PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0034596
BFO_0000050: Synthesis of PIPs at the plasma membrane
directly activates: PI is hydrolyzed to 1-acyl LPI by PLA2[15]
directly activates: PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
directly activates: Catalysis2362
directly activates: Catalysis2410
directly activates: Catalysis2415

PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
type: GO_0003674
BFO_0000050: PIPs transport between plasma and early endosome membranes
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
directly activates: Catalysis2417

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016316
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: GO_0000285
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane
directly activates: PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane
directly activates: Catalysis2419
directly activates: Catalysis2420

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031901
type: GO_0043813
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Synthesis of PIPs at the early endosome membrane

PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
directly activates: Catalysis2418
directly activates: Catalysis2422

PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
directly activates: PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
directly activates: Catalysis2421
directly activates: Catalysis2423

PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004430
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
directly activates: Catalysis2424

PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035005
BFO_0000050: Synthesis of PIPs at the early endosome membrane
directly activates: PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
directly activates: Catalysis2417

PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: PIPs transport between early endosome and Golgi membranes
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome
directly activates: Catalysis2395

Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome
type: GO_0003674
BFO_0000050: PIPs transport between early and late endosome membranes
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
directly activates: PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
directly activates: Catalysis2426
directly activates: Catalysis2427

PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0000285
BFO_0000050: Synthesis of PIPs at the late endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
directly activates: PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
directly activates: PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
directly activates: Catalysis2426
directly activates: Catalysis2427

PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0043813
BFO_0000050: Synthesis of PIPs at the late endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
directly activates: Catalysis2425
directly activates: Catalysis2430

PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052629
BFO_0000050: Synthesis of PIPs at the late endosome membrane

PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: Restriction
  on property: BFO_0000066
  some values from: GO_0031902
type: GO_0052810
BFO_0000050: Synthesis of PIPs at the late endosome membrane

PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016303
BFO_0000050: Synthesis of PIPs at the late endosome membrane
directly activates: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
directly activates: PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
directly activates: Catalysis2425
directly activates: Catalysis2430

PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004438
BFO_0000050: Synthesis of PIPs at the late endosome membrane
directly activates: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
directly activates: PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
directly activates: Catalysis2428
directly activates: Catalysis2429

PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
type: GO_0003674
BFO_0000050: PIPs transport between late endosome and Golgi membranes
directly activates: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
directly activates: Catalysis2395

Phospholipid metabolism
type: GO_0008150

Glycerophospholipid biosynthesis
type: GO_0008150
BFO_0000050: Phospholipid metabolism

Synthesis of PA
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Acyl chain remodeling of DAG and TAG
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Synthesis of PE
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Acyl chain remodelling of PE
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Hydrolysis of LPE
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Synthesis of PC
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

PI and PC transport between ER and Golgi membranes
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis
BFO_0000050: PI Metabolism

Acyl chain remodelling of PC
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Hydrolysis of LPC
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Synthesis of PS
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Acyl chain remodelling of PS
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Synthesis of PI
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Acyl chain remodelling of PI
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Synthesis of PG
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Acyl chain remodelling of PG
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Synthesis of CL
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Acyl chain remodeling of CL
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

Synthesis of BMP
type: GO_0008150
BFO_0000050: Glycerophospholipid biosynthesis

PI Metabolism
type: GO_0008150
BFO_0000050: Phospholipid metabolism

Synthesis of PIPs at the ER membrane
type: GO_0008150
BFO_0000050: PI Metabolism

Synthesis of PIPs at the Golgi membrane
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between Golgi and plasma membranes
type: GO_0008150
BFO_0000050: PI Metabolism

Synthesis of PIPs at the plasma membrane
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between plasma and early endosome membranes
type: GO_0008150
BFO_0000050: PI Metabolism

Synthesis of PIPs at the early endosome membrane
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between early endosome and Golgi membranes
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between early and late endosome membranes
type: GO_0008150
BFO_0000050: PI Metabolism

Synthesis of PIPs at the late endosome membrane
type: GO_0008150
BFO_0000050: PI Metabolism

PIPs transport between late endosome and Golgi membranes
type: GO_0008150
BFO_0000050: PI Metabolism