DAPAT
DHAPAT
GNPAT
UniProt:O15228 GNPAT
PLA2G6
PLPLA9
UniProt:O60733 PLA2G6
CDS2
UniProt:O95674 CDS2
CHAT
UniProt:P28329 CHAT
KIAA0024
PSSA
PTDSS1
UniProt:P48651 PTDSS1
EFE2
TAZ
UniProt:Q16635 TAZ
PGS1
UniProt:Q32NB8 PGS1
PLB
PLB1
UniProt:Q6P1J6 PLB1
AGPAT8
ALCAT1
LCLAT1
LYCAT
UniProt:Q6UWP7 LCLAT1
TPIP
TPTE2
UniProt:Q6XPS3 TPTE2
AGPAT6
GPAT4
UniProt:Q86UL3 AGPAT6
MOSP
PLIP
PNAS-129
PTPMT1
UniProt:Q8WUK0 PTPMT1
BB1
LENG4
MBOAT7
OACT7
UniProt:Q96N66 MBOAT7
PSS2
PTDSS2
UniProt:Q9BVG9 PTDSS2
GDE5
GPCPD1
KIAA1434
UniProt:Q9NPB8 GPCPD1
KIAA0851
SACM1L
UniProt:Q9NTJ5 SACM1L
AGPAT5
UniProt:Q9NUQ2 AGPAT5
PEMPT
PEMT
PNMT
UniProt:Q9UBM1 PEMT
CLS1
CRLS1
UniProt:Q9UJA2 CRLS1
PLA2G4C
UniProt:Q9UP65 PLA2G4C
CTL1-5 can mediate the uptake of choline
Cho transports from the extracellular space to the cytosol
Cho is acetylated to AcCho by CHAT
Synthesis of o-acetylcholine
AcCho is hydrolyzed to Cho and acetate by ACHE
Acetylcholine clearance from synaptic cleft
Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate
DHAP is converted to G3P by GPD1/GPD1L
Conversion of glycerol-3-phosphate to lysophosphatidic acid
G3P is acylated to 1-acyl LPA by AGPAT6
glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated]
1-acyl LPA is acylated to PA by AGPAT (LPAAT)
1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH
lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)
DHAP is converted to 1-acyl GO3P by GNPAT
PA is hydrolysed to 1-acyl LPA by PLA2[1]
PA is hydrolysed to 1-acyl LPA by PLA2G2A
G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)
1-acyl LPA is acylated to PA by AGPAT5 (OM)
PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)
PC is hydrolyzed to PA and choline by PLD1/2
PA is hydrolyzed to 1-acyl LPA by PLA2[15]
TAG is hydrolyzed to DAG by PNPLA2/3
DAG is acylated to TAG by DGAT1/2
DAG is hydrolyzed to 2-MAG by PNPLA2/3
2-MAG is transacylated to DAG by PNPLA2/3
2-MAG and DAG are transacylated to TAG by PNPLA2/3
2-MAG is hydrolyzed to fatty acid and glycerol by MGLL
ETA is phosphorylated to PETA by CHK/ETNK
PETA is dephosphorylated to ETA by PHOSPHO1
PETA and CTP are condensed to CDP-ETA by PCY2
PA is dephosphorylated to DAG by LPIN
CDP-ETA and DAG are converted to PE by CEPT1/EPT1
PS transports from the ER membrane to the IM membrane
PS is decarboxylated to PE by PISD
PE transports from the mitochondrial membrane to the ER
PE is hydrolyzed to 1-acyl LPE by PLA2[2]
PE is hydrolyzed to 1-acyl LPE by PLA2[3]
1-acyl LPE is acylated to PE by LPEAT
PE is hydrolyzed to 2-acyl LPE by PLA2[4]
PE is hydrolyzed to 2-acyl LPE by PLA2G4C
2-acyl LPE is acylated to PE by LPEAT
PE is hydrolyzed to 1-acyl LPE by PLA2[16]
1-acyl LPE is hydrolyzed to GPETA by PLA2G4C
2-acyl LPE is hydrolyzed to GPETA by PLA2G4C
GPETA is hydrolyzed to ETA and G3P by GPCPD1
PE is methylated to PC by PEMT
Cho is phosphorylated to PCho by CHK dimer
PCho is dephosphorylated to Cho by PHOSPHO1
PCho and CTP are condensed to CDP-Cho by PCYT1 dimer
CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane
CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane
PI:PITPNB is transported from the ER membrane to the Golgi membrane
PI is exchanged with PC by PITPNB
PC:PITPNB is transported from the Golgi membrane to the ER membrane
PC is exchanged with PI by PITPNB
PC is hydrolyzed to 1-acyl LPC by PLA2[5]
PC is hydrolyzed to 1-acyl LPC by PLA2[6]
1-acyl LPC is acylated to PC by LPCAT
PC is hydrolysed to 2-acyl LPC by PLA2[7]
PC is hydrolyzed to 2-acyl LPC by PLA2G4C
2-acyl LPC is acylated to PC by LPCAT
PC is hydrolyzed to 1-acyl LPC by PLA2[16]
PC is hydrolyzed to 1-acyl LPC by PLB1
1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
2-acyl LPC is hydrolyzed to GPCho by PLA2G4C
GPCho is hydrolyzed to Cho and G3P by GPCPD1
PC is converted to PS by PTDSS1
PE is converted to PS by PTDSS2
PS is hydrolyzed to 1-acyl LPS by PLA2[9]
PS is hydrolyzed to 1-acyl LPS by PLA2G2A
1-acyl LPS is acylated to PS by LPSAT
PS is hydrolyzed to 2-acyl LPS by PLA2[10]
2-acyl LPS is acylated to PS by LPSAT
PS is hydrolyzed to 1-acyl LPS by PLA2[15]
PA is converted to CDP-DAG by CDS1
CDP-DAG is converted to PI by CDIPT
PI is hydrolyzed to 1-acyl LPI by PLA2[11]
PI is hydrolyzed to 1-acyl LPI by PLA2[12]
1-acyl LPI is acylated to PI by MBOAT7
PI is hydrolyzed to 2-acyl LPI by PLA2[13]
2-acyl LPI is acylated to PI by MBOAT7
PI is hydrolyzed to 1-acyl LPI by PLA2[15]
PC is transphosphatidylated to PG by PLD1-4/6
PA transports from the outer to the inner mitochondrial membrane
PA is converted to CDP-DAG by CDS2
CDP-DAG is converted to PGP by PGS1
PTPMT1 dephosphorylates PGP to PG
PG is hydrolyzed to 1-acyl LPG by PLA2[1]
PG is hydrolyzed to 1-acyl LPG by PLA2G2A
1-acyl LPG is acylated to PG by LPGAT
PG is hydrolyzed to 2-acyl LPG by PLA2[14]
2-acyl LPG is acylated to PG by LPGAT
PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)
1-acyl LPG is acylated to PG by CRLS1 (IM)
PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)
2-acyl LPG is acylated to PG by CRLS1 (IM)
PG is hydrolyzed to 1-acyl LPG by PLA2[16]
PG and CDP-DAG are converted to CL by CRLS1
CL is hydrolyzed to MLCL by PLA2G6 (IM)
MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)
CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)
MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)
CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)
MLCL is acylated to CL by HADH (IM)
MLCL transports from the IM to the ER
MLCL is acylated to CL by LCLAT1 (ER)
CL transports from the ER to the IM
MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
DLCL transports from the IM to the ER
DLCL is acylated to MLCL by LCLAT1 (ER)
PG transports from the ER membrane to the late endosome membrane
PG is converted to BMP
PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
PI4P is dephosphorylated to PI by SACM1L at the ER membrane
PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane
PI4KB binds to ARF1/3:GTP at the Golgi membrane
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane
PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane
PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane
PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane
PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
PI4P transports from the Golgi membrane to the plasma membrane
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane
PI3P is dephosphorylated to PI by SYNJ/MTM[1] at the plasma membrane
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTM[1] at the plasma membrane
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2A/B at the plasma membrane
PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane
PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane
PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane
PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane
PI(3,5)P2 is dephosphorylated to PI5P by MTM[2] at the early endosome membrane
PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane
PI3P is dephosphorylated to PI by MTM[2] at the early endosome membrane
PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane
PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane
PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane
Presence of PI(3,5)P2 stimulates the maturation of the early endosome into the late endosome
PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane
PI(3,5)P2 is dephosphorylated to PI5P by MTM[3] at the late endosome membrane
PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane
PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane
PI3P is dephosphorylated to PI by MTM[3] at the late endosome membrane
PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane
Phospholipid metabolism
Glycerophospholipid biosynthesis
Synthesis of PA
Acyl chain remodeling of DAG and TAG
Synthesis of PE
Acyl chain remodelling of PE
Hydrolysis of LPE
Synthesis of PC
PI and PC transport between ER and Golgi membranes
Acyl chain remodelling of PC
Hydrolysis of LPC
Synthesis of PS
Acyl chain remodelling of PS
Synthesis of PI
Acyl chain remodelling of PI
Synthesis of PG
Acyl chain remodelling of PG
Synthesis of CL
Acyl chain remodeling of CL
Synthesis of BMP
PI Metabolism
Synthesis of PIPs at the ER membrane
Synthesis of PIPs at the Golgi membrane
PIPs transport between Golgi and plasma membranes
Synthesis of PIPs at the plasma membrane
PIPs transport between plasma and early endosome membranes
Synthesis of PIPs at the early endosome membrane
PIPs transport between early endosome and Golgi membranes
PIPs transport between early and late endosome membranes
Synthesis of PIPs at the late endosome membrane
PIPs transport between late endosome and Golgi membranes