AKT1
label: PKB
label: RAC
label: UniProt:P31749 AKT1

PI3K gain of function mutants phosphorylate PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer
directly activates: PTEN cancer mutants do not dephosphorylate PIP3
directly activates: Catalysis1405

PTEN cancer mutants do not dephosphorylate PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant binds PIP2
type: GO_0003674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer
directly activates: AKT1 E17K mutant is phosphorylated by TORC2 complex
directly activates: Catalysis1406

AKT1 E17K mutant is phosphorylated by TORC2 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer
directly activates: PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1

PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
type: GO_0003674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer
directly activates: PDPK1 phosphorylates AKT1 E17K mutant
directly activates: Catalysis1407

PDPK1 phosphorylates AKT1 E17K mutant
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer
directly activates: AKT1 E17K mutant phosphorylates GSK3
directly activates: AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1
directly activates: AKT1 E17K mutant phosphorylates BAD
directly activates: AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
directly activates: AKT1 E17K mutant phosphorylates MDM2
directly activates: AKT1 E17K mutant phosphorylates TSC2, inhibiting it
directly activates: AKT1 E17K mutant phosphorylates CHUK (IKKalpha)
directly activates: AKT1 E17K mutant phosphorylates caspase-9
directly activates: AKT1 E17K mutant translocates to the nucleus
directly activates: Catalysis1408
directly activates: Catalysis1409
directly activates: Catalysis1410
directly activates: Catalysis1411
directly activates: Catalysis1412
directly activates: Catalysis1413
directly activates: Catalysis1414
directly activates: Catalysis1415

AKT1 E17K mutant phosphorylates GSK3
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates BAD
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates MDM2
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates TSC2, inhibiting it
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates CHUK (IKKalpha)
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates caspase-9
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant translocates to the nucleus
type: GO_0003674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer
directly activates: AKT1 E17K mutant phosphorylates forkhead box transcription factors
directly activates: AKT1 E17K mutant phosphorylates CREB1
directly activates: AKT1 E17K mutant phosphorylates RSK
directly activates: AKT1 E17K mutant phosphorylates NR4A1 (NUR77)
directly activates: Catalysis1416
directly activates: Catalysis1417
directly activates: Catalysis1418
directly activates: Catalysis1419

AKT1 E17K mutant phosphorylates forkhead box transcription factors
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates CREB1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates RSK
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT1 E17K mutant phosphorylates NR4A1 (NUR77)
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

PI3K inhibitors block PI3K catalytic activity
type: GO_0003674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

AKT inhibitors block AKT membrane recruitment
type: GO_0003674
BFO_0000050: Constitutive PI3K/AKT Signaling in Cancer

PIP3 recruits PDPK1 to the membrane
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PIP3 recruits AKT to the membrane
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

TORC2 (mTOR) phosphorylates AKT at S473
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: PIP3 activates AKT signaling
directly activates: BiochemicalReaction684
directly activates: AKT phosphorylates BAD
directly activates: AKT phosphorylates GSK3
directly activates: AKT phosphorylates caspase-9
directly activates: AKT phosphorylates MDM2
directly activates: AKT phosphorylates IKKalpha
directly activates: AKT phosphorylates p21Cip1 and p27Kip1
directly activates: AKT phosphorylates TSC2, inhibiting it
directly activates: AKT phosphorylates AKT1S1 (PRAS40)
directly activates: Catalysis252
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

AKT binds PDPK1
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PDPK1 phosphorylates AKT at T308
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT phosphorylates BAD
directly activates: AKT phosphorylates GSK3
directly activates: AKT phosphorylates caspase-9
directly activates: AKT phosphorylates MDM2
directly activates: AKT phosphorylates IKKalpha
directly activates: AKT phosphorylates p21Cip1 and p27Kip1
directly activates: AKT phosphorylates TSC2, inhibiting it
directly activates: AKT phosphorylates AKT1S1 (PRAS40)
directly activates: Catalysis282
directly activates: Catalysis283
directly activates: Catalysis284
directly activates: Catalysis285
directly activates: Catalysis286
directly activates: Catalysis287
directly activates: Catalysis288
directly activates: Catalysis289

PI3K phosphorylates PIP2 to PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0046934
BFO_0000050: PIP3 activates AKT signaling

AKT phosphorylates BAD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol
directly activates: BiochemicalReaction6004

AKT phosphorylates GSK3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates caspase-9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates MDM2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates IKKalpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates p21Cip1 and p27Kip1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates TSC2, inhibiting it
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT phosphorylates AKT1S1 (PRAS40)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the cytosol

AKT translocates to the nucleus
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling
directly activates: AKT phosphorylates CREB1
directly activates: AKT can phosphorylate forkhead box transcription factors
directly activates: AKT can phosphorylate RSK
directly activates: AKT can phosphorylate NR4A1 (NUR77)
directly activates: Catalysis290
directly activates: Catalysis291
directly activates: Catalysis292
directly activates: Catalysis293

AKT phosphorylates CREB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate forkhead box transcription factors
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate RSK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

AKT can phosphorylate NR4A1 (NUR77)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: AKT phosphorylates targets in the nucleus

PTEN dephosphorylates PIP3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016314
BFO_0000050: Negative regulation of the PI3K/AKT network
directly activates: BiochemicalReaction3944
directly activates: Catalysis1796

THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
type: GO_0003674
BFO_0000050: Negative regulation of the PI3K/AKT network

PHLPP dephosphorylates S473 in AKT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Negative regulation of the PI3K/AKT network

PDPK1 binds PIP2
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling
directly activates: PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1

MIR26A microRNAs bind PTEN mRNA
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PTEN mRNA translation negatively regulated by microRNAs
type: GO_0003674
BFO_0000050: PIP3 activates AKT signaling

PIP3 activates AKT signaling
type: GO_0008150
BFO_0000050: PI3K/AKT Signaling in Cancer

AKT phosphorylates targets in the cytosol
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

AKT phosphorylates targets in the nucleus
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

Negative regulation of the PI3K/AKT network
type: GO_0008150
BFO_0000050: PIP3 activates AKT signaling

PI3K/AKT Signaling in Cancer
type: GO_0008150

Constitutive PI3K/AKT Signaling in Cancer
type: GO_0008150
BFO_0000050: PI3K/AKT Signaling in Cancer