AKT1
PKB
RAC
UniProt:P31749 AKT1
PI3K gain of function mutants phosphorylate PIP2 to PIP3
PTEN cancer mutants do not dephosphorylate PIP3
AKT1 E17K mutant binds PIP2
AKT1 E17K mutant is phosphorylated by TORC2 complex
PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
PDPK1 phosphorylates AKT1 E17K mutant
AKT1 E17K mutant phosphorylates GSK3
AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1
AKT1 E17K mutant phosphorylates BAD
AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
AKT1 E17K mutant phosphorylates MDM2
AKT1 E17K mutant phosphorylates TSC2, inhibiting it
AKT1 E17K mutant phosphorylates CHUK (IKKalpha)
AKT1 E17K mutant phosphorylates caspase-9
AKT1 E17K mutant translocates to the nucleus
AKT1 E17K mutant phosphorylates forkhead box transcription factors
AKT1 E17K mutant phosphorylates CREB1
AKT1 E17K mutant phosphorylates RSK
AKT1 E17K mutant phosphorylates NR4A1 (NUR77)
PI3K inhibitors block PI3K catalytic activity
AKT inhibitors block AKT membrane recruitment
PIP3 recruits PDPK1 to the membrane
PIP3 recruits AKT to the membrane
TORC2 (mTOR) phosphorylates AKT at S473
AKT binds PDPK1
PDPK1 phosphorylates AKT at T308
PI3K phosphorylates PIP2 to PIP3
AKT phosphorylates BAD
AKT phosphorylates GSK3
AKT phosphorylates caspase-9
AKT phosphorylates MDM2
AKT phosphorylates IKKalpha
AKT phosphorylates p21Cip1 and p27Kip1
AKT phosphorylates TSC2, inhibiting it
AKT phosphorylates AKT1S1 (PRAS40)
AKT translocates to the nucleus
AKT phosphorylates CREB1
AKT can phosphorylate forkhead box transcription factors
AKT can phosphorylate RSK
AKT can phosphorylate NR4A1 (NUR77)
PTEN dephosphorylates PIP3
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
PHLPP dephosphorylates S473 in AKT
PDPK1 binds PIP2
MIR26A microRNAs bind PTEN mRNA
PTEN mRNA translation negatively regulated by microRNAs
PIP3 activates AKT signaling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
PI3K/AKT Signaling in Cancer
Constitutive PI3K/AKT Signaling in Cancer