LIG1
UniProt:P18858 LIG1
XPC binds to HR23B forming a heterodimeric complex
XPC:HR23B complex binds to damaged DNA site with lesion
Recruitment of repair factors to form preincision complex
Formation of open bubble structure in DNA by helicases
Formation of ERCC1-XPF heterodimeric complex
Binding of ERCC1-XPF to preincision complex
3'- incision of DNA by XPG in GG-NER
5'-incision of DNA by ERCC1-XPF in GG-NER
Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon
Repair synthesis of patch ~27-30 bases long by DNA Pol Delta
Ligation of newly synthesized repair patch to incised DNA in GG-NER
Formation of active Pol II complex with lesioned DNA template
RNA Pol II is blocked by the lesion leading to reduced transcription
Assembly of repair proteins at the site of Pol II blockage
Displacement of stalled Pol II from the lesion site
3' incision of the lesioned strand of DNA in TC-NER
5' incision leading to excision of DNA fragment with lesion in TC-NER
Repair synthesis for gap-filling by DNA pol delta in TC-NER
Repair synthesis for gap-filling by DNA pol epsilon in TC-NER
Ligation of newly synthesized repair patch to incised DNA in TC-NER
Resumption of transcription after TC-NER
Nucleotide Excision Repair
Global Genomic NER (GG-NER)
DNA Damage Recognition in GG-NER
Formation of incision complex in GG-NER
Dual incision reaction in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Transcription-coupled NER (TC-NER)
Formation of transcription-coupled NER (TC-NER) repair complex
Dual incision reaction in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Repair synthesis for gap-filling by DNA polymerase in TC-NER