LIG1
label: UniProt:P18858 LIG1

XPC binds to HR23B forming a heterodimeric complex
type: GO_0003674
BFO_0000050: DNA Damage Recognition in GG-NER
directly activates: XPC:HR23B complex binds to damaged DNA site with lesion

XPC:HR23B complex binds to damaged DNA site with lesion
type: GO_0003674
BFO_0000050: DNA Damage Recognition in GG-NER
directly activates: Recruitment of repair factors to form preincision complex

Recruitment of repair factors to form preincision complex
type: GO_0006294
BFO_0000050: Formation of incision complex in GG-NER
directly activates: Formation of open bubble structure in DNA by helicases
directly activates: Catalysis79

Formation of open bubble structure in DNA by helicases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000717
type: GO_0004386
BFO_0000050: Formation of incision complex in GG-NER
directly activates: Binding of ERCC1-XPF to preincision complex

Formation of ERCC1-XPF heterodimeric complex
type: GO_0003674
BFO_0000050: Formation of incision complex in GG-NER
directly activates: Binding of ERCC1-XPF to preincision complex

Binding of ERCC1-XPF to preincision complex
type: GO_0006293
BFO_0000050: Formation of incision complex in GG-NER
directly activates: 3'- incision of DNA by XPG in GG-NER
directly activates: Catalysis80

3'- incision of DNA by XPG in GG-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
type: GO_0006295
BFO_0000050: Dual incision reaction in GG-NER
directly activates: 5'-incision of DNA by ERCC1-XPF in GG-NER
directly activates: Catalysis81

5'-incision of DNA by ERCC1-XPF in GG-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
type: GO_0006296
BFO_0000050: Dual incision reaction in GG-NER
directly activates: Repair synthesis of patch ~27-30 bases long by DNA polymerase

Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Repair synthesis of patch ~27-30 bases long by DNA polymerase
directly activates: Ligation of newly synthesized repair patch to incised DNA in GG-NER
directly activates: Catalysis84

Repair synthesis of patch ~27-30 bases long by DNA Pol Delta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Repair synthesis of patch ~27-30 bases long by DNA polymerase
directly activates: Ligation of newly synthesized repair patch to incised DNA in GG-NER
directly activates: Catalysis84

Ligation of newly synthesized repair patch to incised DNA in GG-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: GO_0003909
BFO_0000050: Gap-filling DNA repair synthesis and ligation in GG-NER

Formation of active Pol II complex with lesioned DNA template
type: GO_0003674
BFO_0000050: Formation of transcription-coupled NER (TC-NER) repair complex
directly activates: RNA Pol II is blocked by the lesion leading to reduced transcription

RNA Pol II is blocked by the lesion leading to reduced transcription
type: GO_0000716
BFO_0000050: Formation of transcription-coupled NER (TC-NER) repair complex
directly activates: Assembly of repair proteins at the site of Pol II blockage

Assembly of repair proteins at the site of Pol II blockage
type: GO_0003674
BFO_0000050: Formation of transcription-coupled NER (TC-NER) repair complex
directly activates: Displacement of stalled Pol II from the lesion site

Displacement of stalled Pol II from the lesion site
type: GO_0003674
BFO_0000050: Dual incision reaction in TC-NER
directly activates: 3' incision of the lesioned strand of DNA in TC-NER
directly activates: Catalysis85

3' incision of the lesioned strand of DNA in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
BFO_0000050: Dual incision reaction in TC-NER
directly activates: 5' incision leading to excision of DNA fragment with lesion in TC-NER
directly activates: Catalysis86

5' incision leading to excision of DNA fragment with lesion in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004520
BFO_0000050: Dual incision reaction in TC-NER
directly activates: Repair synthesis for gap-filling by DNA pol delta in TC-NER
directly activates: Repair synthesis for gap-filling by DNA pol epsilon in TC-NER
directly activates: Catalysis87
directly activates: Catalysis88
directly activates: Repair synthesis for gap-filling by DNA polymerase in TC-NER

Repair synthesis for gap-filling by DNA pol delta in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Repair synthesis for gap-filling by DNA polymerase in TC-NER
directly activates: Ligation of newly synthesized repair patch to incised DNA in TC-NER
directly activates: Catalysis89

Repair synthesis for gap-filling by DNA pol epsilon in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Repair synthesis for gap-filling by DNA polymerase in TC-NER
directly activates: Ligation of newly synthesized repair patch to incised DNA in TC-NER
directly activates: Catalysis89

Ligation of newly synthesized repair patch to incised DNA in TC-NER
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: GO_0003909
BFO_0000050: Gap-filling DNA repair synthesis and ligation in TC-NER
directly activates: Resumption of transcription after TC-NER

Resumption of transcription after TC-NER
type: GO_0003674
BFO_0000050: Transcription-coupled NER (TC-NER)

Nucleotide Excision Repair
type: GO_0008150

Global Genomic NER (GG-NER)
type: GO_0008150
BFO_0000050: Nucleotide Excision Repair

DNA Damage Recognition in GG-NER
type: GO_0008150
BFO_0000050: Global Genomic NER (GG-NER)

Formation of incision complex in GG-NER
type: GO_0008150
BFO_0000050: Global Genomic NER (GG-NER)

Dual incision reaction in GG-NER
type: GO_0008150
BFO_0000050: Global Genomic NER (GG-NER)

Gap-filling DNA repair synthesis and ligation in GG-NER
type: GO_0008150
BFO_0000050: Global Genomic NER (GG-NER)

Repair synthesis of patch ~27-30 bases long by DNA polymerase
type: GO_0008150
BFO_0000050: Gap-filling DNA repair synthesis and ligation in GG-NER

Transcription-coupled NER (TC-NER)
type: GO_0008150
BFO_0000050: Nucleotide Excision Repair

Formation of transcription-coupled NER (TC-NER) repair complex
type: GO_0008150
BFO_0000050: Transcription-coupled NER (TC-NER)

Dual incision reaction in TC-NER
type: GO_0008150
BFO_0000050: Transcription-coupled NER (TC-NER)

Gap-filling DNA repair synthesis and ligation in TC-NER
type: GO_0008150
BFO_0000050: Transcription-coupled NER (TC-NER)

Repair synthesis for gap-filling by DNA polymerase in TC-NER
type: GO_0008150
BFO_0000050: Gap-filling DNA repair synthesis and ligation in TC-NER