JNK1
label: MAPK8
label: PRKM8
label: SAPK1
label: SAPK1C
label: UniProt:P45983 MAPK8

NGF:p75NTR complex binds to NRAGE
type: GO_0003674
BFO_0000050: NRAGE signals death through JNK
directly activates: NRAGE sequesters CHE1 in the cytoplasm
directly activates: NRAGE activates JNK
directly activates: Catalysis1765

NRAGE sequesters CHE1 in the cytoplasm
type: GO_0003674
BFO_0000050: NRAGE signals death through JNK

NRAGE activates JNK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004705
BFO_0000050: NRAGE signals death through JNK
directly activates: JNK phosphorylates BIM, BAD and other targets
directly activates: Catalysis1767

p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: NRAGE signals death through JNK

GTP-bound RAC contributes to JNK activation
type: GO_0003674
BFO_0000050: NRAGE signals death through JNK
directly activates: JNK phosphorylates BIM, BAD and other targets
directly activates: Catalysis1767

JNK phosphorylates BIM, BAD and other targets
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: JNK1
type: GO_0004705
BFO_0000050: NRAGE signals death through JNK

Active JNK moves to the nucleus and phosphorylates different transcription factors
type: GO_0003674
BFO_0000050: NRAGE signals death through JNK

NRAGE signals death through JNK
type: GO_0008150