JNK1
MAPK8
PRKM8
SAPK1
SAPK1C
UniProt:P45983 MAPK8
NGF:p75NTR complex binds to NRAGE
NRAGE sequesters CHE1 in the cytoplasm
NRAGE activates JNK
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
GTP-bound RAC contributes to JNK activation
JNK phosphorylates BIM, BAD and other targets
Active JNK moves to the nucleus and phosphorylates different transcription factors
NRAGE signals death through JNK