MSK1
RPS6KA5
UniProt:O75582 RPS6KA5
CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
MAPKAPK2
UniProt:P49137 MAPKAPK2
BMK1
ERK5
MAPK7
PRKM7
UniProt:Q13164 MAPK7
RNF85
TRAF6
UniProt:Q9Y4K3 TRAF6
TRAF6 binds MEKK1
Activated TAK1 mediates phosphorylation of the IKK Complex
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
Released NFkB complex is transported to nucleus
Activated TAK1 phosphorylates MKK4/MKK7
Phosphorylation of human JNKs by activated MKK4/MKK7
Activated human JNKs migrate to nucleoplasm
activated human TAK1 phosphorylates MKK3/MKK6
phosphorylated MKK3/MKK6 migrates to nucleus
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
Active p38 MAPK phosphorylates MAPKAPK2 or 3
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
ERK1/2 activates ELK1
ERK1/2 phosphorylates MSK1
p38MAPK phosphorylates MSK1
ERK1/2/5 activate RSK1/2/3
ERK5 activates the transcription factor MEF2
ERKs are inactivated by protein phosphatase 2A
ERKs are inactivated by dual-specific phosphatases (DUSPs)
MSK1 activates CREB
MSK1 activates ATF1
RSK1/2/3 phosphorylates CREB at Serine 133
MAPKAPK2 phosphorylates CREB at Serine 133
Phosphorylated MAPKs phosphorylate ATF-2
Activated JNKs phosphorylate c-JUN
c-FOS activation by phospho ERK1/2
Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
MyD88 interacts with the activated TLR receptor 7, 8 or 9
MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9.
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation
Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
Dimerization of p-IRF7
Translocation of p-IRF7:p-IRF7 to nucleus
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
MAP kinase activation in TLR cascade
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
activated TAK1 mediates p38 MAPK activation
ERK activation
ERK1 activation
ERK2 activation
MAPK targets/ Nuclear events mediated by MAP kinases
ERK/MAPK targets
ERKs are inactivated
CREB phosphorylation
Activation of the AP-1 family of transcription factors
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling