MSK1
label: RPS6KA5
label: UniProt:O75582 RPS6KA5

CDC2
label: CDC28A
label: CDK1
label: CDKN1
label: P34CDC2
label: UniProt:P06493 CDK1

MAPKAPK2
label: UniProt:P49137 MAPKAPK2

BMK1
label: ERK5
label: MAPK7
label: PRKM7
label: UniProt:Q13164 MAPK7

RNF85
label: TRAF6
label: UniProt:Q9Y4K3 TRAF6

TRAF6 binds MEKK1
type: GO_0003674
BFO_0000050: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Activated TAK1 mediates phosphorylation of the IKK Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
directly activates: BiochemicalReaction1425
directly activates: Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
directly activates: Catalysis337
directly activates: Catalysis516

Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
directly activates: Released NFkB complex is transported to nucleus
directly activates: Control55
directly activates: Control56

Released NFkB complex is transported to nucleus
type: GO_0003674
BFO_0000050: TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Activated TAK1 phosphorylates MKK4/MKK7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
directly activates: Phosphorylation of human JNKs by activated MKK4/MKK7
directly activates: Catalysis339

Phosphorylation of human JNKs by activated MKK4/MKK7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008545
BFO_0000050: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
directly activates: Activated human JNKs migrate to nucleoplasm

Activated human JNKs migrate to nucleoplasm
type: GO_0003674
BFO_0000050: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
directly activates: Phosphorylated MAPKs phosphorylate ATF-2
directly activates: Activated JNKs phosphorylate c-JUN
directly activates: Catalysis357
directly activates: Catalysis358

activated human TAK1 phosphorylates MKK3/MKK6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: activated TAK1 mediates p38 MAPK activation
directly activates: phosphorylated MKK3/MKK6 migrates to nucleus

phosphorylated MKK3/MKK6 migrates to nucleus
type: GO_0003674
BFO_0000050: activated TAK1 mediates p38 MAPK activation
directly activates: Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
directly activates: Catalysis341

Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004712
BFO_0000050: activated TAK1 mediates p38 MAPK activation
directly activates: Active p38 MAPK phosphorylates MAPKAPK2 or 3
directly activates: Phosphorylated MAPKs phosphorylate ATF-2
directly activates: Catalysis342
directly activates: Catalysis357

Active p38 MAPK phosphorylates MAPKAPK2 or 3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: activated TAK1 mediates p38 MAPK activation
directly activates: Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3

Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
type: GO_0003674
BFO_0000050: activated TAK1 mediates p38 MAPK activation

Inactivation of MEK1 by p34cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: GO_0004674
BFO_0000050: ERK1 activation

MEK1 binds ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: MEK1 phosphorylates ERK-1
directly activates: Catalysis344
directly activates: Control57

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation
directly activates: Dissociation of phospho-ERK-1:MEK1

Dissociation of phospho-ERK-1:MEK1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Dimerisation of phospho-ERK-1

Dimerisation of phospho-ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Nuclear translocation of phospho-ERK-1 dimer

Nuclear translocation of phospho-ERK-1 dimer
type: GO_0000189
BFO_0000050: ERK1 activation
directly activates: ERK1/2 activates ELK1
directly activates: ERK1/2 phosphorylates MSK1
directly activates: ERK1/2/5 activate RSK1/2/3
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

MEK2 binds ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: MEK2 phosphorylates ERK-2
directly activates: Catalysis345

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK2 activation
directly activates: Dissociation of phospho-ERK-2:MEK2

Dissociation of phospho-ERK-2:MEK2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Dimerisation of phospho-ERK-2

Dimerisation of phospho-ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Nuclear translocation of phospho-ERK-2 dimer

Nuclear translocation of phospho-ERK-2 dimer
type: GO_0000189
BFO_0000050: ERK2 activation
directly activates: ERK1/2 activates ELK1
directly activates: ERK1/2 phosphorylates MSK1
directly activates: ERK1/2/5 activate RSK1/2/3
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

ERK1/2 activates ELK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets

ERK1/2 phosphorylates MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets
directly activates: MSK1 activates CREB
directly activates: MSK1 activates ATF1
directly activates: Catalysis353
directly activates: Catalysis354

p38MAPK phosphorylates MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets
directly activates: MSK1 activates CREB
directly activates: MSK1 activates ATF1
directly activates: Catalysis353
directly activates: Catalysis354

ERK1/2/5 activate RSK1/2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets
directly activates: RSK1/2/3 phosphorylates CREB at Serine 133
directly activates: Catalysis355

ERK5 activates the transcription factor MEF2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets

ERKs are inactivated by protein phosphatase 2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004722
BFO_0000050: ERK/MAPK targets
BFO_0000050: ERKs are inactivated

ERKs are inactivated by dual-specific phosphatases (DUSPs)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004725
BFO_0000050: ERKs are inactivated

MSK1 activates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CREB phosphorylation

MSK1 activates ATF1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CREB phosphorylation

RSK1/2/3 phosphorylates CREB at Serine 133
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CREB phosphorylation

MAPKAPK2 phosphorylates CREB at Serine 133
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CREB phosphorylation

Phosphorylated MAPKs phosphorylate ATF-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Activation of the AP-1 family of transcription factors
directly activates: Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.

Activated JNKs phosphorylate c-JUN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004705
BFO_0000050: Activation of the AP-1 family of transcription factors
directly activates: Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
directly activates: Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

c-FOS activation by phospho ERK1/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Activation of the AP-1 family of transcription factors
directly activates: Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
type: GO_0003674
BFO_0000050: Activation of the AP-1 family of transcription factors

Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
type: GO_0003674
BFO_0000050: Activation of the AP-1 family of transcription factors

MyD88 interacts with the activated TLR receptor 7, 8 or 9
type: GO_0003674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88

MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
type: GO_0003674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex

IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
type: GO_0003674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
directly activates: Catalysis365

IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9.

IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9.
type: GO_0003674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
directly activates: First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
directly activates: Catalysis366
directly activates: Catalysis367

Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9

First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
directly activates: Catalysis368

Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
directly activates: Catalysis369

Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9

TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
type: GO_0003674
BFO_0000050: MyD88 dependent cascade initiated on endosome
directly activates: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
directly activates: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation

Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
type: GO_0003674
BFO_0000050: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
directly activates: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments

Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
type: GO_0003674
BFO_0000050: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
directly activates: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
directly activates: Catalysis370

IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004672
BFO_0000050: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
directly activates: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
directly activates: Catalysis371

Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0034450
BFO_0000050: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
directly activates: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.

NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
type: GO_0003674
BFO_0000050: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
type: GO_0003674
BFO_0000050: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
directly activates: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
directly activates: Catalysis372

Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004842
BFO_0000050: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
directly activates: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
directly activates: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
directly activates: Catalysis373

Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RNF85
type: Restriction
  on property: enabled by
  some values from: RNF85
type: Restriction
  on property: enabled by
  some values from: RNF85
type: Restriction
  on property: enabled by
  some values from: RNF85
type: GO_0004842
BFO_0000050: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
directly activates: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation

Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
type: GO_0003674
BFO_0000050: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
directly activates: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation

Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
type: GO_0003674
BFO_0000050: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
directly activates: TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation
directly activates: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
directly activates: Catalysis374

TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004842
BFO_0000050: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling

Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
directly activates: Dimerization of p-IRF7

Dimerization of p-IRF7
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
directly activates: Translocation of p-IRF7:p-IRF7 to nucleus
directly activates: Control66

Translocation of p-IRF7:p-IRF7 to nucleus
type: GO_0003674
BFO_0000050: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
directly activates: BiochemicalReaction1129

TAK1 activates NFkB by phosphorylation and activation of IKKs complex
type: GO_0008150
BFO_0000050: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

MAP kinase activation in TLR cascade
type: GO_0008150
BFO_0000050: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
type: GO_0008150
BFO_0000050: MAP kinase activation in TLR cascade

activated TAK1 mediates p38 MAPK activation
type: GO_0008150
BFO_0000050: MAP kinase activation in TLR cascade

ERK activation
type: GO_0008150
BFO_0000050: MAP kinase activation in TLR cascade

ERK1 activation
type: GO_0008150
BFO_0000050: ERK activation

ERK2 activation
type: GO_0008150
BFO_0000050: ERK activation

MAPK targets/ Nuclear events mediated by MAP kinases
type: GO_0008150
BFO_0000050: MAP kinase activation in TLR cascade

ERK/MAPK targets
type: GO_0008150
BFO_0000050: MAPK targets/ Nuclear events mediated by MAP kinases

ERKs are inactivated
type: GO_0008150
BFO_0000050: ERK/MAPK targets

CREB phosphorylation
type: GO_0008150
BFO_0000050: MAPK targets/ Nuclear events mediated by MAP kinases

Activation of the AP-1 family of transcription factors
type: GO_0008150
BFO_0000050: MAPK targets/ Nuclear events mediated by MAP kinases

MyD88 dependent cascade initiated on endosome
type: GO_0008150

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
type: GO_0008150
BFO_0000050: MyD88 dependent cascade initiated on endosome

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
type: GO_0008150
BFO_0000050: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
type: GO_0008150
BFO_0000050: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
type: GO_0008150
BFO_0000050: MyD88 dependent cascade initiated on endosome