GDA
label: SLC25A16
label: UniProt:P16260 SLC25A16

ABCC1
label: MRP
label: MRP1
label: UniProt:P33527 ABCC1

FLOT1
label: RFC1
label: SLC19A1
label: UniProt:P41440 SLC19A1

BTD
label: UniProt:P43251 BTD

NAMPT
label: PBEF
label: PBEF1
label: UniProt:P43490 NAMPT

HLCS
label: UniProt:P50747 HLCS

FPGS
label: UniProt:Q05932-1 FPGS

FPGS
label: UniProt:Q05932-2 FPGS

COASY
label: PSEC0106
label: UniProt:Q13057 COASY

QPRT
label: UniProt:Q15274 QPRT

FLAD1
label: PP591
label: UniProt:Q8NFF5 FLAD1

HCP1
label: PCFT
label: SLC46A1
label: UniProt:Q96NT5 SLC46A1

C20orf48
label: PANK2
label: UniProt:Q9BZ23 PANK2

MFT
label: MFTC
label: SLC25A32
label: UniProt:Q9H2D1 SLC25A32

8D6A
label: CD320
label: UNQ198/PRO224
label: UniProt:Q9NPF0 CD320

C20orf54
label: RFT2
label: SLC52A3
label: UniProt:Q9NQ40 SLC52A3

AASDHPPT
label: CGI-80
label: HAH-P
label: HSPC223
label: UniProt:Q9NRN7 AASDHPPT
label: x0005

BM-021
label: C6orf209
label: CD001
label: LMBRD1
label: MSTP044
label: NESI
label: UniProt:Q9NUN5 LMBRD1

SLC5A6
label: SMVT
label: UniProt:Q9Y289 SLC5A6

MMACHC
label: UniProt:Q9Y4U1 MMACHC

L-methylmalonyl-CoA <=> succinyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004494
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: BiochemicalReaction5414
directly activates: BiochemicalReaction5415
directly activates: Catalysis2610
directly activates: Catalysis2611
label: MUT transfers adenosyl group from AdoCbl to L-MM-CoA

Dehydroascorbate transport across the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0033300
BFO_0000050: Vitamin C (ascorbate) metabolism
label: GLUT1/3 transports extracellular DHvitC to cytosol
label: dehydroascorbate [extracellular] => dehydroascorbate [cytosol]

Ascorbate transport across the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015229
BFO_0000050: Vitamin C (ascorbate) metabolism
label: SVCT1/2 cotransports extracellular VitC and 2Na+ to cytosol
label: ascorbate [extracellular] + 2 Na+ [extracellular] => ascorbate [cytosol] + 2 Na+ [cytosol]

CYB5A:heme reduces SDA to VitC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004033
BFO_0000050: Vitamin C (ascorbate) metabolism
directly activates: CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme
directly activates: Catalysis2741
label: Reduction of semidehydroascorbate to ascorbate

CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004128
BFO_0000050: Vitamin C (ascorbate) metabolism
directly activates: CYB5A:heme reduces SDA to VitC
directly activates: Catalysis2740
label: ferric CYB5A + NADH + H+ => ferrous CYPB5A + NAD+

2xGSTOs reduce DHvitC to VitC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0045174
BFO_0000050: Vitamin C (ascorbate) metabolism
directly activates: BiochemicalReaction5531
directly activates: Catalysis2717
label: dehydroascorbate (DHA) + 2 glutathione (GSH) => ascorbate + oxidized glutathione (GSSG)

SLC19A2/3 transport extracellular THMN to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015234
BFO_0000050: Vitamin B1 (thiamin) metabolism
directly activates: 2xTPK1:Mg2+ phosphorylates THMN
directly activates: Catalysis2744
label: Thiamin transport across the plasma membrane
label: thiamin [extracellular] => thiamin [cytosol]

2xTPK1:Mg2+ phosphorylates THMN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004788
BFO_0000050: Vitamin B1 (thiamin) metabolism
directly activates: TDPK phosphorylates ThDP to ThTP
directly activates: Catalysis2745
label: Thiamin is pyrophosphorylated

TDPK phosphorylates ThDP to ThTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050331
BFO_0000050: Vitamin B1 (thiamin) metabolism
directly activates: THTPA:Mg2+ hydrolyzes ThTP to TDP
directly activates: Catalysis2746
label: ThDP + ATP <-> ThTP + ADP

THTPA:Mg2+ hydrolyzes ThTP to TDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050333
BFO_0000050: Vitamin B1 (thiamin) metabolism
label: Thiamin triphosphate can be hydrolysed back to thiamin diphosphate

SLC52A3 transports extracellular RIB to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: C20orf54
type: Restriction
  on property: enabled by
  some values from: C20orf54
type: Restriction
  on property: enabled by
  some values from: C20orf54
type: Restriction
  on property: enabled by
  some values from: C20orf54
type: GO_0032217
BFO_0000050: Vitamin B2 (riboflavin) metabolism

RFK:Mg2+ phosphorylates RIB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008531
BFO_0000050: Vitamin B2 (riboflavin) metabolism
directly activates: FLAD1 phosphorylates FMN
directly activates: Catalysis2749

FLAD1 phosphorylates FMN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FLAD1
type: Restriction
  on property: enabled by
  some values from: FLAD1
type: Restriction
  on property: enabled by
  some values from: FLAD1
type: Restriction
  on property: enabled by
  some values from: FLAD1
type: GO_0003919
BFO_0000050: Vitamin B2 (riboflavin) metabolism
directly activates: 2xENPP1 hydrolyzes FAD to FMN
directly activates: Catalysis2750
label: FMN is futher phosphorylated to FAD

2xENPP1 hydrolyzes FAD to FMN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004551
BFO_0000050: Vitamin B2 (riboflavin) metabolism
directly activates: FLAD1 phosphorylates FMN
directly activates: 2xTRAP hydrolyzes FMN to RIB
directly activates: Catalysis2749
directly activates: Catalysis2751
label: FAD can be hydrolyzed back to FMN

2xTRAP hydrolyzes FMN to RIB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003993
BFO_0000050: Vitamin B2 (riboflavin) metabolism
directly activates: RFK:Mg2+ phosphorylates RIB
directly activates: Catalysis2748
label: FMN can be hydrolyzed back to riboflavin

SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: GO_0008523
BFO_0000050: Vitamin B5 (pantothenate) metabolism
directly activates: PANK2 phosphorylates PanK
directly activates: PANK1/3/4 phosphorylate PanK
directly activates: Catalysis2753
directly activates: Catalysis2754
label: pantothenate [extracellular] + 2 Na+ [extracellular] => pantothenate [cytosol] + 2 Na+ [cytosol]

PANK2 phosphorylates PanK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: Restriction
  on property: enabled by
  some values from: C20orf48
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: GO_0004594
BFO_0000050: Coenzyme A biosynthesis
directly activates: 2xPPCS ligates PPanK with Cys
directly activates: Catalysis2755
label: Pantothenate is phosphorylated [PANK2]

PANK1/3/4 phosphorylate PanK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004594
BFO_0000050: Coenzyme A biosynthesis
directly activates: 2xPPCS ligates PPanK with Cys
directly activates: Catalysis2755
label: Pantothenate is phosphorylated [PANK1;3;4]
label: pantothenate + ATP => phosphopanthothenate + ADP

2xPPCS ligates PPanK with Cys
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004632
BFO_0000050: Coenzyme A biosynthesis
directly activates: 3xPPCDC:3FMN decarboxylates PPC
directly activates: Catalysis2756
label: Condensation of phosphopantothenate with cysteine

3xPPCDC:3FMN decarboxylates PPC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004633
BFO_0000050: Coenzyme A biosynthesis
directly activates: Adenylation of phosphopantetheine
directly activates: Catalysis2757
label: Phosphopantothenoylcysteine is decarboxylated

Adenylation of phosphopantetheine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004595
BFO_0000050: Coenzyme A biosynthesis
directly activates: COASY phosphorylates DP-CoA
directly activates: Catalysis2758
label: COASY transfers an adenylyl group from ATP to PPANT

COASY phosphorylates DP-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: enabled by
  some values from: COASY
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: GO_0004140
BFO_0000050: Coenzyme A biosynthesis
directly activates: CoA-SH + FAS apoenzyme => adenosine 3',5'-bisphosphate + FAS holoenzyme
directly activates: Catalysis2760
label: Phosphorylation of dephospho-CoA to produce CoA

CoA transport across the inner mitochondrial membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: enabled by
  some values from: GDA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0015291
BFO_0000050: Coenzyme A biosynthesis
label: SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix

CoA-SH + FAS apoenzyme => adenosine 3',5'-bisphosphate + FAS holoenzyme
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AASDHPPT
type: Restriction
  on property: enabled by
  some values from: AASDHPPT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AASDHPPT
type: Restriction
  on property: enabled by
  some values from: AASDHPPT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008897
BFO_0000050: Vitamin B5 (pantothenate) metabolism
label: Phosphopantetheine conjugation of the ACP domain of FAS

2xPDXK:2xZn2+ phosphorylates PXL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008478
BFO_0000050: Vitamins B6 activation to pyridoxal phosphate
label: PLP results from phosphorylation of pyridoxal

2xPDXK:2xZn2+ phosphorylates PXA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008478
BFO_0000050: Vitamins B6 activation to pyridoxal phosphate
directly activates: 2xPNPO:2xFMN oxidizes PXAP to PXLP
directly activates: Catalysis2764
label: Pyridoxamine is phosphorylated

2xPDKX:2xZn2+ phosphorylates PDX
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008478
BFO_0000050: Vitamins B6 activation to pyridoxal phosphate
directly activates: 2xPNPO:2xFMN oxidizes PDXP to PXLP
directly activates: Catalysis2765
label: Pyridoxine is phosphorylated

2xPNPO:2xFMN oxidizes PXAP to PXLP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004733
BFO_0000050: Vitamins B6 activation to pyridoxal phosphate
label: PLP from oxidation of pyridoxamine phosphate

2xPNPO:2xFMN oxidizes PDXP to PXLP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004733
BFO_0000050: Vitamins B6 activation to pyridoxal phosphate
label: PLP from oxidation of pyridoxine phosphate

AOX1 oxidises PXL to PDXate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004031
BFO_0000050: Vitamins B6 activation to pyridoxal phosphate

TCN1 binds Cbl
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: Pancreatic proteases degrade TCN1:Cbl
directly activates: Catalysis2767

Pancreatic proteases degrade TCN1:Cbl
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0008236
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: GIF binds Cbl

GIF binds Cbl
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: CUBN:AMN binds GIF:Cbl

CUBN:AMN binds GIF:Cbl
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: CUBN:AMN transports extracellular GIF:Cbl to endosome

CUBN:AMN transports extracellular GIF:Cbl to endosome
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: Endosomal GIF:Cbl translocates to lysosome

Endosomal GIF:Cbl translocates to lysosome
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: GIF:Cbl is degraded to release Cbl

GIF:Cbl is degraded to release Cbl
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: LMBRD1 transports lysosomal Cbl to cytosol
directly activates: Catalysis2768

LMBRD1 transports lysosomal Cbl to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: enabled by
  some values from: BM-021
type: Restriction
  on property: enabled by
  some values from: BM-021
type: Restriction
  on property: enabled by
  some values from: BM-021
type: Restriction
  on property: enabled by
  some values from: BM-021
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: GO_0015235
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MMACHC reduces Cbl
directly activates: ABCC1 transports cytosolic Cbl to extracellular region
directly activates: Catalysis2769
directly activates: Catalysis2776

MMACHC reduces Cbl
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MMACHC
type: Restriction
  on property: enabled by
  some values from: MMACHC
type: Restriction
  on property: enabled by
  some values from: MMACHC
type: Restriction
  on property: enabled by
  some values from: MMACHC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016491
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MMACHC:B12r binds MMADHC

MMACHC decyanates CNCbl
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MMACHC
type: Restriction
  on property: enabled by
  some values from: MMACHC
type: Restriction
  on property: enabled by
  some values from: MMACHC
type: Restriction
  on property: enabled by
  some values from: MMACHC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0033787
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MMACHC:B12r binds MMADHC
label: MMACHC reductively decyanates CNCbl

MMACHC:B12r binds MMADHC
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: B12r dissociates from MMACHC:MMADHC
directly activates: MMADHC targets cytosolic B12r for entry to mitochondria

B12r dissociates from MMACHC:MMADHC
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: B12r binds to MTRR:MTR

B12r binds to MTRR:MTR
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MTRR reduces B12r to B12s
directly activates: Catalysis2771

MTRR reduces B12r to B12s
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030586
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MTR transfers CH3 group from MTHF to B12s
directly activates: Catalysis2772

MTR transfers CH3 group from MTHF to B12s
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008705
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MTR transfers CH3 group from MeCbl to HCYS
directly activates: Catalysis2773

MTR transfers CH3 group from MeCbl to HCYS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008705
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MTRR reduces B12r to B12s
directly activates: Catalysis2771
label: Methionine is reformed

MMADHC targets cytosolic B12r for entry to mitochondria
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MMAB reduces B12r to B12s
directly activates: Catalysis2774
label: MMADHC targets transport of cytosolic B12r to mitochondria

MMAB reduces B12r to B12s
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0050453
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MMAB transfers adenosyl group from ATP to B12s
directly activates: Catalysis2775

MMAB transfers adenosyl group from ATP to B12s
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008817
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: MMAA:MUT binds AdoCbl

MMAA:MUT binds AdoCbl
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: L-methylmalonyl-CoA <=> succinyl-CoA
directly activates: Catalysis2166

ABCC1 transports cytosolic Cbl to extracellular region
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCC1
type: Restriction
  on property: enabled by
  some values from: ABCC1
type: Restriction
  on property: enabled by
  some values from: ABCC1
type: Restriction
  on property: enabled by
  some values from: ABCC1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015420
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: TCN2 binds Cbl in the circulation
directly activates: TCN1 binds Cbl in the circulation

TCN2 binds Cbl in the circulation
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: CD320 transports extracellular TCN2:Cbl to endosome
directly activates: Catalysis2777

TCN1 binds Cbl in the circulation
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism

CD320 transports extracellular TCN2:Cbl to endosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: 8D6A
type: Restriction
  on property: enabled by
  some values from: 8D6A
type: Restriction
  on property: enabled by
  some values from: 8D6A
type: Restriction
  on property: enabled by
  some values from: 8D6A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015235
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: CD320:TCN2:Cbl dissociates into CD320 and TCN2:Cbl

CD320:TCN2:Cbl dissociates into CD320 and TCN2:Cbl
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: Endosomal TCN2:Cbl translocates to lysosome

Endosomal TCN2:Cbl translocates to lysosome
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism
directly activates: TCN2:Cbl is degraded to release Cbl

TCN2:Cbl is degraded to release Cbl
type: GO_0003674
BFO_0000050: Cobalamin (Cbl, vitamin B12) transport and metabolism

SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: Restriction
  on property: enabled by
  some values from: SLC5A6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008523
BFO_0000050: Biotin transport and metabolism
directly activates: HLCS biotinylates PCCA:PCCB
directly activates: HLCS biotinylates PC:Mn2+
directly activates: HLCS biotinylates MCCC1:MCCC2
directly activates: HLCS biotinylates ACACA/B:Mn2+
directly activates: Catalysis2779
directly activates: Catalysis2780
directly activates: Catalysis2781
directly activates: Catalysis2782
label: biotin [extracellular] + 2 Na+ [extracellular] => biotin [cytosol] + 2 Na+ [cytosol]

HLCS biotinylates PCCA:PCCB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018271
BFO_0000050: Biotin transport and metabolism
directly activates: Cytoslic carboxylases translocate to mitochondrial matrix
directly activates: An unknown protease degrades hCBXs
directly activates: Catalysis2783

HLCS biotinylates PC:Mn2+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0018271
BFO_0000050: Biotin transport and metabolism
directly activates: Cytoslic carboxylases translocate to mitochondrial matrix
directly activates: An unknown protease degrades hCBXs
directly activates: Catalysis2783

HLCS biotinylates MCCC1:MCCC2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: GO_0018271
BFO_0000050: Biotin transport and metabolism
directly activates: Cytoslic carboxylases translocate to mitochondrial matrix
directly activates: An unknown protease degrades hCBXs
directly activates: Catalysis2783

Cytoslic carboxylases translocate to mitochondrial matrix
type: GO_0003674
BFO_0000050: Biotin transport and metabolism

HLCS biotinylates ACACA/B:Mn2+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: Restriction
  on property: enabled by
  some values from: HLCS
type: GO_0018271
BFO_0000050: Biotin transport and metabolism
directly activates: An unknown protease degrades ACACA/B:Mn2+
directly activates: Catalysis2784

An unknown protease degrades hCBXs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0070011
BFO_0000050: Biotin transport and metabolism
directly activates: BCTN translocates to extracellular region

An unknown protease degrades ACACA/B:Mn2+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0070011
BFO_0000050: Biotin transport and metabolism
directly activates: BCTN translocates to extracellular region

BCTN translocates to extracellular region
type: GO_0003674
BFO_0000050: Biotin transport and metabolism
directly activates: BTD hydrolyses BCTN
directly activates: Catalysis2785

BTD hydrolyses BCTN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: BTD
type: Restriction
  on property: enabled by
  some values from: BTD
type: Restriction
  on property: enabled by
  some values from: BTD
type: Restriction
  on property: enabled by
  some values from: BTD
type: GO_0047708
BFO_0000050: Biotin transport and metabolism

2-amino 3-carboxymuconate semialdehyde transforms non-enzymatically to quinolinate
type: GO_0003674
BFO_0000050: Nicotinate metabolism
directly activates: A phospho-ribosyl group is added to quinolinate
directly activates: Catalysis2786

A phospho-ribosyl group is added to quinolinate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: QPRT
type: Restriction
  on property: enabled by
  some values from: QPRT
type: Restriction
  on property: enabled by
  some values from: QPRT
type: Restriction
  on property: enabled by
  some values from: QPRT
type: GO_0004514
BFO_0000050: Nicotinate metabolism
directly activates: Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1]
directly activates: Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2]
directly activates: Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]
directly activates: Catalysis2787
directly activates: Catalysis2788
directly activates: Catalysis2789

Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000309
BFO_0000050: Nicotinate metabolism
directly activates: Amidation of deamino-NAD+ to NAD+
directly activates: Catalysis2790

Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000309
BFO_0000050: Nicotinate metabolism
directly activates: Amidation of deamino-NAD+ to NAD+
directly activates: Catalysis2790

Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000309
BFO_0000050: Nicotinate metabolism
directly activates: Amidation of deamino-NAD+ to NAD+
directly activates: Catalysis2790

Amidation of deamino-NAD+ to NAD+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003952
BFO_0000050: Nicotinate metabolism
directly activates: NAD+ is phosphorylated to NADP+
directly activates: Catalysis2791

NAD+ is phosphorylated to NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003951
BFO_0000050: Nicotinate metabolism

Deamination of nicotinamide to nicotinate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008936
BFO_0000050: Nicotinamide salvaging
directly activates: A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN)
directly activates: Catalysis2794
directly activates: Control476

Condensation of nicotinamide to nicotinamide D-ribonucleotide (NMN)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: NAMPT
type: Restriction
  on property: enabled by
  some values from: NAMPT
type: Restriction
  on property: enabled by
  some values from: NAMPT
type: Restriction
  on property: enabled by
  some values from: NAMPT
type: Restriction
  on property: enabled by
  some values from: NAMPT
type: Restriction
  on property: enabled by
  some values from: NAMPT
type: Restriction
  on property: enabled by
  some values from: NAMPT
type: Restriction
  on property: enabled by
  some values from: NAMPT
type: GO_0047280
BFO_0000050: Nicotinamide salvaging
directly activates: Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1]
directly activates: Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2]
directly activates: Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3]
directly activates: Catalysis2787
directly activates: Catalysis2788
directly activates: Catalysis2789

A phosphoribosyl group is added to nicotinate to form nicotinate mononucleotide (NaMN)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004516
BFO_0000050: Nicotinamide salvaging

Extracellular folate import across the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: HCP1
type: Restriction
  on property: enabled by
  some values from: HCP1
type: Restriction
  on property: enabled by
  some values from: HCP1
type: Restriction
  on property: enabled by
  some values from: HCP1
type: GO_0008517
BFO_0000050: Metabolism of folate and pterines
directly activates: Folate is reduced to dihydrofolate (DHF)
directly activates: Catalysis2798

Cytosolic folate export across the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: HCP1
type: Restriction
  on property: enabled by
  some values from: HCP1
type: Restriction
  on property: enabled by
  some values from: HCP1
type: Restriction
  on property: enabled by
  some values from: HCP1
type: GO_0008517
BFO_0000050: Metabolism of folate and pterines

Extracellular 5-methyltetrahydrofolate import across the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: FLOT1
type: Restriction
  on property: enabled by
  some values from: FLOT1
type: Restriction
  on property: enabled by
  some values from: FLOT1
type: Restriction
  on property: enabled by
  some values from: FLOT1
type: GO_0008517
BFO_0000050: Metabolism of folate and pterines
directly activates: Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate
directly activates: Catalysis2801

Folate is reduced to dihydrofolate (DHF)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0033560
BFO_0000050: Metabolism of folate and pterines
directly activates: DHF is reduced to tetrahydrofolate (THF)
directly activates: Catalysis2799

DHF is reduced to tetrahydrofolate (THF)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0033560
BFO_0000050: Metabolism of folate and pterines
directly activates: Conversion of cytosolic THF to THF-polyglutamate
directly activates: Cytosolic tetrahydrofolate import across the inner mitochondrial membrane
directly activates: Catalysis2800
directly activates: Catalysis2802

Conversion of cytosolic THF to THF-polyglutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: GO_0004326
BFO_0000050: Metabolism of folate and pterines
directly activates: THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate
directly activates: Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine
directly activates: Catalysis2805
directly activates: Catalysis2808

Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: GO_0004326
BFO_0000050: Metabolism of folate and pterines
directly activates: MTR transfers CH3 group from MeCbl to HCYS
directly activates: Catalysis2773

Cytosolic tetrahydrofolate import across the inner mitochondrial membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: MFT
type: Restriction
  on property: enabled by
  some values from: MFT
type: Restriction
  on property: enabled by
  some values from: MFT
type: Restriction
  on property: enabled by
  some values from: MFT
type: GO_0008517
BFO_0000050: Metabolism of folate and pterines
directly activates: Conversion of mitochondrial THF to THF-polyglutamate
directly activates: Catalysis2804

Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: enabled by
  some values from: MFT
type: Restriction
  on property: enabled by
  some values from: MFT
type: Restriction
  on property: enabled by
  some values from: MFT
type: Restriction
  on property: enabled by
  some values from: MFT
type: GO_0008517
BFO_0000050: Metabolism of folate and pterines

Conversion of mitochondrial THF to THF-polyglutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: Restriction
  on property: enabled by
  some values from: FPGS
type: GO_0004326
BFO_0000050: Metabolism of folate and pterines

THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004329
BFO_0000050: Metabolism of folate and pterines
directly activates: 10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O
directly activates: Catalysis2806

10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004477
BFO_0000050: Metabolism of folate and pterines
directly activates: 5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+
directly activates: Catalysis2807

5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004486
BFO_0000050: Metabolism of folate and pterines
directly activates: 5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
directly activates: Catalysis2809

Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004372
BFO_0000050: Metabolism of folate and pterines
directly activates: 5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
directly activates: Catalysis2809

5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004489
BFO_0000050: Metabolism of folate and pterines
directly activates: MTR transfers CH3 group from MeCbl to HCYS
directly activates: Catalysis2773

5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004372
BFO_0000050: Metabolism of folate and pterines

5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004486
BFO_0000050: Metabolism of folate and pterines
directly activates: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
directly activates: Catalysis2812

5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004477
BFO_0000050: Metabolism of folate and pterines

Cyclisation of GTP to precursor Z
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0070283
BFO_0000050: Molybdenum cofactor biosynthesis
directly activates: Sulfhydrylation and ring cleavage of precursor Z
directly activates: Catalysis2816

NFS1 transfers sulfur from cysteine onto MOCS3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0031071
BFO_0000050: Molybdenum cofactor biosynthesis
directly activates: Transfer of sulfur from MOCS3-S-S onto MOCS2A
directly activates: Catalysis2815

Transfer of sulfur from MOCS3-S-S onto MOCS2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016783
BFO_0000050: Molybdenum cofactor biosynthesis
directly activates: Sulfhydrylation and ring cleavage of precursor Z
directly activates: Catalysis2816

Sulfhydrylation and ring cleavage of precursor Z
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0030366
BFO_0000050: Molybdenum cofactor biosynthesis
directly activates: Molybdenum ion transfer onto molybdopterin
directly activates: Catalysis2817

Molybdenum ion transfer onto molybdopterin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0016740
BFO_0000050: Molybdenum cofactor biosynthesis
directly activates: Exchange of oxygen with sulfur in MoCo
directly activates: Catalysis2818

Exchange of oxygen with sulfur in MoCo
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008265
BFO_0000050: Molybdenum cofactor biosynthesis

Metabolism of vitamins and cofactors
type: GO_0008150

Metabolism of water-soluble vitamins and cofactors
type: GO_0008150
BFO_0000050: Metabolism of vitamins and cofactors

Vitamin C (ascorbate) metabolism
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Vitamin B1 (thiamin) metabolism
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Vitamin B2 (riboflavin) metabolism
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Vitamin B5 (pantothenate) metabolism
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Coenzyme A biosynthesis
type: GO_0008150
BFO_0000050: Vitamin B5 (pantothenate) metabolism

Vitamins B6 activation to pyridoxal phosphate
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Cobalamin (Cbl, vitamin B12) transport and metabolism
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Biotin transport and metabolism
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Nicotinate metabolism
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Nicotinamide salvaging
type: GO_0008150
BFO_0000050: Nicotinate metabolism

Metabolism of folate and pterines
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors

Molybdenum cofactor biosynthesis
type: GO_0008150
BFO_0000050: Metabolism of water-soluble vitamins and cofactors