PKCA
PRKACA
PRKCA
UniProt:P17252 PRKCA
AKT1
PKB
RAC
UniProt:P31749 AKT1
MAPKAPK2
UniProt:P49137 MAPKAPK2
PRKCD
UniProt:Q05655 PRKCD
SEP1
UniProt:Q8IZH2 XRN1
XRN1
KIAA0221
RENT1
UPF1
UniProt:Q92900 UPF1
DCPS
DCS1
HINT5
HSPC015
UniProt:Q96C86 DCPS
Partial Deadenylation of mRNA by the PAN2-PAN3 Complex
Deadenylation of mRNA by PARN
Deadenylation of mRNA by the CCR4-NOT Complex
3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex
Scavenging of the 7-methylguanosine Cap by DCPS
Binding of Lsm1-7 Complex to Deadenylated mRNA
Decapping of mRNA by the DCP1-DCP2 Complex
5' to 3' Exoribonuclease Digestion of Decapped mRNA
UPF1 Binds an mRNP with a Termination Codon Preceding an Exon Junction Complex
SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)
Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A
SMG6 Cleaves mRNA with Premature Termination Codon
Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
Formation of UPF1:eRF3 Complex on mRNA with a Premature Termination Codon and No Exon Junction Complex
AUF1(hnRNP D0) Dimers Bind AU-rich Element in 3' UTR of Transcripts
Association of AUF1 with Translation and Heat Shock Proteins
Ubiquitination of AUF1 (hnRNP D0)
Destruction of AUF1 and mRNA
Butyrate Response Factor1 (BRF1) Binds AU-rich Element in 3' UTR of mRNA
BRF1 Complex Recruits RNA Degradation Activities
Phosphorylation of BRF1 by Protein Kinase B/Akt
Phosphorylation of BRF1 by MK2
Phosphorylated BRF1 (Ser92, Ser203) Binds 14-3-3
Phosphorylated BRF1 (Ser54, Ser92, Ser203) Binds 14-3-3
Tristetraproline (TTP) Binds AU-rich Elements in 3' UTR of Target mRNAs
TTP Recruits RNA Degradation Activities
Phosphorylation of Tristetraproline (TTP) by MK2
Phosphorylated Tristetraproline (TTP) binds 14-3-3beta
KSRP Binds AU-rich Element in 3' UTR of mRNA
KSRP Recruits RNA Degradation Activities
Phosphorylation of KSRP by Protein Kinase B/Akt
Phosphorylated KSRP (Ser193) Binds 14-3-3zeta in the Nucleus
Phosphorylation of KSRP by MAP kinase p38
Phosphorylation of HuR by PKCalpha
Phosphorylation of HuR by PKCdelta
Phosphorylated HuR (Ser221, Ser158) Binds mRNA
Phosphorylated HuR (Ser221, Ser318) Binds mRNA
HuR Binds mRNAs in the Nucleus
Association of HuR with the CRM1 Nuclear Export Machinery
Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm
Deadenylation-dependent mRNA decay
Deadenylation of mRNA
mRNA Decay by 3' to 5' Exoribonuclease
mRNA Decay by 5' to 3' Exoribonuclease
Nonsense-Mediated Decay
Nonsense Mediated Decay Enhanced by the Exon Junction Complex
Nonsense Mediated Decay Independent of the Exon Junction Complex
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Destabilization of mRNA by AUF1 (hnRNP D0)
Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
Destabilization of mRNA by Tristetraprolin (TTP)
Destabilization of mRNA by KSRP
Stabilization of mRNA by HuR
Metabolism of mRNA