PKCA
label: PRKACA
label: PRKCA
label: UniProt:P17252 PRKCA

AKT1
label: PKB
label: RAC
label: UniProt:P31749 AKT1

MAPKAPK2
label: UniProt:P49137 MAPKAPK2

PRKCD
label: UniProt:Q05655 PRKCD

SEP1
label: UniProt:Q8IZH2 XRN1
label: XRN1

KIAA0221
label: RENT1
label: UPF1
label: UniProt:Q92900 UPF1

DCPS
label: DCS1
label: HINT5
label: HSPC015
label: UniProt:Q96C86 DCPS

HCA137
label: NCOA6IP
label: PIMT
label: TGS1
label: UniProt:Q96RS0 TGS1

Partial Deadenylation of mRNA by the PAN2-PAN3 Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004535
BFO_0000050: Deadenylation of mRNA
directly activates: Deadenylation of mRNA by PARN
directly activates: Deadenylation of mRNA by the CCR4-NOT Complex
directly activates: Catalysis187
directly activates: Catalysis188

Deadenylation of mRNA by PARN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004535
BFO_0000050: Deadenylation of mRNA
directly activates: 3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex
directly activates: Binding of Lsm1-7 Complex to Deadenylated mRNA
directly activates: Catalysis189

Deadenylation of mRNA by the CCR4-NOT Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004535
BFO_0000050: Deadenylation of mRNA
directly activates: 3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex
directly activates: Binding of Lsm1-7 Complex to Deadenylated mRNA
directly activates: Catalysis189

3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000175
BFO_0000050: mRNA Decay by 3' to 5' Exoribonuclease
directly activates: Scavenging of the 7-methylguanosine Cap by DCPS
directly activates: Catalysis190

Scavenging of the 7-methylguanosine Cap by DCPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004532
BFO_0000050: mRNA Decay by 3' to 5' Exoribonuclease

Binding of Lsm1-7 Complex to Deadenylated mRNA
type: GO_0003674
BFO_0000050: mRNA Decay by 5' to 3' Exoribonuclease
directly activates: Decapping of mRNA by the DCP1-DCP2 Complex
directly activates: Catalysis191

Decapping of mRNA by the DCP1-DCP2 Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016896
BFO_0000050: mRNA Decay by 5' to 3' Exoribonuclease
directly activates: 5' to 3' Exoribonuclease Digestion of Decapped mRNA
directly activates: Catalysis192

5' to 3' Exoribonuclease Digestion of Decapped mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004534
BFO_0000050: mRNA Decay by 5' to 3' Exoribonuclease

UPF1 Binds an mRNP with a Termination Codon Preceding an Exon Junction Complex
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)
directly activates: Catalysis193

SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A

Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: SMG6 Cleaves mRNA with Premature Termination Codon
directly activates: Catalysis194

SMG6 Cleaves mRNA with Premature Termination Codon
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004521
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
directly activates: Catalysis195
directly activates: Catalysis196

Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004004
type: GO_0004722
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex

Formation of UPF1:eRF3 Complex on mRNA with a Premature Termination Codon and No Exon Junction Complex
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Independent of the Exon Junction Complex

AUF1(hnRNP D0) Dimers Bind AU-rich Element in 3' UTR of Transcripts
type: GO_0003674
BFO_0000050: Destabilization of mRNA by AUF1 (hnRNP D0)
directly activates: Association of AUF1 with Translation and Heat Shock Proteins

Association of AUF1 with Translation and Heat Shock Proteins
type: GO_0003674
BFO_0000050: Destabilization of mRNA by AUF1 (hnRNP D0)
directly activates: Ubiquitination of AUF1 (hnRNP D0)

Ubiquitination of AUF1 (hnRNP D0)
type: GO_0003674
BFO_0000050: Destabilization of mRNA by AUF1 (hnRNP D0)
directly activates: Destruction of AUF1 and mRNA
directly activates: Catalysis204

Destruction of AUF1 and mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Destabilization of mRNA by AUF1 (hnRNP D0)

Butyrate Response Factor1 (BRF1) Binds AU-rich Element in 3' UTR of mRNA
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
directly activates: BRF1 Complex Recruits RNA Degradation Activities
directly activates: Phosphorylation of BRF1 by Protein Kinase B/Akt
directly activates: Phosphorylation of BRF1 by MK2
directly activates: Catalysis205
directly activates: Catalysis206

BRF1 Complex Recruits RNA Degradation Activities
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Phosphorylation of BRF1 by Protein Kinase B/Akt
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
directly activates: Phosphorylated BRF1 (Ser92, Ser203) Binds 14-3-3

Phosphorylation of BRF1 by MK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
directly activates: Phosphorylated BRF1 (Ser54, Ser92, Ser203) Binds 14-3-3

Phosphorylated BRF1 (Ser92, Ser203) Binds 14-3-3
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Phosphorylated BRF1 (Ser54, Ser92, Ser203) Binds 14-3-3
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Tristetraproline (TTP) Binds AU-rich Elements in 3' UTR of Target mRNAs
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Tristetraprolin (TTP)
directly activates: TTP Recruits RNA Degradation Activities
directly activates: Phosphorylation of Tristetraproline (TTP) by MK2
directly activates: Catalysis207

TTP Recruits RNA Degradation Activities
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Tristetraprolin (TTP)

Phosphorylation of Tristetraproline (TTP) by MK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Destabilization of mRNA by Tristetraprolin (TTP)
directly activates: Phosphorylated Tristetraproline (TTP) binds 14-3-3beta

Phosphorylated Tristetraproline (TTP) binds 14-3-3beta
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Tristetraprolin (TTP)

KSRP Binds AU-rich Element in 3' UTR of mRNA
type: GO_0003674
BFO_0000050: Destabilization of mRNA by KSRP
directly activates: KSRP Recruits RNA Degradation Activities
directly activates: Phosphorylation of KSRP by Protein Kinase B/Akt
directly activates: Catalysis208

KSRP Recruits RNA Degradation Activities
type: GO_0003674
BFO_0000050: Destabilization of mRNA by KSRP

Phosphorylation of KSRP by Protein Kinase B/Akt
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Destabilization of mRNA by KSRP
directly activates: Phosphorylated KSRP (Ser193) Binds 14-3-3zeta in the Nucleus

Phosphorylated KSRP (Ser193) Binds 14-3-3zeta in the Nucleus
type: GO_0003674
BFO_0000050: Destabilization of mRNA by KSRP

Phosphorylation of KSRP by MAP kinase p38
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Destabilization of mRNA by KSRP

Phosphorylation of HuR by PKCalpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Phosphorylated HuR (Ser221, Ser158) Binds mRNA

Phosphorylation of HuR by PKCdelta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Phosphorylated HuR (Ser221, Ser318) Binds mRNA

Phosphorylated HuR (Ser221, Ser158) Binds mRNA
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Association of HuR with the CRM1 Nuclear Export Machinery

Phosphorylated HuR (Ser221, Ser318) Binds mRNA
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Association of HuR with the CRM1 Nuclear Export Machinery

HuR Binds mRNAs in the Nucleus
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Association of HuR with the CRM1 Nuclear Export Machinery

Association of HuR with the CRM1 Nuclear Export Machinery
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm

Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR

Nuclear export of snRNA transcripts
type: GO_0051168
BFO_0000050: snRNP Assembly
directly activates: snRNP complex assembly

Loading and methylation of Sm proteins onto SMN Complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000387
type: GO_0016274
BFO_0000050: snRNP Assembly
directly activates: snRNP complex assembly

snRNP complex assembly
type: GO_0000387
BFO_0000050: snRNP Assembly
directly activates: snRNA Cap hypermethylation
directly activates: Catalysis224

snRNA Cap hypermethylation
type: Restriction
  on property: enabled by
  some values from: HCA137
type: Restriction
  on property: enabled by
  some values from: HCA137
type: Restriction
  on property: enabled by
  some values from: HCA137
type: Restriction
  on property: enabled by
  some values from: HCA137
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000387
type: GO_0008173
BFO_0000050: snRNP Assembly
directly activates: snRNP:Snurportin complex formation

snRNP:Snurportin complex formation
type: GO_0000387
BFO_0000050: snRNP Assembly
directly activates: snRNP nuclear import and release
directly activates: Control48

snRNP nuclear import and release
type: GO_0051170
BFO_0000050: snRNP Assembly

Deadenylation-dependent mRNA decay
type: GO_0008150
BFO_0000050: Metabolism of mRNA

Deadenylation of mRNA
type: GO_0008150
BFO_0000050: Deadenylation-dependent mRNA decay

mRNA Decay by 3' to 5' Exoribonuclease
type: GO_0008150
BFO_0000050: Deadenylation-dependent mRNA decay

mRNA Decay by 5' to 3' Exoribonuclease
type: GO_0008150
BFO_0000050: Deadenylation-dependent mRNA decay

Nonsense-Mediated Decay
type: GO_0008150
BFO_0000050: Metabolism of mRNA

Nonsense Mediated Decay Enhanced by the Exon Junction Complex
type: GO_0008150
BFO_0000050: Nonsense-Mediated Decay

Nonsense Mediated Decay Independent of the Exon Junction Complex
type: GO_0008150
BFO_0000050: Nonsense-Mediated Decay

Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
type: GO_0008150
BFO_0000050: Metabolism of mRNA

Destabilization of mRNA by AUF1 (hnRNP D0)
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Destabilization of mRNA by Tristetraprolin (TTP)
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Destabilization of mRNA by KSRP
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Stabilization of mRNA by HuR
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Metabolism of non-coding RNA
type: GO_0008150
BFO_0000050: Metabolism of RNA
label: Non-coding RNA Metabolism

snRNP Assembly
type: GO_0008150
BFO_0000050: Metabolism of non-coding RNA

Metabolism of RNA
type: GO_0008150

Metabolism of mRNA
type: GO_0008150
BFO_0000050: Metabolism of RNA