CHST1
label: UniProt:O43916 CHST1

GNS
label: UniProt:P15586 GNS

HFRC
label: SLC35D2
label: UGTREL8
label: UniProt:Q76EJ3 SLC35D2

SLC35D2 exchanges UDP-sugars for UMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: enabled by
  some values from: HFRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0005338
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
directly activates: BiochemicalReaction3086
directly activates: Catalysis1303
directly activates: Catalysis1318

B4GALTs add galactose to the N-glycan precursor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
directly activates: Catalysis1303

B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0008532
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B4GALTs add another galactose to the chain
directly activates: Catalysis1304

B4GALTs add another galactose to the chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: B4GALTs can add galactose to a branch of keratan
directly activates: Catalysis1305

B4GALTs can add galactose to a branch of keratan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Keratan sulfate biosynthesis
directly activates: The keratan chain can be capped by N-acetylneuraminic acid
directly activates: Catalysis1306

The keratan chain can be capped by N-acetylneuraminic acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003836
BFO_0000050: Keratan sulfate biosynthesis
directly activates: Sulfation of GlcNAc residues on Keratan-PG forms KSPG
directly activates: Catalysis1307

Sulfation of GlcNAc residues on Keratan-PG forms KSPG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0001517
BFO_0000050: Keratan sulfate biosynthesis
directly activates: Further sulfation on galactose residues produces KSPG
directly activates: Catalysis1308

Further sulfation on galactose residues produces KSPG
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: enabled by
  some values from: CHST1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0045130
BFO_0000050: Keratan sulfate biosynthesis
directly activates: KSPG is secreted from the cell

KSPG is secreted from the cell
type: GO_0003674
BFO_0000050: Keratan sulfate biosynthesis

Extracellular KSPG translocates to the lysosome for degradation
type: GO_0003674
BFO_0000050: Keratan sulfate degradation
directly activates: Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
directly activates: Catalysis1309

Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: Keratan sulfate degradation
directly activates: N-acetylgalactosamine-6-sulfatase (GALNS) hydrolyses the sulfate groups of galactose 6-sulfate units of keratan sulfate
directly activates: Catalysis1310

N-acetylgalactosamine-6-sulfatase (GALNS) hydrolyses the sulfate groups of galactose 6-sulfate units of keratan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0043890
BFO_0000050: Keratan sulfate degradation
directly activates: Beta-galactosidase (GLB1) can cleave galactose from a glycosaminoglycan
directly activates: Catalysis1311

Beta-galactosidase (GLB1) can cleave galactose from a glycosaminoglycan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: Keratan sulfate degradation
directly activates: N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
directly activates: Catalysis1312

N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: GNS
type: Restriction
  on property: enabled by
  some values from: GNS
type: GO_0008449
BFO_0000050: Keratan sulfate degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from keratan sulfate
directly activates: Catalysis1313

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from keratan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: Keratan sulfate degradation

Keratan sulfate/keratin metabolism
type: GO_0008150

Keratan sulfate biosynthesis
type: GO_0008150
BFO_0000050: Keratan sulfate/keratin metabolism

Keratan sulfate degradation
type: GO_0008150
BFO_0000050: Keratan sulfate/keratin metabolism