DCT1
DMT1
NRAMP2
OK/SW-cl.20
SLC11A2
UniProt:P49281 SLC11A2
STEAP3
TSAP6
UniProt:Q658P3 STEAP3
HCP1
PCFT
SLC46A1
UniProt:Q96NT5 SLC46A1
MCOLN1
ML4
MSTP080
UniProt:Q9GZU1 MCOLN1
FLVCR
FLVCR1
UniProt:Q9Y5Y0 FLVCR1
DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes
Ferroportin mediates iron influx across the basolateral membrane of enterocytes
Ferroportin mediates iron efflux on macrophages
Reduction of extracellular Fe3+
Oxidation of Fe2+ by ceruloplasmin
Oxidation of Fe2+ by hephaestin
apo-Transferrin is loaded with two iron ions
Extracellular ferriheme uptake through the apical membrane of enterocytes
The heme ring is cleaved by heme oxygenase
Export of heme to the blood by FLVCR
Export of heme to the blood by ABCG2
Loaded transferrin binds to TfR1
Separation of endosome from the plasma membrane
Acidification of Tf:TfR1 containing endosome
Iron separates from the Tf:TfR1 complex
Reduction of Fe3+ in the endosome
Iron diffuses out of the endosome
Recycling of Tf endosome to plasma membrane
apo-Transferrin dissociates from the receptor complex
Ferritin stores iron
Iron uptake and transport
Transferrin endocytosis and recycling