DCT1
label: DMT1
label: NRAMP2
label: OK/SW-cl.20
label: SLC11A2
label: UniProt:P49281 SLC11A2

STEAP3
label: TSAP6
label: UniProt:Q658P3 STEAP3

HCP1
label: PCFT
label: SLC46A1
label: UniProt:Q96NT5 SLC46A1

MCOLN1
label: ML4
label: MSTP080
label: UniProt:Q9GZU1 MCOLN1

FLVCR
label: FLVCR1
label: UniProt:Q9Y5Y0 FLVCR1

DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes
type: Restriction
  on property: enabled by
  some values from: DCT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005381
BFO_0000050: Iron uptake and transport
directly activates: Ferroportin mediates iron influx across the basolateral membrane of enterocytes
directly activates: Ferroportin mediates iron efflux on macrophages
directly activates: Catalysis662
directly activates: Catalysis663

Ferroportin mediates iron influx across the basolateral membrane of enterocytes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005381
BFO_0000050: Iron uptake and transport
directly activates: Oxidation of Fe2+ by hephaestin
directly activates: Catalysis759

Ferroportin mediates iron efflux on macrophages
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005381
BFO_0000050: Iron uptake and transport
directly activates: Oxidation of Fe2+ by ceruloplasmin
directly activates: Catalysis758

Reduction of extracellular Fe3+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0016722
BFO_0000050: Iron uptake and transport
directly activates: DCT1 (NRAMP2) mediates divalent iron uptake across the apical membrane of enterocytes
directly activates: Catalysis661

Oxidation of Fe2+ by ceruloplasmin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004322
BFO_0000050: Iron uptake and transport
directly activates: apo-Transferrin is loaded with two iron ions

Oxidation of Fe2+ by hephaestin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004322
BFO_0000050: Iron uptake and transport
directly activates: apo-Transferrin is loaded with two iron ions

apo-Transferrin is loaded with two iron ions
type: GO_0003674
BFO_0000050: Iron uptake and transport
directly activates: Loaded transferrin binds to TfR1
directly activates: Transferrin endocytosis and recycling

Extracellular ferriheme uptake through the apical membrane of enterocytes
type: Restriction
  on property: enabled by
  some values from: HCP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015232
BFO_0000050: Iron uptake and transport
directly activates: The heme ring is cleaved by heme oxygenase
directly activates: Catalysis761

The heme ring is cleaved by heme oxygenase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004392
BFO_0000050: Iron uptake and transport
directly activates: BiochemicalReaction5838
directly activates: Catalysis2980

Export of heme to the blood by FLVCR
type: Restriction
  on property: enabled by
  some values from: FLVCR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015232
BFO_0000050: Iron uptake and transport

Export of heme to the blood by ABCG2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015232
BFO_0000050: Iron uptake and transport

Loaded transferrin binds to TfR1
type: GO_0003674
BFO_0000050: Transferrin endocytosis and recycling
directly activates: Separation of endosome from the plasma membrane

Separation of endosome from the plasma membrane
type: GO_0003674
BFO_0000050: Transferrin endocytosis and recycling
directly activates: Acidification of Tf:TfR1 containing endosome
directly activates: Catalysis764

Acidification of Tf:TfR1 containing endosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0015078
BFO_0000050: Transferrin endocytosis and recycling
directly activates: Iron separates from the Tf:TfR1 complex
directly activates: Catalysis764

Iron separates from the Tf:TfR1 complex
type: GO_0003674
BFO_0000050: Transferrin endocytosis and recycling
directly activates: Reduction of Fe3+ in the endosome
directly activates: Recycling of Tf endosome to plasma membrane
directly activates: Catalysis765

Reduction of Fe3+ in the endosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: enabled by
  some values from: STEAP3
type: Restriction
  on property: enabled by
  some values from: STEAP3
type: GO_0016723
BFO_0000050: Transferrin endocytosis and recycling
directly activates: Iron diffuses out of the endosome
directly activates: Catalysis766

Iron diffuses out of the endosome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: enabled by
  some values from: MCOLN1
type: Restriction
  on property: enabled by
  some values from: MCOLN1
type: GO_0005381
BFO_0000050: Transferrin endocytosis and recycling

Recycling of Tf endosome to plasma membrane
type: GO_0003674
BFO_0000050: Transferrin endocytosis and recycling
directly activates: apo-Transferrin dissociates from the receptor complex

apo-Transferrin dissociates from the receptor complex
type: GO_0003674
BFO_0000050: Transferrin endocytosis and recycling
directly activates: Loaded transferrin binds to TfR1

Ferritin stores iron
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004322
BFO_0000050: Iron uptake and transport

Iron uptake and transport
type: GO_0008150

Transferrin endocytosis and recycling
type: GO_0008150
BFO_0000050: Iron uptake and transport