UBCH8
UBE2L6
UniProt:O14933 UBE2L6
PTPN2
PTPT
UniProt:P17706-2 PTPN2
PTP1B
PTPN1
UniProt:P18031 PTPN1
HCP
PTP1C
PTPN6
UniProt:P29350 PTPN6
UBA7
UBE1L
UBE2
UniProt:P41226 UBA7
PTP2C
PTPN11
SHPTP2
UniProt:Q06124 PTPN11
ISG43
USP18
UniProt:Q9UMW8 USP18
PIN1 mediated IRF3 degradation
IFN alpha/beta binds to IFNAR2
Recruitment of IFNAR1
Activation of JAK kinases
Phosphorylation of INFAR1 by TYK2
Recruitment of STAT2 to p-IFNAR1
Phosphorylation of STAT2
Phosphorylation of STAT1
Release of p-STAT2:p-STAT1 dimer
Interaction of IRF9 with p-STAT2:p-STAT1
Translocation of ISGF3 complex to nucleus
Formation of p-STAT1 homodimer
Translocation of p-STAT1:p-STAT1 dimer to nucleus
ISGF3 binds the ISRE promoter elements in IFN-stimulated genes
Expression of IFN-induced genes
Inhibition of JAK kinase activity by SOCS1/3
UBP43 binds IFNAR2 and prevents JAK1 interaction
Dephosphorylation of TYK2 by PTP1B
Dephosphorylation of JAK1 by SHP1
Dephosphorylation of STAT1 by SHP2
Interaction of IFNG with IFNGR
Phosphorylation of JAK2
Transphosphorylation of JAK1
Phosphorylation of IFNGR1 by JAK kinases
Binding of STAT1 to p-IFNGR1
Phoshorylation of STAT1 by JAK kinases
Phosphorylation of STAT1 at Ser727
Release of STAT1 dimer from active receptor unit
Translocation of STAT1 dimer to nucleus
GAF binds the GAS promoter elements in the IFNG-regulated genes
Expression of IFNG-stimulated genes
SOCS-1 and SOCS-3 binds to p-JAK2
Dephosphorylation of JAKs by PTPs
PIAS1 binds p-STAT1 dimer
Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP
Activation of ISG15 by UBE1L E1 ligase
Transfer of ISG15 from E1 to E2 (UBCH8)
Interaction of E3 ligase with ISG15:E2 complex
ISGylation of host proteins
ISGylation of host protein filamin B
ISGylation of protein phosphatase 1 beta (PP2CB)
ISGylation of E2 conjugating enzymes
Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding
ISGylation of viral protein NS1
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
ISGylation of IRF3
ISGylation of protein translation regulator 4EHP
Competitive inhibition of translation initiation by ISGylated 4EHP
Monoubiquitination of N-myristoyl GAG (P12493) protein
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
Interferon Signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling
Interferon gamma signaling
Regulation of IFNG signaling
Antiviral mechanism by IFN-stimulated genes
ISG15 antiviral mechanism