UBCH8
label: UBE2L6
label: UniProt:O14933 UBE2L6

PTPN2
label: PTPT
label: UniProt:P17706-2 PTPN2

PTP1B
label: PTPN1
label: UniProt:P18031 PTPN1

HCP
label: PTP1C
label: PTPN6
label: UniProt:P29350 PTPN6

UBA7
label: UBE1L
label: UBE2
label: UniProt:P41226 UBA7

PTP2C
label: PTPN11
label: SHPTP2
label: UniProt:Q06124 PTPN11

ISG43
label: USP18
label: UniProt:Q9UMW8 USP18

PIN1 mediated IRF3 degradation
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

IFN alpha/beta binds to IFNAR2
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling
directly activates: Recruitment of IFNAR1

Recruitment of IFNAR1
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling
directly activates: Activation of JAK kinases
directly activates: Catalysis485

Activation of JAK kinases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon alpha/beta signaling
directly activates: Phosphorylation of INFAR1 by TYK2
directly activates: Catalysis486

Phosphorylation of INFAR1 by TYK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon alpha/beta signaling
directly activates: Recruitment of STAT2 to p-IFNAR1

Recruitment of STAT2 to p-IFNAR1
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling
directly activates: Phosphorylation of STAT2
directly activates: Catalysis487
directly activates: Control97

Phosphorylation of STAT2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon alpha/beta signaling
directly activates: Phosphorylation of STAT1
directly activates: Catalysis488
directly activates: Control98

Phosphorylation of STAT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon alpha/beta signaling
directly activates: Release of p-STAT2:p-STAT1 dimer
directly activates: Formation of p-STAT1 homodimer
directly activates: Catalysis489

Release of p-STAT2:p-STAT1 dimer
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling
directly activates: Interaction of IRF9 with p-STAT2:p-STAT1

Interaction of IRF9 with p-STAT2:p-STAT1
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling
directly activates: Translocation of ISGF3 complex to nucleus

Translocation of ISGF3 complex to nucleus
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling
directly activates: ISGF3 binds the ISRE promoter elements in IFN-stimulated genes

Formation of p-STAT1 homodimer
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon alpha/beta signaling
directly activates: Translocation of p-STAT1:p-STAT1 dimer to nucleus

Translocation of p-STAT1:p-STAT1 dimer to nucleus
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling

ISGF3 binds the ISRE promoter elements in IFN-stimulated genes
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling
directly activates: Expression of IFN-induced genes
directly activates: Control99

Expression of IFN-induced genes
type: GO_0003674
BFO_0000050: Interferon alpha/beta signaling

Inhibition of JAK kinase activity by SOCS1/3
type: GO_0003674
BFO_0000050: Regulation of IFNA signaling

UBP43 binds IFNAR2 and prevents JAK1 interaction
type: GO_0003674
BFO_0000050: Regulation of IFNA signaling

Dephosphorylation of TYK2 by PTP1B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: GO_0004725
BFO_0000050: Regulation of IFNA signaling

Dephosphorylation of JAK1 by SHP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HCP
type: Restriction
  on property: enabled by
  some values from: HCP
type: Restriction
  on property: enabled by
  some values from: HCP
type: Restriction
  on property: enabled by
  some values from: HCP
type: GO_0004725
BFO_0000050: Regulation of IFNA signaling

Dephosphorylation of STAT1 by SHP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PTP2C
type: Restriction
  on property: enabled by
  some values from: PTP2C
type: Restriction
  on property: enabled by
  some values from: PTP2C
type: Restriction
  on property: enabled by
  some values from: PTP2C
type: GO_0004725
BFO_0000050: Regulation of IFNA signaling

Interaction of IFNG with IFNGR
type: GO_0003674
BFO_0000050: Interferon gamma signaling
directly activates: Phosphorylation of JAK2
directly activates: Catalysis493

Phosphorylation of JAK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon gamma signaling
directly activates: Transphosphorylation of JAK1
directly activates: Catalysis494
directly activates: Control100
directly activates: Control101

Transphosphorylation of JAK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon gamma signaling
directly activates: Phosphorylation of IFNGR1 by JAK kinases
directly activates: Catalysis495

Phosphorylation of IFNGR1 by JAK kinases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon gamma signaling
directly activates: Binding of STAT1 to p-IFNGR1

Binding of STAT1 to p-IFNGR1
type: GO_0003674
BFO_0000050: Interferon gamma signaling
directly activates: Phoshorylation of STAT1 by JAK kinases
directly activates: Catalysis496

Phoshorylation of STAT1 by JAK kinases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Interferon gamma signaling
directly activates: Phosphorylation of STAT1 at Ser727
directly activates: Catalysis497

Phosphorylation of STAT1 at Ser727
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Interferon gamma signaling
directly activates: Release of STAT1 dimer from active receptor unit

Release of STAT1 dimer from active receptor unit
type: GO_0003674
BFO_0000050: Interferon gamma signaling
directly activates: Translocation of STAT1 dimer to nucleus

Translocation of STAT1 dimer to nucleus
type: GO_0003674
BFO_0000050: Interferon gamma signaling

GAF binds the GAS promoter elements in the IFNG-regulated genes
type: GO_0003674
BFO_0000050: Interferon gamma signaling

Expression of IFNG-stimulated genes
type: GO_0003674
BFO_0000050: Interferon gamma signaling

SOCS-1 and SOCS-3 binds to p-JAK2
type: GO_0003674
BFO_0000050: Regulation of IFNG signaling

Dephosphorylation of JAKs by PTPs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004725
BFO_0000050: Regulation of IFNG signaling

PIAS1 binds p-STAT1 dimer
type: GO_0003674
BFO_0000050: Regulation of IFNG signaling

Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PTPN2
type: Restriction
  on property: enabled by
  some values from: PTPN2
type: Restriction
  on property: enabled by
  some values from: PTPN2
type: Restriction
  on property: enabled by
  some values from: PTPN2
type: GO_0004725
BFO_0000050: Regulation of IFNG signaling

Activation of ISG15 by UBE1L E1 ligase
type: Restriction
  on property: enabled by
  some values from: UBA7
type: Restriction
  on property: enabled by
  some values from: UBA7
type: Restriction
  on property: enabled by
  some values from: UBA7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: UBA7
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism
directly activates: Transfer of ISG15 from E1 to E2 (UBCH8)
directly activates: Catalysis501

Transfer of ISG15 from E1 to E2 (UBCH8)
type: Restriction
  on property: enabled by
  some values from: UBCH8
type: Restriction
  on property: enabled by
  some values from: UBCH8
type: Restriction
  on property: enabled by
  some values from: UBCH8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: UBCH8
type: GO_0043130
BFO_0000050: ISG15 antiviral mechanism
directly activates: Interaction of E3 ligase with ISG15:E2 complex

Interaction of E3 ligase with ISG15:E2 complex
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism
directly activates: ISGylation of host proteins
directly activates: ISGylation of host protein filamin B
directly activates: ISGylation of protein phosphatase 1 beta (PP2CB)
directly activates: ISGylation of E2 conjugating enzymes
directly activates: ISGylation of viral protein NS1
directly activates: ISGylation of IRF3
directly activates: Catalysis502
directly activates: Catalysis503
directly activates: Catalysis504
directly activates: Catalysis505
directly activates: Catalysis506
directly activates: Catalysis508

ISGylation of host proteins
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

ISGylation of host protein filamin B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

ISGylation of protein phosphatase 1 beta (PP2CB)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

ISGylation of E2 conjugating enzymes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

ISGylation of viral protein NS1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005635
type: GO_0005487
type: GO_0075733
BFO_0000050: ISG15 antiviral mechanism

ISGylation of IRF3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: ISG15 antiviral mechanism

ISGylation of protein translation regulator 4EHP
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

Competitive inhibition of translation initiation by ISGylated 4EHP
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

Monoubiquitination of N-myristoyl GAG (P12493) protein
type: GO_0003674
BFO_0000050: ISG15 antiviral mechanism

Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
type: Restriction
  on property: enabled by
  some values from: ISG43
type: Restriction
  on property: enabled by
  some values from: ISG43
type: Restriction
  on property: enabled by
  some values from: ISG43
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ISG43
type: GO_0019785
BFO_0000050: ISG15 antiviral mechanism

Interferon Signaling
type: GO_0008150

Interferon alpha/beta signaling
type: GO_0008150
BFO_0000050: Interferon Signaling

Regulation of IFNA signaling
type: GO_0008150
BFO_0000050: Interferon alpha/beta signaling

Interferon gamma signaling
type: GO_0008150
BFO_0000050: Interferon Signaling

Regulation of IFNG signaling
type: GO_0008150
BFO_0000050: Interferon gamma signaling

Antiviral mechanism by IFN-stimulated genes
type: GO_0008150
BFO_0000050: Interferon Signaling

ISG15 antiviral mechanism
type: GO_0008150
BFO_0000050: Antiviral mechanism by IFN-stimulated genes