ABCC5
label: MRP5
label: UniProt:O15440 ABCC5

HYAL1
label: LUCA1
label: UniProt:Q12794 HYAL1

HAS1,2,3 mediate the polymerisation of HA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0050501
BFO_0000050: Hyaluronan biosynthesis and export
directly activates: Growing HA is extruded from the cell by ABCC5
directly activates: Catalysis1294

Growing HA is extruded from the cell by ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: enabled by
  some values from: ABCC5
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008514
BFO_0000050: Hyaluronan biosynthesis and export
directly activates: Receptor-mediated uptake of HA

Receptor-mediated uptake of HA
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: HYAL2 interacts with NHE1 to create an acidic environment

HYAL2 interacts with NHE1 to create an acidic environment
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments
directly activates: Catalysis1295

Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004415
BFO_0000050: Hyaluronan uptake and degradation
directly activates: 20kDa HA fragments are translocated to lysosomes

20kDa HA fragments are translocated to lysosomes
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Hyaluronidase 1 (HYAL1) hydrolyses HA from 20kDa to 800Da fragments
directly activates: Catalysis1296

Hyaluronidase 1 (HYAL1) hydrolyses HA from 20kDa to 800Da fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: enabled by
  some values from: HYAL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004415
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
directly activates: Catalysis1297

Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from small HA fragments
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
directly activates: Catalysis1298

Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from small HA fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004563
BFO_0000050: Hyaluronan uptake and degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
directly activates: Catalysis1299

Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: Hyaluronan uptake and degradation
directly activates: The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol

The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
type: GO_0003674
BFO_0000050: Hyaluronan uptake and degradation

Hyaluronan metabolism
type: GO_0008150

Hyaluronan biosynthesis and export
type: GO_0008150
BFO_0000050: Hyaluronan metabolism

Hyaluronan uptake and degradation
type: GO_0008150
BFO_0000050: Hyaluronan metabolism