ABCC5
MRP5
UniProt:O15440 ABCC5
HYAL1
LUCA1
UniProt:Q12794 HYAL1
HAS1,2,3 mediate the polymerisation of HA
Growing HA is extruded from the cell by ABCC5
Receptor-mediated uptake of HA
HYAL2 interacts with NHE1 to create an acidic environment
Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments
20kDa HA fragments are translocated to lysosomes
Hyaluronidase 1 (HYAL1) hydrolyses HA from 20kDa to 800Da fragments
Beta-glucuronidase (GUSB) hydrolyses glucuronate from HA tetrasaccharides
Beta-hexosaminidase A (BHEXA) cleaves the terminal GalNAc from small HA fragments
Beta-glucuronidase (GUSB) hydrolyses glucuronate from the HA disaccharides
The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
Hyaluronan metabolism
Hyaluronan biosynthesis and export
Hyaluronan uptake and degradation