LIG1
UniProt:P18858 LIG1
ATM
UniProt:Q13315 ATM
Intermolecular autophosphorylation of ATM within dimeric ATM complexes
Dissociation of dimeric phospho-ATM complexes
Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB
Phosphorylation of BRCA1 at multiple sites by ATM
Phosphorylation of NBS1 by ATM
Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains)
MDC1/NFBD1 associates with gamma H2AX at nuclear foci
phospho-ATM (Serine 1981) associates with DNA at the site of double-strand breaks
53BP1 associates with gamma H2AX at nuclear foci
Association of gamma-H2AX with NBS1
Formation of RAD50:MRE11 complex
Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction
Association of MRN with sites of DSB
BRCA1 associates with 53BP1at the site of DNA double-strand break
Resection of double-strand break ends
Association of RPA complexes with ssDNA
Association of RAD51 with BRCA2
Formation of RAD52 heptameric ring structure complexes on ssDNA
Association of RAD52 with the RPA complex
Association of RAD52 with ssDNA at resected ends of double-strand break
Association of RAD51 with RAD52:DNA double-strand break ends
Association of RAD51 with the RPA complex
Association of RAD51 with the resected ends of the DNA double-strand break
Strand exchange/Branch migration
DNA repair synthesis
Ligation of DNA and formation of Holliday structures following repair synthesis
Cleavage of Holliday junctions
Dissociation of the extended strands
Fill-in DNA synthesis
Homologous Recombination Repair
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated response to DNA double-strand break
ATM mediated phosphorylation of repair proteins
Recruitment of repair and signaling proteins to double-strand breaks
MRN complex relocalizes to nuclear foci
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
Processing of DNA double-strand break ends
Homologous DNA pairing and strand exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Assembly of the RAD51-ssDNA nucleoprotein complex
Resolution of D-loop structures
Resolution of D-loop structures through Holliday junction intermediates
Resolution of D-loop structures through synthesis-dependent strand-annealing
Homologous recombination repair of replication-dependent double-strand breaks