LIG1
label: UniProt:P18858 LIG1

ATM
label: UniProt:Q13315 ATM

Intermolecular autophosphorylation of ATM within dimeric ATM complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: GO_0016301
type: GO_0046777
BFO_0000050: ATM mediated response to DNA double-strand break
directly activates: Dissociation of dimeric phospho-ATM complexes

Dissociation of dimeric phospho-ATM complexes
type: GO_0003674
BFO_0000050: ATM mediated response to DNA double-strand break
directly activates: Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB
directly activates: phospho-ATM (Serine 1981) associates with DNA at the site of double-strand breaks
directly activates: Formation of RAD50:MRE11 complex
directly activates: BiochemicalReaction1833
directly activates: BiochemicalReaction1834
directly activates: BiochemicalReaction1845
directly activates: BiochemicalReaction1848
directly activates: Catalysis70
directly activates: Catalysis803
directly activates: Catalysis804
directly activates: Catalysis813
directly activates: Catalysis816
directly activates: ATM mediated phosphorylation of repair proteins
directly activates: Recruitment of repair and signaling proteins to double-strand breaks

Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: ATM mediated phosphorylation of repair proteins
directly activates: MDC1/NFBD1 associates with gamma H2AX at nuclear foci
directly activates: Control8

Phosphorylation of BRCA1 at multiple sites by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: GO_0016301
BFO_0000050: ATM mediated phosphorylation of repair proteins

Phosphorylation of NBS1 by ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: GO_0016301
BFO_0000050: ATM mediated phosphorylation of repair proteins

Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: ATM
type: Restriction
  on property: enabled by
  some values from: ATM
type: GO_0016301
BFO_0000050: ATM mediated phosphorylation of repair proteins

MDC1/NFBD1 associates with gamma H2AX at nuclear foci
type: GO_0003674
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks
directly activates: phospho-ATM (Serine 1981) associates with DNA at the site of double-strand breaks

phospho-ATM (Serine 1981) associates with DNA at the site of double-strand breaks
type: GO_0003674
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks
directly activates: 53BP1 associates with gamma H2AX at nuclear foci
directly activates: Association of gamma-H2AX with NBS1
directly activates: Control9
directly activates: MRN complex relocalizes to nuclear foci

53BP1 associates with gamma H2AX at nuclear foci
type: GO_0003674
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks
directly activates: BRCA1 associates with 53BP1at the site of DNA double-strand break
directly activates: Control10

Association of gamma-H2AX with NBS1
type: GO_0003674
BFO_0000050: MRN complex relocalizes to nuclear foci
directly activates: Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction
directly activates: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks

Formation of RAD50:MRE11 complex
type: GO_0003674
BFO_0000050: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
directly activates: Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction

Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction
type: GO_0003674
BFO_0000050: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
directly activates: Association of MRN with sites of DSB

Association of MRN with sites of DSB
type: GO_0003674
BFO_0000050: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks

BRCA1 associates with 53BP1at the site of DNA double-strand break
type: GO_0003674
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks

Resection of double-strand break ends
type: GO_0000729
BFO_0000050: Processing of DNA double-strand break ends
directly activates: Association of RPA complexes with ssDNA
directly activates: Association of RAD52 with ssDNA at resected ends of double-strand break

Association of RPA complexes with ssDNA
type: GO_0003674
BFO_0000050: Processing of DNA double-strand break ends
directly activates: Association of RAD51 with the RPA complex
directly activates: Homologous DNA pairing and strand exchange
directly activates: Presynaptic phase of homologous DNA pairing and strand exchange

Association of RAD51 with BRCA2
type: GO_0003674
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange

Formation of RAD52 heptameric ring structure complexes on ssDNA
type: GO_0003674
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange

Association of RAD52 with the RPA complex
type: GO_0003674
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange

Association of RAD52 with ssDNA at resected ends of double-strand break
type: GO_0003674
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange
directly activates: Association of RAD51 with RAD52:DNA double-strand break ends
directly activates: Association of RAD51 with the resected ends of the DNA double-strand break
directly activates: Assembly of the RAD51-ssDNA nucleoprotein complex

Association of RAD51 with RAD52:DNA double-strand break ends
type: GO_0003674
BFO_0000050: Assembly of the RAD51-ssDNA nucleoprotein complex

Association of RAD51 with the RPA complex
type: GO_0003674
BFO_0000050: Assembly of the RAD51-ssDNA nucleoprotein complex

Association of RAD51 with the resected ends of the DNA double-strand break
type: GO_0003674
BFO_0000050: Assembly of the RAD51-ssDNA nucleoprotein complex

Strand exchange/Branch migration
type: GO_0003674
BFO_0000050: Homologous DNA pairing and strand exchange
directly activates: DNA repair synthesis

DNA repair synthesis
type: GO_0000731
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks
directly activates: Ligation of DNA and formation of Holliday structures following repair synthesis
directly activates: Dissociation of the extended strands
directly activates: Catalysis74
directly activates: Resolution of D-loop structures
directly activates: Resolution of D-loop structures through Holliday junction intermediates
directly activates: Resolution of D-loop structures through synthesis-dependent strand-annealing

Ligation of DNA and formation of Holliday structures following repair synthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: GO_0003909
BFO_0000050: Resolution of D-loop structures through Holliday junction intermediates
directly activates: Cleavage of Holliday junctions

Cleavage of Holliday junctions
type: GO_0003674
BFO_0000050: Resolution of D-loop structures through Holliday junction intermediates

Dissociation of the extended strands
type: GO_0000732
BFO_0000050: Resolution of D-loop structures through synthesis-dependent strand-annealing
directly activates: Fill-in DNA synthesis

Fill-in DNA synthesis
type: GO_0003674
BFO_0000050: Resolution of D-loop structures through synthesis-dependent strand-annealing

Homologous Recombination Repair
type: GO_0008150

Homologous recombination repair of replication-independent double-strand breaks
type: GO_0008150
BFO_0000050: Homologous Recombination Repair

ATM mediated response to DNA double-strand break
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

ATM mediated phosphorylation of repair proteins
type: GO_0008150
BFO_0000050: ATM mediated response to DNA double-strand break

Recruitment of repair and signaling proteins to double-strand breaks
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

MRN complex relocalizes to nuclear foci
type: GO_0008150
BFO_0000050: Recruitment of repair and signaling proteins to double-strand breaks

Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
type: GO_0008150
BFO_0000050: MRN complex relocalizes to nuclear foci

Processing of DNA double-strand break ends
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

Homologous DNA pairing and strand exchange
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

Presynaptic phase of homologous DNA pairing and strand exchange
type: GO_0008150
BFO_0000050: Homologous DNA pairing and strand exchange

Assembly of the RAD51-ssDNA nucleoprotein complex
type: GO_0008150
BFO_0000050: Presynaptic phase of homologous DNA pairing and strand exchange

Resolution of D-loop structures
type: GO_0008150
BFO_0000050: Homologous recombination repair of replication-independent double-strand breaks

Resolution of D-loop structures through Holliday junction intermediates
type: GO_0008150
BFO_0000050: Resolution of D-loop structures

Resolution of D-loop structures through synthesis-dependent strand-annealing
type: GO_0008150
BFO_0000050: Resolution of D-loop structures

Homologous recombination repair of replication-dependent double-strand breaks
type: GO_0003674
BFO_0000050: Homologous Recombination Repair