NMT2
label: UniProt:O60551 NMT2

UniProt:P04585 gag-pol
label: gag-pol

FUR
label: FURIN
label: PACE
label: PCSK3
label: UniProt:P09958 FURIN

CHC1
label: RCC1
label: UniProt:P18754 RCC1

NMT
label: NMT1
label: UniProt:P30419 NMT1

CTDP1
label: FCP1
label: UniProt:Q9Y5B0 CTDP1

Transesterification to connect viral DNA 3' ends to host DNA 5' ends
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0008907
BFO_0000050: Integration of viral DNA into host genomic DNA
directly activates: Gap repair completes provirus integration

Gap repair completes provirus integration
type: GO_0003674
BFO_0000050: Integration of viral DNA into host genomic DNA

Cleavage of the viral Env gp160 precursor polyprotein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: GO_0004252
BFO_0000050: Synthesis and processing of ENV and VPU
directly activates: Transport of trimeric gp41:gp120 to plasma membrane

Binding of gp120 of ENV oligomer to the host CD4
type: GO_0003674
BFO_0000050: Binding and entry of HIV virion
directly activates: Conformational change in gp120 of Env oligomer

Conformational change in gp120 of Env oligomer
type: GO_0003674
BFO_0000050: Binding and entry of HIV virion
directly activates: CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4

CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4
type: GO_0003674
BFO_0000050: Binding and entry of HIV virion
directly activates: Conformational changes in gp120 exposes gp41

Conformational changes in gp120 exposes gp41
type: GO_0003674
BFO_0000050: Binding and entry of HIV virion
directly activates: Fusogenic activation of gp41

Fusogenic activation of gp41
type: GO_0003674
BFO_0000050: Binding and entry of HIV virion
directly activates: Insertion of gp41 fusion peptide into the target membrane
label: gp41 N terminal fusion peptide released from viral membrane

Insertion of gp41 fusion peptide into the target membrane
type: GO_0003674
BFO_0000050: Binding and entry of HIV virion
directly activates: N and C terminal heptad repeat helices of gp41 form six-helix bundle

N and C terminal heptad repeat helices of gp41 form six-helix bundle
type: GO_0003674
BFO_0000050: Binding and entry of HIV virion
directly activates: Fusion of viral membrane with host cell membrane

Fusion of viral membrane with host cell membrane
type: GO_0019064
BFO_0000050: Binding and entry of HIV virion
directly activates: Disintegration of matrix layer

Disintegration of matrix layer
type: GO_0003674
BFO_0000050: Uncoating of the HIV Virion
directly activates: Disassembly of viral capsid

Disassembly of viral capsid
type: GO_0003674
BFO_0000050: Uncoating of the HIV Virion
directly activates: Formation of RTC (Reverse Transcription Complex)

Formation of RTC (Reverse Transcription Complex)
type: GO_0019061
BFO_0000050: Early Phase of HIV Life Cycle
directly activates: Annealing of 3'-end of unwound transfer RNA primer with genomic RNA

Annealing of 3'-end of unwound transfer RNA primer with genomic RNA
type: GO_0006278
BFO_0000050: Early Phase of HIV Life Cycle
directly activates: Synthesis of minus strand strong stop DNA (-sssDNA)
directly activates: Catalysis1127
directly activates: Reverse Transcription of HIV RNA

Synthesis of minus strand strong stop DNA (-sssDNA)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003964
BFO_0000050: Minus-strand DNA synthesis
directly activates: RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
directly activates: Catalysis1128

RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004523
BFO_0000050: Minus-strand DNA synthesis
directly activates: RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
directly activates: Catalysis1129

RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004523
BFO_0000050: Minus-strand DNA synthesis
directly activates: First strand transfer mediated by Repeated (R) sequence

First strand transfer mediated by Repeated (R) sequence
type: GO_0003674
BFO_0000050: Minus-strand DNA synthesis
directly activates: Minus strand DNA synthesis resumes
directly activates: Catalysis1130

Minus strand DNA synthesis resumes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003964
BFO_0000050: Minus-strand DNA synthesis
directly activates: RNase H-mediated cleavage of the template strand
directly activates: Catalysis1131

RNase H-mediated cleavage of the template strand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004523
BFO_0000050: Minus-strand DNA synthesis
directly activates: RNase H-mediated degradation of the template strand
directly activates: Catalysis1132

RNase H-mediated degradation of the template strand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004523
BFO_0000050: Minus-strand DNA synthesis
directly activates: 3' PPT-primed initiation of plus-strand DNA synthesis
directly activates: Catalysis1133

3' PPT-primed initiation of plus-strand DNA synthesis
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003887
BFO_0000050: Plus-strand DNA synthesis
directly activates: RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
directly activates: Catalysis1134

RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004523
BFO_0000050: Plus-strand DNA synthesis
directly activates: Second strand transfer by annealing complementary PBS sequences

Second strand transfer by annealing complementary PBS sequences
type: GO_0003674
BFO_0000050: Plus-strand DNA synthesis
directly activates: Synthesis of full-length duplex viral DNA with a discontinuous plus strand
directly activates: Catalysis1135

Synthesis of full-length duplex viral DNA with a discontinuous plus strand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003887
BFO_0000050: Plus-strand DNA synthesis
directly activates: Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
directly activates: Control180
directly activates: Control181

Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
type: GO_0006278
BFO_0000050: Early Phase of HIV Life Cycle
directly activates: Formation of Pre-Integration Complex (PIC)

Formation of Pre-Integration Complex (PIC)
type: GO_0003674
BFO_0000050: Integration of provirus
directly activates: Integrase binds viral DNA ends

Integrase binds viral DNA ends
type: GO_0003674
BFO_0000050: Integration of provirus
directly activates: Terminal (3' end) cleavage of viral DNA

Terminal (3' end) cleavage of viral DNA
type: GO_0003674
BFO_0000050: Integration of provirus
directly activates: Import of PIC to the Host Nucleus
directly activates: Control182
directly activates: Control183

Import of PIC to the Host Nucleus
type: GO_0051169
BFO_0000050: Integration of provirus
directly activates: Target DNA binding
directly activates: 1-LTR circle formation
directly activates: Association of Ku heterodimer with viral DNA ends
directly activates: Suicidal integration leading to inverted circle formation
directly activates: Suicidal integration leading to smaller circles of viral DNA
directly activates: Integration of viral DNA into host genomic DNA
directly activates: 2-LTR circle formation
directly activates: Autointegration results in viral DNA circles

Target DNA binding
type: GO_0003674
BFO_0000050: Integration of viral DNA into host genomic DNA
directly activates: Transesterification to connect viral DNA 3' ends to host DNA 5' ends
directly activates: Catalysis96

1-LTR circle formation
type: GO_0003674
BFO_0000050: Integration of provirus

Association of Ku heterodimer with viral DNA ends
type: GO_0003674
BFO_0000050: 2-LTR circle formation
directly activates: Association of XRCC4:DNA ligase IV complex with viral DNA ends

Association of XRCC4:DNA ligase IV complex with viral DNA ends
type: GO_0003674
BFO_0000050: 2-LTR circle formation
directly activates: 2-LTR formation due to circularization of viral DNA
directly activates: Catalysis1136

2-LTR formation due to circularization of viral DNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
BFO_0000050: 2-LTR circle formation

Suicidal integration leading to inverted circle formation
type: GO_0003674
BFO_0000050: Autointegration results in viral DNA circles

Suicidal integration leading to smaller circles of viral DNA
type: GO_0003674
BFO_0000050: Autointegration results in viral DNA circles

HIV Promoter Opening: First Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004386
BFO_0000050: Transcription of the HIV genome
directly activates: Fall Back to Closed Pre-initiation Complex
directly activates: NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex
directly activates: HIV Transcription Initiation

Fall Back to Closed Pre-initiation Complex
type: GO_0003674
BFO_0000050: Transcription of the HIV genome

NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex
type: GO_0003674
BFO_0000050: HIV Transcription Initiation
directly activates: Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP

Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP
type: GO_0003674
BFO_0000050: HIV Transcription Initiation
directly activates: Newly formed phosphodiester bond stabilized and PPi released

Newly formed phosphodiester bond stabilized and PPi released
type: GO_0003674
BFO_0000050: HIV Transcription Initiation
directly activates: Addition of the third nucleotide on the nascent HIV-1 transcript
directly activates: Catalysis1138
directly activates: Catalysis1139

Abortive HIV-1 initiation after formation of the first phosphodiester bond
type: GO_0003674
BFO_0000050: HIV Transcription Initiation

Addition of the third nucleotide on the nascent HIV-1 transcript
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
type: GO_0004386
BFO_0000050: RNA Polymerase II HIV Promoter Escape
directly activates: Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
directly activates: Abortive HIV-1 Initiation Before Second Transition
directly activates: Catalysis1140
directly activates: Catalysis1141

Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
type: GO_0004386
BFO_0000050: RNA Polymerase II HIV Promoter Escape
directly activates: Abortive HIV-1 Initiation Before Second Transition
directly activates: Addition of nucleotides 5 through 9 on the growing HIV-1 transcript
directly activates: Catalysis1142

Abortive HIV-1 Initiation Before Second Transition
type: GO_0003674
BFO_0000050: RNA Polymerase II HIV Promoter Escape

Addition of nucleotides 5 through 9 on the growing HIV-1 transcript
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II HIV Promoter Escape
directly activates: Abortive HIV-1 Initiation After Second Transition
directly activates: Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition
directly activates: Catalysis1143

Abortive HIV-1 Initiation After Second Transition
type: GO_0003674
BFO_0000050: RNA Polymerase II HIV Promoter Escape

Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II HIV Promoter Escape
directly activates: Addition of nucleotides between position +11 and +30 on HIV-1 transcript
directly activates: Catalysis1144

Addition of nucleotides between position +11 and +30 on HIV-1 transcript
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II HIV Promoter Escape
directly activates: Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex

Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: Phosphorylation (Ser5) of RNA pol II CTD
directly activates: Catalysis1145

Phosphorylation (Ser5) of RNA pol II CTD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: RNA Polymerase II CTD (phosphorylated) binds to CE

RNA Polymerase II CTD (phosphorylated) binds to CE
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: Activation of GT

Activation of GT
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)

SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE

Hypophosphorylation of RNA Pol II CTD by FCP1P protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: GO_0004721
BFO_0000050: Formation of the HIV-1 Early Elongation Complex
directly activates: DSIF complex binds to RNA Pol II (hypophosphorylated)

DSIF complex binds to RNA Pol II (hypophosphorylated)
type: GO_0003674
BFO_0000050: Formation of the HIV-1 Early Elongation Complex
directly activates: Formation of DSIF:NELF:HIV-1 early elongation complex

Formation of DSIF:NELF:HIV-1 early elongation complex
type: GO_0003674
BFO_0000050: Formation of the HIV-1 Early Elongation Complex
directly activates: Abortive termination of HIV-1 early transcription elongation by DSIF:NELF
directly activates: Limited elongation of the HIV-1 transcript
directly activates: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
directly activates: Catalysis1150

Abortive termination of HIV-1 early transcription elongation by DSIF:NELF
type: GO_0003674
BFO_0000050: Formation of the HIV-1 Early Elongation Complex

Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex
type: GO_0003674
BFO_0000050: Formation of the HIV-1 Early Elongation Complex
directly activates: Hypophosphorylation of RNA Pol II CTD by FCP1P protein
directly activates: Catalysis1146

Association of Tat with P-TEFb(Cyclin T1:Cdk9)
type: GO_0003674
BFO_0000050: Formation of HIV-1 elongation complex containing HIV-1 Tat

Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Formation of HIV-1 elongation complex containing HIV-1 Tat

Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Formation of HIV-1 elongation complex containing HIV-1 Tat
directly activates: Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
directly activates: Catalysis1149

Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Formation of HIV-1 elongation complex containing HIV-1 Tat
directly activates: Recruitment of elongation factors to form HIV-1 elongation complex

Recruitment of elongation factors to form HIV-1 elongation complex
type: GO_0003674
BFO_0000050: Formation of HIV-1 elongation complex containing HIV-1 Tat
directly activates: Addition of nucleotides leads to HIV-1 transcript elongation

Addition of nucleotides leads to HIV-1 transcript elongation
type: GO_0003674
BFO_0000050: Tat-mediated elongation of the HIV-1 transcript
directly activates: Pol II elongation complex moves on the HIV-1 template as transcript elongates
directly activates: 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
directly activates: 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing

Pol II elongation complex moves on the HIV-1 template as transcript elongates
type: GO_0003674
BFO_0000050: Tat-mediated elongation of the HIV-1 transcript
directly activates: Separation of elongating HIV-1 transcript from template

Separation of elongating HIV-1 transcript from template
type: GO_0003674
BFO_0000050: Tat-mediated elongation of the HIV-1 transcript

Limited elongation of the HIV-1 transcript
type: GO_0003674
BFO_0000050: Abortive elongation of HIV-1 transcript in the absence of Tat
directly activates: Separation of abortive HIV-1 transcript from template
directly activates: 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
directly activates: 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing

Separation of abortive HIV-1 transcript from template
type: GO_0003674
BFO_0000050: Abortive elongation of HIV-1 transcript in the absence of Tat

7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
type: GO_0003674
BFO_0000050: HIV elongation arrest and recovery
directly activates: Abortive termination of HIV-1 elongation after arrest
directly activates: TFIIS-mediated recovery of HIV-1 elongation from arrest

Abortive termination of HIV-1 elongation after arrest
type: GO_0003674
BFO_0000050: HIV elongation arrest and recovery

TFIIS-mediated recovery of HIV-1 elongation from arrest
type: GO_0003674
BFO_0000050: HIV elongation arrest and recovery

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Formation of HIV elongation complex in the absence of HIV Tat
directly activates: Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
directly activates: Recruitment of elongation factors to form HIV-1 elongation complex
directly activates: Catalysis1148

Recruitment of elongation factors to form HIV-1 elongation complex
type: GO_0003674
BFO_0000050: Formation of HIV elongation complex in the absence of HIV Tat

2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
type: GO_0003674
BFO_0000050: Pausing and recovery of HIV elongation
directly activates: Resumption of elongation of HIV-1 transcript after recovery from pausing

Resumption of elongation of HIV-1 transcript after recovery from pausing
type: GO_0003674
BFO_0000050: Pausing and recovery of HIV elongation

TFIIS-mediated recovery of elongation from arrest
type: GO_0003674
BFO_0000050: Tat-mediated HIV elongation arrest and recovery
directly activates: Pol II elongation complex moves on the HIV-1 template as transcript elongates

Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex)
type: GO_0003674
BFO_0000050: Tat-mediated HIV elongation arrest and recovery

7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
type: GO_0003674
BFO_0000050: Tat-mediated HIV elongation arrest and recovery
directly activates: TFIIS-mediated recovery of elongation from arrest
directly activates: Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex)

2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
type: GO_0003674
BFO_0000050: Pausing and recovery of Tat-mediated HIV elongation
directly activates: Resumption of elongation of HIV-1 transcript after recovery from pausing

Resumption of elongation of HIV-1 transcript after recovery from pausing
type: GO_0003674
BFO_0000050: Pausing and recovery of Tat-mediated HIV elongation
directly activates: Pol II elongation complex moves on the HIV-1 template as transcript elongates

Rev molecules assemble onto the RRE RNA sequence through their ARM sequence
type: GO_0003674
BFO_0000050: Rev-mediated nuclear export of HIV RNA
directly activates: Multimerization of Rev

Multimerization of Rev
type: GO_0003674
BFO_0000050: Rev-mediated nuclear export of HIV RNA
directly activates: Rev multimer-bound HIV mRNA associates with Crm1
directly activates: Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP

Rev multimer-bound HIV mRNA associates with Crm1
type: GO_0003674
BFO_0000050: Rev-mediated nuclear export of HIV RNA

Conversion of Ran-GDP to Ran-GTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CHC1
type: Restriction
  on property: enabled by
  some values from: CHC1
type: Restriction
  on property: enabled by
  some values from: CHC1
type: Restriction
  on property: enabled by
  some values from: CHC1
type: GO_0005087
BFO_0000050: Rev-mediated nuclear export of HIV RNA
directly activates: Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP
directly activates: BiochemicalReaction2703

Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP
type: GO_0003674
BFO_0000050: Rev-mediated nuclear export of HIV RNA
directly activates: Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC

Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
type: GO_0003674
BFO_0000050: Rev-mediated nuclear export of HIV RNA
directly activates: Translocation of nuclear RNA transport complex to cytoplasm

Translocation of nuclear RNA transport complex to cytoplasm
type: GO_0003674
BFO_0000050: Rev-mediated nuclear export of HIV RNA
directly activates: Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex
directly activates: Hydrolysis of Ran:GTP to Ran:GDP
directly activates: Catalysis1152
directly activates: Control184
directly activates: Control185

Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex
type: GO_0003674
BFO_0000050: Rev-mediated nuclear export of HIV RNA
directly activates: Release of the HIV mRNA and Crm1 from Rev in the cytoplasm

Release of the HIV mRNA and Crm1 from Rev in the cytoplasm
type: GO_0003674
BFO_0000050: Rev-mediated nuclear export of HIV RNA
directly activates: Hydrolysis of Ran:GTP to Ran:GDP
directly activates: BiochemicalReaction2699
directly activates: Catalysis1152
directly activates: Control184
directly activates: Control185

Hydrolysis of Ran:GTP to Ran:GDP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003924
BFO_0000050: Rev-mediated nuclear export of HIV RNA

Myristoylation of Nef
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: NMT
type: Restriction
  on property: enabled by
  some values from: NMT
type: GO_0006499
type: GO_0019107
BFO_0000050: Late Phase of HIV Life Cycle

Synthesis of GAG polyprotein
type: GO_0003674
BFO_0000050: Synthesis And Processing Of GAG, GAGPOL Polyproteins

Splicing of HIV RNA transcript
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU
directly activates: Synthesis of ENV polyprotein
directly activates: Synthesis of VPU protein

Synthesis of ENV polyprotein
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU
directly activates: Glycosylation of ENV polyprotein

Glycosylation of ENV polyprotein
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU
directly activates: Folding and Oligomerization of ENV glycoprotein

Folding and Oligomerization of ENV glycoprotein
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU
directly activates: Transport of trimeric ENV precursor to Golgi apparatus

Transport of trimeric ENV precursor to Golgi apparatus
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU
directly activates: Cleavage of the viral Env gp160 precursor polyprotein
directly activates: Catalysis1126

Transport of trimeric gp41:gp120 to plasma membrane
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU

Synthesis of VPU protein
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU
directly activates: Transport of VPU to Golgi apparatus

Transport of VPU to Golgi apparatus
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU
directly activates: Transport of VPU to Plasma Membrane

Transport of VPU to Plasma Membrane
type: GO_0003674
BFO_0000050: Synthesis and processing of ENV and VPU

Packaging of HIV virion on the host cell plasma membrane
type: GO_0003674
BFO_0000050: Assembly Of The HIV Virion

Recruitment Of HIV Virion Budding Machinery
type: GO_0003674
BFO_0000050: Budding and maturation of HIV virion
directly activates: HIV Virion Budding
directly activates: Control186

HIV Virion Budding
type: GO_0003674
BFO_0000050: Budding and maturation of HIV virion
directly activates: Maturation of HIV Virion
directly activates: Catalysis1154

Maturation of HIV Virion
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: Restriction
  on property: enabled by
  some values from: UniProt:P04585 gag-pol
type: Restriction
  on property: enabled by
  some values from: UniProt:P04585 gag-pol
type: Restriction
  on property: enabled by
  some values from: UniProt:P04585 gag-pol
type: Restriction
  on property: enabled by
  some values from: UniProt:P04585 gag-pol
type: GO_0008233
BFO_0000050: Budding and maturation of HIV virion

N-myristoylation of GAG polyprotein by NMT2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: Restriction
  on property: enabled by
  some values from: NMT2
type: GO_0004379
BFO_0000050: Membrane binding and targetting of GAG proteins
directly activates: Monoubiquitination of N-myristoyl GAG polyprotein

Monoubiquitination of N-myristoyl GAG polyprotein
type: GO_0003674
BFO_0000050: Membrane binding and targetting of GAG proteins
directly activates: Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
directly activates: Catalysis18

Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0008565
BFO_0000050: Membrane binding and targetting of GAG proteins
directly activates: Transport of GAG to the Plasma Membrane
directly activates: Catalysis19

Transport of GAG to the Plasma Membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0008565
BFO_0000050: Membrane binding and targetting of GAG proteins

Membrane binding and targetting of GAG proteins
type: GO_0008150
BFO_0000050: Synthesis And Processing Of GAG, GAGPOL Polyproteins

HIV Life Cycle
type: GO_0008150

Early Phase of HIV Life Cycle
type: GO_0008150
BFO_0000050: HIV Life Cycle

Binding and entry of HIV virion
type: GO_0008150
BFO_0000050: Early Phase of HIV Life Cycle

Uncoating of the HIV Virion
type: GO_0008150
BFO_0000050: Early Phase of HIV Life Cycle

Reverse Transcription of HIV RNA
type: GO_0008150
BFO_0000050: Early Phase of HIV Life Cycle

Minus-strand DNA synthesis
type: GO_0008150
BFO_0000050: Reverse Transcription of HIV RNA
label: minus-strand DNA synthesis

Plus-strand DNA synthesis
type: GO_0008150
BFO_0000050: Reverse Transcription of HIV RNA

Integration of provirus
type: GO_0008150
BFO_0000050: Early Phase of HIV Life Cycle

Integration of viral DNA into host genomic DNA
type: GO_0008150
BFO_0000050: Integration of provirus

2-LTR circle formation
type: GO_0008150
BFO_0000050: Integration of provirus

Autointegration results in viral DNA circles
type: GO_0008150
BFO_0000050: Integration of provirus

Late Phase of HIV Life Cycle
type: GO_0008150
BFO_0000050: HIV Life Cycle

Transcription of the HIV genome
type: GO_0008150
BFO_0000050: Late Phase of HIV Life Cycle

HIV Transcription Initiation
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

RNA Polymerase II HIV Promoter Escape
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

RNA Pol II CTD phosphorylation and interaction with CE
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

HIV Transcription Elongation
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

Formation of the HIV-1 Early Elongation Complex
type: GO_0008150
BFO_0000050: HIV Transcription Elongation

Tat-mediated elongation of the HIV-1 transcript
type: GO_0008150
BFO_0000050: HIV Transcription Elongation

Formation of HIV-1 elongation complex containing HIV-1 Tat
type: GO_0008150
BFO_0000050: Tat-mediated elongation of the HIV-1 transcript

Abortive elongation of HIV-1 transcript in the absence of Tat
type: GO_0008150
BFO_0000050: HIV Transcription Elongation

HIV elongation arrest and recovery
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

Formation of HIV elongation complex in the absence of HIV Tat
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

Pausing and recovery of HIV elongation
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

Tat-mediated HIV elongation arrest and recovery
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

Pausing and recovery of Tat-mediated HIV elongation
type: GO_0008150
BFO_0000050: Transcription of the HIV genome

HIV Transcription Termination
type: GO_0006369
BFO_0000050: Transcription of the HIV genome

Rev-mediated nuclear export of HIV RNA
type: GO_0008150
BFO_0000050: Late Phase of HIV Life Cycle

Assembly Of The HIV Virion
type: GO_0008150
BFO_0000050: Late Phase of HIV Life Cycle

Synthesis And Processing Of GAG, GAGPOL Polyproteins
type: GO_0008150
BFO_0000050: Assembly Of The HIV Virion
label: Synthesis and organization of GAG, GAGPOL polyproteins

Synthesis and processing of ENV and VPU
type: GO_0008150
BFO_0000050: Assembly Of The HIV Virion

Budding and maturation of HIV virion
type: GO_0008150
BFO_0000050: Late Phase of HIV Life Cycle