Formation of ARC coactivator complex
type: GO_0003674
BFO_0000050: Generic Transcription Pathway

Formation of DRIP coactivator complex
type: GO_0003674
BFO_0000050: Generic Transcription Pathway

Formation of TRAP coactivator complex
type: GO_0003674
BFO_0000050: Generic Transcription Pathway

Formation of CSL-NICD coactivator complex
type: GO_0003674
BFO_0000050: Notch-HLH transcription pathway

Formation of NR-MED1 Coactivator Complex
type: GO_0003674
BFO_0000050: Nuclear Receptor transcription pathway

KRAB-ZNF / KAP Interaction
type: GO_0003674
BFO_0000050: Generic Transcription Pathway

WWTR1 (TAZ) binds TEAD
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression
directly activates: Expression of CTGF
directly activates: TemplateReactionRegulation40
directly activates: TemplateReactionRegulation41
directly activates: TemplateReactionRegulation42

YAP1 binds TEAD
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression
directly activates: Expression of CTGF
directly activates: TemplateReactionRegulation40
directly activates: TemplateReactionRegulation41
directly activates: TemplateReactionRegulation42

WWTR1 (TAZ), TBX5, and PCAF form a complex
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression
directly activates: Expression of NPPA (ANF)
directly activates: TemplateReactionRegulation43

WWTR1 (TAZ) binds RUNX2
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: The SMAD2/3:SMAD4 complex transfers to the nucleus
directly activates: WWTR1 binds SMAD2/3:SMAD4 heterotrimer

The SMAD2/3:SMAD4 complex transfers to the nucleus
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
directly activates: SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2
directly activates: SMAD2/3:SMAD4 heterotrimer binds SP1
directly activates: MEN1 binds SMAD2/3:SMAD4 heterotrimer
directly activates: SMAD2/3:SMAD4 complex positively regulates JUNB transcription
directly activates: SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling
directly activates: TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
directly activates: TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
directly activates: PARP1 binds SMAD2/3:SMAD4 heterotrimer
directly activates: PPM1A protein phosphatase binds phosphorylated SMAD2/3
directly activates: BiochemicalReaction4524
directly activates: BiochemicalReaction6282
directly activates: Catalysis115
directly activates: Catalysis123
directly activates: Control22
directly activates: Control356
directly activates: Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling

Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: NEDD4L binds phosphorylated linker region of SMAD2/3
directly activates: SMURF2 binds SMAD3 phosphorylated in the linker region

WWTR1 binds SMAD2/3:SMAD4 heterotrimer
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: WWTR1:SMAD translocates to the nucleus

WWTR1:SMAD translocates to the nucleus
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: WWTR1:SMAD stimulates transcription of SMAD7
directly activates: WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
directly activates: Control16
directly activates: Control17
directly activates: Control18
directly activates: Control19

WWTR1:SMAD stimulates transcription of SMAD7
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: RNF111 binds SMAD7
directly activates: BiochemicalReaction4112
directly activates: BiochemicalReaction4119
directly activates: BiochemicalReaction4121
directly activates: BiochemicalReaction4124

WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

RNF111 binds SMAD7
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: RNF111 ubiquitinates SMAD7
directly activates: Catalysis116

RNF111 ubiquitinates SMAD7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: Degradation of Ub-SMAD7

SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
directly activates: Control20

MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: TemplateReaction36
directly activates: TemplateReactionRegulation52

SMAD2/3:SMAD4 heterotrimer binds SP1
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
directly activates: Control21

SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

MEN1 binds SMAD2/3:SMAD4 heterotrimer
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SMAD2/3:SMAD4 complex positively regulates JUNB transcription
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Ubiquitination of SKI/SKIL by RNF111/SMURF2
directly activates: Catalysis117

Ubiquitination of SKI/SKIL by RNF111/SMURF2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Degradation of ubiquitinated SKI/SKIL

TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: TRIM33 monoubiquitinates SMAD4
directly activates: Catalysis118

TRIM33 monoubiquitinates SMAD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Ubiquitinated SMAD4 translocates from the nucleus to the cytosol

Ubiquitinated SMAD4 translocates from the nucleus to the cytosol
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: USP9X (FAM) binds to ubiquitinated SMAD4

USP9X (FAM) binds to ubiquitinated SMAD4
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: USP9X (FAM) deubiquitinates SMAD4
directly activates: Catalysis119

USP9X (FAM) deubiquitinates SMAD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004221
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

NEDD4L binds phosphorylated linker region of SMAD2/3
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: NEDD4L ubiquitinates SMAD2/3

NEDD4L ubiquitinates SMAD2/3
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Degradation of SMAD2/3:SMAD4 complex

SMURF2 binds SMAD3 phosphorylated in the linker region
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: SMURF2 monoubiquitinates SMAD3
directly activates: Catalysis120

SMURF2 monoubiquitinates SMAD3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

PARP1 binds SMAD2/3:SMAD4 heterotrimer
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: PARP1 ADP-ribosylates SMAD3 and SMAD4
directly activates: Catalysis121

PARP1 ADP-ribosylates SMAD3 and SMAD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003950
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

PPM1A protein phosphatase binds phosphorylated SMAD2/3
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: PPM1A dephosphorylates nuclear SMAD2/3
directly activates: Catalysis122

PPM1A dephosphorylates nuclear SMAD2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004722
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Dephosphorylated SMAD2/3 translocates to the cytosol

Dephosphorylated SMAD2/3 translocates to the cytosol
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

Degradation of Ub-SMAD7
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Degradation of ubiquitinated SKI/SKIL
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

Degradation of SMAD2/3:SMAD4 complex
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

Generic Transcription Pathway
type: GO_0008150

Notch-HLH transcription pathway
type: GO_0008150
BFO_0000050: Generic Transcription Pathway

Nuclear Receptor transcription pathway
type: GO_0008150
BFO_0000050: Generic Transcription Pathway

YAP1- and WWTR1 (TAZ)-stimulated gene expression
type: GO_0008150
BFO_0000050: Generic Transcription Pathway

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
type: GO_0008150
BFO_0000050: Generic Transcription Pathway

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
type: GO_0008150
BFO_0000050: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Downregulation of SMAD2/3:SMAD4 transcriptional activity
type: GO_0008150
BFO_0000050: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Expression of CTGF
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Expression of NPPA (ANF)
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression