Formation of ARC coactivator complex
Formation of DRIP coactivator complex
Formation of TRAP coactivator complex
Formation of CSL-NICD coactivator complex
Formation of NR-MED1 Coactivator Complex
KRAB-ZNF / KAP Interaction
WWTR1 (TAZ) binds TEAD
YAP1 binds TEAD
WWTR1 (TAZ), TBX5, and PCAF form a complex
WWTR1 (TAZ) binds RUNX2
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
The SMAD2/3:SMAD4 complex transfers to the nucleus
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
WWTR1 binds SMAD2/3:SMAD4 heterotrimer
WWTR1:SMAD translocates to the nucleus
WWTR1:SMAD stimulates transcription of SMAD7
WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
RNF111 binds SMAD7
RNF111 ubiquitinates SMAD7
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
SMAD2/3:SMAD4 heterotrimer binds SP1
SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
MEN1 binds SMAD2/3:SMAD4 heterotrimer
SMAD2/3:SMAD4 complex positively regulates JUNB transcription
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling
SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL
Ubiquitination of SKI/SKIL by RNF111/SMURF2
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
TRIM33 monoubiquitinates SMAD4
Ubiquitinated SMAD4 translocates from the nucleus to the cytosol
USP9X (FAM) binds to ubiquitinated SMAD4
USP9X (FAM) deubiquitinates SMAD4
NEDD4L binds phosphorylated linker region of SMAD2/3
NEDD4L ubiquitinates SMAD2/3
SMURF2 binds SMAD3 phosphorylated in the linker region
SMURF2 monoubiquitinates SMAD3
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
PARP1 binds SMAD2/3:SMAD4 heterotrimer
PARP1 ADP-ribosylates SMAD3 and SMAD4
PPM1A protein phosphatase binds phosphorylated SMAD2/3
PPM1A dephosphorylates nuclear SMAD2/3
Dephosphorylated SMAD2/3 translocates to the cytosol
Degradation of Ub-SMAD7
Degradation of ubiquitinated SKI/SKIL
Degradation of SMAD2/3:SMAD4 complex
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
Generic Transcription Pathway
Notch-HLH transcription pathway
Nuclear Receptor transcription pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Expression of CTGF
Expression of NPPA (ANF)