prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
factor V -> factor Va + factor V activation peptide
factor Va + factor Xa -> Va:Xa complex (prothrombinase)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
n fibrin monomers -> fibrin multimer
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain
fibrin multimer -> fibrin multimer, crosslinked + NH4+
antithrombin III + heparin -> antithrombin III:heparin
activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin
thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
protein C -> activated protein C + protein C heavy chain activation peptide
factor Va -> factor Vi
Common Pathway