prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: factor V -> factor Va + factor V activation peptide
directly activates: Catalysis1055

factor V -> factor Va + factor V activation peptide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: factor Va + factor Xa -> Va:Xa complex (prothrombinase)
directly activates: factor Va -> factor Vi
directly activates: Catalysis1062
directly activates: Control166

factor Va + factor Xa -> Va:Xa complex (prothrombinase)
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
directly activates: Catalysis1056

prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: BiochemicalReaction2385
directly activates: BiochemicalReaction2388
directly activates: factor V -> factor Va + factor V activation peptide
directly activates: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
directly activates: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
directly activates: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin
directly activates: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
directly activates: Catalysis1050
directly activates: Catalysis1052
directly activates: Catalysis1055
directly activates: Catalysis1057
directly activates: Catalysis1058
directly activates: Control164

fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: n fibrin monomers -> fibrin multimer

n fibrin monomers -> fibrin multimer
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: fibrin multimer -> fibrin multimer, crosslinked + NH4+
directly activates: Catalysis1059

factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain

factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: fibrin multimer -> fibrin multimer, crosslinked + NH4+
directly activates: Catalysis1059

fibrin multimer -> fibrin multimer, crosslinked + NH4+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0003810
BFO_0000050: Common Pathway
directly activates: BiochemicalReaction2412

antithrombin III + heparin -> antithrombin III:heparin
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin

activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
directly activates: Catalysis1060

thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin

thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin
type: GO_0003674
BFO_0000050: Common Pathway

activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin
type: GO_0003674
BFO_0000050: Common Pathway
directly activates: protein C -> activated protein C + protein C heavy chain activation peptide
directly activates: Catalysis1061
directly activates: Control165

protein C -> activated protein C + protein C heavy chain activation peptide
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway
directly activates: factor Va -> factor Vi
directly activates: Catalysis1062
directly activates: Control166

factor Va -> factor Vi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Common Pathway

Common Pathway
type: GO_0008150