Formation of BMAL1:CLOCK/NPAS2 Heterodimer
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer
directly activates: Stabilization of Unphosphorylated BMAL1:CLOCK/NPAS2 Heterodimer by CRY Proteins

Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Binding of CRY:PER Heterodimer to the BMAL1:CLOCK/NPAS2 Heterodimer
directly activates: BMAL1:CLOCK/NPAS2 Activates Circadian Expression
directly activates: Expression of DEC1 (BHLHE40, BHLHB2)
directly activates: Expression of DEC2 (BHLHE41, BHLHB3)
directly activates: Expression of FACTOR VII (F7)
directly activates: Expression of NOCTURNIN
directly activates: Expression of PAI-1
directly activates: Expression of PPARA
directly activates: Expression of NAMPT (NamPRT, PBEF, Visfatin)
directly activates: Expression of CRYPTOCHROME-1
directly activates: Expression of CRYPTOCHROME-2
directly activates: Expression of PERIOD-1
directly activates: Expression of PERIOD-2
directly activates: Expression of NR1D1 (REV-ERBA)
directly activates: Expression of AVP
directly activates: Expression of DBP
directly activates: TemplateReactionRegulation11
directly activates: TemplateReactionRegulation12
directly activates: TemplateReactionRegulation13
directly activates: TemplateReactionRegulation14
directly activates: TemplateReactionRegulation15
directly activates: TemplateReactionRegulation16
directly activates: TemplateReactionRegulation17
directly activates: TemplateReactionRegulation18
directly activates: TemplateReactionRegulation19
directly activates: TemplateReactionRegulation20
directly activates: TemplateReactionRegulation21
directly activates: TemplateReactionRegulation22
directly activates: TemplateReactionRegulation23
directly activates: TemplateReactionRegulation24
directly activates: TemplateReactionRegulation25
directly activates: TemplateReactionRegulation26
directly activates: TemplateReactionRegulation27
directly activates: TemplateReactionRegulation28
directly activates: TemplateReactionRegulation29

NR1D1 (REV-ERBA) Binds Heme and Corepressors
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Circadian Repression of Expression by REV-ERBA

Stabilization of Unphosphorylated BMAL1:CLOCK/NPAS2 Heterodimer by CRY Proteins
type: GO_0003674
BFO_0000050: Circadian Clock

Formation of CRY:PER:Kinase Complex
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Phosphorylation of CRY and PER Proteins
directly activates: Catalysis109

Phosphorylation of CRY and PER Proteins
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Circadian Clock
directly activates: Translocation of CRY:PER:Kinase Ternary Complex into the Nucleus

Translocation of CRY:PER:Kinase Ternary Complex into the Nucleus
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Binding of CRY:PER Heterodimer to the BMAL1:CLOCK/NPAS2 Heterodimer

Binding of CRY:PER Heterodimer to the BMAL1:CLOCK/NPAS2 Heterodimer
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Binding of Beta-TrCP1 to phosphorylated PER proteins
directly activates: Binding of FBXL3 to Phosphorylated CRY proteins

Binding of Beta-TrCP1 to phosphorylated PER proteins
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Ubiquitination of PER Proteins
directly activates: Catalysis110

Binding of FBXL3 to Phosphorylated CRY proteins
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Ubiquitination of CRY Proteins

Ubiquitination of CRY Proteins
type: GO_0003674
BFO_0000050: Circadian Clock

Ubiquitination of PER Proteins
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: Circadian Clock

Formation of ROR-alpha Coactivator Complex
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: RORA Activates Circadian Expression
directly activates: Expression of CPT1A
directly activates: Expression of BMAL1 (ARNTL).
directly activates: TemplateReactionRegulation38
directly activates: TemplateReactionRegulation39
directly activates: TemplateReactionRegulation5
directly activates: TemplateReactionRegulation6

Circadian Clock
type: GO_0008150

BMAL1:CLOCK/NPAS2 Activates Circadian Expression
type: GO_0008150
BFO_0000050: Circadian Clock

Circadian Repression of Expression by REV-ERBA
type: GO_0008150
BFO_0000050: Circadian Clock

RORA Activates Circadian Expression
type: GO_0008150
BFO_0000050: Circadian Clock

Expression of DEC1 (BHLHE40, BHLHB2)
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Expression of DEC2 (BHLHE41, BHLHB3)
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Expression of FACTOR VII (F7)
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression
directly activates: BiochemicalReaction3471
directly activates: Catalysis1472

Expression of NOCTURNIN
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Expression of PAI-1
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Expression of PPARA
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression
directly activates: BiochemicalReaction4813

Expression of NAMPT (NamPRT, PBEF, Visfatin)
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Expression of CRYPTOCHROME-1
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression
directly activates: Stabilization of Unphosphorylated BMAL1:CLOCK/NPAS2 Heterodimer by CRY Proteins
directly activates: Formation of CRY:PER:Kinase Complex

Expression of CRYPTOCHROME-2
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression
directly activates: Stabilization of Unphosphorylated BMAL1:CLOCK/NPAS2 Heterodimer by CRY Proteins
directly activates: Formation of CRY:PER:Kinase Complex

Expression of PERIOD-1
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression
directly activates: Formation of CRY:PER:Kinase Complex

Expression of PERIOD-2
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression
directly activates: Formation of CRY:PER:Kinase Complex

Expression of NR1D1 (REV-ERBA)
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression
BFO_0000050: RORA Activates Circadian Expression
directly activates: NR1D1 (REV-ERBA) Binds Heme and Corepressors

Expression of ELOVL3
type: GO_0003674
BFO_0000050: Circadian Repression of Expression by REV-ERBA

Expression of PPARGC1A (PGC-1alpha)
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Formation of ROR-alpha Coactivator Complex

Expression of RORA (ROR-alpha)
type: GO_0003674
BFO_0000050: Circadian Clock
directly activates: Formation of ROR-alpha Coactivator Complex
directly activates: Expression of NR1D1 (REV-ERBA)
directly activates: Expression of SREBF1 (SREBP1)
directly activates: Expression of NPAS2
directly activates: TemplateReactionRegulation10
directly activates: TemplateReactionRegulation27
directly activates: TemplateReactionRegulation28
directly activates: TemplateReactionRegulation29
directly activates: TemplateReactionRegulation37
directly activates: TemplateReactionRegulation8
directly activates: TemplateReactionRegulation9

Expression of SREBF1 (SREBP1)
type: GO_0003674
BFO_0000050: RORA Activates Circadian Expression

Expression of CPT1A
type: GO_0003674
BFO_0000050: RORA Activates Circadian Expression

Expression of BMAL1 (ARNTL).
type: GO_0003674
BFO_0000050: Circadian Clock
BFO_0000050: Circadian Repression of Expression by REV-ERBA
BFO_0000050: RORA Activates Circadian Expression
directly activates: Formation of BMAL1:CLOCK/NPAS2 Heterodimer

Expression of CLOCK
type: GO_0003674
BFO_0000050: Circadian Clock
BFO_0000050: Circadian Repression of Expression by REV-ERBA
directly activates: Formation of BMAL1:CLOCK/NPAS2 Heterodimer

Expression of NPAS2
type: GO_0003674
BFO_0000050: Circadian Clock
BFO_0000050: Circadian Repression of Expression by REV-ERBA
BFO_0000050: RORA Activates Circadian Expression
directly activates: Formation of BMAL1:CLOCK/NPAS2 Heterodimer

Expression of AVP
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression

Expression of DBP
type: GO_0003674
BFO_0000050: BMAL1:CLOCK/NPAS2 Activates Circadian Expression