Formation of BMAL1:CLOCK/NPAS2 Heterodimer
Phosphorylation and Nuclear Translocation of the BMAL1:CLOCK/NPAS2 Heterodimer
NR1D1 (REV-ERBA) Binds Heme and Corepressors
Stabilization of Unphosphorylated BMAL1:CLOCK/NPAS2 Heterodimer by CRY Proteins
Formation of CRY:PER:Kinase Complex
Phosphorylation of CRY and PER Proteins
Translocation of CRY:PER:Kinase Ternary Complex into the Nucleus
Binding of CRY:PER Heterodimer to the BMAL1:CLOCK/NPAS2 Heterodimer
Binding of Beta-TrCP1 to phosphorylated PER proteins
Binding of FBXL3 to Phosphorylated CRY proteins
Ubiquitination of CRY Proteins
Ubiquitination of PER Proteins
Formation of ROR-alpha Coactivator Complex
Circadian Clock
BMAL1:CLOCK/NPAS2 Activates Circadian Expression
Circadian Repression of Expression by REV-ERBA
RORA Activates Circadian Expression
Expression of DEC1 (BHLHE40, BHLHB2)
Expression of DEC2 (BHLHE41, BHLHB3)
Expression of FACTOR VII (F7)
Expression of NOCTURNIN
Expression of PAI-1
Expression of PPARA
Expression of NAMPT (NamPRT, PBEF, Visfatin)
Expression of CRYPTOCHROME-1
Expression of CRYPTOCHROME-2
Expression of PERIOD-1
Expression of PERIOD-2
Expression of NR1D1 (REV-ERBA)
Expression of ELOVL3
Expression of PPARGC1A (PGC-1alpha)
Expression of RORA (ROR-alpha)
Expression of SREBF1 (SREBP1)
Expression of CPT1A
Expression of BMAL1 (ARNTL).
Expression of CLOCK
Expression of NPAS2
Expression of AVP
Expression of DBP