LIG1
label: UniProt:P18858 LIG1

FEN1
label: RAD2
label: UniProt:P39748 FEN1

Mis18 Complex Binds the Centromere.
type: GO_0003674
BFO_0000050: Deposition of New CENPA-containing Nucleosomes at the Centromere
directly activates: HJURP:CENPA Complex Localizes to the Centromere.

HJURP:CENPA Complex Localizes to the Centromere.
type: GO_0003674
BFO_0000050: Deposition of New CENPA-containing Nucleosomes at the Centromere
directly activates: Deposition of New CENPA-containing Nucleosomes at the Centromere.

Deposition of New CENPA-containing Nucleosomes at the Centromere.
type: GO_0003674
BFO_0000050: Deposition of New CENPA-containing Nucleosomes at the Centromere
directly activates: RSF Complex Binds the Centromere.

RSF Complex Binds the Centromere.
type: GO_0003674
BFO_0000050: Deposition of New CENPA-containing Nucleosomes at the Centromere

Biogenesis And Assembly Of The Telomerase RNP
type: GO_0007004
BFO_0000050: Telomere Extension By Telomerase
directly activates: Recruitment of Telomerase RNP to the Telomeric Chromosome End
label: TERC RNA + 2 TERT + 2 DKC1 (dyskerin) => telomerase RNP

Recruitment of Telomerase RNP to the Telomeric Chromosome End
type: GO_0007004
BFO_0000050: Telomere Extension By Telomerase
directly activates: Alignment Of The RNA Template On The Telomeric Chromosome End

Alignment Of The RNA Template On The Telomeric Chromosome End
type: GO_0007004
BFO_0000050: Telomere Extension By Telomerase
directly activates: Elongation Of The Telomeric Chromosome End
directly activates: Catalysis919

Elongation Of The Telomeric Chromosome End
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003720
type: GO_0007004
BFO_0000050: Telomere Extension By Telomerase
directly activates: Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End

Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End
type: GO_0007004
BFO_0000050: Telomere Extension By Telomerase
directly activates: Elongation of Extended Telomeric Chromosome End
directly activates: Catalysis920

Elongation of Extended Telomeric Chromosome End
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003720
type: GO_0007004
BFO_0000050: Telomere Extension By Telomerase
directly activates: Disassociation of Telomerase RNP and the Chromosome End
directly activates: Telomere C-strand synthesis initiation

Disassociation of Telomerase RNP and the Chromosome End
type: GO_0007004
BFO_0000050: Telomere Extension By Telomerase

The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0003899
BFO_0000050: Telomere C-strand synthesis initiation
directly activates: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
directly activates: Catalysis922

The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0003887
BFO_0000050: Telomere C-strand synthesis initiation
directly activates: RFC binding displaces Pol Alpha on the C-strand of the telomere

RFC binding displaces Pol Alpha on the C-strand of the telomere
type: GO_0000722
BFO_0000050: Polymerase switching on the C-strand of the telomere
directly activates: Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere

Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
type: GO_0000722
BFO_0000050: Polymerase switching on the C-strand of the telomere
directly activates: RFC dissociates after sliding clamp formation on the C-strand of the telomere

RFC dissociates after sliding clamp formation on the C-strand of the telomere
type: GO_0000722
BFO_0000050: Polymerase switching on the C-strand of the telomere
directly activates: Formation of Processive Complex on the C-strand of the telomere

Formation of Processive Complex on the C-strand of the telomere
type: GO_0000722
BFO_0000050: Polymerase switching on the C-strand of the telomere
directly activates: Formation of C-strand Okazaki fragments
directly activates: Catalysis923

Formation of C-strand Okazaki fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0003887
BFO_0000050: Processive synthesis on the C-strand of the telomere
directly activates: Formation of the Flap Intermediate on the C-strand

Formation of the Flap Intermediate on the C-strand
type: GO_0000722
BFO_0000050: Processive synthesis on the C-strand of the telomere
directly activates: RPA binds to the Flap on the C-strand
directly activates: Removal of the Flap Intermediate from the C-strand

RPA binds to the Flap on the C-strand
type: GO_0000722
BFO_0000050: Removal of the Flap Intermediate from the C-strand
directly activates: Recruitment of Dna2 endonuclease to the C strand

Recruitment of Dna2 endonuclease to the C strand
type: GO_0000722
BFO_0000050: Removal of the Flap Intermediate from the C-strand
directly activates: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand

Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
type: GO_0000722
BFO_0000050: Removal of the Flap Intermediate from the C-strand
directly activates: Removal of remaining Flap from the C-strand
directly activates: Catalysis924

Removal of remaining Flap from the C-strand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0017108
BFO_0000050: Removal of the Flap Intermediate from the C-strand

Joining of adjacent Okazaki fragments of the C-strand
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000722
type: GO_0003909
BFO_0000050: Processive synthesis on the C-strand of the telomere
directly activates: Disassociation of Processive Complex and Completed Telomere End

Disassociation of Processive Complex and Completed Telomere End
type: GO_0000723
BFO_0000050: Telomere C-strand (Lagging Strand) Synthesis
directly activates: Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure
directly activates: Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure

Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure
type: GO_0016233
BFO_0000050: Packaging Of Telomere Ends

Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure
type: GO_0016233
BFO_0000050: Packaging Of Telomere Ends

Formation of Axial/Lateral Elements of Synaptonemal Complex
type: GO_0003674
BFO_0000050: Meiotic Synapsis
directly activates: Formation of the telomere bouquet

Formation of the telomere bouquet
type: GO_0003674
BFO_0000050: Meiotic Synapsis
directly activates: Formation of Central Elements of the Synaptonemal Complex
directly activates: Recruitment of BRCA1 to Unsynapsed Regions
label: Telomere clustering at the nuclear membrane

Formation of Central Elements of the Synaptonemal Complex
type: GO_0003674
BFO_0000050: Meiotic Synapsis
label: Synapsis

Recruitment of BRCA1 to Unsynapsed Regions
type: GO_0003674
BFO_0000050: Meiotic Synapsis
directly activates: Recruitment of ATR Kinase to Unsynapsed Regions

Recruitment of ATR Kinase to Unsynapsed Regions
type: GO_0003674
BFO_0000050: Meiotic Synapsis
directly activates: ATR Phosphorylates Histone H2A.X at Unsynapsed Regions
directly activates: Catalysis926

ATR Phosphorylates Histone H2A.X at Unsynapsed Regions
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Meiotic Synapsis

Chromosome Maintenance
type: GO_0008150

Nucleosome assembly
type: GO_0008150
BFO_0000050: Chromosome Maintenance

Deposition of New CENPA-containing Nucleosomes at the Centromere
type: GO_0008150
BFO_0000050: Nucleosome assembly

Maintenance of Telomeres
type: GO_0008150
BFO_0000050: Chromosome Maintenance
label: Telomere Maintenance

Extension of Telomeres
type: GO_0008150
BFO_0000050: Maintenance of Telomeres

Telomere Extension By Telomerase
type: GO_0008150
BFO_0000050: Extension of Telomeres

Telomere C-strand (Lagging Strand) Synthesis
type: GO_0008150
BFO_0000050: Extension of Telomeres

Telomere C-strand synthesis initiation
type: GO_0008150
BFO_0000050: Telomere C-strand (Lagging Strand) Synthesis

Polymerase switching on the C-strand of the telomere
type: GO_0008150
BFO_0000050: Telomere C-strand (Lagging Strand) Synthesis

Processive synthesis on the C-strand of the telomere
type: GO_0008150
BFO_0000050: Telomere C-strand (Lagging Strand) Synthesis

Removal of the Flap Intermediate from the C-strand
type: GO_0008150
BFO_0000050: Processive synthesis on the C-strand of the telomere

Packaging Of Telomere Ends
type: GO_0008150
BFO_0000050: Maintenance of Telomeres

Meiotic Synapsis
type: GO_0008150
BFO_0000050: Chromosome Maintenance