ACOT8
label: ACTEIII
label: PTE1
label: PTE2
label: UniProt:O14734 ACOT8

ACSVL1
label: FACVL1
label: FATP2
label: SLC27A2
label: UniProt:O14975 SLC27A2
label: VLACS

ABCC3
label: CMOAT2
label: MLP2
label: MRP3
label: UniProt:O15438 ABCC3

ABCB11
label: BSEP
label: UniProt:O95342 ABCB11

SCP2
label: UniProt:P22307-1 SCP2

OATP
label: OATP1
label: OATP1A2
label: SLC21A3
label: SLCO1A2
label: UniProt:P46721 SLCO1A2

AKR1D1
label: SRD5B1
label: UniProt:P51857 AKR1D1

CYP27
label: CYP27A1
label: UniProt:Q02318 CYP27A1

ASBT
label: ISBT
label: NTCP2
label: SLC10A2
label: UniProt:Q12908 SLC10A2

BAAT
label: UniProt:Q14032 BAAT

GIG29
label: NTCP
label: SLC10A1
label: UniProt:Q14973 SLC10A1

HSD3B7
label: UniProt:Q9H2F3 HSD3B7

LST2
label: OATP1B3
label: OATP8,SLC21A8
label: SLCO1B3
label: UniProt:Q9NPD5 SLCO1B3

CYP39A1
label: UniProt:Q9NYL5 CYP39A1

AMACR
label: UniProt:Q9UHK6 AMACR

ACSB
label: ACSVL6
label: FACVL3
label: FATP5
label: SLC27A5
label: UniProt:Q9Y2P5 SLC27A5

CYP46
label: CYP46A1
label: UniProt:Q9Y6A2 CYP46A1

LST1
label: OATP1B1
label: OATP2
label: OATPC
label: SLC21A6
label: SLCO1B1
label: UniProt:Q9Y6L6 SLCO1B1

Transport (influx) of bile salts and acids by OATP-A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: OATP
type: Restriction
  on property: enabled by
  some values from: OATP
type: GO_0015125
BFO_0000050: Recycling of bile acids and salts
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)
directly activates: Catalysis2262
directly activates: Catalysis2296

Transport (influx) of glycocholate and taurocholate by OATP-8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: LST2
type: Restriction
  on property: enabled by
  some values from: LST2
type: GO_0015125
BFO_0000050: Recycling of bile acids and salts
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262

Transport (influx) of glycocholate and taurocholate by OATP-C
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: LST1
type: Restriction
  on property: enabled by
  some values from: LST1
type: GO_0015125
BFO_0000050: Recycling of bile acids and salts
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262

Cholesterol + NADPH + H+ + O2 => 7-alpha-hydroxycholesterol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008123
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
directly activates: Catalysis2233
label: Cholesterol is hydroxylated to 7alpha-hydroxycholesterol by CYP7A1

7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: GO_0003854
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one
directly activates: 4-cholesten-7alpha-ol-3-one + NADPH + H+ => 5beta-cholestan-7alpha-ol-3-one + NADP+
directly activates: Catalysis2234
directly activates: Catalysis2236

4-Cholesten-7alpha-ol-3-one is 12alpha-hydroxylated to 7-alpha,12-alpha-dihydroxycholest-4-en-3-one
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 4-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholesten-7alpha,12alpha-diol-3-one + NADP+
directly activates: Catalysis2235
label: 7-alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 => 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O

4-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholesten-7alpha,12alpha-diol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 5Beta-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NAPDP+
directly activates: Catalysis2237
label: 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one

4-cholesten-7alpha-ol-3-one + NADPH + H+ => 5beta-cholestan-7alpha-ol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol
directly activates: Catalysis2238
label: 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one

5Beta-cholesten-7alpha, 12alpha-diol-3-one + NADPH + H+ => 5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NAPDP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix
label: 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol

5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix
label: 5beta-cholestan-7alpha-ol-3-one+ NADPH + H+ => 5beta-cholestan-3alpha, 7alpha-diol + NADP+

5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol + NADP+ + H2O
directly activates: Catalysis2239

5beta-cholestan-3alpha, 7alpha-diol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha, 7alpha-diol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ + H2O
directly activates: Catalysis2240

5beta-cholestan-3alpha, 7alpha, 12alpha-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NADP+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+
directly activates: Catalysis2241
label: 5beta-cholestan-3alpha, 7alpha, 12alpha-triol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol

5beta-cholestan-3alpha, 7alpha-diol + NADPH + H+ + O2 => 5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ => 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+
directly activates: Catalysis2242
label: 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol

5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NADP+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) + NADP+ + H2O
directly activates: Catalysis2243
label: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ => 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+ + O2 => 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) + NADP+ + H2O
directly activates: Catalysis2244
label: 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: THCA [mitochondrial matrix] => THCA [cytosol]
label: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)

3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+ + O2 => 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: DHCA [mitochondrial matrix] => DHCA [cytosol]
label: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)

THCA [mitochondrial matrix] => THCA [cytosol]
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
directly activates: THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
directly activates: Catalysis2245
directly activates: Catalysis2247
label: THCA is translocated from the mitochondrial matrix to the cytosol

DHCA [mitochondrial matrix] => DHCA [cytosol]
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
directly activates: DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
directly activates: Catalysis2246
directly activates: Catalysis2248
label: DHCA is translocated from the mitochondrial matrix to the cytosol

THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(R) THCA-CoA [ cytosol] => 25(R) THCA-CoA [peroxisome]
label: THCA is conjugated with Coenzyme A (SLC27A2 VLCS)

DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(R) DHCA-CoA [ cytosol] => 25(R) DHCA-CoA [peroxisome]
label: DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)

THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(R) THCA-CoA [ cytosol] => 25(R) THCA-CoA [peroxisome]
label: THCA is conjugated with Coenzyme A (SLC27A5 BACS)

DHCA + ATP + CoASH => 25(R) DHCA-CoA + AMP + pyrophosphate (SCLS25A5 "BACS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(R) DHCA-CoA [ cytosol] => 25(R) DHCA-CoA [peroxisome]
label: DHCA is conjugated with Coenzyme A (SLC27A5 BACS)

25(R) THCA-CoA [ cytosol] => 25(R) THCA-CoA [peroxisome]
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(R) THCA-CoA => 25(S) THCA-CoA
directly activates: Catalysis2249
label: 25(R) THCA-CoA is translocated from the cytosol to the peroxisome

25(R) DHCA-CoA [ cytosol] => 25(R) DHCA-CoA [peroxisome]
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(R) DHCA-CoA => 25(S) DHCA-CoA
directly activates: Catalysis2250
label: 25(R) DHCA-CoA is translocated from the cytosol to the peroxisome

25(R) THCA-CoA => 25(S) THCA-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0008111
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(S) THCA-CoA + O2 => THCA-CoA + H2O2
directly activates: Catalysis2251
label: Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA

25(R) DHCA-CoA => 25(S) DHCA-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0008111
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(S) DHCA-CoA + O2 => 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O2
directly activates: Catalysis2252
label: Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA

25(S) THCA-CoA + O2 => THCA-CoA + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003997
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
directly activates: Catalysis2253
label: 25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)

25(S) DHCA-CoA + O2 => 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003997
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
directly activates: Catalysis2254
label: 25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA

3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0033989
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
directly activates: Catalysis2255
label: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0033989
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA + NADH + H+
directly activates: Catalysis2256
label: 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003857
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA + CoASH => choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
directly activates: Catalysis2257
label: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA

(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003857
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA + CoASH => chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
directly activates: Catalysis2258
label: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA

3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA + CoASH => choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0050632
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: Hydrolysis of choloyl-CoA to cholate and CoASH
directly activates: Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate
directly activates: Catalysis2259
directly activates: Catalysis2260
label: Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA + CoASH => chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) + propionyl CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0050632
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate
directly activates: Catalysis2261
label: Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA

Hydrolysis of choloyl-CoA to cholate and CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016289
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: Cholate is translocated from the peroxisomal matrix to the cytosol

Cholate is translocated from the peroxisomal matrix to the cytosol
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
label: cholate [peroxisomal matrix] => cholate [cytosol]

Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016746
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: Bile salts are translocated from the peroxisomal matrix to the cytosol

Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016746
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: Bile salts are translocated from the peroxisomal matrix to the cytosol

Bile salts are translocated from the peroxisomal matrix to the cytosol
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262
label: bile salts [peroxisomal matrix] => cholate bile salts [cytosol]

Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: enabled by
  some values from: ABCB11
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015432
BFO_0000050: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
BFO_0000050: Recycling of bile acids and salts

Cholesterol is hydroxylated to 24-hydroxycholesterol by CYP46A1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: enabled by
  some values from: CYP46
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033781
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: Efflux of 24-hydroxycholesterol
label: cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O

Efflux of 24-hydroxycholesterol
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: Influx of 24-hydroxycholesterol

Influx of 24-hydroxycholesterol
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
directly activates: Catalysis2264

24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: enabled by
  some values from: CYP39A1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008396
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: Cholest-5-ene-3beta,7alpha,24(S)-triol + NAD+ => 4-cholesten-7alpha,24(S)-diol-3-one + NADH + H+
directly activates: Catalysis2265
label: 24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol

Cholest-5-ene-3beta,7alpha,24(S)-triol + NAD+ => 4-cholesten-7alpha,24(S)-diol-3-one + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0003854
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O
directly activates: 4-cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,24(S)-diol-3-one + NADP+
directly activates: Catalysis2266
directly activates: Catalysis2268
label: Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one

4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 4-cholesten-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADP+
directly activates: Catalysis2267
label: 4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one

4-cholesten-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NAPDP+
directly activates: Catalysis2269
label: 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one

4-cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,24(S)-diol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol
directly activates: Catalysis2270
label: 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one

5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one + NADPH + H+ => 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NAPDP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix
label: 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol

5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix
label: 5beta-cholestan-7alpha,24(S)-diol-3-one+ NADPH + H+ => 5beta-cholestan-3alpha,7alpha,24(S)-triol + NADP+

5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADP+ + H2O
directly activates: Catalysis2271

5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,24(S)-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADP+ + H2O
directly activates: Catalysis2272

5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADP+ + H2O
directly activates: Catalysis2273
label: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol

5beta-cholestan-3alpha,7alpha,24(S)-triol + NADPH + H+ + O2 => 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADPH + H+ + O2 => 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al + NADP+ + H2O
directly activates: Catalysis2274
label: 5beta-cholestan-3alpha,7alpha,24(S)-triol is hydroxylated to 5beta-cholestan-3alpha,7alpha,24(S), 27-tetrol

5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) + NADP+ + H2O
directly activates: Catalysis2275
label: 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al

5beta-cholestan-3alpha,7alpha,24(S),27-tetrol + NADPH + H+ + O2 => 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) + NADP+ + H2O
directly activates: Catalysis2276
label: 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al

3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: TetraHCA [mitochondrial matrix] => TetraHCA [cytosol]
label: 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)

3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 3,7,24THCA [mitochondrial matrix] => 3,7,24THCA [cytosol]
label: 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)

TetraHCA [mitochondrial matrix] => TetraHCA [cytosol]
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: TetraHCA + ATP + CoASH => 25(R) TetraHCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
directly activates: TetraHCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
directly activates: Catalysis2277
directly activates: Catalysis2279
label: TetraHCA is translocated from the mitochondrial matrix to the cytosol

3,7,24THCA [mitochondrial matrix] => 3,7,24THCA [cytosol]
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
directly activates: 3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
directly activates: Catalysis2278
directly activates: Catalysis2280
label: 3,7,24THCA is translocated from the mitochondrial matrix to the cytosol

TetraHCA + ATP + CoASH => 25(R) TetraHCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 25(R) TetraHCA-CoA [ cytosol] => 25(R) TetraHCA-CoA [peroxisome]
label: TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)

3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 3,7,24THCA-CoA [ cytosol] => 3,7,24THCA-CoA [peroxisome]
label: 3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)

TetraHCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 25(R) TetraHCA-CoA [ cytosol] => 25(R) TetraHCA-CoA [peroxisome]
label: TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)

3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SLC27A2 "VLCS")
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004467
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 3,7,24THCA-CoA [ cytosol] => 3,7,24THCA-CoA [peroxisome]
label: 3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)

25(R) TetraHCA-CoA [ cytosol] => 25(R) TetraHCA-CoA [peroxisome]
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 25(R) TetraHCA-CoA => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
directly activates: Catalysis2281
label: 25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome

3,7,24THCA-CoA [ cytosol] => 3,7,24THCA-CoA [peroxisome]
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: 3,7,24THCA-CoA => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
directly activates: Catalysis2282
label: 3,7,24THCA-CoA is translocated from the cytosol to the peroxisome

25(R) TetraHCA-CoA => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0008111
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + NADH + H+
directly activates: Catalysis2255
label: Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA

3,7,24THCA-CoA => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0008111
BFO_0000050: Synthesis of bile acids and bile salts via 24-hydroxycholesterol
directly activates: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA + NAD+ => 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA + NADH + H+
directly activates: Catalysis2256
label: Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

Cholesterol is hydroxylated to 27-hydroxycholesterol by CYP27
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: Restriction
  on property: enabled by
  some values from: CYP27
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: Efflux of 27-hydroxycholesterol
label: cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+

Efflux of 27-hydroxycholesterol
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: Influx of 27-hydroxycholesterol

Influx of 27-hydroxycholesterol
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
directly activates: Catalysis2284

27-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,27-triol + H2O + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008396
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: Cholest-5-ene-3beta,7alpha,27-triol + NAD+ => 4-cholesten-7alpha,27-diol-3-one +NADH + H+
directly activates: Catalysis2285
label: 27-hydroxycholesterol is 7alpha-hydroxylated

Cholest-5-ene-3beta,7alpha,27-triol + NAD+ => 4-cholesten-7alpha,27-diol-3-one +NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: Restriction
  on property: enabled by
  some values from: HSD3B7
type: GO_0003854
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 4-Cholesten-7alpha,27-diol-3-one + NADPH + H+ + O2 => 4-Cholesten-7alpha,12alpha,27-triol-3-one + NADP+ + H2O
directly activates: 4-cholesten-7alpha,27-diol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,27-diol-3-one + NADP+
directly activates: Catalysis2286
directly activates: Catalysis2288
label: Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one

4-Cholesten-7alpha,27-diol-3-one + NADPH + H+ + O2 => 4-Cholesten-7alpha,12alpha,27-triol-3-one + NADP+ + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0033778
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 4-cholesten-7alpha,12alpha,27-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,27-triol-3-one + NADP+
directly activates: Catalysis2287
label: 4-Cholesten-7alpha,27-diol-3-one is 12alpha-hydroxylated to 4-Cholesten-7alpha,12alpha,27-triol-3-one

4-cholesten-7alpha,12alpha,27-triol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,12alpha,27-triol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 5Beta-cholestan-7alpha,12alpha,27-triol-3-one + NADPH + H+ => 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NAPDP+
directly activates: Catalysis2289
label: 4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one

4-cholesten-7alpha,27-diol-3-one + NADPH + H+ => 5beta-cholestan-7alpha,27-diol-3-one + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: Restriction
  on property: enabled by
  some values from: AKR1D1
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol
directly activates: Catalysis2290
label: 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one

5Beta-cholestan-7alpha,12alpha,27-triol-3-one + NADPH + H+ => 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NAPDP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix
label: 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol

5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004033
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix
label: 5beta-cholestan-7alpha,27-diol-3-one+ NADPH + H+ => 5beta-cholestan-3alpha,7alpha,27-triol + NADP+

5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol + NADP+ => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+
directly activates: Catalysis2241

5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix
type: GO_0003674
BFO_0000050: Synthesis of bile acids and bile salts via 27-hydroxycholesterol
directly activates: 5beta-cholestan-3alpha, 7alpha, 26-triol + NADP+ => 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al + NADPH + H+
directly activates: Catalysis2242

Cholesterol is hydroxylated to 25-hydroxycholesterol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008395
BFO_0000050: Synthesis of bile acids and bile salts
directly activates: 25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1
directly activates: Catalysis2292

25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0008396
BFO_0000050: Synthesis of bile acids and bile salts

Co-transport (influx) of bile salts and acids and sodium ions by ASBT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ASBT
type: Restriction
  on property: enabled by
  some values from: ASBT
type: GO_0008508
BFO_0000050: Recycling of bile acids and salts
directly activates: Transport (efflux) of bile salts by ABCC3 (MRP3)
directly activates: Catalysis2294

Transport (efflux) of bile salts by ABCC3 (MRP3)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: ABCC3
type: Restriction
  on property: enabled by
  some values from: ABCC3
type: GO_0015432
BFO_0000050: Recycling of bile acids and salts
directly activates: Transport (influx) of bile salts and acids by OATP-A
directly activates: Transport (influx) of glycocholate and taurocholate by OATP-8
directly activates: Transport (influx) of glycocholate and taurocholate by OATP-C
directly activates: Co-transport (influx) of bile salts and sodium ions by NTCP
directly activates: Catalysis2295
directly activates: Catalysis731
directly activates: Catalysis732
directly activates: Catalysis733

Co-transport (influx) of bile salts and sodium ions by NTCP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: GIG29
type: Restriction
  on property: enabled by
  some values from: GIG29
type: GO_0008508
BFO_0000050: Recycling of bile acids and salts
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262

Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: ACSB
type: Restriction
  on property: enabled by
  some values from: ACSB
type: GO_0004467
BFO_0000050: Recycling of bile acids and salts
directly activates: Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine
directly activates: Catalysis2297

Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: BAAT
type: Restriction
  on property: enabled by
  some values from: BAAT
type: GO_0008206
type: GO_0016746
BFO_0000050: Recycling of bile acids and salts
directly activates: Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
directly activates: Catalysis2262

Bile acid and bile salt metabolism
type: GO_0008150

Synthesis of bile acids and bile salts
type: GO_0008150
BFO_0000050: Bile acid and bile salt metabolism

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
type: GO_0008150
BFO_0000050: Synthesis of bile acids and bile salts

Synthesis of bile acids and bile salts via 24-hydroxycholesterol
type: GO_0008150
BFO_0000050: Synthesis of bile acids and bile salts

Synthesis of bile acids and bile salts via 27-hydroxycholesterol
type: GO_0008150
BFO_0000050: Synthesis of bile acids and bile salts

Recycling of bile acids and salts
type: GO_0008150
BFO_0000050: Bile acid and bile salt metabolism