ADORA2
label: ADORA2A
label: UniProt:P29274 ADORA2A

ADCYAP1R1
label: UniProt:P41586 ADCYAP1R1

beta-NGF dimer binds to TrkA receptor
type: GO_0003674
BFO_0000050: TRKA activation by NGF
directly activates: The bound receptor dimerizes

The bound receptor dimerizes
type: GO_0003674
BFO_0000050: TRKA activation by NGF
directly activates: TrkA receptor autophosphorylates
directly activates: Catalysis1781

TrkA receptor autophosphorylates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004714
BFO_0000050: TRKA activation by NGF
directly activates: BiochemicalReaction3917
directly activates: BiochemicalReaction3939

Activated TrkA receptor internalizes to endosomes
type: GO_0003674
BFO_0000050: TRKA activation by NGF
directly activates: BiochemicalReaction3928

TRKA activation by adenosine A2a receptor
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: ADORA2
type: Restriction
  on property: enabled by
  some values from: ADORA2
type: GO_0001609
BFO_0000050: NGF-independant TRKA activation

TRKA activation by PACAP type 1 receptor
type: Restriction
  on property: enabled by
  some values from: ADCYAP1R1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: ADCYAP1R1
type: GO_0001634
BFO_0000050: NGF-independant TRKA activation

Activation of TRKA receptors
type: GO_0008150

TRKA activation by NGF
type: GO_0008150
BFO_0000050: Activation of TRKA receptors

NGF-independant TRKA activation
type: GO_0008150
BFO_0000050: Activation of TRKA receptors