GO Monthly Release Notes for June 2003 ======================== Generated on Mon Oct 27 12:29:28 2003 Files used: component old: 2.360 new: 2.371 function old: 2.708 new: 2.724 process old: 2.793 new: 2.818 definitions old: 2.1138 new: 2.1176 GO Slim: Generic.0208 Key: |----1----||----2-----||-3--||4||----5----||-----------6-----------| GO:0009941 GO:0009536 TAIR D SF:575119 chloroplast envelope (obs) 1. GO ID number 2. GO-slim term(s) that new term was added under or "obs" if the term is obsolete. Terms with more than one GO-slim parent have further parents listed underneath the first parent. 3. Database that added term 4. indicates the existence of a definition for the term 5. the sourceforge request ID the term was added in response to 6. term name Columns are tab-delimited and can be imported into Excel for ease of reading. New terms in component ontology (13 new terms) GO:0000932 GO:0005737 SGD D 752209 cytoplasmic mRNA processing body GO:0000933 GO:0005623 SGD D 745245 adventitious septum GO:0000934 GO:0005623 SGD D 745245 porous septum GO:0000935 GO:0005623 SGD D 745245 barrier septum GO:0000936 GO:0005623 SGD D 745245 primary septum GO:0000937 GO:0005623 SGD D 745245 dolipore septum GO:0000938 GO:0005794 SGD D 755620 GARP complex GO:0016023 GO:0030694 GO:0005623 MAH D flagellar basal body, rod (sensu Bacteria) GO:0030700 GO:0005737 MAH D 756122 glycine reductase complex GO:0042757 GO:0005623 JL D giant axon GO:0042763 GO:0005623 JL D 747457 immature spore GO:0042764 GO:0005623 JL D 747457 prospore GO:0042765 GO:0005623 JL D 755325 GPI-anchor transamidase complex GO:0005783 Term name changes in component ontology GO:0030176: endoplasmic reticulum membrane, intrinsic protein --> integral to endoplasmic reticulum membrane GO:0042406: endoplasmic reticulum membrane, extrinsic protein --> extrinsic to endoplasmic reticulum membrane New definitions for component ontology terms (13 new definitions) GO:0009420, flagellar filament (sensu Bacteria) GO:0009421, flagellar filament cap (sensu Bacteria) GO:0009422, flagellar hook-filament junction (sensu Bacteria) GO:0009424, flagellar hook (sensu Bacteria) GO:0009425, flagellar basal body (sensu Bacteria) GO:0009426, flagellar basal body, distal rod (sensu Bacteria) GO:0009427, flagellar basal body, distal rod, L ring (sensu Bacteria) GO:0009428, flagellar basal body, distal rod, P ring (sensu Bacteria) GO:0009429, flagellar basal body, proximal rod (sensu Bacteria) GO:0009431, flagellar basal body, MS ring (sensu Bacteria) GO:0009433, flagellar basal body, C ring (sensu Bacteria) GO:0030428, septum GO:0042406, extrinsic to endoplasmic reticulum membrane New term merges in component ontology GO:0009430 has been merged into GO:0009431, flagellar basal body, MS ring (sensu Bacteria) GO:0030028 has been merged into GO:0030175, filopodium Term movements in component ontology: Terms movements under GO Slim term 'extracellular ; GO:0005576' - GO:0019034, viral replication complex - GO:0019035, viral integration complex - GO:0019036, viral transcriptional complex - GO:0019037, viral assembly intermediate Terms movements under GO Slim term 'nucleus ; GO:0005634' + GO:0019034, viral replication complex + GO:0019035, viral integration complex + GO:0019036, viral transcriptional complex Terms movements under GO Slim term 'cytoplasm ; GO:0005737' + GO:0019037, viral assembly intermediate New terms in function ontology (9 new terms) GO:0030695 GO:0030234 MAH D 648174 GTPase regulator activity GO:0030696 GO:0003824 MAH D tRNA (m5U54) methyltransferase GO:0030697 GO:0003824 MAH D S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase GO:0030698 GO:0003824 MAH D 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase GO:0030699 GO:0003824 MAH D 756122 glycine reductase activity GO:0030701 GO:0003824 MAH D 756141 NAD-dinitrogen-reductase ADP-D-ribosyltransferase GO:0042767 GO:0003824 JL D 751844 ecdysteroid 22-hydroxylase activity GO:0019825 GO:0042768 GO:0003824 JL D 751844 ecdysteroid 2-hydroxylase activity GO:0019825 GO:0048101 GO:0003824 JIC D 752008 calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity Term name changes in function ontology GO:0000035: acyl binding activity --> acyl binding GO:0000049: tRNA binding activity --> tRNA binding GO:0000062: acyl-CoA binding activity --> acyl-CoA binding GO:0000149: SNARE binding activity --> SNARE binding GO:0000166: nucleotide binding activity --> nucleotide binding GO:0000182: ribosomal DNA (rDNA) binding activity --> ribosomal DNA (rDNA) binding GO:0000217: DNA secondary structure binding activity --> DNA secondary structure binding GO:0000268: peroxisome targeting sequence binding activity --> peroxisome targeting sequence binding GO:0000287: magnesium ion binding activity --> magnesium ion binding GO:0000339: RNA cap binding activity --> RNA cap binding GO:0000340: RNA 7-methylguanosine cap binding activity --> RNA 7-methylguanosine cap binding GO:0000341: RNA trimethylguanosine cap binding activity --> RNA trimethylguanosine cap binding GO:0000342: RNA cap 4 binding activity --> RNA cap 4 binding GO:0001530: lipopolysaccharide binding activity --> lipopolysaccharide binding GO:0001531: interleukin-21 receptor binding activity --> interleukin-21 receptor binding GO:0001540: beta-amyloid binding activity --> beta-amyloid binding GO:0001664: G-protein-coupled receptor binding activity --> G-protein-coupled receptor binding GO:0003676: nucleic acid binding activity --> nucleic acid binding GO:0003677: DNA binding activity --> DNA binding GO:0003680: AT DNA binding activity --> AT DNA binding GO:0003681: bent DNA binding activity --> bent DNA binding GO:0003682: chromatin binding activity --> chromatin binding GO:0003683: lamin/chromatin binding activity --> lamin/chromatin binding GO:0003684: damaged DNA binding activity --> damaged DNA binding GO:0003688: DNA replication origin binding activity --> DNA replication origin binding GO:0003690: double-stranded DNA binding activity --> double-stranded DNA binding GO:0003691: double-stranded telomeric DNA binding activity --> double-stranded telomeric DNA binding GO:0003692: left-handed Z-DNA binding activity --> left-handed Z-DNA binding GO:0003693: P-element binding activity --> P-element binding GO:0003695: random coil DNA binding activity --> random coil DNA binding GO:0003696: satellite DNA binding activity --> satellite DNA binding GO:0003697: single-stranded DNA binding activity --> single-stranded DNA binding GO:0003719: transcription factor binding activity, cytoplasmic sequestering --> transcription factor binding, cytoplasmic sequestering GO:0003723: RNA binding activity --> RNA binding GO:0003725: double-stranded RNA binding activity --> double-stranded RNA binding GO:0003727: single-stranded RNA binding activity --> single-stranded RNA binding GO:0003729: mRNA binding activity --> mRNA binding GO:0003730: mRNA 3' UTR binding activity --> mRNA 3' UTR binding GO:0003779: actin binding activity --> actin binding GO:0003785: actin monomer binding activity --> actin monomer binding GO:0003786: actin lateral binding activity --> actin lateral binding GO:0003823: antigen binding activity --> antigen binding GO:0003824: enzyme activity --> catalytic activity GO:0003878: ATP-citrate (pro-S)-lyase activity --> ATP citrate synthase activity GO:0005046: KDEL sequence binding activity --> KDEL sequence binding GO:0005047: signal recognition particle binding activity --> signal recognition particle binding GO:0005048: signal sequence binding activity --> signal sequence binding GO:0005080: protein kinase C binding activity --> protein kinase C binding GO:0005084: RAB escort protein activity --> Rab escort protein activity GO:0005102: receptor binding activity --> receptor binding GO:0005103: baboon binding activity --> baboon binding GO:0005104: fibroblast growth factor receptor binding activity --> fibroblast growth factor receptor binding GO:0005105: type 1 fibroblast growth factor receptor binding activity --> type 1 fibroblast growth factor receptor binding GO:0005109: frizzled binding activity --> frizzled binding GO:0005110: frizzled-2 binding activity --> frizzled-2 binding GO:0005111: type 2 fibroblast growth factor receptor binding activity --> type 2 fibroblast growth factor receptor binding GO:0005112: Notch binding activity --> Notch binding GO:0005113: patched binding activity --> patched binding GO:0005114: punt binding activity --> punt binding GO:0005115: receptor tyrosine kinase-like orphan receptor binding activity --> receptor tyrosine kinase-like orphan receptor binding GO:0005116: saxophone binding activity --> saxophone binding GO:0005117: wishful thinking binding activity --> wishful thinking binding GO:0005118: sevenless binding activity --> sevenless binding GO:0005119: smoothened binding activity --> smoothened binding GO:0005120: thickveins binding activity --> thickveins binding GO:0005121: Toll binding activity --> Toll binding GO:0005122: torso binding activity --> torso binding GO:0005123: death receptor binding activity --> death receptor binding GO:0005124: scavenger receptor binding activity --> scavenger receptor binding GO:0005126: hematopoietin/interferon-class (D200-domain) cytokine receptor binding activity --> hematopoietin/interferon-class (D200-domain) cytokine receptor binding GO:0005127: ciliary neurotrophic factor receptor binding activity --> ciliary neurotrophic factor receptor binding GO:0005128: erythropoietin receptor binding activity --> erythropoietin receptor binding GO:0005129: granulocyte macrophage colony-stimulating factor receptor binding activity --> granulocyte macrophage colony-stimulating factor receptor binding GO:0005130: granulocyte colony-stimulating factor receptor binding activity --> granulocyte colony-stimulating factor receptor binding GO:0005131: growth hormone receptor binding activity --> growth hormone receptor binding GO:0005132: interferon-alpha/beta receptor binding activity --> interferon-alpha/beta receptor binding GO:0005133: interferon-gamma receptor binding activity --> interferon-gamma receptor binding GO:0005134: interleukin-2 receptor binding activity --> interleukin-2 receptor binding GO:0005135: interleukin-3 receptor binding activity --> interleukin-3 receptor binding GO:0005136: interleukin-4 receptor binding activity --> interleukin-4 receptor binding GO:0005137: interleukin-5 receptor binding activity --> interleukin-5 receptor binding GO:0005138: interleukin-6 receptor binding activity --> interleukin-6 receptor binding GO:0005139: interleukin-7 receptor binding activity --> interleukin-7 receptor binding GO:0005140: interleukin-9 receptor binding activity --> interleukin-9 receptor binding GO:0005141: interleukin-10 receptor binding activity --> interleukin-10 receptor binding GO:0005142: interleukin-11 receptor binding activity --> interleukin-11 receptor binding GO:0005143: interleukin-12 receptor binding activity --> interleukin-12 receptor binding GO:0005144: interleukin-13 receptor binding activity --> interleukin-13 receptor binding GO:0005145: interleukin-14 receptor binding activity --> interleukin-14 receptor binding GO:0005146: leukemia inhibitory factor receptor binding activity --> leukemia inhibitory factor receptor binding GO:0005147: oncostatin-M receptor binding activity --> oncostatin-M receptor binding GO:0005148: prolactin receptor binding activity --> prolactin receptor binding GO:0005149: interleukin-1 receptor binding activity --> interleukin-1 receptor binding GO:0005150: interleukin-1, Type I receptor binding activity --> interleukin-1, Type I receptor binding GO:0005151: interleukin-1, Type II receptor binding activity --> interleukin-1, Type II receptor binding GO:0005153: interleukin-8 receptor binding activity --> interleukin-8 receptor binding GO:0005154: epidermal growth factor receptor binding activity --> epidermal growth factor receptor binding GO:0005157: macrophage colony stimulating factor receptor binding activity --> macrophage colony stimulating factor receptor binding GO:0005158: insulin receptor binding activity --> insulin receptor binding GO:0005159: insulin-like growth factor receptor binding activity --> insulin-like growth factor receptor binding GO:0005160: transforming growth factor-beta receptor binding activity --> transforming growth factor-beta receptor binding GO:0005161: platelet-derived growth factor receptor binding activity --> platelet-derived growth factor receptor binding GO:0005163: nerve growth factor receptor binding activity --> nerve growth factor receptor binding GO:0005164: tumor necrosis factor receptor binding activity --> tumor necrosis factor receptor binding GO:0005165: neurotrophin receptor binding activity --> neurotrophin receptor binding GO:0005166: neurotrophin p75 receptor binding activity --> neurotrophin p75 receptor binding GO:0005167: neurotrophin TRK receptor binding activity --> neurotrophin TRK receptor binding GO:0005168: neurotrophin TRKA receptor binding activity --> neurotrophin TRKA receptor binding GO:0005169: neurotrophin TRKB receptor binding activity --> neurotrophin TRKB receptor binding GO:0005170: neurotrophin TRKC receptor binding activity --> neurotrophin TRKC receptor binding GO:0005171: hepatocyte growth factor receptor binding activity --> hepatocyte growth factor receptor binding GO:0005172: vascular endothelial growth factor receptor binding activity --> vascular endothelial growth factor receptor binding GO:0005173: stem cell factor receptor binding activity --> stem cell factor receptor binding GO:0005174: CD40 receptor binding activity --> CD40 receptor binding GO:0005175: CD27 receptor binding activity --> CD27 receptor binding GO:0005176: Neu/ErbB-2 receptor binding activity --> Neu/ErbB-2 receptor binding GO:0005178: integrin binding activity --> integrin binding GO:0005488: binding activity --> binding GO:0005496: steroid binding activity --> steroid binding GO:0005497: androgen binding activity --> androgen binding GO:0005499: vitamin D binding activity --> vitamin D binding GO:0005500: juvenile hormone binding activity --> juvenile hormone binding GO:0005501: retinoid binding activity --> retinoid binding GO:0005502: 11-cis retinal binding activity --> 11-cis retinal binding GO:0005503: all-trans retinal binding activity --> all-trans retinal binding GO:0005504: fatty acid binding activity --> fatty acid binding GO:0005505: heavy metal binding activity --> heavy metal binding GO:0005506: iron ion binding activity --> iron ion binding GO:0005507: copper ion binding activity --> copper ion binding GO:0005509: calcium ion binding activity --> calcium ion binding GO:0005515: protein binding activity --> protein binding GO:0005516: calmodulin binding activity --> calmodulin binding GO:0005518: collagen binding activity --> collagen binding GO:0005519: cytoskeletal regulatory protein binding activity --> cytoskeletal regulatory protein binding GO:0005520: insulin-like growth factor binding activity --> insulin-like growth factor binding GO:0005521: lamin binding activity --> lamin binding GO:0005522: profilin binding activity --> profilin binding GO:0005523: tropomyosin binding activity --> tropomyosin binding GO:0005524: ATP binding activity --> ATP binding GO:0005525: GTP binding activity --> GTP binding GO:0005527: macrolide binding activity --> macrolide binding GO:0005528: FK506 binding activity --> FK506 binding GO:0005529: sugar binding activity --> sugar binding GO:0005534: galactose binding activity --> galactose binding GO:0005536: glucose binding activity --> glucose binding GO:0005537: mannose binding activity --> mannose binding GO:0005539: glycosaminoglycan binding activity --> glycosaminoglycan binding GO:0005540: hyaluronic acid binding activity --> hyaluronic acid binding GO:0005541: acyl-CoA or acyl binding activity --> acyl-CoA or acyl binding GO:0005542: folic acid binding activity --> folic acid binding GO:0005543: phospholipid binding activity --> phospholipid binding GO:0005544: calcium-dependent phospholipid binding activity --> calcium-dependent phospholipid binding GO:0005545: phosphatidylinositol binding activity --> phosphatidylinositol binding GO:0005546: phosphatidylinositol-4,5-bisphosphate binding activity --> phosphatidylinositol-4,5-bisphosphate binding GO:0005547: phosphatidylinositol-3,4,5-triphosphate binding activity --> phosphatidylinositol-3,4,5-triphosphate binding GO:0005549: odorant binding activity --> odorant binding GO:0005550: pheromone binding activity --> pheromone binding GO:0008013: beta-catenin binding activity --> beta-catenin binding GO:0008017: microtubule binding activity --> microtubule binding GO:0008022: protein C-terminus binding activity --> protein C-terminus binding GO:0008034: lipoprotein binding activity --> lipoprotein binding GO:0008035: high-density lipoprotein binding activity --> high-density lipoprotein binding GO:0008061: chitin binding activity --> chitin binding GO:0008092: cytoskeletal protein binding activity --> cytoskeletal protein binding GO:0008097: 5S RNA binding activity --> 5S RNA binding GO:0008098: 5S RNA primary transcript binding activity --> 5S RNA primary transcript binding GO:0008134: transcription factor binding activity --> transcription factor binding GO:0008139: nuclear localization sequence binding activity --> nuclear localization sequence binding GO:0008140: cAMP response element binding protein binding activity --> cAMP response element binding protein binding GO:0008142: oxysterol binding activity --> oxysterol binding GO:0008143: poly(A) binding activity --> poly(A) binding GO:0008144: drug binding activity --> drug binding GO:0008145: phenylalkylamine binding activity --> phenylalkylamine binding GO:0008157: protein phosphatase 1 binding activity --> protein phosphatase 1 binding GO:0008179: adenylate cyclase binding activity --> adenylate cyclase binding GO:0008185: transforming growth factor-alpha receptor binding activity --> transforming growth factor-alpha receptor binding GO:0008187: poly-pyrimidine tract binding activity --> poly-pyrimidine tract binding GO:0008190: eukaryotic initiation factor 4E binding activity --> eukaryotic initiation factor 4E binding GO:0008198: ferrous iron binding activity --> ferrous iron binding GO:0008199: ferric iron binding activity --> ferric iron binding GO:0008201: heparin binding activity --> heparin binding GO:0008266: poly(U) binding activity --> poly(U) binding GO:0008267: poly-glutamine tract binding activity --> poly-glutamine tract binding GO:0008270: zinc ion binding activity --> zinc ion binding GO:0008289: lipid binding activity --> lipid binding GO:0008312: 7S RNA binding activity --> 7S RNA binding GO:0008317: gurken receptor binding activity --> gurken receptor binding GO:0008327: methyl-CpG binding activity --> methyl-CpG binding GO:0008367: bacterial binding activity --> bacterial binding GO:0008368: Gram-negative bacterial binding activity --> Gram-negative bacterial binding GO:0008429: phosphatidylethanolamine binding activity --> phosphatidylethanolamine binding GO:0008430: selenium binding activity --> selenium binding GO:0008431: tocopherol binding activity --> tocopherol binding GO:0008432: JUN kinase binding activity --> JUN kinase binding GO:0008536: RAN protein binding activity --> RAN protein binding GO:0008658: penicillin binding activity --> penicillin binding GO:0009374: biotin binding activity --> biotin binding GO:0009940: amino-terminal propeptide binding activity --> amino-terminal propeptide binding GO:0010011: auxin binding activity --> auxin binding GO:0010013: N-1-naphthylphthalamic acid binding activity --> N-1-naphthylphthalamic acid binding GO:0015485: cholesterol binding activity --> cholesterol binding GO:0015631: tubulin binding activity --> tubulin binding GO:0015643: toxin binding activity --> toxin binding GO:0016018: cyclosporin A binding activity --> cyclosporin A binding GO:0016030: metarhodopsin binding activity --> metarhodopsin binding GO:0016151: nickel ion binding activity --> nickel ion binding GO:0016168: chlorophyll binding activity --> chlorophyll binding GO:0016169: bacteriochlorophyll c binding activity --> bacteriochlorophyll c binding GO:0016170: interleukin-15 receptor binding activity --> interleukin-15 receptor binding GO:0016208: AMP binding activity --> AMP binding GO:0016594: glycine binding activity --> glycine binding GO:0016595: glutamate binding activity --> glutamate binding GO:0016596: thienylcyclohexylpiperidine binding activity --> thienylcyclohexylpiperidine binding GO:0016597: amino acid binding activity --> amino acid binding GO:0016918: retinal binding activity --> retinal binding GO:0016936: galactoside binding activity --> galactoside binding GO:0017016: RAS interactor activity --> Ras interactor activity GO:0017021: myosin phosphatase myosin binding activity --> myosin phosphatase myosin binding GO:0017022: myosin binding activity --> myosin binding GO:0017024: myosin I binding activity --> myosin I binding GO:0017025: TATA-binding protein binding activity --> TATA-binding protein binding GO:0017033: DNA topoisomerase I binding activity --> DNA topoisomerase I binding GO:0017046: polypeptide hormone binding activity --> polypeptide hormone binding GO:0017047: adrenocorticotropin-releasing hormone binding activity --> adrenocorticotropin-releasing hormone binding GO:0017048: Rho binding activity --> Rho binding GO:0017049: GTP-Rho binding activity --> GTP-Rho binding GO:0017058: FH1-domain binding activity --> FH1-domain binding GO:0017069: snRNA binding activity --> snRNA binding GO:0017070: U6 snRNA binding activity --> U6 snRNA binding GO:0017075: syntaxin-1 binding activity --> syntaxin-1 binding GO:0017076: purine nucleotide binding activity --> purine nucleotide binding GO:0017091: AU-specific RNA binding activity --> AU-specific RNA binding GO:0017098: sulfonylurea receptor binding activity --> sulfonylurea receptor binding GO:0017124: SH3-domain binding activity --> SH3-domain binding GO:0017129: triglyceride binding activity --> triglyceride binding GO:0017130: poly(rC) binding activity --> poly(rC) binding GO:0017131: uridine-rich cytoplasmic polyadenylation element binding activity --> uridine-rich cytoplasmic polyadenylation element binding GO:0017134: fibroblast growth factor binding activity --> fibroblast growth factor binding GO:0017137: RAB interactor activity --> Rab interactor activity GO:0017147: Wnt-protein binding activity --> Wnt-protein binding GO:0017151: DEAD/H-box RNA helicase binding activity --> DEAD/H-box RNA helicase binding GO:0017160: RAL interactor activity --> Ral interactor activity GO:0017162: aryl hydrocarbon-receptor binding activity --> aryl hydrocarbon-receptor binding GO:0017166: vinculin binding activity --> vinculin binding GO:0017170: KU70 binding activity --> KU70 binding GO:0019001: guanyl nucleotide binding activity --> guanyl nucleotide binding GO:0019002: GMP binding activity --> GMP binding GO:0019003: GDP binding activity --> GDP binding GO:0019103: pyrimidine nucleotide binding activity --> pyrimidine nucleotide binding GO:0019215: intermediate filament binding activity --> intermediate filament binding GO:0019237: centromeric DNA binding activity --> centromeric DNA binding GO:0019808: polyamine binding activity --> polyamine binding GO:0019809: spermidine binding activity --> spermidine binding GO:0019810: putrescine binding activity --> putrescine binding GO:0019811: cocaine binding activity --> cocaine binding GO:0019825: oxygen binding activity --> oxygen binding GO:0019838: growth factor binding activity --> growth factor binding GO:0019840: isoprenoid binding activity --> isoprenoid binding GO:0019841: retinol binding activity --> retinol binding GO:0019842: vitamin binding activity --> vitamin binding GO:0019843: rRNA binding activity --> rRNA binding GO:0019862: IgA binding activity --> IgA binding GO:0019863: IgE binding activity --> IgE binding GO:0019864: IgG binding activity --> IgG binding GO:0019865: immunoglobulin binding activity --> immunoglobulin binding GO:0019894: kinesin binding activity --> kinesin binding GO:0019899: enzyme binding activity --> enzyme binding GO:0019900: kinase binding activity --> kinase binding GO:0019901: protein kinase binding activity --> protein kinase binding GO:0019902: phosphatase binding activity --> phosphatase binding GO:0019903: protein phosphatase binding activity --> protein phosphatase binding GO:0019904: protein domain specific binding activity --> protein domain specific binding GO:0019905: syntaxin binding activity --> syntaxin binding GO:0019955: cytokine binding activity --> cytokine binding GO:0019956: chemokine binding activity --> chemokine binding GO:0019957: C-C chemokine binding activity --> C-C chemokine binding GO:0019958: C-X-C chemokine binding activity --> C-X-C chemokine binding GO:0019959: interleukin-8 binding activity --> interleukin-8 binding GO:0019960: C-X3-C chemokine binding activity --> C-X3-C chemokine binding GO:0019961: interferon binding activity --> interferon binding GO:0019962: interferon-alpha/beta binding activity --> interferon-alpha/beta binding GO:0019964: interferon-gamma binding activity --> interferon-gamma binding GO:0019965: interleukin binding activity --> interleukin binding GO:0019966: interleukin-1 binding activity --> interleukin-1 binding GO:0019967: interleukin-1, Type I, activating binding activity --> interleukin-1, Type I, activating binding GO:0019968: interleukin-1, Type II, blocking binding activity --> interleukin-1, Type II, blocking binding GO:0019969: interleukin-10 binding activity --> interleukin-10 binding GO:0019970: interleukin-11 binding activity --> interleukin-11 binding GO:0019972: interleukin-12 binding activity --> interleukin-12 binding GO:0019973: interleukin-13 binding activity --> interleukin-13 binding GO:0019974: interleukin-14 binding activity --> interleukin-14 binding GO:0019975: interleukin-17 binding activity --> interleukin-17 binding GO:0019976: interleukin-2 binding activity --> interleukin-2 binding GO:0019977: interleukin-21 binding activity --> interleukin-21 binding GO:0019978: interleukin-3 binding activity --> interleukin-3 binding GO:0019979: interleukin-4 binding activity --> interleukin-4 binding GO:0019980: interleukin-5 binding activity --> interleukin-5 binding GO:0019981: interleukin-6 binding activity --> interleukin-6 binding GO:0019982: interleukin-7 binding activity --> interleukin-7 binding GO:0019983: interleukin-9 binding activity --> interleukin-9 binding GO:0019992: diacylglycerol binding activity --> diacylglycerol binding GO:0020037: heme binding activity --> heme binding GO:0030116: glial cell line-derived neurotrophic factor receptor binding activity --> glial cell line-derived neurotrophic factor receptor binding GO:0030145: manganese ion binding activity --> manganese ion binding GO:0030151: molybdenum ion binding activity --> molybdenum ion binding GO:0030156: benzodiazepine receptor binding activity --> benzodiazepine receptor binding GO:0030165: PDZ-domain binding activity --> PDZ-domain binding GO:0030169: low-density lipoprotein binding activity --> low-density lipoprotein binding GO:0030170: pyridoxal phosphate binding activity --> pyridoxal phosphate binding GO:0030172: troponin C binding activity --> troponin C binding GO:0030215: semaphorin receptor binding activity --> semaphorin receptor binding GO:0030246: carbohydrate binding activity --> carbohydrate binding GO:0030247: polysaccharide binding activity --> polysaccharide binding GO:0030248: cellulose binding activity --> cellulose binding GO:0030274: LIM-domain binding activity --> LIM-domain binding GO:0030275: LRR-domain binding activity --> LRR-domain binding GO:0030276: clathrin binding activity --> clathrin binding GO:0030306: ARF binding activity --> ARF binding GO:0030331: estrogen receptor binding activity --> estrogen receptor binding GO:0030332: cyclin binding activity --> cyclin binding GO:0030346: protein phosphatase 2B binding activity --> protein phosphatase 2B binding GO:0030347: syntaxin-2 binding activity --> syntaxin-2 binding GO:0030348: syntaxin-3 binding activity --> syntaxin-3 binding GO:0030349: syntaxin-13 binding activity --> syntaxin-13 binding GO:0030350: iron-responsive element binding activity --> iron-responsive element binding GO:0030367: interleukin-17 receptor binding activity --> interleukin-17 receptor binding GO:0030370: intercellular adhesion molecule-3 receptor binding activity --> intercellular adhesion molecule-3 receptor binding GO:0030372: high molecular weight B-cell growth factor receptor binding activity --> high molecular weight B-cell growth factor receptor binding GO:0030380: interleukin-17E receptor binding activity --> interleukin-17E receptor binding GO:0030395: lactose binding activity --> lactose binding GO:0030492: hemoglobin binding activity --> hemoglobin binding GO:0030506: ankyrin binding activity --> ankyrin binding GO:0030507: spectrin binding activity --> spectrin binding GO:0030515: snoRNA binding activity --> snoRNA binding GO:0030519: snoRNP binding activity --> snoRNP binding GO:0030544: Hsp70 protein binding activity --> Hsp70 protein binding GO:0030551: cyclic nucleotide binding activity --> cyclic nucleotide binding GO:0030552: 3',5'-cAMP binding activity --> 3',5'-cAMP binding GO:0030553: 3',5'-cGMP binding activity --> 3',5'-cGMP binding GO:0030554: adenyl nucleotide binding activity --> adenyl nucleotide binding GO:0030619: U1 snRNA binding activity --> U1 snRNA binding GO:0030620: U2 snRNA binding activity --> U2 snRNA binding GO:0030621: U4 snRNA binding activity --> U4 snRNA binding GO:0030622: U4atac snRNA binding activity --> U4atac snRNA binding GO:0030623: U5 snRNA binding activity --> U5 snRNA binding GO:0030624: U6atac snRNA binding activity --> U6atac snRNA binding GO:0030625: U11 snRNA binding activity --> U11 snRNA binding GO:0030626: U12 snRNA binding activity --> U12 snRNA binding GO:0030627: pre-mRNA 5' splice site binding activity --> pre-mRNA 5' splice site binding GO:0030628: pre-mRNA 3' splice site binding activity --> pre-mRNA 3' splice site binding GO:0030629: U6 snRNA 3' end binding activity --> U6 snRNA 3' end binding GO:0030674: protein binding activity, bridging --> protein binding, bridging GO:0042007: interleukin-18 binding activity --> interleukin-18 binding GO:0042009: interleukin-15 binding activity --> interleukin-15 binding GO:0042011: interleukin-16 binding activity --> interleukin-16 binding GO:0042013: interleukin-19 binding activity --> interleukin-19 binding GO:0042015: interleukin-20 binding activity --> interleukin-20 binding GO:0042017: interleukin-22 binding activity --> interleukin-22 binding GO:0042019: interleukin-23 binding activity --> interleukin-23 binding GO:0042021: granulocyte macrophage colony-stimulating factor complex binding activity --> granulocyte macrophage colony-stimulating factor complex binding GO:0042043: neurexin binding activity --> neurexin binding GO:0042134: rRNA primary transcript binding activity --> rRNA primary transcript binding GO:0042153: RPTP-like protein binding activity --> RPTP-like protein binding GO:0042162: telomeric DNA binding activity --> telomeric DNA binding GO:0042163: interleukin-12 beta subunit binding activity --> interleukin-12 beta subunit binding GO:0042164: interleukin-12 alpha subunit binding activity --> interleukin-12 alpha subunit binding GO:0042165: neurotransmitter binding activity --> neurotransmitter binding GO:0042166: acetylcholine binding activity --> acetylcholine binding GO:0042169: SH2-domain binding activity --> SH2-domain binding GO:0042277: peptide binding activity --> peptide binding GO:0042287: MHC protein binding activity --> MHC protein binding GO:0042288: MHC class I protein binding activity --> MHC class I protein binding GO:0042289: MHC class II protein binding activity --> MHC class II protein binding GO:0042301: phosphate binding activity --> phosphate binding GO:0042314: bacteriochlorophyll binding activity --> bacteriochlorophyll binding GO:0042324: hypocretin receptor binding activity --> hypocretin receptor binding GO:0042379: chemokine receptor binding activity --> chemokine receptor binding GO:0042393: histone binding activity --> histone binding GO:0042497: triacylated lipoprotein binding activity --> triacylated lipoprotein binding GO:0042498: diacylated lipoprotein binding activity --> diacylated lipoprotein binding GO:0042562: hormone binding activity --> hormone binding GO:0042569: APJ receptor binding activity --> APJ receptor binding GO:0042608: T-cell receptor binding activity --> T-cell receptor binding GO:0042609: CD4 receptor binding activity --> CD4 receptor binding GO:0042610: CD8 receptor binding activity --> CD8 receptor binding GO:0042614: CD70 receptor binding activity --> CD70 receptor binding GO:0042615: CD154 receptor binding activity --> CD154 receptor binding GO:0042657: MHC class II protein binding activity, via lateral surface --> MHC class II protein binding, via lateral surface GO:0042658: MHC class II protein binding activity, via antigen binding groove --> MHC class II protein binding, via antigen binding groove GO:0042731: PH-domain binding activity --> PH-domain binding GO:0045015: HDEL sequence binding activity --> HDEL sequence binding GO:0045027: DNA end binding activity --> DNA end binding GO:0045093: interleukin-18 alpha subunit binding activity --> interleukin-18 alpha subunit binding GO:0045094: interleukin-18 beta subunit binding activity --> interleukin-18 beta subunit binding GO:0045131: pre-mRNA branch point binding activity --> pre-mRNA branch point binding GO:0045142: triplex DNA binding activity --> triplex DNA binding GO:0045152: antisigma factor binding activity --> antisigma factor binding GO:0045159: myosin II binding activity --> myosin II binding GO:0045236: CXCR chemokine receptor binding activity --> CXCR chemokine receptor binding GO:0045237: CXCR1 chemokine receptor binding activity --> CXCR1 chemokine receptor binding GO:0045238: CXCR2 chemokine receptor binding activity --> CXCR2 chemokine receptor binding GO:0045294: alpha-catenin binding activity --> alpha-catenin binding GO:0045295: gamma-catenin binding activity --> gamma-catenin binding GO:0045296: cadherin binding activity --> cadherin binding GO:0045308: protein amino acid binding activity --> protein amino acid binding GO:0045309: phosphoprotein amino acid binding activity --> phosphoprotein amino acid binding GO:0045310: phosphoserine/phosphothreonine binding activity --> phosphoserine/phosphothreonine binding GO:0045322: unmethylated CpG binding activity --> unmethylated CpG binding GO:0045340: mercury ion binding activity --> mercury ion binding GO:0045502: dynein binding activity --> dynein binding GO:0045503: dynein light chain binding activity --> dynein light chain binding GO:0045504: dynein heavy chain binding activity --> dynein heavy chain binding GO:0045505: dynein intermediate chain binding activity --> dynein intermediate chain binding GO:0045510: interleukin-24 binding activity --> interleukin-24 binding GO:0045511: interleukin-25 binding activity --> interleukin-25 binding GO:0045512: interleukin-26 binding activity --> interleukin-26 binding GO:0045513: interleukin-27 binding activity --> interleukin-27 binding GO:0045514: interleukin-16 receptor binding activity --> interleukin-16 receptor binding GO:0045515: interleukin-18 receptor binding activity --> interleukin-18 receptor binding GO:0045516: interleukin-19 receptor binding activity --> interleukin-19 receptor binding GO:0045517: interleukin-20 receptor binding activity --> interleukin-20 receptor binding GO:0045518: interleukin-22 receptor binding activity --> interleukin-22 receptor binding GO:0045519: interleukin-23 receptor binding activity --> interleukin-23 receptor binding GO:0045520: interleukin-24 receptor binding activity --> interleukin-24 receptor binding GO:0045521: interleukin-25 receptor binding activity --> interleukin-25 receptor binding GO:0045522: interleukin-26 receptor binding activity --> interleukin-26 receptor binding GO:0045523: interleukin-27 receptor binding activity --> interleukin-27 receptor binding GO:0045545: syndecan binding activity --> syndecan binding GO:0045569: TRAIL binding activity --> TRAIL binding GO:0046332: SMAD binding activity --> SMAD binding GO:0046625: sphingolipid binding activity --> sphingolipid binding GO:0046703: natural killer cell lectin-like receptor binding activity --> natural killer cell lectin-like receptor binding GO:0046714: boron binding activity --> boron binding GO:0046789: host cell surface receptor binding activity --> host cell surface receptor binding GO:0046790: virion binding activity --> virion binding GO:0046810: host cell extracellular matrix binding activity --> host cell extracellular matrix binding GO:0046812: host cell surface binding activity --> host cell surface binding GO:0046848: hydroxyapatite binding activity --> hydroxyapatite binding GO:0046870: cadmium ion binding activity --> cadmium ion binding GO:0046871: N-acetylgalactosamine binding activity --> N-acetylgalactosamine binding GO:0046872: metal ion binding activity --> metal ion binding GO:0046875: ephrin receptor binding activity --> ephrin receptor binding GO:0046876: 3,4-didehydroretinal binding activity --> 3,4-didehydroretinal binding GO:0046904: calcium oxalate binding activity --> calcium oxalate binding GO:0046906: tetrapyrrole binding activity --> tetrapyrrole binding GO:0046914: transition metal ion binding activity --> transition metal ion binding GO:0046923: ER retention sequence binding activity --> ER retention sequence binding GO:0048020: CCR chemokine receptor binding activity --> CCR chemokine receptor binding GO:0048027: mRNA 5' UTR binding activity --> mRNA 5' UTR binding GO:0048028: galacturonan binding activity --> galacturonan binding GO:0048029: monosaccharide binding activity --> monosaccharide binding GO:0048030: disaccharide binding activity --> disaccharide binding GO:0048031: trisaccharide binding activity --> trisaccharide binding GO:0048032: galacturonate binding activity --> galacturonate binding GO:0048037: cofactor binding activity --> cofactor binding GO:0048038: quinone binding activity --> quinone binding GO:0048039: ubiquinone binding activity --> ubiquinone binding New definitions for function ontology terms (36 new definitions) GO:0004703, G-protein coupled receptor kinase activity GO:0004858, dUTP pyrophosphatase inhibitor activity GO:0008047, enzyme activator activity GO:0008173, RNA methyltransferase activity GO:0008174, mRNA methyltransferase activity GO:0008175, tRNA methyltransferase activity GO:0008276, protein methyltransferase activity GO:0008395, steroid hydroxylase activity GO:0008649, rRNA methyltransferase activity GO:0008650, rRNA (uridine-2'-O-)-methyltransferase activity GO:0008656, caspase activator activity GO:0008657, DNA gyrase inhibitor activity GO:0008757, S-adenosylmethionine-dependent methyltransferase activity GO:0009008, DNA-methyltransferase activity GO:0015066, alpha-amylase inhibitor activity GO:0016206, catechol O-methyltransferase activity GO:0016273, arginine N-methyltransferase activity GO:0016274, protein-arginine N-methyltransferase activity GO:0016278, lysine N-methyltransferase activity GO:0016279, protein-lysine N-methyltransferase activity GO:0016300, tRNA (uracil) methyltransferase activity GO:0016423, tRNA (guanine) methyltransferase activity GO:0016424, tRNA (guanosine) methyltransferase activity GO:0016426, tRNA (adenine)-methyltransferase activity GO:0016427, tRNA (cytosine)-methyltransferase activity GO:0016431, tRNA (uridine) methyltransferase activity GO:0016433, rRNA (adenine) methyltransferase activity GO:0016434, rRNA (cytosine) methyltransferase activity GO:0016435, rRNA (guanine) methyltransferase activity GO:0016436, rRNA (uridine) methyltransferase activity GO:0018423, protein-leucine O-methyltransferase activity GO:0019010, farnesoic acid O-methyltransferase activity GO:0019210, kinase inhibitor activity GO:0019838, growth factor binding GO:0030276, clathrin binding GO:0042054, histone methyltransferase activity New term merges in function ontology GO:0000505 has been merged into GO:0003962, cystathionine gamma-synthase activity GO:0004646 has been merged into GO:0004648, phosphoserine transaminase activity GO:0004678 has been merged into GO:0004703, G-protein coupled receptor kinase activity GO:0018843 has been merged into GO:0008704, 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity GO:0046913 has been merged into GO:0003878, ATP citrate synthase activity Term movements in function ontology: Terms movements under GO Slim term 'defense/immunity protein activity ; GO:0003793' - GO:0003810, protein-glutamine gamma-glutamyltransferase activity Terms movements under GO Slim term 'signal transducer activity ; GO:0004871' + GO:0004675, transmembrane receptor protein serine/threonine kinase activity - GO:0004703, G-protein coupled receptor kinase activity + GO:0005023, transforming growth factor-alpha receptor activity + GO:0005024, transforming growth factor-beta receptor activity + GO:0005025, type I transforming growth factor-beta receptor activity + GO:0005026, type II transforming growth factor-beta receptor activity - GO:0005083, small GTPase regulatory/interacting protein activity - GO:0005084, Rab escort protein activity - GO:0005085, guanyl-nucleotide exchange factor activity - GO:0005086, ARF guanyl-nucleotide exchange factor activity - GO:0005087, Ran guanyl-nucleotide exchange factor activity - GO:0005088, Ras guanyl-nucleotide exchange factor activity - GO:0005089, Rho guanyl-nucleotide exchange factor activity - GO:0005090, Sar guanyl-nucleotide exchange factor activity - GO:0005091, guanyl-nucleotide exchange factor adaptor activity - GO:0005092, GDP-dissociation inhibitor activity - GO:0005093, RAB GDP-dissociation inhibitor activity - GO:0005094, Rho GDP-dissociation inhibitor activity - GO:0005095, GTPase inhibitor activity - GO:0005096, GTPase activator activity - GO:0005097, Rab GTPase activator activity - GO:0005098, Ran GTPase activator activity - GO:0005099, Ras GTPase activator activity - GO:0005100, Rho GTPase activator activity - GO:0005101, Sar GTPase activator activity - GO:0008060, ARF GTPase activator activity - GO:0008321, Ral guanyl-nucleotide exchange factor activity - GO:0016219, GDP-dissociation stimulator activity - GO:0016220, RAL GDP-dissociation stimulator activity + GO:0016361, type I activin receptor activity + GO:0016362, type II activin receptor activity + GO:0017002, activin receptor activity - GO:0017016, Ras interactor activity - GO:0017031, Rho interactor activity - GO:0017034, Rap guanyl-nucleotide exchange factor activity - GO:0017112, Rab guanyl-nucleotide exchange factor activity - GO:0017123, Ral GTPase activator activity - GO:0017132, cyclic nucleotide dependent guanyl-nucleotide exchange factor activity - GO:0017137, Rab interactor activity - GO:0017160, Ral interactor activity - GO:0030675, Rac GTPase activator activity - GO:0030676, Rac guanyl-nucleotide exchange factor activity - GO:0046582, Rap GTPase activator activity Terms movements under GO Slim term 'enzyme regulator activity ; GO:0030234' + GO:0005083, small GTPase regulatory/interacting protein activity + GO:0005084, Rab escort protein activity + GO:0005085, guanyl-nucleotide exchange factor activity + GO:0005086, ARF guanyl-nucleotide exchange factor activity + GO:0005087, Ran guanyl-nucleotide exchange factor activity + GO:0005088, Ras guanyl-nucleotide exchange factor activity + GO:0005089, Rho guanyl-nucleotide exchange factor activity + GO:0005090, Sar guanyl-nucleotide exchange factor activity + GO:0005091, guanyl-nucleotide exchange factor adaptor activity + GO:0005092, GDP-dissociation inhibitor activity + GO:0005093, RAB GDP-dissociation inhibitor activity + GO:0005094, Rho GDP-dissociation inhibitor activity + GO:0008321, Ral guanyl-nucleotide exchange factor activity + GO:0016219, GDP-dissociation stimulator activity + GO:0016220, RAL GDP-dissociation stimulator activity + GO:0017016, Ras interactor activity + GO:0017031, Rho interactor activity + GO:0017034, Rap guanyl-nucleotide exchange factor activity + GO:0017112, Rab guanyl-nucleotide exchange factor activity + GO:0017132, cyclic nucleotide dependent guanyl-nucleotide exchange factor activity + GO:0017137, Rab interactor activity + GO:0017160, Ral interactor activity + GO:0030676, Rac guanyl-nucleotide exchange factor activity New terms in process ontology (47 new terms) GO:0001759 GO:0007154 MGI D induction of an organ GO:0007275 GO:0030702 GO:0006259 MAH D 759950 chromatin silencing at centromere GO:0006350 GO:0008152 GO:0016043 GO:0040029 GO:0030703 GO:0000003 MAH D eggshell formation GO:0030704 GO:0000003 MAH D vitelline membrane formation GO:0030705 GO:0006810 MAH D cytoskeleton-dependent intracellular transport GO:0042745 GO:0007582 JL D 731446 circadian sleep/wake cycle GO:0007610 GO:0042746 GO:0007582 JL D 731446 circadian sleep/wake cycle, wakefulness GO:0007610 GO:0042747 GO:0007582 JL D 731446 circadian sleep/wake cycle, REM sleep GO:0007610 GO:0042748 GO:0007582 JL D 731446 circadian sleep/wake cycle, non-REM sleep GO:0007610 GO:0042749 GO:0007582 JL D 731446 regulation of circadian sleep/wake cycle GO:0007610 GO:0042750 GO:0007582 JL D 731446 hibernation GO:0042751 GO:0007582 JL D 731446 estivation GO:0042752 GO:0007610 JL D 731446 regulation of circadian rhythm GO:0042753 GO:0007610 JL D 731446 positive regulation of circadian rhythm GO:0042754 GO:0007610 JL D 731446 negative regulation of circadian rhythm GO:0042755 GO:0007610 JL D 731446 eating behavior GO:0042756 GO:0007610 JL D 731446 drinking behavior GO:0042758 GO:0006629 JL D 751892 long-chain fatty acid catabolism GO:0008152 GO:0009056 GO:0042759 GO:0006629 JL D 751892 long-chain fatty acid biosynthesis GO:0008152 GO:0009058 GO:0042760 GO:0006629 JL D 751892 very-long-chain fatty acid catabolism GO:0008152 GO:0009056 GO:0042761 GO:0006629 JL D 751892 very-long-chain fatty acid biosynthesis GO:0008152 GO:0009058 GO:0042762 GO:0008152 JL D 753336 regulation of sulfur metabolism GO:0042766 GO:0006259 JL D 751871 nucleosome mobilization GO:0016043 GO:0042769 GO:0006950 JL D 632111 DNA damage response, perception of DNA damage GO:0009719 GO:0042770 GO:0006950 JL D 632111 DNA damage response, signal transduction GO:0009719 GO:0042771 GO:0006950 JL D 632111 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis GO:0008219 GO:0009719 GO:0042772 GO:0006950 JL D 632111 DNA damage response, signal transduction resulting in transcription GO:0009719 GO:0046946 GO:0006519 AI D 751338 hydroxylysine metabolism GO:0008152 GO:0046947 GO:0006519 AI D 751338 hydroxylysine biosynthesis GO:0008152 GO:0009058 GO:0046948 GO:0006519 AI D 751338 hydroxylysine catabolism GO:0008152 GO:0009056 GO:0046949 GO:0006629 AI D 751335 acyl-CoA biosynthesis GO:0006731 GO:0008152 GO:0009058 GO:0046950 GO:0008152 AI D 751343 ketone body metabolism GO:0046951 GO:0008152 AI D 751343 ketone body biosynthesis GO:0009058 GO:0046952 GO:0008152 AI D 751343 ketone body catabolism GO:0009056 GO:0048096 GO:0006259 JIC D 737015 chromatin-mediated maintenance of transcription GO:0006350 GO:0016043 GO:0040029 GO:0048097 GO:0008152 JIC D 737015 long-term maintenance of gene activation GO:0048098 GO:0007275 JIC D 751888 antennal joint morphogenesis GO:0048099 GO:0007275 JIC D 751917 anterior/posterior lineage restriction, imaginal disc GO:0048100 GO:0007275 JIC D 751924 wing disc anterior/posterior pattern formation GO:0048102 GO:0008151 JIC D 752477 autophagic cell death GO:0008219 GO:0048103 GO:0008283 JIC D 752696 somatic stem cell renewal GO:0048104 GO:0007010 JIC D 757800 establishment of body hair/bristle orientation GO:0007275 GO:0048105 GO:0007010 JIC D 757800 establishment of body hair orientation GO:0007275 GO:0048106 GO:0007010 JIC D 757800 establishment of body bristle orientation GO:0007275 GO:0048107 GO:0008152 JIC D 760563 4-amino-3-isothiazolidinone biosynthesis GO:0009058 GO:0048108 GO:0006464 JIC D 760563 protein-protein cross-linking via 4-amino-3-isothiazolidinone GO:0048109 GO:0006464 JIC D 760563 protein-protein cross-linking via 2-amino-3-isothiazolidinone-L-serine New obsoletions in process ontology GO:0006339, OBSOLETE. positive regulation of transcription of homeotic gene (trithorax group): relates to a specific gene family rather than a process. GO:0006340, OBSOLETE. negative regulation of transcription of homeotic gene (Polycomb group): relates to a specific gene family rather than a process. GO:0007577, autophagic death (sensu Saccharomyces): No reason given. GO:0030465, autophagic death (sensu Fungi): No reason given. GO:0045888, OBSOLETE. regulation of transcription of homeotic gene (Polycomb group): relates to a specific gene family rather than a process. GO:0045889, OBSOLETE. positive regulation of transcription of homeotic gene (Polycomb group): relates to a specific gene family rather than a process. GO:0045890, OBSOLETE. regulation of transcription of homeotic gene (trithorax group): relates to a specific gene family rather than a process. GO:0045891, OBSOLETE. negative regulation of transcription of homeotic gene (trithorax group): relates to a specific gene family rather than a process. Term name changes in process ontology GO:0000077: DNA damage checkpoint --> DNA damage response, signal transduction resulting in cell cycle arrest GO:0006339: positive regulation of transcription of homeotic gene (trithorax group) --> OBSOLETE. positive regulation of transcription of homeotic gene (trithorax group) GO:0006340: negative regulation of transcription of homeotic gene (Polycomb group) --> OBSOLETE. negative regulation of transcription of homeotic gene (Polycomb group) GO:0006974: response to DNA damage --> response to DNA damage stimulus GO:0006977: DNA damage response, induction of cell arrest by p53 --> DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006978: DNA damage response, induction of cyclin-dependent protein kinase inhibitor p21 --> DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0007053: male meiotic spindle assembly (sensu Drosophila, sensu Mus) --> male meiotic spindle assembly (sensu Animalia) GO:0007054: male meiosis I spindle assembly --> male meiosis I spindle assembly (sensu Animalia) GO:0007055: male meiosis II spindle assembly --> male meiosis II spindle assembly (sensu Animalia) GO:0007056: female meiotic spindle assembly (sensu Drosophila, sensu Mus) --> female meiotic spindle assembly (sensu Animalia) GO:0007057: female meiosis I spindle assembly --> female meiosis I spindle assembly (sensu Animalia) GO:0007058: female meiosis II spindle assembly --> female meiosis II spindle assembly (sensu Animalia) GO:0007293: egg chamber formation --> egg chamber formation (sensu Insecta) GO:0007294: oocyte cell fate determination --> oocyte cell fate determination (sensu Insecta) GO:0007295: egg chamber growth --> egg chamber growth (sensu Insecta) GO:0007297: follicle cell migration --> follicle cell migration (sensu Insecta) GO:0007298: border cell migration --> border cell migration (sensu Insecta) GO:0007299: follicle cell adhesion --> follicle cell adhesion (sensu Insecta) GO:0007300: nurse cell/oocyte transport --> nurse cell/oocyte transport (sensu Insecta) GO:0007304: eggshell formation --> eggshell formation (sensu Insecta) GO:0007305: vitelline membrane formation --> vitelline membrane formation (sensu Insecta) GO:0008016: regulation of heart --> regulation of heart rate GO:0008069: dorsal/ventral axis determination, follicular epithelium --> dorsal/ventral axis determination, follicular epithelium (sensu Insecta) GO:0008071: maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded --> maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded (sensu Insecta) GO:0008103: polarization of the oocyte microtubule cytoskeleton --> oocyte microtubule cytoskeleton polarization GO:0008630: induction of apoptosis by DNA damage --> DNA damage response, signal transduction resulting in induction of apoptosis GO:0010044: response to aluminium ion --> response to aluminum ion GO:0016325: organization of the oocyte microtubule cytoskeleton --> oocyte microtubule cytoskeleton organization GO:0016350: maintenance of oocyte identity --> maintenance of oocyte identity (sensu Insecta) GO:0019749: cytoskeletal dependent cytoplasmic transport --> cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte GO:0030330: p53-mediated DNA damage response --> DNA damage response, signal transduction by p53 class mediator GO:0030381: eggshell pattern formation --> eggshell pattern formation (sensu Insecta) GO:0045822: negative regulation of heart --> negative regulation of heart rate GO:0045823: positive regulation of heart --> positive regulation of heart rate GO:0045888: regulation of transcription of homeotic gene (Polycomb group) --> OBSOLETE. regulation of transcription of homeotic gene (Polycomb group) GO:0045889: positive regulation of transcription of homeotic gene (Polycomb group) --> OBSOLETE. positive regulation of transcription of homeotic gene (Polycomb group) GO:0045890: regulation of transcription of homeotic gene (trithorax group) --> OBSOLETE. regulation of transcription of homeotic gene (trithorax group) GO:0045891: negative regulation of transcription of homeotic gene (trithorax group) --> OBSOLETE. negative regulation of transcription of homeotic gene (trithorax group) New definitions for process ontology terms (51 new definitions) GO:0000077, DNA damage response, signal transduction resulting in cell cycle arrest GO:0006338, chromatin modeling GO:0006366, transcription from Pol II promoter GO:0006975, DNA damage induced protein phosphorylation GO:0006977, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006978, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0007292, oogenesis GO:0007293, egg chamber formation (sensu Insecta) GO:0007295, egg chamber growth (sensu Insecta) GO:0007296, vitellogenesis GO:0007297, follicle cell migration (sensu Insecta) GO:0007298, border cell migration (sensu Insecta) GO:0007300, nurse cell/oocyte transport (sensu Insecta) GO:0007302, nurse cell nucleus anchoring GO:0007303, cytoplasmic transport, nurse cell to oocyte GO:0007304, eggshell formation (sensu Insecta) GO:0007305, vitelline membrane formation (sensu Insecta) GO:0007306, insect chorion formation GO:0007307, chorion gene amplification GO:0007309, oocyte axis determination GO:0007310, oocyte dorsal/ventral axis determination GO:0007311, maternal determination of dorsal/ventral axis, oocyte, germ-line encoded GO:0007312, oocyte nucleus migration GO:0007313, maternal determination of dorsal/ventral axis, oocyte, soma encoded GO:0007314, oocyte anterior/posterior axis determination GO:0007315, pole plasm assembly GO:0007448, anterior/posterior pattern formation, imaginal disc GO:0007623, circadian rhythm GO:0007624, ultradian rhythm GO:0007635, chemosensory behavior GO:0007638, mechanosensory behavior GO:0008069, dorsal/ventral axis determination, follicular epithelium (sensu Insecta) GO:0008070, maternal determination of dorsal/ventral axis, follicular epithelium, germ-line encoded GO:0008071, maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded (sensu Insecta) GO:0008103, oocyte microtubule cytoskeleton polarization GO:0008302, ring canal formation, actin assembly GO:0008407, bristle morphogenesis GO:0009299, mRNA transcription GO:0009301, snRNA transcription GO:0009302, snoRNA transcription GO:0009303, rRNA transcription GO:0016325, oocyte microtubule cytoskeleton organization GO:0016458, gene silencing GO:0017145, stem cell renewal GO:0019095, pole plasm mitochondrial rRNA localization GO:0019096, pole plasm mitochondrial lrRNA localization GO:0019097, pole plasm mitochondrial srRNA localization GO:0030330, DNA damage response, signal transduction by p53 class mediator GO:0030381, eggshell pattern formation (sensu Insecta) GO:0030465, autophagic death (sensu Fungi) GO:0042070, oocyte nucleus anchoring New term merges in process ontology GO:0006976 has been merged into GO:0030330, DNA damage response, signal transduction by p53 class mediator Term movements in process ontology: Terms movements under GO Slim term 'reproduction ; GO:0000003' - GO:0008063, Tl receptor signaling pathway - GO:0008592, regulation of Tl receptor signaling pathway - GO:0045751, negative regulation of Tl receptor signaling pathway - GO:0045752, positive regulation of Tl receptor signaling pathway Terms movements under GO Slim term 'DNA metabolism ; GO:0006259' - GO:0006339, OBSOLETE. positive regulation of transcription of homeotic gene (trithorax group) - GO:0006340, OBSOLETE. negative regulation of transcription of homeotic gene (Polycomb group) - GO:0045888, OBSOLETE. regulation of transcription of homeotic gene (Polycomb group) - GO:0045889, OBSOLETE. positive regulation of transcription of homeotic gene (Polycomb group) - GO:0045890, OBSOLETE. regulation of transcription of homeotic gene (trithorax group) - GO:0045891, OBSOLETE. negative regulation of transcription of homeotic gene (trithorax group) Terms movements under GO Slim term 'transcription ; GO:0006350' - GO:0006339, OBSOLETE. positive regulation of transcription of homeotic gene (trithorax group) - GO:0006340, OBSOLETE. negative regulation of transcription of homeotic gene (Polycomb group) - GO:0045888, OBSOLETE. regulation of transcription of homeotic gene (Polycomb group) - GO:0045889, OBSOLETE. positive regulation of transcription of homeotic gene (Polycomb group) - GO:0045890, OBSOLETE. regulation of transcription of homeotic gene (trithorax group) - GO:0045891, OBSOLETE. negative regulation of transcription of homeotic gene (trithorax group) Terms movements under GO Slim term 'transport ; GO:0006810' + GO:0007018, microtubule-based movement + GO:0030050, vesicle transport along actin filament Terms movements under GO Slim term 'response to stress ; GO:0006950' + GO:0000012, single strand break repair + GO:0000715, nucleotide-excision repair, DNA damage recognition + GO:0000716, transcription-coupled nucleotide-excision repair, DNA damage recognition + GO:0000717, nucleotide-excision repair, DNA duplex unwinding + GO:0000718, nucleotide-excision repair, DNA damage removal + GO:0000719, photoreactive repair + GO:0000720, pyrimidine dimer repair via nucleotide excision repair + GO:0000724, double-strand break repair via homologous recombination + GO:0000725, recombinational repair + GO:0000726, non-recombinational repair + GO:0000727, double-strand break repair via break-induced replication + GO:0000729, DNA double-strand break processing + GO:0000730, DNA recombinase assembly + GO:0000731, DNA repair synthesis + GO:0000732, strand displacement + GO:0000733, DNA strand renaturation + GO:0000736, double-strand break repair via single-strand annealing, removal of nonhomologous ends + GO:0006266, DNA ligation + GO:0006281, DNA repair + GO:0006282, regulation of DNA repair + GO:0006283, transcription-coupled nucleotide-excision repair + GO:0006284, base-excision repair + GO:0006285, base-excision repair, AP site formation + GO:0006286, base-excision repair, base-free sugar-phosphate removal + GO:0006287, base-excision repair, gap-filling + GO:0006288, base-excision repair, DNA ligation + GO:0006289, nucleotide-excision repair + GO:0006290, pyrimidine dimer repair + GO:0006293, nucleotide-excision repair, preincision complex stabilization + GO:0006294, nucleotide-excision repair, preincision complex formation + GO:0006295, nucleotide-excision repair, DNA incision, 3' to lesion + GO:0006296, nucleotide-excision repair, DNA incision, 5' to lesion + GO:0006297, nucleotide-excision repair, DNA gap filling + GO:0006298, mismatch repair + GO:0006299, short patch mismatch repair system + GO:0006300, long patch mismatch repair system + GO:0006301, postreplication repair + GO:0006302, double-strand break repair + GO:0006303, double-strand break repair via nonhomologous end-joining + GO:0006307, DNA dealkylation + GO:0019985, bypass DNA synthesis + GO:0030491, heteroduplex formation + GO:0042148, strand invasion + GO:0042275, error-free postreplication DNA repair + GO:0042276, error-prone postreplication DNA repair + GO:0045002, double-strand break repair via single-strand annealing + GO:0045003, double-strand break repair via synthesis-dependent strand annealing + GO:0045004, DNA replication proofreading + GO:0045007, depurination + GO:0045008, depyrimidination + GO:0045020, error-prone DNA repair + GO:0045021, error-free DNA repair + GO:0045738, negative regulation of DNA repair + GO:0045739, positive regulation of DNA repair + GO:0046787, viral DNA repair + GO:0046799, recruitment of helicase-primase complex to DNA lesions Terms movements under GO Slim term 'cell cycle ; GO:0007049' + GO:0006977, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Terms movements under GO Slim term 'development ; GO:0007275' - GO:0007577, autophagic death (sensu Saccharomyces) - GO:0008063, Tl receptor signaling pathway - GO:0008592, regulation of Tl receptor signaling pathway - GO:0030465, autophagic death (sensu Fungi) - GO:0045751, negative regulation of Tl receptor signaling pathway - GO:0045752, positive regulation of Tl receptor signaling pathway Terms movements under GO Slim term 'cell growth and/or maintenance ; GO:0008151' + GO:0000045, autophagic vacuole formation + GO:0000046, autophagic vacuole fusion + GO:0006914, autophagy + GO:0016236, macroautophagy + GO:0016237, microautophagy + GO:0016238, chaperone-mediated autophagy + GO:0016239, positive regulation of macroautophagy + GO:0016240, autophagic vacuole docking + GO:0016241, regulation of macroautophagy + GO:0016242, negative regulation of macroautophagy + GO:0016243, regulation of autophagic vacuole size + GO:0030399, autophagic membrane degradation + GO:0045771, negative regulation of autophagic vacuole size + GO:0045772, positive regulation of autophagic vacuole size Terms movements under GO Slim term 'metabolism ; GO:0008152' - GO:0000045, autophagic vacuole formation - GO:0000046, autophagic vacuole fusion - GO:0006856, eye pigment precursor transport - GO:0006914, autophagy - GO:0016236, macroautophagy - GO:0016237, microautophagy - GO:0016238, chaperone-mediated autophagy - GO:0016239, positive regulation of macroautophagy - GO:0016240, autophagic vacuole docking - GO:0016241, regulation of macroautophagy - GO:0016242, negative regulation of macroautophagy - GO:0016243, regulation of autophagic vacuole size - GO:0030399, autophagic membrane degradation - GO:0045771, negative regulation of autophagic vacuole size - GO:0045772, positive regulation of autophagic vacuole size Terms movements under GO Slim term 'cell death ; GO:0008219' - GO:0007577, autophagic death (sensu Saccharomyces) - GO:0030465, autophagic death (sensu Fungi) Terms movements under GO Slim term 'response to biotic stimulus ; GO:0009607' - GO:0000077, DNA damage response, signal transduction resulting in cell cycle arrest - GO:0000722, telomerase-independent telomere maintenance - GO:0000723, telomere maintenance - GO:0006974, response to DNA damage stimulus - GO:0006975, DNA damage induced protein phosphorylation - GO:0006977, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest - GO:0006978, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator - GO:0007004, telomerase-dependent telomere maintenance - GO:0008630, DNA damage response, signal transduction resulting in induction of apoptosis - GO:0016233, telomere capping - GO:0030330, DNA damage response, signal transduction by p53 class mediator Terms movements under GO Slim term 'response to endogenous stimulus ; GO:0009719' + GO:0000012, single strand break repair + GO:0000077, DNA damage response, signal transduction resulting in cell cycle arrest + GO:0000715, nucleotide-excision repair, DNA damage recognition + GO:0000716, transcription-coupled nucleotide-excision repair, DNA damage recognition + GO:0000717, nucleotide-excision repair, DNA duplex unwinding + GO:0000718, nucleotide-excision repair, DNA damage removal + GO:0000719, photoreactive repair + GO:0000720, pyrimidine dimer repair via nucleotide excision repair + GO:0000722, telomerase-independent telomere maintenance + GO:0000723, telomere maintenance + GO:0000724, double-strand break repair via homologous recombination + GO:0000725, recombinational repair + GO:0000726, non-recombinational repair + GO:0000727, double-strand break repair via break-induced replication + GO:0000729, DNA double-strand break processing + GO:0000730, DNA recombinase assembly + GO:0000731, DNA repair synthesis + GO:0000732, strand displacement + GO:0000733, DNA strand renaturation + GO:0000736, double-strand break repair via single-strand annealing, removal of nonhomologous ends + GO:0006266, DNA ligation + GO:0006281, DNA repair + GO:0006282, regulation of DNA repair + GO:0006283, transcription-coupled nucleotide-excision repair + GO:0006284, base-excision repair + GO:0006285, base-excision repair, AP site formation + GO:0006286, base-excision repair, base-free sugar-phosphate removal + GO:0006287, base-excision repair, gap-filling + GO:0006288, base-excision repair, DNA ligation + GO:0006289, nucleotide-excision repair + GO:0006290, pyrimidine dimer repair + GO:0006293, nucleotide-excision repair, preincision complex stabilization + GO:0006294, nucleotide-excision repair, preincision complex formation + GO:0006295, nucleotide-excision repair, DNA incision, 3' to lesion + GO:0006296, nucleotide-excision repair, DNA incision, 5' to lesion + GO:0006297, nucleotide-excision repair, DNA gap filling + GO:0006298, mismatch repair + GO:0006299, short patch mismatch repair system + GO:0006300, long patch mismatch repair system + GO:0006301, postreplication repair + GO:0006302, double-strand break repair + GO:0006303, double-strand break repair via nonhomologous end-joining + GO:0006307, DNA dealkylation + GO:0006974, response to DNA damage stimulus + GO:0006975, DNA damage induced protein phosphorylation + GO:0006977, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest + GO:0006978, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + GO:0007004, telomerase-dependent telomere maintenance + GO:0008630, DNA damage response, signal transduction resulting in induction of apoptosis + GO:0016233, telomere capping + GO:0019985, bypass DNA synthesis + GO:0030330, DNA damage response, signal transduction by p53 class mediator + GO:0030491, heteroduplex formation + GO:0042148, strand invasion + GO:0042275, error-free postreplication DNA repair + GO:0042276, error-prone postreplication DNA repair + GO:0045002, double-strand break repair via single-strand annealing + GO:0045003, double-strand break repair via synthesis-dependent strand annealing + GO:0045004, DNA replication proofreading + GO:0045007, depurination + GO:0045008, depyrimidination + GO:0045020, error-prone DNA repair + GO:0045021, error-free DNA repair + GO:0045738, negative regulation of DNA repair + GO:0045739, positive regulation of DNA repair + GO:0046787, viral DNA repair + GO:0046799, recruitment of helicase-primase complex to DNA lesions Terms movements under GO Slim term 'cell organization and biogenesis ; GO:0016043' - GO:0006339, OBSOLETE. positive regulation of transcription of homeotic gene (trithorax group) - GO:0006340, OBSOLETE. negative regulation of transcription of homeotic gene (Polycomb group) - GO:0007462, R1/R6 cell fate commitment - GO:0007463, R2/R5 cell fate commitment - GO:0007464, R3/R4 cell fate commitment - GO:0045888, OBSOLETE. regulation of transcription of homeotic gene (Polycomb group) - GO:0045889, OBSOLETE. positive regulation of transcription of homeotic gene (Polycomb group) - GO:0045890, OBSOLETE. regulation of transcription of homeotic gene (trithorax group) - GO:0045891, OBSOLETE. negative regulation of transcription of homeotic gene (trithorax group) Terms movements under GO Slim term 'death ; GO:0016265' - GO:0007577, autophagic death (sensu Saccharomyces) - GO:0030465, autophagic death (sensu Fungi) Terms movements under GO Slim term 'regulation of gene expression, epigenetic ; GO:0040029' + GO:0000183, chromatin silencing at ribosomal DNA (rDNA) + GO:0006342, chromatin silencing + GO:0006343, establishment of chromatin silencing + GO:0006344, maintenance of chromatin silencing + GO:0006345, loss of chromatin silencing + GO:0006346, methylation-dependent chromatin silencing + GO:0006347, chromatin silencing at HML and HMR (sensu Saccharomyces) + GO:0006348, chromatin silencing at telomere + GO:0030466, chromatin silencing at silent mating type cassettes (sensu Fungi) SourceForge items closed this month: SF id Resolution SF item title GO ids added, if any 632111 Fixed apoptosis by DNA damage ; GO:0008630 GO:0042769-42772 715611 None more yeast aging/death terms [none] 731446 Accepted April GO term suggestions from Incyte GO:0042730-42733 GO:0042745-42756 737015 Fixed Epigenetic control of regulation GO:0048096-48097 741233 Fixed Change of DAG assignment [none] 745245 None New Septum terms GO:0000933-00938 747457 Fixed forespore or prospore GO:0042763-42764 749828 Accepted true path violation?, response to DNA damage [none] 751335 Accepted term: acyl-CoA biosynthesis ; GO:newtermacyl-CoA biosynthes GO:0046949 751338 Accepted hydroxylysine metabolism GO:0046946-46948 751343 Accepted ketone body catabolismterm: GO:0046950-46952 751844 Accepted ecdysteroid 22/2 hydroxylase GO:0042767-42768 751871 Accepted nucleosome mobilization GO:0042766 751888 Accepted antennal joint morphogenesis GO:0048098 751892 Accepted very-long-chain fatty acid catabolism GO:0042758-42761 751917 Accepted anterior/posterior lineage restriction\, imaginal disc GO:0048099 751924 Accepted wing disc anterior/posterior pattern formation GO:0048100 751931 Fixed giant axon GO:0042734 ????? GO:0042734 752008 Accepted calcium/calmodulin-regulated cGMP-specific phosphodiesterase GO:0048101 752209 None Add term: P bodies - cytoplasmic processing bodies GO:0000932 752477 Accepted autophagic cell death GO:0048102 752696 Accepted somatic stem cell renewal GO:0048103 753181 Accepted cone cell terms [none] 753336 Accepted new term request GO:0042762 753342 Rejected term merge? transcription from Pol II promoter / [none] 753463 Accepted add synonyms for beta-fructofuranosidase (GO:0004564) [none] 755325 Accepted GPI transamidase complex GO:0042765 755351 Accepted Merge GO:0046913 and GO:0003878? [none] 755620 None GARP (golgi associated retrograde protein) complex GO:0000938 755777 Fixed Rab GTPase activator activity ; GO:0005097- can't find term [none] 756122 Accepted glycine reductase GO:0030699-30700 756141 Accepted function term for EC 2.4.2.37 GO:0030701 757220 Fixed enzyme activity [none] 757800 Fixed additional children of planar cell polarity GO:0048104-48106 758083 Fixed change path for protein-glutamine gamma-glutamyltransferase [none] 758084 Accepted Broader definition for siderochrome terms [none] 759126 Fixed filopodia definition [none] 759739 Accepted GO:0019005 [none] 759950 Accepted centromeric silencing GO:0030702 760004 Fixed merge or define 2 GPCR kinase terms? [none] 760007 Fixed remove sensu on female meiotic spindle assembly? [none] 760563 Accepted 4-amino-3-isothiazolinone biosynthesis GO:0048107-48109 761588 Fixed mistake in definition of cellularization? [none] 761903 Duplicate changes to cell aging node [none] Statistics: Component: 1306 terms, 79.3% defined (1036 terms defined) Function: 5404 terms, 70.4% defined (3807 terms defined) Process: 7310 terms, 85.7% defined (6267 terms defined) Total: 14020 terms, 79.2% defined (11110 terms defined) Term errors none