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<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J033</accession>
    <name>A0A646J033_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFZ77_05880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000056">
        <property type="protein sequence ID" value="MQS35164.1"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
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        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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            <begin position="26"/>
            <end position="365"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="198"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="223"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="312"/>
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            <end position="341"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MQS35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="365" mass="38864" checksum="4BF8DF35E09F9636" modified="2020-04-22" version="1">MRVTRRPLIYGVSALAVLLALSAPALGVNFGTPDDRVLPAEVSSRVVQDQIRAGFVAEEVDALQVLTPGLTDRSAIADTARDLSRLDGIAQVDALTGSYADGRRILEPGESAERFEGSDATWFSVVATQDGLSDDPDAVIAEVRSTVADGAATEVRVGGYPAELADFRTVLVDRLPLVFGLVLLVTFVILFLMTGSLLLPAKAMVLNTLSMAVMFGALVWIFQDGNLSSALGFTATGALEPSIPILMFCTAFGLSMDYEVFMLSRIKEEYHRVGDTTAAVAAGLERSGPLITSAAVILAASFATYASSGIVYLKMLGLGMAVVILVDATLIRAVLVPVLMRLAGRANWWAPAPLRRVHTRFDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J044</accession>
    <name>A0A646J044_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_14250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000145">
        <property type="protein sequence ID" value="MQS36732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS36732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="60" mass="5889" checksum="25C08F1EE4A171D5" modified="2020-04-22" version="1">MAAALPGIVAASGVPETLPWVASALAIAGGAARVMALPAVEQLLDRFGIGMVDGGSASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J047</accession>
    <name>A0A646J047_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_16505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000171">
        <property type="protein sequence ID" value="MQS37166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS37166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="242" mass="26445" checksum="D7E0B7B313826C8C" modified="2020-04-22" version="1">MTTAGQDLPSQGLHSQVLDTLGLAITAGDYPRGSVLRTDEIAQRFDVSRTVVREVVRVLESMHLVESRRRVGVTVRAIEEWNVYDPRVIRWRLAGSDRPRQLRSLTVLRSAVEPVAAGLAARNATPEQCAELTECALGMVATSRGQRLGEYLQHDIAFHRVILNASGNEMFARLGDVVAEILTGRTAHQVMFDDPDPAAVTLHVQVAEAVREGDAVRAEEVTREIAVGALAELDVLAPDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J050</accession>
    <name>A0A646J050_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_14995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000152">
        <property type="protein sequence ID" value="MQS36880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025019767" evidence="1">
        <location>
            <begin position="34"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS36880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="235" mass="25256" checksum="C1283277EA8A5638" modified="2020-04-22" version="1">MHSRSHRLLYALPLAAAASVLLAGCGDAGMVQSAGPTATATGPVRLWPDLPPVTSPPYDYGEADTALVPGVKVPASGVRGLDPVAVLNAEKSAGPDGRSGIEGLYQETTAKLRTCEEKPKTCPVLTPYHRDVTGDGREELIIGVTMPEQQTAVRCYMPEKDGRLTRIMATSDQLVSVDLAGRDIILRSVSAGIPGYEYRTTWSWDGRHRAMLPTSDEIVRVRPRAAELPRPGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J061</accession>
    <name>A0A646J061_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_12415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000127">
        <property type="protein sequence ID" value="MQS36378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS36378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="245" mass="26788" checksum="E802B6A1B0C6BA0E" modified="2020-04-22" version="1">MEQVHTTHNGVAATAGAQRRVLVVEDDTTIVDAIAARLRAEGFLVQTAADGPAAVDAAEAWQPDLMVLDVMLPGFDGLEVCRRVQAQRPVPVLMLTARDDETDMLVGLGVGADDYMTKPFSMRELAARVHVLLRRVERAALAAVTPRSGILRLGELEIDHAQRRVRVRGDDVHLTPTEFDLLVCLANTPRAVLSREQLLAEVWDWADASGTRTVDSHIKALRRKIGAERIRTVHGVGYALETPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J063</accession>
    <name>A0A646J063_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF305 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_18010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000200">
        <property type="protein sequence ID" value="MQS37451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024867325" evidence="1">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="44"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="217" mass="22831" checksum="C9456158AE1A9CB0" modified="2020-04-22" version="1">MTRTHWAAITAVVLALLFAGAVTVASAGDSDSAAPAVPASDSADAGFARDMSVHHQQAVEMSFIVRDRTENTEIRRLAYDIANTQANQRGMMMGWLDLWGLPKVTPGSAPMAWMADGGGSHSGHSAAKGAGGPLMPGMATEAQLARLGELSGKAAEVEYLQLMIVHHNGGVDMAEGCVRLCSVDSEKELAQGMVDAQRSEVELMVDLLAKRGAQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J071</accession>
    <name>A0A646J071_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_14985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000152">
        <property type="protein sequence ID" value="MQS36878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS36878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="498" mass="52013" checksum="ED48FF166298B677" modified="2020-04-22" version="1" fragment="single">AATAQECPGSRSYDAGLRLSALAQLARCSPQALPADVVPEVMGLLRELRAGPVSTRPGPPPGCPGAARPTPWTGDLLRTLHSGLGDRVADRTALLADQLCSPDCGQRIDAVRMSSGLLRTWRGEYGELVALIGEQLADPEPRLADAAAVALGELFGLAAPAADALADLVTAEPGCWVREWAGGPRMLGNAVAALARTGDVRAVPVLARLLELPDAPQDLGYALDRLGTAAAPLAPALRGRLARIELDDRLYDVAGPLLSGLSAVRAVEALPEVLRVLRGAPEYRREWVVELVLRTLTAFGPAARAAIPDLRALLAGAARSGSLSGAFGARTAAALWAVEGDAGAVLPALRTALAALDSGARRSAASALGAMGPAAVEAAPELRLLLRSSDPWTRVDAALALWRVTGAAEPGWPLLMAAWETLPFTRAPVAERLAEPSGDGGRPVAAYAEGAERTLCAELSRVRRHNAIDGGYGSHDIVRDERLLALCRRALTRERPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J097</accession>
    <name>A0A646J097_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">treS</name>
        <name evidence="8" type="ORF">FFZ77_21825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="VDEQ01000240">
        <property type="protein sequence ID" value="MQS38163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="31"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS38163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="568" mass="65870" checksum="974396D402C63214" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0A8</accession>
    <name>A0A646J0A8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Virulence factor MviN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFZ77_19620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000211">
        <property type="protein sequence ID" value="MQS37754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MQS37754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="514" mass="52996" checksum="02DE1EA156563358" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0A9</accession>
    <name>A0A646J0A9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFZ77_23120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="VDEQ01000256">
        <property type="protein sequence ID" value="MQS38396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="193"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MQS38396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="384" mass="41949" checksum="1EC9C1DDEF630284" modified="2020-04-22" version="1" fragment="single">MRLPSPARAARFCLRWLSRLMPRRVRMRLTLLYGSLFVALGAVLLTITYLLVSSRNSRVIVRGPIAGPTPDSGVHLSAGTQIPSSTPGFAQEEQQRAMRARAAEVQDLLMDSGTALAIMSVIAIGLGWVVAGRVLRPLRTMTTTIQRISAHNVHERLAMKGPGDELTDLADTVDGLLGRLEKSLDSHKRFVANAAHELRTPLTVEHALLEEALIDRDATVDSFRSNFERLLVLSEQQARLLESLLTLSSSERGLDRREPLELDELAGQLALGCRQEAERRGLRLKRAIEPAGIWGDSALVERLLANLLNNAMGYNVPDGWVEVTTWAKGGHAVVRVANTGPRIPAERVSQLLEPFQRLGRTAGDGHHGLGLSIVRSIAAAHDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0C2</accession>
    <name>A0A646J0C2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_20845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000229">
        <property type="protein sequence ID" value="MQS37976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="66" mass="6927" checksum="C5ED28BE5F7DFCDD" modified="2020-04-22" version="1" fragment="single">PRSPDGDPLAGAVLLASALATGTLRLPRHPTLLHIPSPPGFMSQQSGADETGGTQMDDIHRINTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0C7</accession>
    <name>A0A646J0C7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_24635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000272">
        <property type="protein sequence ID" value="MQS38658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="167" mass="17622" checksum="04C03085CD217F1E" modified="2020-04-22" version="1" fragment="single">ARSIGAAIGRPLRLHRRTTGRAATAARVGELLADVGLPADFAGRYPPELSGGQRQRVSIARALAADPDVLLCDEVTSALDASTAEAIMDLLDRLRAERGLSVVHISHDLRLLGARTDTMLVLADGRVAHSGPTEGVLTDHTDADAGKAEPHDARLGRTATPHHAEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0D0</accession>
    <name>A0A646J0D0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional DNA primase/polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000026">
        <property type="protein sequence ID" value="MQS34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="24"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="365" mass="37848" checksum="88DBE4543EA22C8C" modified="2020-04-22" version="1">MATELRSPGGDSPWPAASASRATALWCAGQGWPVHPLAAGRKTPAGNCDACRGPGHTRTGCDCVAAGRWCHGFHAATRDPDRINRWWGNNPGYGVGVSCGPARLVVIDIDAHARSLPERGRLLPGIPIDERVDLTGLANGFHTMAVLAALRGAVDPAADETTLRVRTPSGGLHVWYRVTDGRAWQCSTGSGGVRALAWQVDVRAHGGYIVAPGTVTAAGSYTPLGPTKLPAPLPGWLAGELERTGHLPEARIPGPRPVPARARQAVIAAGGGRERTTAALSGVLAEVAACAAVPEGAGFSEKLNRAAYTAGGLVAAGYLTQLQAEDILRSAADVARPGQDRRSAQIIRGGLNAGLRQPLHPGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0D4</accession>
    <name>A0A646J0D4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rfbB</name>
        <name evidence="8" type="ORF">FFZ77_25790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="VDEQ01000297">
        <property type="protein sequence ID" value="MQS38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="331" mass="35970" checksum="FC1B2B828AAC436E" modified="2020-04-22" version="1">MRILVTGGAGFIGSHFVRSFAGVDAVTVLDKLTYAGNPANLEPVAGRFTFVRGDICDAGLLREVVPGHDVVVNFAAESHVDRSIAGAGEFVHSNVLGVQTLMQACLDAGAPRVVHVSTDEVYGSIEAGSWDETAPLSPNSPYAASKAGGDLIALAYARTHELPVSITRCGNNYGPYQYPEKVIPLFLTQLLDGLNVPLYGDGGHVRDWIHVDDHCRAVRLVAERGERGEVYHIAGTTELTNRELTVRLLHALGAGWQRVERAPDRKGHDRRYSLADGKLRALGYAPRIAFERGLAETVEWYAANRRWWEPLKERAPWAAPAGLRGGVFATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0D7</accession>
    <name>A0A646J0D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_21930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000246">
        <property type="protein sequence ID" value="MQS38182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DIOX_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="94" mass="10197" checksum="16C21D75603CC72C" modified="2020-04-22" version="1" fragment="single">MSDIPVLELPESLTGSPADRALAAGMIEAWRTHGIFYLATGPAEQEIVRAAMSESRRFFALPFAEKARYVNDTTYSGYIASGEEVTAGEADHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-02-10" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0F6</accession>
    <name>A0A646J0F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ergothioneine biosynthesis glutamate--cysteine ligase EgtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_28440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000324">
        <property type="protein sequence ID" value="MQS39368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="126" mass="13515" checksum="811EA3A54F577A3F" modified="2020-04-22" version="1" fragment="single">QPGDNGWMVPLAVVTALFEDPEAAETVYRTVKPLAEFAGELPAPINPLWVGAARRGLTDPELRSAAVSCFRLALEALPRIGASTAVCETVAAFNEHHVLRGRCPADDLLMETHRQEPTADGKEASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0F8</accession>
    <name>A0A646J0F8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-2-hydroxyacid dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_27555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000310">
        <property type="protein sequence ID" value="MQS39198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS39198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="163" mass="17808" checksum="EDB9533D6679A1FD" modified="2020-04-22" version="1" fragment="single">MTRLRCAVLDDYQDAARSLADWPRIDSRVETRFLTAHLASHDALVDAVGDCEILVVMRERTPFPAELFARLPRLRLLITSGMRNASLDLAAAARHGVTVCGTASNSEPPAELTWALILGLARHIVPENNALRSDGPWQRTIGADLHGRRLGLLGLGRIGQKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0F9</accession>
    <name>A0A646J0F9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_14990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000152">
        <property type="protein sequence ID" value="MQS36879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="zinc_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_15" evidence="2">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS36879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="127" mass="13324" checksum="C5707452283F4063" modified="2020-04-22" version="1">MIIFGTKGYLHQLAILTLVCGSCGNPSAHALRKRVTKFTLFFVPLFPVSTKYGTQCTFCGAEQKLTQQQSDQLLAQSSGAAGTAGVPGLGGSGQPGPYGQQGQQSPYGQQGPYGQQGQQPGGNPYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0G3</accession>
    <name>A0A646J0G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_28790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000334">
        <property type="protein sequence ID" value="MQS39437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="157" mass="16901" checksum="62FE22204F5CC9FE" modified="2020-04-22" version="1" fragment="single">MPVTLSRGAEPAVGFPPRPPAGRHAAVFECHNPGDGEGVRPQDARRVAQMRRIGRAALRKWGFHRAVDDAELIISELVTNAIENGSGCSVGFSISYSGATVRIEVADGSHSRPQVRRGGLYEEGGRGMVLIEYLASAWGTSEDGTRTWCELQVGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0G5</accession>
    <name>A0A646J0G5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_25545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000293">
        <property type="protein sequence ID" value="MQS38828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="73" mass="7187" checksum="5325524512BCEDDE" modified="2020-04-22" version="1">MSCADLVGDTSAAAATLQIAAVLATARRTPAAVGRTALVTSADRDGTVGCALLRLLPGAVRGWGAAAQPLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0G7</accession>
    <name>A0A646J0G7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_28420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000321">
        <property type="protein sequence ID" value="MQS39364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="80" mass="8788" checksum="4826E018E183B358" modified="2020-04-22" version="1" fragment="single">AVAFLPDMLWCDRVPGLLLDRAPGPLLDGSAGHTRTVLATIRAGAGEHPLIRTFLTAIRHAIGELPARTGYPPHRRRRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0H1</accession>
    <name>A0A646J0H1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_25835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000299">
        <property type="protein sequence ID" value="MQS38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="184" mass="20732" checksum="FA4F173314318F4D" modified="2020-04-22" version="1">MGRARSGKDTVAARLMDHGYKRLAFADPLKAMVRDMDPYVITSPGVAVRLNTLVGDVGWEYAKDKYPEVRALLQRTGQAVRDRDPYFWVRLLMAQVEGARDVGYPIVVSDVRYPNEADTLAAHGFTLVRVQRDRWEAETVTPDELTNRRHTSEQALAGYAPDRTMRNLGSLTALRRQADTLISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0H4</accession>
    <name>A0A646J0H4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3105 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_18005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000200">
        <property type="protein sequence ID" value="MQS37450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="215" mass="23940" checksum="8AE846600A85B591" modified="2020-04-22" version="1">MASRKTTDDRRARIEAMRRAEQSRERRSRIITIAVSGLVVAGLVGFGVYVLNKESEQQEQRVALAKKPIKAEKSWDAKKLGRNHVKEAVSYPQTPPVGGDHNQAWLNCDRNVYKEAVPNENAVHSLEHGAVWVTYNDKASKDDVKKLEEKVKETSYSFISPVQDQADPLMLTAWGKQVSVDGADDKRVLQFFEKYVQGDQTPEPGAACTGGVTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0H9</accession>
    <name>A0A646J0H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ergothioneine biosynthesis glutamate--cysteine ligase EgtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000348">
        <property type="protein sequence ID" value="MQS39589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="103" mass="11050" checksum="2DCF27E9158F7101" modified="2020-04-22" version="1" fragment="single">FKNGPPVSVGVELEWLIQEHRNPRRTIAADRLTAAHDQVRSLPLTSALTFEPGGQLELSSRPAASLMECIDSVAADLDAVRTALQPGGLSLTGLGIDPWQPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0I0</accession>
    <name>A0A646J0I0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="1">1.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_29660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="VDEQ01000350">
        <property type="protein sequence ID" value="MQS39599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="74" mass="7777" checksum="FD387F63FC2FDC73" modified="2020-04-22" version="1" fragment="single">MKKTKAAVIGSGNIGTDLMIKILRLSETLEMAALVGIDPASDGLARARRLKVPTTHEGVAGLIAMDGFEDIDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0I1</accession>
    <name>A0A646J0I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000342">
        <property type="protein sequence ID" value="MQS39559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="255" mass="26342" checksum="091D1FE3AFAD68C3" modified="2020-04-22" version="1">MTSTPHNETATPATRPSVLLVHGAFADGSSWREVAERLEGEGYRVTAAELELRGLSSDAARVRALLDQQDGATVVVGHSYGGAVIGQAATGHAKAAALVHVAAFAPAKGESVGELDASFGDGESTLAITDARPLPANPDVPDEYNVELTIKKDAFRERFGADLAEDRAAAMNEAQRPTAAAVFGEPAAAPAWETLPSWYVVAGADLMIPAAGQRRMAERMGATVVEVPGAGHAVAASRPDEVARVIIAAARTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0I5</accession>
    <name>A0A646J0I5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="11" type="ORF">FFZ77_27925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8"/>
    <dbReference type="EMBL" id="VDEQ01000318">
        <property type="protein sequence ID" value="MQS39269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="48"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MQS39269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="220" mass="23962" checksum="BA74757644878263" modified="2020-04-22" version="1">MKEIVEPGWADALEPVAGRIAAMGDFLRAEIAAGRTYLPSGANVLRAFQQPFDEVRVLIVGQDPYPTPGHAVGLSFSVAPEVRPVPGSLDNIFREMHTDLGCPRPANGDLTPWTEQGVLLLNRALTTAPRKPAAHRGKGWEEVTEQAIRALAARGKPLVSVLWGRDARNLRPLLGDLPAIESAHPSPMSADRGFFGSRPFSRTNELLERQGAQPVDWRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0J5</accession>
    <name>A0A646J0J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_29690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000352">
        <property type="protein sequence ID" value="MQS39605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="205" mass="22790" checksum="F18A9B939CB28CE2" modified="2020-04-22" version="1" fragment="single">NVYEGLFKLTDDGEVEKLLAQDHKVSGDGLTYTFTLRDNVTFHSGKKLTSQDVEYSLKKVIAKDSQSARKSNLDVIESIATPDARTVKVRLSKKSISFVYNLSYVWIINSEAENLKTSEDGTGPYQLKKWTRGSALSLDRFPGYWGDAAANKQVVFRYFKDATALNNALLTNAVDIVTSGQSPDALDQFENNPNYKVNDGDSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0J8</accession>
    <name>A0A646J0J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_29455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000342">
        <property type="protein sequence ID" value="MQS39558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="113" mass="12249" checksum="DE50F9D66E6422E3" modified="2020-04-22" version="1" fragment="single">MSEKPLPARERILGAALRLFYEEGVRAVGVDRLIAESGVTKATFYRHFPSKEELVVAYVQSIDRDIRGLVGSIRVQLSAHAAIEAFFSGPGGVGDQLCRPGFRGCPFLNAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0J9</accession>
    <name>A0A646J0J9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFZ77_30320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000363">
        <property type="protein sequence ID" value="MQS39724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UvrA_DNA-bind" evidence="13">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MQS39724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="220" mass="23830" checksum="DB70FCEE3CD71F7E" modified="2020-04-22" version="1" fragment="single">SRSSVGTVTTLSNSLRMLFSRAGDYPEGVPRLDSDAFSPNTAAGACPECHGLGRVHRTDEELLVPDPSLSIREGAIAAWPGAWQGKNLRDVLDALGYDVDRPWRELARRDREWILFTDEQPVVTVHPVREAGRIQRPYQGTYASARRYVLHTYADSKSQTLRARAERFLTSAPCPSCGGGRLRPQALAVTFAGRTIAELSALPLTVLAGVLGSADGGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0K5</accession>
    <name>A0A646J0K5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000347">
        <property type="protein sequence ID" value="MQS39586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="71"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="224" mass="23457" checksum="9C2C3BE4D33202CF" modified="2020-04-22" version="1" fragment="single">VLAGEAVAEGRVAELGEWVGLLGGVEPLLGRRVLDREADTARTQRRRSWVVPSELAAVLVGRIPALFHCGVHEVLLATLAGAIGHQRPGAASRLVDIEGHGREALGDVDLSRTVGWFTSNHPVRLDVTGVRLDDAMTGGPAAGTLVKAVKEQVRAVPGDGLGYELLRYLNPETGPVLEAAPAAQIGFNYLGRFATSSSENSAQPWQLAGDTAMGGSTAPDIPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0L3</accession>
    <name>A0A646J0L3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_29685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000351">
        <property type="protein sequence ID" value="MQS39604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024888891" evidence="2">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="393" mass="41606" checksum="D904FF26A3CE5C53" modified="2020-04-22" version="1" fragment="single">MESNPTRGAAVRGLLAGALALGGVTALVAPASAADSARAGQRGSVVSVEKRATIDAAGVIAALGDTVDAGAVRYGVTPYVVTYRTTDHTGTPTTASQLVVLPESGDRTLSTVSWLHGTIVYKGDVATVRTDTNDYRAALLFASTGRAVSAPDYIGLGRNSPGVHPYGDPRATVSASVDALRSARSVVHGEGRELEREVQISGFSQGGPAAMTVGRALQREGADPYFRLGALAPVGGPFDLSAFEAAAADDRIDKSAIYLAYFVTAWNRMYGGLYDSPGDAFKSPYDATVEGLFDGNHTQRQILEGLPQASRDLFTPEFLERIRHPEGVLKDRLRALDTTCDWQPQAPVRIFHGRGDKDVAFAHAEHCTAQLKANGAKPRLVDVGPYDHNSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0L9</accession>
    <name>A0A646J0L9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excinuclease ABC subunit UvrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_30220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000361">
        <property type="protein sequence ID" value="MQS39705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="81" mass="9018" checksum="FBF61CE9687817ED" modified="2020-04-22" version="1" fragment="single">VSPLLATLRQTLDSFVKIGLGYLSLDRPSGTLSGGEAQRVKMIRHLGSSLTDVTYVFDEPTTGLHPHDIQRMNELLLRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0M1</accession>
    <name>A0A646J0M1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000386">
        <property type="protein sequence ID" value="MQS39982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="101" mass="10688" checksum="CFAF774CA6771F29" modified="2020-04-22" version="1" fragment="single">MDSEFREMMASFPTGVSVVTARDSSAAPWGMTCSSLCSLSVNPPTLLICLRTESPTLRAVLTSGAFAVNLLHGGAERVAALFASGAPDRFERVAWRPAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0M2</accession>
    <name>A0A646J0M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tryptophan 7-halogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000386">
        <property type="protein sequence ID" value="MQS39984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="150" mass="16812" checksum="7AD76BA5DA0EF029" modified="2020-04-22" version="1" fragment="single">MTHARASEHHGADAVRNVVIVGGGTAGWMTAAYLTAAFGDRVGITLVESADVGTIGVGEATFSDIRHFFEFLGLAEQDWMPACNATYKLAVRFEDWREPGHHFYHPFEQLRSVKGFPLTDWWLRRPTSERFDLDCFVMASLIDAGRSPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0M6</accession>
    <name>A0A646J0M6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_30345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000365">
        <property type="protein sequence ID" value="MQS39729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="170" mass="19019" checksum="0359CC436DB9CE90" modified="2020-04-22" version="1">MAGIDETLWNEGVSPSDYACGKDGYQGAVLEQYKLCVEMADRVSSRRNLTNTFFLTLNTAVVATLAAVFPGEVRQPRPVWVVLSGLLILLTQCLVWWVMMRSYRQLNAAKYAVIGALERRLPAFAYSDGEWGALGEGRDWRRYVPLTYVEQWVPLTFGTAYVVGCLAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0N1</accession>
    <name>A0A646J0N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000393">
        <property type="protein sequence ID" value="MQS40008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="113" mass="12151" checksum="7E3CAF4E5B38A1FA" modified="2020-04-22" version="1" fragment="single">LDEYGMLHLVSDVVGVITALGGGTPAVVIGHDWGATIAAQTALLRPDLVRAVGLLSVPYTPRNEHVPTEVFTALAPKGAEFYISYFQEPGRAEAEIEPDVREWLRGFYAALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0N3</accession>
    <name>A0A646J0N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000370">
        <property type="protein sequence ID" value="MQS39869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="294" mass="32969" checksum="715FAD8EBF814D11" modified="2020-04-22" version="1" fragment="single">YRFFHWHLEFPQIFRVPEPGDEDAEVDPETGWAGGFDCVVGNPPWGKVDFEDLKYFSVVEPSIAEVAGLARRTRIKEWAEENPEAGRQYAQELRKVKSTFLFVSGSGAFPLCARGLTLKGSTMLQTDQLFTERFASIVAPEGRSGCIVPTAIATGAGAQYLFGNLTRRGGIASLYDFENRKPLFSGVDSRYKFCLLSIVGRTSSEVAAKFAFFLLDAGDLEDVERVFALSPEEIALINPNTGTLPIFRTRRDADLTVSIYRYIPVLWDEVECVKNRWRIAFKAGLFHMTHDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0N5</accession>
    <name>A0A646J0N5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF</name>
        <name evidence="3" type="ORF">FFZ77_25115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="VDEQ01000282">
        <property type="protein sequence ID" value="MQS38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="87"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="356" mass="37630" checksum="7ACA56CEB908224D" modified="2020-04-22" version="1">MVVVMVPEATQEEIDGVVGLVRAAGGEAFVSRGVSRTIVGLVGDVNDFEALNLSSRSGVLQVMRVSAPYKLVSREHHATRSVIRVGGVPIGPDTLSVIAGPCAVETPEQTLAAVLMAKQAGASLLRGGAFKPRTSPYSYQGLGERGLKILADVREETGLPVVTEVIDPGSVDMVASYADMLQVGARNMQNFALLQAVGRAGKPVLLKRGFSATIEEWLSAAEYIAQRGNLDIVLCERGIRTFETATRNTLDISAVPVVQRLSHLPVIVDPSHSGGRRDLVVPLTRAAIAAGADGVIIDIHPEPKTARCDGDQALIESDLREVADAVTILSPLMGRSLAMPVRAGARASRKAPVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Q0</accession>
    <name>A0A646J0Q0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4357 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000306">
        <property type="protein sequence ID" value="MQS39189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="228" mass="25778" checksum="2B50315AF691BC32" modified="2020-04-22" version="1" fragment="single">EQVKLVQFHPSYAYEDFFEGFRPREDPDTREVAFRLTPGPLRELADLADSEGNRHIPHFLIIDEINRANLAKVFGELYFLLEYRRRTVRLTYSGDDFALPPNLFVIGTMNTADRSIALVDAAMRRRFAFVELSPGAEPTSGLLGRWLKKEGKDGEPADLLGALNSRIDDADFRIGPAYLMKPGVYREGGLERTWRTRILPLLEEHHYGEGVDVGKRYGLAALRAALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Q4</accession>
    <name>A0A646J0Q4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_14730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000150">
        <property type="protein sequence ID" value="MQS36827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024888599" evidence="3">
        <location>
            <begin position="42"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="190"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS36827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="239" mass="24514" checksum="B0C4AF3F4663C660" modified="2020-04-22" version="1">MLFSGNGKHRRPSKAVRIATFAGVTGAAVAAPLLGATSASAATSAEWDAVAQCESGGNWSINTGNGYYGGLQFSASTWAAYGGTAYAATADQASKAQQIEIAEKVLAGQGKGAWPSCGVGLSSAAYTGGSDTAPAQQTEQQTQPQQQQAQPQPQRAEAPTTRSERTEAPAPAAQPQSKPAASQGYQKGDGEYEVKAGDTLSSIADAEKVDGGWAELHELNKDIVSDADVIYPGQQLHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Q9</accession>
    <name>A0A646J0Q9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_32580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000411">
        <property type="protein sequence ID" value="MQS40154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS40154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="110" mass="11880" checksum="BCC65219B155752A" modified="2020-04-22" version="1" fragment="single">MTVIDAHHHVWDLSVRDQDWITGPGMAVIRRDFSLDDLVPEARAAGVRATVLVQTITVPEETPEFLALAHRGELVAGVVGWTDLTAPGVADALAELKELPGGDRLVGIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0R0</accession>
    <name>A0A646J0R0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_16710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000176">
        <property type="protein sequence ID" value="MQS37206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="331" mass="34696" checksum="F73C125BE8BAB070" modified="2020-04-22" version="1" fragment="single">MSESLDSAPPPRTPTRALRQRLAELRGPAVRPRPLDARALAALAANPGCERRALLDGAGVDKAALATAIGSPGAFGQSQFAFMRGNAFEARVKSDGGAELMRLMGVEGPTAFRVPELTAAGPEGRAARTALALREATAEAAWTLLDHPLLALEVAGSPAYLEPDAVVVHPDGRWTVVEIKSFPMIDARADAAKVGAAARQAAVYVLALERVAAHTEGAEAAHSVLLVCPKDFSNLPTASAVDIRKQLSVTRRQLARLTRIEDIAAALPEGVVFDPERPADELTAAVESVRAAYAPDCLAACELAFHCRDRARAQGAVGALGRSLRGELGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0R3</accession>
    <name>A0A646J0R3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fpg/Nei family DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_32525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000408">
        <property type="protein sequence ID" value="MQS40143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="43" mass="4676" checksum="597201D1C1262A58" modified="2020-04-22" version="1" fragment="single">MPELPEVESLREFLGGRLVGQEIARVLPLAVSVLKTFDPPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0R5</accession>
    <name>A0A646J0R5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_28425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000321">
        <property type="protein sequence ID" value="MQS39365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="158" mass="16235" checksum="F0A64EE00F104E74" modified="2020-04-22" version="1" fragment="single">MELVERNAEISILNGMLDVCMAGRGGVALISGPAASGKTALLRAFGTRVVAAGALFLQATGSGAERDLPLGVMEQLLLGADLPGADVELAAGLQDPEAAATPVRRDEGALPAAVANVLAGLCGILLAKAREKPMVLCIDDVQHVDAYSLECVLYLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0R9</accession>
    <name>A0A646J0R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_32575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000411">
        <property type="protein sequence ID" value="MQS40153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS40153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="106" mass="11604" checksum="73B737AAECAE3942" modified="2020-04-22" version="1">MRVALHTRVRADRIDAYEAAHREVPAELTDAIRAAGVTSWTIWRSGTDLFHVIEGPDLADYAGLLAALERLPVNIAWQARMDELLAAGHDYSAAGADAVLPVVWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0S0</accession>
    <name>A0A646J0S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase TatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_17210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000188">
        <property type="protein sequence ID" value="MQS37298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012022">
        <property type="entry name" value="UCP005295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42658">
        <property type="entry name" value="PTHR42658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005295">
        <property type="entry name" value="UCP005295_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="282" mass="31200" checksum="E1AD242ED5F43AAD" modified="2020-04-22" version="1">MRIFDPHIHMTSRTTDDYQAMYTAGVRALVEPSFWLGQPRTSPASFYDYFDSLLGWEPFRAAQYGIAHHCTIALNPKEANDPRCAPVLDELPRYLVKDSVVAVGEIGYDSMTPAEDTALAAQLQLAADHGLPALVHTPHRDKLAGLHRTIDVIRESALPPERVLLDHLNETTVEHATDSGCWLGFSIYPDTKMDEERMVAVLKTYGTEKTLVNSAADWGKSDPLTTRRVADAMLAAGFTEDDVDQVLWRNPVAFYGLSGRLQLDTAPPQALHEGNSILRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0T9</accession>
    <name>A0A646J0T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000352">
        <property type="protein sequence ID" value="MQS39606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="219" mass="24898" checksum="FFD65846FD86FB78" modified="2020-04-22" version="1" fragment="single">PFTDVRVRQAVSAAIDDEKLLESVWGGRGKLIGSMVPPTDPWYEDLTAIDAYDTERARRLLADAGYEDGFDFTLDTPNYDPHPTAATLIKSQLAKVGINVKINTITSDEWYTKVYKNRAFTATLQEHVNDRDLVWYGNPDFYWGYDDKQVTRWVEQAEQASTTAEQTELLKKVNRKTAEDAASEWLYLYPQIVVASSELSGYPRNGLNSQFHAYDIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0U7</accession>
    <name>A0A646J0U7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_21720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000238">
        <property type="protein sequence ID" value="MQS38143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="21" mass="2336" checksum="25D982872749E192" modified="2020-04-22" version="1" fragment="single">RADAKSALITLVEHALMARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0V5</accession>
    <name>A0A646J0V5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF348 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_21920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000245">
        <property type="protein sequence ID" value="MQS38180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="192"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS38180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="359" mass="38594" checksum="CA286344FC2BE71F" modified="2020-04-22" version="1" fragment="single">RRFLPQALVVVVLAGGTSAFVASDKAVRLTVDGRPRTLHTFAEDVRELLADEGVGVGAHDIVAPAPGEELASGDEIVVRYGRPVSLTLDGQRRQVWTTARTVEGALRQLGVRAEGAYLSASRSSAISRHGLALDVRTERAVTFLADGRTRTVRTNAATVGEALVRAGIPLGGQDTTSVPLGSFPRDGQTVTVLRITGSREVHEEPIPYEVVRTGDPSLFTGTEIVAQQGRPGVRRVTYQLRTVNGGREHPRKIEDEVIQEPVAQRVLVGTARLPGSVVGADGLDWRALARCESGGRAGAVDPSGTYGGLYQFDTVTWRALGGRGRPQDAPAAEQTYRAKKLYIQRGASPWPHCGRRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0V7</accession>
    <name>A0A646J0V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_31305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000372">
        <property type="protein sequence ID" value="MQS39908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="4"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS39908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="224" mass="24166" checksum="65572097290C6136" modified="2020-04-22" version="1" fragment="single">ALVGESGAGKTTLLRMLLGLARPTSGTVRFDGDELRPRDREQMRRFRRGVQCVFQDPYSSLDPRRRVGGIVAEPLRSLGIDTRRTAGPKVAAALERVGLPADAAERYPHEFSGGQRQRIAIARATVCEPRVLLADEPVSALDVTTRVKVVELLGELKREHGLTLVMVSHDLSVVASLCERTAVLERGRVVEQGPTAQVLGAPAHPYTARLVASVPRLPTAAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0W3</accession>
    <name>A0A646J0W3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_31690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000385">
        <property type="protein sequence ID" value="MQS39981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="197" mass="20900" checksum="F74C040054D45F90" modified="2020-04-22" version="1">MRQKRRGPGDDLLGRLIVEHGAELTEAELLGTATTLLASLIQNVAGTLGLGTLALLENPEQLALLLKRPELIDHAVEEVIRSVSVIAMASPRTALEDVPIAGRVIRTGETVACSLLGANGTTAPGEPKAPLDITRDNSGHMAFGHGIHYCIGALVTRMELRIAIAGLLERFPTVRLAVPPGGLRFSSRAVETLPVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0W8</accession>
    <name>A0A646J0W8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_31740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000389">
        <property type="protein sequence ID" value="MQS39991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="89" mass="9109" checksum="891CBDD24E7D176C" modified="2020-04-22" version="1" fragment="single">MGPVSRTVSVCPGRPREPPVRAAPSAPPVGGGLAALDAEGPNRIGLGWFTLTRDGREVTWHNGGTGGSCSFIGIDRENGRGAVVLSNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Y4</accession>
    <name>A0A646J0Y4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_25825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000299">
        <property type="protein sequence ID" value="MQS38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="207" mass="22612" checksum="F97A05064CB29687" modified="2020-04-22" version="1">MRKLQNDHMDGNGWADFGYNLAVCEHGYVFEGRGKNAQNAANGNTTLNRNHFAVLALVGNSGHVSPTVDQVAGLKDAIAYLRANGAGREIKGHKDGYATLCPGGPLYKMLKAGELEPTKPPTPPVAYEPFPGDAWFRKKPNSAVVTAMGKRLVAVKCSAYTDGPGPKWTNADRESFRKWQRKLGDSPEFCDGWPGKRQWDALKVPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Z1</accession>
    <name>A0A646J0Z1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000308">
        <property type="protein sequence ID" value="MQS39195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="613" mass="68409" checksum="E220E9104F36E096" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J115</accession>
    <name>A0A646J115_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_29585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000346">
        <property type="protein sequence ID" value="MQS39584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS39584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="180" mass="18494" checksum="3AE1F3E290F6DC55" modified="2020-04-22" version="1" fragment="single">AALRPAIGRIVERAADVLMLLPAVLGILLIALSWPDGGRLAVIAAAVVMGVPYAVRLVTGAAAPIAASGYIEAATVGGERLWHLAVRDVLPNLRATLLALFGLRFVAAVYIVATAGFLQVGPQPPAADWALMIRENSGGIVLNPWAVLAPSIAIGLLAMSVNLAASALIPRSGRKAVNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J152</accession>
    <name>A0A646J152_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4157 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000387">
        <property type="protein sequence ID" value="MQS39987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="77" mass="8117" checksum="F095AE1B22D49282" modified="2020-04-22" version="1" fragment="single">RVRLHTDRDAGALTAMLGADAVAVGQDILFREGAYLPGTADGRRLLAHELLHTVQNPHGLGALRAGREPGAVSLPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J167</accession>
    <name>A0A646J167_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_16515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000171">
        <property type="protein sequence ID" value="MQS37168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="465" mass="47672" checksum="7C7C6EDC57E0FE7E" modified="2020-04-22" version="1">MTSLSVEMLAADATAPITSAGNAQLGIAVLAGIAVIVLLITKFKLHAFLALTIGSLALGAFAGAPLGKAIESFSKGLGSTVAGVGVLIALGAILGKLLADSGGGDQIVDTILAKANGRTMPWAMVLIASVIGLPLFFEVGIVLLIPVVLMVAKRGNYSLMRIGIPALAGLSVMHGLIPPHPGPLVAIDALNANLGVTLALGVLVSIPTVIIAGPVFAKYAARWVDIPAPEKMIPARPSEELDRRPGFGATVFTVMLPVVLMLSNALVEIVVDDPENPVQKVTDVIGSPLIALLAAVLVGLFTLGRAAGFTKDRLSSTVEKSLAPIAGVLMIVGAGGGFKQTLIDVGVGQMILDFSENWSIPTLLLAWLIAVAIRLATGSATVATISAAGLVAPLATGMTSTESALLVLAIGCGSLFFSHVNDAGFWLVKEYFGMSVGQTIKTWSVMETIISVVGIVFVLLLSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J172</accession>
    <name>A0A646J172_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_32565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000410">
        <property type="protein sequence ID" value="MQS40151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS40151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="169" mass="18764" checksum="6189036632CCB6AB" modified="2020-04-22" version="1" fragment="single">WADPDDDPRDSVGIGPDGELATLQDFLTSYRMTLRMKCEGLDAEQLARRSVPPSTMSLLGLVRHLAEVERDWRNWISEGEPLPKLYGERDADFDGAVAEQAEVDAAYAALEREQAATDAALAEHPDPSERLAKDGIAVRELLVHRIDEYARHCGHADLLRECVDGRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J181</accession>
    <name>A0A646J181_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_18450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000204">
        <property type="protein sequence ID" value="MQS37535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="41" mass="4316" checksum="C27C9080CB012A25" modified="2020-04-22" version="1" fragment="single">GAWTNWVDVTLTVPLQAGANTIRVSATTANGAPNLDYLDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1A9</accession>
    <name>A0A646J1A9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_21915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000244">
        <property type="protein sequence ID" value="MQS38179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="132" mass="14452" checksum="DA050D17FDE8046E" modified="2020-04-22" version="1" fragment="single">MDRSRTEVARVLGEIEKLGLIDAAEHSEVLSVLSDDFPFAAAVRHTDSVHAHIKVEDVDALPHQDLVALGHRPENAEPGYVKYATLTGVHFIFSSIPIAQDDSIPGAVTLPKPFMDHIGIDMRDESDTTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1C0</accession>
    <name>A0A646J1C0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_24925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000279">
        <property type="protein sequence ID" value="MQS38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="100" mass="10377" checksum="C30A72CC6C1F87C3" modified="2020-04-22" version="1" fragment="single">RAGRHLYADLGPLRAGLAARGVGDSMELEEYLTDRLGTPVPGGHRFGDELGALRVRLATAPLLGATAEQRAASLAAPEPVELPYVAAALSDLGAAFAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1I9</accession>
    <name>A0A646J1I9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxogl_dehyd_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_12405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000127">
        <property type="protein sequence ID" value="MQS36376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024867940" description="2-oxogl_dehyd_N domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxogl_dehyd_N" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS36376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="76" mass="8305" checksum="AC6BFE8AF1E98D0F" modified="2020-04-22" version="1" fragment="single">MKRKRAVAAVSSQSPSNSSSPSLRPGGAPTTDQGGQGIDPAAAFGPNEWLVDEIYQQYLQDPNSVDRAWWDFFADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1J8</accession>
    <name>A0A646J1J8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_30920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000368">
        <property type="protein sequence ID" value="MQS39837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="97" mass="10721" checksum="ABB91F88D04366FC" modified="2020-04-22" version="1">MLHEIAHMLWGHELLPDTASLTGLFPDLDPRTVLDALSLHRTGYAERQEQQAEMTASLLGQAIDRLQAPRGLSGSLGRLQDALGGSDEPPDDHRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1K2</accession>
    <name>A0A646J1K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_16715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000176">
        <property type="protein sequence ID" value="MQS37207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="7">
        <location>
            <begin position="46"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS37207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="296" mass="32017" checksum="BB8FC29AB43096E4" modified="2020-04-22" version="1">MPHSGPGRRPRWWTELILIAVVYVAYSAGRLLARGDVNTAVDHGIAILRAEKALFLNAETPLNKLFTEHPAIGVPADFLYASLHYLVTPAILIWLFHRRPARYRAARTWLMLSTLLGLVGFTLMPTCPPRLLDASYGFVDTMAQYSSYGWWGTEASAPRGLGGLTNQYAAMPSLHVGWALWCGVLLWRYGRTPLLRALGVAYPLITVIVVMGTANHYFLDAVAGAAVMGLGALLARPGMRLADRVRTRLTASRAKAPSGIAAPTVGAGCQTSPGERIPGQRTTPEDADESTPAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1K7</accession>
    <name>A0A646J1K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000380">
        <property type="protein sequence ID" value="MQS39924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="644" mass="69771" checksum="E778D668D0EE45E1" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1M9</accession>
    <name>A0A646J1M9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_32560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000410">
        <property type="protein sequence ID" value="MQS40150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_6" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="81" mass="8589" checksum="B80D350A77DBBC13" modified="2020-04-22" version="1" fragment="single">DEVLREDLAKATLVWVQEVAALLGQVRPTAPASSLAAAAERLTALLEGLSMRWLSGGIGIRHARELMRGAIDAELAGLRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1P3</accession>
    <name>A0A646J1P3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_21925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000246">
        <property type="protein sequence ID" value="MQS38181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="242" mass="24628" checksum="FFDDBD5846132C0B" modified="2020-04-22" version="1" fragment="single">VHSGRCLEVKDSSLLPGAPIGQADCTGQAGALWTLRESAAGGGAVNVVNVNSGRCMAAPTGSVGAPVRQADCTGQAATSFVLVDRATHVWLQPLGVTPAVCLEVTGSSHTPGTAVRVAECSGQPGAAFRQRQPRTGNDPATGDPDPQDCPKGSFCIYSGLDQSGTLRVVTAGDWVTPQLTFYGSVFNNGLTGPGAGRVQFGYSSGPTGFSVCLDAHPGPGVYKMNASSFLNAAVSATWRGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1T6</accession>
    <name>A0A646J1T6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ricin-type beta-trefoil lectin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_28720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000330">
        <property type="protein sequence ID" value="MQS39423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="126"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="256" mass="28526" checksum="21645904B0E26948" modified="2020-04-22" version="1" fragment="single">CAFGLGGGVDHSDHGVGARYFRRVGYALGVPVSSYLGYTMSPLKANLTPGESAEKDEVARWYLANRKCRATGTCANVAPFKGPLQKDWSLWIHRQYKQNHRAPRAGEILGDIGRTTYFTGRDPAQCLHAGTGPPNAGEVGIHGCDGSAAQKWDMGHDGTIRPRDDRGSCLTALAPAVGLERCEPGRRSQRWSREPWRSTTWKRTAWRISGSADRCLYQDDRELPARWDDRDRQSPELKLADCGTRPLPELYWRWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1U7</accession>
    <name>A0A646J1U7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000347">
        <property type="protein sequence ID" value="MQS39585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="143" mass="15912" checksum="2139D87A4579357C" modified="2020-04-22" version="1" fragment="single">MKSSTAANGSALAEVWPLSPLQEGLLFHADFDDRGPDIYTVQFLLAVDGPLDAPRLRATWEGLLARHASLRASFHRRKSGEAVQLITRNVMLPWREVDLSELAEPDISDQADKLAAQERAERLDVTVPPLLRLLLIRLGDGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1Z3</accession>
    <name>A0A646J1Z3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-F family ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000403">
        <property type="protein sequence ID" value="MQS40031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="114" mass="12803" checksum="3A5E2B7470FC7589" modified="2020-04-22" version="1" fragment="single">EHFTTIGDDWDIEERTRAQLDRLGLAGLALDRSLSTLSGGQVVSLGLAAQLLRRPDVLLLDEPTNNLDLEARHKLYDVLTDFNGCLLLVSHDRALLDRMERIAELASDELRFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2S9</accession>
    <name>A0A646J2S9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">FFZ77_03380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="VDEQ01000031">
        <property type="protein sequence ID" value="MQS34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MQS34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="222" mass="23120" checksum="2699E2E1714B2B23" modified="2020-04-22" version="1">MLNKYARAFFTRVLTPIAAFLLRRGVSPDAVTLIGTAGVMAGALVFFPRGEFFWGTIVITLFVFSDLIDGNMARQAGISSRWGAFLDSTLDRVADAAIFGGFALWYAGRGDDNVLCAVSIFCLASGQVVSYTKARGEAIGLPVAVNGLVERAERLVISLVAAGLAGLHAFGVPGVDVLLPIALWIVAVGSAVTIGQRVVTVRRESAEADAADAAGRSEAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2T8</accession>
    <name>A0A646J2T8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_06585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000063">
        <property type="protein sequence ID" value="MQS35288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS35288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="498" mass="51430" checksum="4D9C55B818B55447" modified="2020-04-22" version="1">MLKGMLTAPDPGRLRLRTAARAVLGIALAVLLGALTGHTITAVITGGLAALLALFTVTDATVRAQALTTALLPAAGFPVLALAAGLHDRSLARDTAFLAVAVAGVYARRWGPRGHTLGVFAFMTFFVAQFLGTVPGELPGLCSAMLIGLLAASAVRFGLWCIERRQPPPAVPAPPAASGLARVTTRQAVQVAVAGALALTLGQLLSQERWYWAVGAAWWIFVNTASRGETLVRGFRRVAGTVTGIAAGLLVAVPAQGETIPTAVMAALCVFGIFYTAAVSYTWMMAFVTVLVSLLYGLLGVLDGALLALRVAETGVGALCAALAVVLVLPVTTHATTDAWIQQALRSVHRCTAEAAARLAGSAAADPAPRVAELETLLGRVRLSVTPLVHPLSPLRARKERARKVLALLDDCARELRGLASVAADPAASHDARLAAACRRVETAVHALVPPAQREPGRHTAGAQAAHPGAEAALAHLHALERALADLAAPLRASAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2U9</accession>
    <name>A0A646J2U9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_14255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000145">
        <property type="protein sequence ID" value="MQS36733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS36733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="208" mass="22615" checksum="7F47A77C20E4AB19" modified="2020-04-22" version="1">MGLRERKKQRTRKTISDTAIALFLEHGFDQVSVVDIAAMAEVSKPTLFTYFPAKEDLVVHRFADHQTAGSTVVEQRPPGVSALDALHQHFLDGLAARDPITGLNDDSDVLAFHSLVYSTPSLVARVGEYLSQAEQTLARTLAETLGTEYREVTAPLLAGQVVAAQRLLASVNWQRIVGGRTADDVFPEATADADHAFALLRRGLLGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2X8</accession>
    <name>A0A646J2X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_20705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000226">
        <property type="protein sequence ID" value="MQS37962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="93" mass="10281" checksum="A3FF69796920B4A1" modified="2020-04-22" version="1" fragment="single">MRRLREELARALEEAAPAGPEDVFAALCAHLGERRGRPVVLHLVDFPPQTASGLYLDMADRDVICVQAGTHPLHQLIIFGHEVWHMMAGHGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2Z4</accession>
    <name>A0A646J2Z4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_21910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000244">
        <property type="protein sequence ID" value="MQS38178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="149" mass="16274" checksum="79E5129A7E33B18C" modified="2020-04-22" version="1">MKIRQSPWDDPDATALRERQRAEIAAVYGTPDSDPGVPPSTADIAVFLVAHEDDGTAVGCAGLRYLGEGVGEVKRMYVAPDQRGSGLAALILRSLEDWARGQGWKALRVETGDRLSTAMRFYTRSGYESIPNFGAYADSECSLCFERIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J315</accession>
    <name>A0A646J315_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_25455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000289">
        <property type="protein sequence ID" value="MQS38812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="101" mass="10064" checksum="4B8689211508DECD" modified="2020-04-22" version="1" fragment="single">MPTGNGPPAVPSSNVLGREQFGREQFMAARGETRDVPGTPCGRLMRAASDNVRGVLITEGDAAPGTALLIAAAPAGKGRLVDASSVLPSLAAVPPSALTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J336</accession>
    <name>A0A646J336_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phospholipid carrier-dependent glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFZ77_27775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000316">
        <property type="protein sequence ID" value="MQS39239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="82"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MQS39239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="304" mass="33391" checksum="1FA364FF21A7E202" modified="2020-04-22" version="1" fragment="single">MPGADRPRADVRVRVLPRPVIRFRSSRPDLLLCLGLLTVILAVQGWNITHFPTLSDDEGTYLAQAWAVQQGEGLAHYTYWYDHPPLGWIQIAGLTYLPSVIAPESMTVATMRFAMLVVSAACAVLLYVLARRLFLPRWSAALAMALFGLSPLSVVLQREIFLDNLAVMWMLLAFCLAASPSRHLWHHFAAGLVGAVSVLTKETMLVVLPALLVTMWRHSHRDTRKFAVTGAITACVLIGLSYPLYALLNNELFPGPGHVSLIDGITYQMGREGSGFILDAGSGSHGVLQSWLYYDRVLPLGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J378</accession>
    <name>A0A646J378_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_30915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000368">
        <property type="protein sequence ID" value="MQS39836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="154" mass="16532" checksum="3CA7479117FFE785" modified="2020-04-22" version="1" fragment="single">MRTSALATLLLLWAVVLWRAPKAVRSPRQRPLTTAFAALAVVATLGRESVSTPLEELLGVSSAASLLKHLSGLVASAAVLEFIARMTGRTETRRTRRIRYGLCAAAGTTMSAVFPFVPRDGGNSTFLIESISAPLALVYWIVWLGYLGTALFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3A3</accession>
    <name>A0A646J3A3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ACP S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000401">
        <property type="protein sequence ID" value="MQS40028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS40028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="240" mass="25531" checksum="EF23F4769C6C7F7E" modified="2020-04-22" version="1" fragment="single">HPVMRELYARVSRWTGLAVEQILTDELPGTPEERQSAATIRESALALGVHDVLVERGLRPGVLGGLSLGAMTASCLAGAIGRRELFEMLAYARHTPRLPPEEPEQGLALAFAPADGGNAGFPGEGRPGVHLSGDFGPTADGELRILMLSGERTALDALEGELPPGSLVPLPDRTIAVHSPLRRHFRAFMASRIAAIPFSDPRVPLVSCLERKALTTGAEVRDLFARNPTDPISLVDVCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3B0</accession>
    <name>A0A646J3B0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_32555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000410">
        <property type="protein sequence ID" value="MQS40149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS40149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="98" mass="11171" checksum="F13897E2E066B5D2" modified="2020-04-22" version="1" fragment="single">MASRSTQILEAAARVIARRGVRGLRVEELAAEAGVSTALIYYHFKDRTGVLRQTLEFISDRAERYTTDRDPDEPPPTPREELEQSLLLELQDTVEVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3E3</accession>
    <name>A0A646J3E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF998 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_12230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000123">
        <property type="protein sequence ID" value="MQS36341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS36341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="229" mass="23570" checksum="AA07352CE0C106F8" modified="2020-04-22" version="1">MIAVLLALGALVYTAWLIEVVLSTGLDPVQTYVSELAAEDQPFGGLFRATDLTAGLLVLAGALWALRGALRTAPREPWTLIGWGGVVLFGAATAVDSRLPLSCAPTADPECAARESAGLVPATHTAHAVSSSAAMTGAVIGIVALTVAARRYGRLPLLARTGPALVALELIATGWTLASVAAFQAGGDTYALGAGQRLQVLIVAVWLGVLALSLARERRVPQARKDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3E8</accession>
    <name>A0A646J3E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_12750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000132">
        <property type="protein sequence ID" value="MQS36443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS36443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="389" mass="41050" checksum="611DA67C309DD12D" modified="2020-04-22" version="1">MMLTTATNPTLDDRITGSLIGAAVGDALGGPVEGYTPEQIAERHGGRVQGIVGPWNGDDWRTARPIAPYHKGDGHITDDTLMTHALIRVYTEVRDHLDAYAVAGHLVPDLMTRPRWIPELEAEALPLQRIFLAEKWLVARLHYGHHDPREAGAGNIVNCGAAMYMAPVGLVNAADPRAAYAEALDIAGAHQSSYGREAAGVFAAAVAAACLPGATPASVVDTALGLAKDGTRAAIGAVAEAAAAHTDFETALVPLRTAVAPFDTVGPDYRAPSLAARRPSRLHSIEELPIALGMLLIGGGDYRRTVLGSVNYGRDCDSIATMAGAIAGALGGETAVPRDWAKSVAEASRLDLHAPARELAAVVREVFVRDRERRRAHEAAFARLTGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3F4</accession>
    <name>A0A646J3F4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFZ77_15000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="VDEQ01000152">
        <property type="protein sequence ID" value="MQS36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="169"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="236"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MQS36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="404" mass="43309" checksum="3BDADD88AE24FB4D" modified="2020-04-22" version="1" fragment="single">MRAPRPRPRRRRPGWLRLPRWTATLTWKAALFITVMCCALAALLGALVHAAVTAQTVSQSREKALGKLTEVTEAYEAGEPLPPYAGVDPPGLPGSLRELAVGGERGTMVSTFQDRPIMWAAGPADGRALAVYIDYSLSVRTITGLDRAIVGSSVLAIGATLLVGAFAVTRVTRRLHLTAQVARRISAGDLDARVRDPRTEDPTRPQDEVATVSAALDTMASSLQRKLLSEQRFTADVAHELRTPLTGLTAAAELLPEGRPAELVRDRVRTMRSLTEDLLEISRLDAGSERVDLDVHELGPLAGRVVRASGTDTEVRIVRDTCVETDRRRLERVLGNLIANAHQHGRAPVVLTVDGRVVTVADAGPGYPAYLLEHGPARFRTEGGSKGHGLGLTIAAGQSAVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3H6</accession>
    <name>A0A646J3H6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_19700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000213">
        <property type="protein sequence ID" value="MQS37770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="155" mass="17150" checksum="10F0EF0617242964" modified="2020-04-22" version="1">MPTKRGQAQRAENEIRIRAAKDRLLCGDIPPRGKCDVKPLASEAAVDRTAFYGTRPYSDLRVEFGRRLNAMREAGGIPDPREAQVARLKAGNTRLRERFAQSERTINELIDFRSQPLAQLAAQHEEIVRLREAAAGTSTVSRLPAPRTTVIGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3J4</accession>
    <name>A0A646J3J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFZ77_21830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000241">
        <property type="protein sequence ID" value="MQS38164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MQS38164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="178" mass="17707" checksum="F04678F8DD89307C" modified="2020-04-22" version="1" fragment="single">GGLLPVPVLVMIAMGLVTALILNRAYIGRAMYAIGGNEEAARLSGLRVARLKLLVYALSGLFAAVAGVVLAARLGSAQPQAAQGYELDAIAAVVIGGASLAGGVGTASGTLIGALILAVLRNGLNLLSVSAFWQQVVIGAVIALAVLLDTARRRTGTGAAAMASAGSGNRRKKAAGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3K9</accession>
    <name>A0A646J3K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_24650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000274">
        <property type="protein sequence ID" value="MQS38661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="105"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="457"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="722"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS38661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="800" mass="89028" checksum="8D58F06823EDDA7F" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3L6</accession>
    <name>A0A646J3L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_25125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000283">
        <property type="protein sequence ID" value="MQS38751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="187" mass="18892" checksum="3C32227706F4AD6F" modified="2020-04-22" version="1" fragment="single">TPAVRSGPGGVGACGSGSGGAEPRRSGVAGGAPAGAARAGVSGSASGAGCGSPRAERLPDLLSALDVFVSASREEAFGLAVVEALAAGLPVFHSTCPAVDDLPADQSPGAHRVDGTPEALTAALRRQRHAAPRRREPPPVVRHYDIAESGRRLTRLYERVLAAPQPSQPSRPPAPPVPPSSTERARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3M7</accession>
    <name>A0A646J3M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000307">
        <property type="protein sequence ID" value="MQS39191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="87" mass="8858" checksum="60BD803E3BD6F2D5" modified="2020-04-22" version="1" fragment="single">MRAGVVVAAQPGVEDLAVRAEELGLHSFWVNDTPMVHGDPFVALSLCAKATSRIRLGIGVTSPALRSAPAAASGLASLNALAPGRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3N6</accession>
    <name>A0A646J3N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_27620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000312">
        <property type="protein sequence ID" value="MQS39210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="117" mass="13479" checksum="02C6F50BE2BC91A8" modified="2020-04-22" version="1">MRAEVDLWVEFSCDGERWTDGPMRATETAEDCEELRKIADAYASVLSQGVALFRPLPHWLRVNMGDQSGRPLATYVHQWDEETGRFRRGRSWLICDVPDACNSWQISSMVERLATML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3P7</accession>
    <name>A0A646J3P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_28785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000334">
        <property type="protein sequence ID" value="MQS39436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="44" mass="4948" checksum="001B4B5D5C7F84AA" modified="2020-04-22" version="1" fragment="single">MVMTNPPKETSHGRSGEANEPTARRRQLGLRLLALREQRGMTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3Q6</accession>
    <name>A0A646J3Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_29565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000345">
        <property type="protein sequence ID" value="MQS39580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="103" mass="10917" checksum="69C936849F6CB8F3" modified="2020-04-22" version="1">MQETGPRDFRRHGHAAADPPRRFEILVVPEHVLGRGPDSLAEAAIRSALVVATGETGASGYPRYAGEGVVADIDPITRTVEALLVDGAELDYGLSVRVRDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3T9</accession>
    <name>A0A646J3T9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tryptophan 7-halogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000386">
        <property type="protein sequence ID" value="MQS39983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="351" mass="39791" checksum="F4B4ACEA16AD3F46" modified="2020-04-22" version="1" fragment="single">PYAYHFEAHLLAKYLTRYATRRGVRHVVDHVLDVGLDDRGWVSHVRTAEHGSLEGDLFVDCTGFRALLLNKALGEPFVSYQDTLPNDSAVALQVPMDMDKDAIRPCTTATAQDAGWIWTIPLISRIGTGYVYARDYMEPEDAERTLREFVGPAAADVPANHMRMRIGRSRRSWVNNCVAIGLSSGFVEPLESTGIFFIHYAIEQLVKHYPAADWDSSLRDLYNSAVTNVMDGVREFLVLHYRGAKRQDNQYWRDTRTRTVPDALAERLELWESKVPDAGTVHPRYHGLPPYSYNCILLGTGGIQVKPSPALDLIDEKYALAEFQSIREKARTLVGSLPTQNEYFKRMRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3V0</accession>
    <name>A0A646J3V0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000400">
        <property type="protein sequence ID" value="MQS40026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS40026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="111" mass="12705" checksum="BEB4229C830B5188" modified="2020-04-22" version="1">MSETYYEFGTAAERWDRAQLFFDAKEYQTAARILRGLVDEAPEQVAQRLLLARTYYHSAQLGRAETELRAILELNPVEDYARLMLGRTLERQGRPDEAAPHLRMAAAMSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3V7</accession>
    <name>A0A646J3V7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_32545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000409">
        <property type="protein sequence ID" value="MQS40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="220" mass="22740" checksum="947596D69ADFE75D" modified="2020-04-22" version="1" fragment="single">PMILGCDAAGYDEDGNEVLVHPVIADPDAGQGDETLDPGRALLSEQHNGAFAEFLSVPTRNLIPKPACLTFDEAACLPVAWGTAYRMLFTQAQITAGDRVLVQGAGGGVASAAIKLAVAAGAVVYTTSRSADKRAQALSWGARAAVPTGERLPERVDAVIETVGEATWSHSLKSLRPGGTVVVAGATSGMNPPADLGRIFYLQQRVLGSTGCTRGELVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V5V1</accession>
    <name>A0A6I1V5V1_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DABA aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ectB</name>
        <name evidence="6" type="ORF">FFZ77_00035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047307">
        <property type="term" value="F:diaminobutyrate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012773">
        <property type="entry name" value="Ectoine_EctB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552:SF2">
        <property type="entry name" value="PTHR43552:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02407">
        <property type="entry name" value="ectoine_ectB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="422" mass="45865" checksum="315FFF27FA15D6BE" modified="2020-08-12" version="1">MTITPPALSVFETLESEVRSYCRGWPAVFDRAQGSRLHDEDGHTYLDFFAGAGSLNYGHNNPVLKRALIDYIERDGITHGLDMATAAKRAFLESFQNVVLRPRDLPYKVMFPGPTGTNAVEAALKLARKVKGRESVVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGQMPDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARAEWLRALQSLCERRDMLLIVDDIQMGCGRTGGFFSFEEAGIVPDIVTLSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFVTAAAALNAYWADGQMEKQTLARGEQVEQALLAMAAESADPGVSLRGRGLVWGLEFTDPARASAICARAFELGLLLETSGPRSEVVKLLPPLTVSPEELDEGLRILARSVRETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V6D7</accession>
    <name>A0A6I1V6D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="121"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="348" mass="35971" checksum="79E4BD9CCC1A6D42" modified="2020-08-12" version="1">METLGGTEFAPESAYLNTSTCGLLPRRAVTAMAELARELAAGRPEGAGDWGQVSAARGSFARLTGVSEGRVAVGGSVSVHTGLIASSLPPGAEVLFPEGEFASVVTPFIARGDLKARYAPLDGLADAVRPGTALVAFSAVQSADGRIVDLRAVREAAAAYGARTLLDASQSAGWLPLDAGAWDFTVTGGFKYLLCPRGVSFLTVTEEAQRTVVPLHAGALAAESPWEAFYGPVKRFARSARRFDEPPAYLSYHGAAPALALLEEIGVEAVHAHATALARRFREGLSSLGHTPVPGDSAIVAVPGLGGRAEELARAGVVVSARAGNLRAAFHLYNSAADVDRALDVIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V6E8</accession>
    <name>A0A6I1V6E8_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 5-dehydro-4-deoxyglucarate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5-keto-4-deoxy-glucarate dehydratase</fullName>
            <shortName evidence="4">KDGDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_00105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:24608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:42819"/>
            <dbReference type="ChEBI" id="CHEBI:58136"/>
            <dbReference type="EC" id="4.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Carbohydrate acid metabolism; D-glucarate degradation; 2,5-dioxopentanoate from D-glucarate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 5">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.41" evidence="4"/>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00564">
        <property type="reaction ID" value="UER00628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047448">
        <property type="term" value="F:5-dehydro-4-deoxyglucarate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042838">
        <property type="term" value="P:D-glucarate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00694">
        <property type="entry name" value="KDGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017655">
        <property type="entry name" value="Dehydro-deoxyglucarate_dehyd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="314" mass="32398" checksum="0BF3E4A8FBFC175E" modified="2020-08-12" version="1">MTTVPLAARLTRVQGPLFFPVTAYGPDGSIDLGACRAHVESGVDAGAAAVFVCCGTGEFHALTPDEYGRCVATAVAAADGEVPVIAGVGYGTALAARYARTAEAAGADGLLALPPYLVLADQAGLLRHYTALAASTCLELIVYQRDNALFAPPTVAELARTDGIIGLKDGHGDLDLMQRIVTAVRRDAPGQDFLYFNGLPTAELTGPAYRGVGITLYSSAAFAFVPDIALAFHRALATGDDKTAARLLDGFFAPLAALRDLGRGYAVSLVKAGVRLEGLDVGGVRPPLSEPDPAHVDALAELIGQGRALLAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V793</accession>
    <name>A0A6I1V793_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_00065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="256" mass="28170" checksum="724EA30F6DB9083B" modified="2020-08-12" version="1">MSTTDSGGTQVKSAVRTVELLEYFAGRPGMHSLAAVQEAVGYPKSSLYMLLRTLVELGWVETDATGTRYGIGVRALLVGTSYIDGDEVVAAARPTLDRLSDDTTETIHLARLDGVNVVYLATRQSQHYLRPFTRVGRRLPAHSTSLGKALLATYSDEQVRAMLPPTLSSLTEHTVTDREKLIGELHSIREQGYAVDREENTLGLRCFGIAIPYRTPARDAISCSVPVARLTPGHEQMIKDALFDARDRLTLATRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V7X8</accession>
    <name>A0A6I1V7X8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_00020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="51"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="365" mass="39393" checksum="3A766B40034B1E61" modified="2020-08-12" version="1">MSDRVTVHVKGRVLVGPEEVRDELWVVGGRISYQRPSGSAGAEALTVTGWALPGLVDAHCHVGLDQHGPVDDAASEKQALADREAGTLLIRDAGSPSDTRWIDDREDLPKIIRAGRHIARTRRYIRNYAHEIEPDDLVAYVAREARRGDGWVKLVGDWIDREAGDLTACWPRGAVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCIEHATGLTEDTIPLFAERGVAIVPTLVNIASFPVLADGGETKFPAWSAHMRRLHERRYDTVRAAYDAGIPVFVGTDAGGSLAHGLVAAEVAELVKAGIPPLQALSATSWGAREWLGRPALEEGAPADLVVYDEDPRADVRALAAPRRVILNGRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J036</accession>
    <name>A0A646J036_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_12235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000123">
        <property type="protein sequence ID" value="MQS36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="196" mass="19389" checksum="9376239EDC66964E" modified="2020-04-22" version="1">MGTGGGGRAGQLLLLVALLFGIATMHTVGHPSDSPAPPPAASAQLPEALPGGGAVALTLSDGGHDRAAPVAFPAGPRELPEAPASAAALADNRHDQAAPVTFPAGPQELPDGSAHGTGHGTGPGSTGPGGHGMDPAMVCLAVLGVWGVLLLLAGPWSRRRGQSAHPALARLRFRLAPGPAPPAPRLLLAQLSVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J043</accession>
    <name>A0A646J043_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_02970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000026">
        <property type="protein sequence ID" value="MQS34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D5_N" evidence="1">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="124" mass="13561" checksum="A5AE3806151C4A95" modified="2020-04-22" version="1" fragment="single">MARSAVPTAPVPSQASGSALETAQVTASGLMPDTLTDRGNAKLFVKLYANDYRHVTGLGWYRWDNTRWQSDENDTVLWAAGEMAENIATTDPRGVHTDSALRKHRRRALSTSGMNALLMQARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J049</accession>
    <name>A0A646J049_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_05465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000052">
        <property type="protein sequence ID" value="MQS35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="267" mass="27931" checksum="E06F3E0CA5C1BE00" modified="2020-04-22" version="1">MTGSEMPSSFRLAYVPGVTPTKWVRIWNERLPGVPLTLVPVSAAEASGALRDGTADAGLLRLPVDRTELSAIPLYTETTVVVIPKDHLVAAVDEVTAADLADEIVLHPLDETLDWEHRPGVPAKERPATTADAVELVAAGVGVLVVPQSLARLHHRKDLTYRPVSDAPESQVALSWPEEETTDLVEEFIGIVRGRTVNSTRGRRAPAAAPAPEQPKRKRPGTGGAQRKPTAGKPGGGGARGGSGGGSGGAKGGGKGSGKRGKPRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J055</accession>
    <name>A0A646J055_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_12110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000121">
        <property type="protein sequence ID" value="MQS36318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS36318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="252" mass="27334" checksum="D459C6A2E204BE7A" modified="2020-04-22" version="1">MERQGTGRQPKYQRIAVELKAAIEDGRYGPGDRLPGENDLMAAYAVARMTARQALGVLQTEGLVEARKGAGVFVREYRPIRRRGVQRLSAGLWGEGRSVWAVDAQGWDLEVQSVTVADEKPPEAIGRVLGLAAGASACVRRRRFALDGRPVMLATSYLDAALVSGTAIAEPDTGPGGIYARLGEIGHGPVRFREEIRSRMPTPQETDRLSLSAGTPVVLICRTAFTAEGWAVEVNDMVLDSSAYILEYDFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J065</accession>
    <name>A0A646J065_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_05460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000052">
        <property type="protein sequence ID" value="MQS35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046039">
        <property type="entry name" value="DUF5997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19460">
        <property type="entry name" value="DUF5997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="135" mass="15008" checksum="6DBA28BE4D9CE4D2" modified="2020-04-22" version="1">MKSHQTAQTMKPATAAKKLGVYLEATPTEFQEGVVSRSELSALQADPPEWLQELRRTGPHPRPVVAAKLGVSIAGLARGGVTEPLTTEQIEELKKDLPEWLQRERATQAEVRKETVRIKEKNAERAEKAARDTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J067</accession>
    <name>A0A646J067_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_18020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000200">
        <property type="protein sequence ID" value="MQS37453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="107" mass="11398" checksum="00B6F988CC899E1A" modified="2020-04-22" version="1" fragment="single">ELVRRCYTTSRVTRGALLEIASYGAVAAELLALRERYELPPGAPVTVLAATAGGRRWTARQRMLALELGARFREVTPAGHLLMLDRPDAVARAVLGEDGPGASGEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J070</accession>
    <name>A0A646J070_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_12105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000121">
        <property type="protein sequence ID" value="MQS36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024865619" evidence="1">
        <location>
            <begin position="32"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="223" mass="23646" checksum="EE45B711C2905866" modified="2020-04-22" version="1" fragment="single">MPHPLRHRTAAVLLAAAPLAPLLLPPAPAAAAPESLEVACTSMDVELAYRLGRDILEAVDAAGSTTAVYVHDRTTGTTCEVNADRRYDSASVVKVTVLGALLLDAQKRGRELTSREKSHAHAMITASSNASTSALWQQLGRARIERFLKAAGMTDTVPGAGGYWGLTQITARDQGRLLDLLTAKNDLLSDDSRAYALKLMGQVIPAQRWGTPAGATATAHLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J074</accession>
    <name>A0A646J074_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_19705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000214">
        <property type="protein sequence ID" value="MQS37771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="125"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="296" mass="32485" checksum="6C5613C224DC4238" modified="2020-04-22" version="1" fragment="single">GRLGSFRGRYARAVESGDDPAAAQRLASLVRPFLLRRRKSDPGIAPELPPKTETDRTVSLTAEQAGLYEAVVRETLAAISEADGMERRGLVVKLLTALKQICNHPAQYLKEEKGRIADRSGKLELLDELLDTILAEGANVLVFTQYVQMARLLERHLAERGVPTQFLHGGTPVAEREAMVGRFQNGEAPVFLLSLKAAGTGLNLTRAEHVVHFDRWWNPAVEAQATDRAYRIGQTRPVQVHRLIAEGTIEDRIAEMLARKRELADAVLGSGEAALTELTDAELADLVELRGDGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J079</accession>
    <name>A0A646J079_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFZ77_12410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="VDEQ01000127">
        <property type="protein sequence ID" value="MQS36377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="66"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="127"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MQS36377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="362" mass="39335" checksum="67AE0669FE99DFB7" modified="2020-04-22" version="1">MTRSPGNGRRRSVLISIKTKLGTLVVVSVFITTGLLVVALHTSTELRFITVFSVITTLLITQFVAHGLTAPLDEMNTVAKGISHGDFTRRVRGADRRDELGDLASTINRMADDLEAEDRHRKELVANVSHELRTPIAALRAVLENVVDGVSAADPETMRTALKQTERLGRMVETLLDLSRLDNGVVPLRARRFEVWPYLSGVLKESNLAAARRGLASGSGHHTRKDVHLHLDVSPPELTAHADAERLHQVMANLIDNAVKHSPPHGRVTVRARRGPYPESLDLEVVDEGPGIPEQERHRVFERFNRGAVSSPHGKGSDGGTGLGLAIARWAVDLHGGSIGVAESARGCRIRVTLPGIPSPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J080</accession>
    <name>A0A646J080_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_20015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000220">
        <property type="protein sequence ID" value="MQS37829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="326" mass="34483" checksum="B901014B0C703D77" modified="2020-04-22" version="1" fragment="single">MPTAASAYAGSRTPPAAITSDLTLDEEPTVTTPPSATTPHPRNSGLRIDLNPAAAVARNAVHHGDTVVIRYAGGDLTYARLDDKAARLATVLAHSGVGDGDRVAYLGLNSSSFLVTMLAAFRLGAVFVPVNFRLAEPELEAVLAGSGAAVLVCEEGHRASVDKVRSGTALTRFLLVDDDPEAPTAGAAGWEPWSALITATVPEPKVSAKHADDAAVLMFTSGTTGRPKGVVLTHGNIWWNSVNVELSLDTRRGDVTYVAAPLFHVGALNSFTLRTLVRGGTVVVRRRFDPQECLDDLLTHRVNSMFGIAQMFAALSRVPGVFDHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J085</accession>
    <name>A0A646J085_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_14740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000150">
        <property type="protein sequence ID" value="MQS36829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS36829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="426" mass="46726" checksum="7A0ABB4D4ADA3ADD" modified="2020-04-22" version="1">MSDTPCPASAPDPAPSPPPAPELFTWEFATDPYPAYAWLREHAPVHRTTLPSGVEAWLVTRYADARQALADQRLSKNPAHHDEPTHAKGKTGIPGERKAELMTHLLNIDPPDHTRLRRLVSKAFTPRRVAAFAPRVQELTDRLIDGFAGRGEADLIHEFAFPLPIYAICDLLGVPPEDQDDFRDWAGMMIRHGGGPRGGVARSVKKMRGYLLELIHRKRGDLGDDLISGLIRASDHGEHLTENEAAAMAFILLFAGFETTVNLIGNGVYALLRNPEQREGLQSSLAAGETGLLETGVEELLRYDGPVEMATWRFAREPLAIGGQEIAAGDAVLVVLAAADRDPERFDGPDVLDLSRRDNQHLGYGHGIHYCLGAPLARLEGQTAIATLLTRLPDLRLAGDPADLRWRGGLIMRGLRTLPVTFDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J086</accession>
    <name>A0A646J086_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_20700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000226">
        <property type="protein sequence ID" value="MQS37961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="391" mass="41590" checksum="DBF20528B377FD72" modified="2020-04-22" version="1">MTNMGMIVPAVLLIGAFLLKLPALYRNRQDILLGAVCGLLLMAGVVFLLAAVPTIAAINRVTGVPNLAAPVVYSAISAFSGACLVLIVIWRGGTTERTRRTARLCVTAYGLVIVALNLLFLIGDAPVERLRDFDTYYATTPFIREMICLYLLAHTVAAVVTAVLCWRWSRQVTGVLRTGLILIVIGYLLNLGFDAAKFSAVAARWAGQDWDGLSTRVAPPLASLAAPLVGGGFVLPLVTQRLGIGWRTAVRYRRLGPLANRLSGAAGQGSSSVAIGPWASLELRLIRREAAIHDGLISLRPYFDETVYDEIRARALTLGHTPAEAAIVADAAMVATAGRAYAADPGRTALAGRAATVQPSTSGDDLVRMSLALRSSPLVQEAYRRAALSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J093</accession>
    <name>A0A646J093_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_16720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000176">
        <property type="protein sequence ID" value="MQS37208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="199" mass="21966" checksum="7653A4F6D596C7A6" modified="2020-04-22" version="1">MAPRILLVRHGQTEWSLLGRHTGRTDIPLLEEGRRGAKLLGERLRRAPWSGLPGLEVRTSPLLRAAETCELAGFGDRAEPWDALMEWDYGAYEGLTPPEIRAEAGPDWVIWQNGVRDGEALAEVAARADEVVEWARSADRDVLVFAHGHILRVLAARWLSLDPSFAARLKLDPASLSVLGWAYGAPAVDHWNDAGHLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0A4</accession>
    <name>A0A646J0A4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SulP family inorganic anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFZ77_21660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000233">
        <property type="protein sequence ID" value="MQS38131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="337"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MQS38131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="411" mass="42144" checksum="5C7C833C57466ED8" modified="2020-04-22" version="1" fragment="single">PGGVLTVGLLAGLMLLVLALARAGRYMAYIPAPVVEGFTLGIALVIGLQQIPSALGVSTEGEKVLVVTWHAVEAFVMEPNWTAAALAAGVAAVMLLGARWRPAVPFSIIAVIAAAVVVQVFRLDRATPIGDLPPGLPAPSFGFVDPSTLGSLLAPAVAVAALAALESLLSAQVADGMTVGQKHDPDRELFGQGLANIAAPLFGGVPATGAIARTAVSVRSGASSRLAALTHAVVLAVIVFAASPLVSRIPLAALAGVLIATAVRMVEVGSLRAMARATRADAVVLVLTALATLVLDLVYAVVIGLAVAGVLALRAVARQARLDQVDLRPDLPGGHSEEEHALLAEHIVAYCIDGPLFFAAAHRFLLELSEVSDARVVILRMSRVTTVDATGALVLKDTVEELARRGIVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0A5</accession>
    <name>A0A646J0A5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_22880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000252">
        <property type="protein sequence ID" value="MQS38357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="181" mass="19932" checksum="A48CF9FF479D5415" modified="2020-04-22" version="1" fragment="single">MGRAVPSLLTFLGGVGTVTGSKFLVEGVRSRVLVDCGLFQGLADLRRRNWRPLPCDARDIHAVVVTHAHLDHCGYLPRLVRHGFRGPILTSANTARLAEIVLRDSARLQTEAAQHANEHGWSKHRPAQPLYDDLDVDRTVSFFDPVGMDTEVEIMTGIRLTLHSAGHILGSAWARLTLEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0B3</accession>
    <name>A0A646J0B3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_24645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000273">
        <property type="protein sequence ID" value="MQS38660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="144"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="272" mass="29254" checksum="5C3E89760E6DC39C" modified="2020-04-22" version="1" fragment="single">EAALRGATLRLLHAWVLLSLESAQSPSEEDQNYWARQIVDGARAAIEQRFPDLPIVEDLVRADPRDALRAAADASGMLVLGSRDMAPLTSYFLGDVGLQVLARSPVPTVLVRARENSADTPDTPDATDTGAEGDVVMGLSLHGPCDALVAFAFESAAKRDVALRAVHGIRIPVPAYTRADVDSYISVSLLEGARRNLSEALRPWRSEYPRVRVEEVVRTESPARAVVRGASGAGLLVVGRRQEPLPLRPRIGPVLQAAVHHAPCPVAVVPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0C3</accession>
    <name>A0A646J0C3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF350 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_25120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000282">
        <property type="protein sequence ID" value="MQS38750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS38750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="99" mass="10341" checksum="8C26A84D32DF3F1E" modified="2020-04-22" version="1" fragment="single">MTDIVNGLGRASAYGALGLVLLILGMVLIDLLTPGKLGRQIWEDRNRNAALLLSSALLGIGGIVFTSIWTTYDDFGKGLASTAAFGVLGLVMMAVAFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0D1</accession>
    <name>A0A646J0D1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LamG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_25780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000296">
        <property type="protein sequence ID" value="MQS38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="675" mass="73357" checksum="8B082B62EDA1678C" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0E0</accession>
    <name>A0A646J0E0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4357 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000306">
        <property type="protein sequence ID" value="MQS39190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025579">
        <property type="entry name" value="DUF4357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14267">
        <property type="entry name" value="DUF4357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4357" evidence="1">
        <location>
            <begin position="30"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="307" mass="34339" checksum="5A4E5186F3853E3D" modified="2020-04-22" version="1" fragment="single">QRFVVLAGSPVRPEVVPSFPSRMPSSYELRQRKIADGAIQESGTWPGRLETTEDITCNSPSAAAEILVGRSANGWKEWMTEDGHPLSDFIDQVWPGPVRAWLVRGANVFGRDLVQRMWLDEGRVTLAARHLRQDAVGMLRKDQLRNAVEEDYESTATYGQKAQLVEEFHAFLIRMRPGHTVCTLSEGRMFVGEIAGAAEQISSDDGRSNLRRPVEWRTAYDYRELPPDLVRKLGTGHDVVELTAVKGLLDGLGMTDEELVEEAEAADRDPSVEIPTITARRVLELPEPTEELADTLNVHSVGWLREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0E3</accession>
    <name>A0A646J0E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_23700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000264">
        <property type="protein sequence ID" value="MQS38494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="450" mass="48242" checksum="541968D42FCCEC7A" modified="2020-04-22" version="1" fragment="single">MTVTEDSPAYGPGIDPERLAVCLSVLDELDKLEVDHPDAIVVRRATAGVYRTVKQRRRQERRAAKTAHDKAVTEATATGSAERIDDETEGLLPTASATGEIAGILQRPRSCYICKTRYVEVDVFYHQLCQECAAENRARRDARTDLTGKRALLTGGRAKIGMYIALRLLRDGAHTTITTRFPNDAIRRFKAMPDSDEWIHRLKIVGIDLRDPAQVVALADSVSAAGPLDILINNAAQTVRRSPGAYRELVSAESAPLPAGELPPAEVIGVFGSGAVDSVAALPSAGGEGLSAQDVTELALVSGSATLARIEAGTAIDAGGLVPDLHDSNSWIQTVSEVDPVELLEVQLCNSTAPFILISRLRAAMAAAEAKRTYVVNVSAMEGVFSRGYKGAGHPHTNMAKAALNMLTRTSAQEMFEADGILMTAVDTGWITDERPHPDKMRLAAEGFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0E5</accession>
    <name>A0A646J0E5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_12115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000121">
        <property type="protein sequence ID" value="MQS36319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS36319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="139" mass="15196" checksum="C95597B8C9EBFC8E" modified="2020-04-22" version="1">MSFSESFSDTVETSWQFPRTPRTAGSARSLLREQLAVWRITGDAVDAAELLLSELVANAIRHANVPGGDELGVRLAYGDGMLRVEVSDTDSRRPEPRVAGADDEGGRGLFLVSALSERWGCDPRRHGAGKTVWVELKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0E8</accession>
    <name>A0A646J0E8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_27625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000312">
        <property type="protein sequence ID" value="MQS39211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="80" mass="8940" checksum="2A4AABC8E3340772" modified="2020-04-22" version="1">MYYVQVCDETNSRDMGGFELATTQSISSASLARYAVTAWDGFGLAYDFNADDLYSIRVWNGEDVVKLHTYRLIDGTLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0F4</accession>
    <name>A0A646J0F4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_25840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000299">
        <property type="protein sequence ID" value="MQS38887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="74" mass="8141" checksum="15165E5CCD8E2373" modified="2020-04-22" version="1" fragment="single">MAITDKTLDEALAGARDSEEFRWVLVGTAKTEHRSGGEIKNDSEITLCEKEPSKLSDGKGRTKCKACATEEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0F5</accession>
    <name>A0A646J0F5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_28430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000322">
        <property type="protein sequence ID" value="MQS39366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="213"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS39366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="407" mass="42574" checksum="729EF0B59E9036A5" modified="2020-04-22" version="1" fragment="single">DPVTSVGVALNTAGRAVVFAGATVCIALAGMLVMNLRFLDGVVIATTLTVVLSVLAAVTLLPALLGFLGPRVLSRRQRRRLAEQGPERGATSGLAVRWSGQVQRRPKSLVALALVALTVLALPVLSLRLGATDQGNHPEGQTTRQAYDLLADGFGPGFNGPLVVVAEGAGPDAVRRLTARVEGDEGVARVAALPPAGGVSVVQIVPTTSPQSEDTDRLIDRLRDDHLPRAGVDGHVGGVTAVFKDFAEKTGERLPYFVAAIVGLGFVLLLIAFRSLLVPLTAAVMNLVAAAASFGVVVAVFQWGWGLELIGLDRSGPISAFLPVIMLSLLFGLSMDYQVFLVSRMHEEWMHTRDNARAVRVGLAETSRVINSAALIMICVFLAFVLSGDMEAVVAGAGLAVAVAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0G6</accession>
    <name>A0A646J0G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_16755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000178">
        <property type="protein sequence ID" value="MQS37215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="32"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS37215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="525" mass="53903" checksum="E63EFEBDC4E27528" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0H0</accession>
    <name>A0A646J0H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000345">
        <property type="protein sequence ID" value="MQS39579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="46"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="204" mass="21665" checksum="7EED111884AC8853" modified="2020-04-22" version="1" fragment="single">EVGLTPQGVDILKRSGAKAVITLAPRRVAGAHSLVMDQSEVGGCAVAHLIQRGRRSIGVVMPSEPGLEHFAEPRFEGARRAAAGTGARIVPLALAYDEKSANDLAAGWAGLGLDAVYAYNDEYAMLLMRALQDAGIDIPGRTAVVGADDLLLGRLLRPRLSTVHIDMVTGQLLAELVDRTVRDPNGEPETRDLMGARAVHRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0I3</accession>
    <name>A0A646J0I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_19630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000211">
        <property type="protein sequence ID" value="MQS37756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS37756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="210" mass="22767" checksum="85BEA0F5CE6A0D45" modified="2020-04-22" version="1" fragment="single">MKALHVITGLGVGGAEQQLRLLLRHLPLECEVVTLTNPGSVADGLRADGVRVHHLRMGGNRDLGALPRLTRLIRRGRYDLVHTHLYRACVYGRIAARLAGVRATVATEHSLGEAEIEGRPLTRPTRALYLGTERLGSATVAVSHTVAGRLRAWGVPQERIHVVPNGIDAARFRFDPERRAAVRARLGIAPDAFVVGGVGRLVAGKRFDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0I8</accession>
    <name>A0A646J0I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_29700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000352">
        <property type="protein sequence ID" value="MQS39607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024935905" evidence="6">
        <location>
            <begin position="38"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="95"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS39607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="321" mass="33843" checksum="C9271D6D3656DE0F" modified="2020-04-22" version="1">MARYLLRRFAFLLVSLALACVVLFVLLRMLPGDPANALTAVGATDEQIAAARHSIGSDKPLPEQFAHWIGQLARGDLGTSFVSSLPVGPEITARLQVTIPLTLAAFALAILIAVPAGFLAAYRRRTWYGALLSGVSQLGIAIPVFWLGMILIAVFALNTGWLPAGGFPPDGWSQPGEAIRSLTLPVLTIALVMSASLIRYVRSATLDVLGSDYLRTARALGSSFAGAMWRHGLRNAAVPVISVLGIELASTLLGAVVVESVFALPGLGSMLATGIEQHDYPVIQGVLFVSTLAVLLIGFAADLVQRIIDPRLRGGLSGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0J1</accession>
    <name>A0A646J0J1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_29835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000355">
        <property type="protein sequence ID" value="MQS39633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="136" mass="14938" checksum="0EC10315ACAE4CDB" modified="2020-04-22" version="1" fragment="single">MTMPKEDTNTMRALQGLENNSSSVRLQAALAVGTNPDPGFIGKLIERCAIEPEFYVREMLTWALTRHTASMTVPVLLDEVRSEHAQARSQALHTLSKIGDRQAWPAITPALLSDADDEVARSAWRAAVVLVPEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0J2</accession>
    <name>A0A646J0J2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Streptomycin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_28725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000331">
        <property type="protein sequence ID" value="MQS39424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="300" mass="32631" checksum="0C1D177A7E33218D" modified="2020-04-22" version="1" fragment="single">MGHARAPVTSLTQGELELQLGYAQIDQNLVVEVEINSLSTADSPRISGSDPDHVESLAAAQAPLPPIIVHRPTMRVIDGLHRLRAAEIRGLDKVAVRFFDGNEAEAFVLAVESNITHGLPLTLAERKHAARRIIDSHPQWSDRMIASVAGIAHGTVAEIRRRAPGGPAAEASRTGQDGRVRPINIAVEGRRLASELISENPGLSLRQIARAAAISPETARDVRNRLRRGEDPLPKPRSRKRTEHANGPAERPNGSAAEEAGTLLDRATVRHRAEIMERLKADPALRFSNTGRTLLRLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0L0</accession>
    <name>A0A646J0L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_30350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000365">
        <property type="protein sequence ID" value="MQS39730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="162" mass="16861" checksum="41207FAAED3419E4" modified="2020-04-22" version="1">MRTVAVTGHMDLAEGAYAPLRDALRDVLGELAEGAHGWVGVSCIAPGADSLFAETVLALGGELAVVLPFRDYRGSLGDERHRARFDRLLEAASDITVMPAVEAGLAAFEAANTELLKRADVLVAVWDGEPSAKGGGTAATVAEAREAGIPVRVVWPSGARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0L7</accession>
    <name>A0A646J0L7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFZ77_31300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000372">
        <property type="protein sequence ID" value="MQS39907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MQS39907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="270" mass="27383" checksum="F64AAD191C47780F" modified="2020-04-22" version="1" fragment="single">GEARKAGEAPASGDAAVLLDPGSRRRIALALCPYLIVIAVFSTAKLLGPAKEFLARSDIAVPWPGLDGRILTAAGEVSATTVYTLPWLSSAGTLLLLSGVLVAALYRVRPAAAAREFAATVAKLRWALLTVAAVLGLSYVMNLSGQTLTIGSWIAGAGAALAFLSPVLGWLGTAVTGSDTSANALFATLQQAAGAKAGIDPTLLVAANTSGGVVGKMISPQNLTIAATAVGLLGRETVLFRATLGWSLLLLAVMCVLVHLQSGVLSGMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0M3</accession>
    <name>A0A646J0M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000383">
        <property type="protein sequence ID" value="MQS39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="100" mass="10710" checksum="CBC652783951EE4A" modified="2020-04-22" version="1" fragment="single">HRFDAGSYVVLTEAMNSHDIGRGRGGTTAALRRISARTLVAGVDSDRLYPLSQQHRLAASIPGADRLRVIESPYGHDGFLIETAQVASLVRELAGDPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0M7</accession>
    <name>A0A646J0M7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000390">
        <property type="protein sequence ID" value="MQS39992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="144" mass="16150" checksum="6EF32D12B4DF2501" modified="2020-04-22" version="1" fragment="single">TTAVTEHTTLLLVRYRFQLTLPSRTGRRQLVAEDARLLAFQGPPHRARWLPEETATRLLDAEATENTHPHFGARTMERLLSRLSACHDHLETHGERLAADLDASHRRVRTANDEIVRGLRVAAQKPADVLGAYVYLPATAEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0N4</accession>
    <name>A0A646J0N4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000388">
        <property type="protein sequence ID" value="MQS39990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046238">
        <property type="entry name" value="DUF6271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19787">
        <property type="entry name" value="DUF6271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="104" mass="11607" checksum="141B348D26577F75" modified="2020-04-22" version="1" fragment="single">VHHFDEAEQRTFLREVIARSGVAAPERVLDLMLPSRVSYGACTNRAFLIAEALGCASVHRRDSDSRYQYLDGEPVFPFHHELMALGRRAAEVAGLVSRSRLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0P1</accession>
    <name>A0A646J0P1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000399">
        <property type="protein sequence ID" value="MQS40023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="239" mass="25866" checksum="80C6F565DBCCB82C" modified="2020-04-22" version="1" fragment="single">MTAKSAAAAARSTVYGYPRQGQHRELKKAIEGYWKGRVTADALRETAAGLRRTNWRQLADAGIDEVPTGDFSYYDHMLDTSVMVGAVPARHRDAVAADALDGYFAMARGTQDIAPLEMTKWFDTNYHYLVPELGPATVFTADPAKQVAEVGEALALGLTARPVLVGPLTYLLLAKPAPGVAADFEPLTLLDRLLPVYAEIIADLRAAGAEWVQLDEPALVQDRTPAELNAAARAYRDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0P7</accession>
    <name>A0A646J0P7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000388">
        <property type="protein sequence ID" value="MQS39989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046238">
        <property type="entry name" value="DUF6271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19787">
        <property type="entry name" value="DUF6271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="91" mass="9945" checksum="6F29417227277E95" modified="2020-04-22" version="1" fragment="single">SFRGAGTASFTGDRTTLTAVSPMRVDMCNIGFDHGVYGRVPLPPATDTIGSDYFLIHLVHDAGLPGVLHNRHIDNYYTGERRSDSGFLAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Q1</accession>
    <name>A0A646J0Q1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-carboxyethylcatechol 2,3-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_32550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.16" evidence="2"/>
    <dbReference type="EMBL" id="VDEQ01000409">
        <property type="protein sequence ID" value="MQS40148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047070">
        <property type="term" value="F:3-carboxyethylcatechol 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="205" mass="21094" checksum="435A52D1BB4E70F9" modified="2020-04-22" version="1" fragment="single">MTAAAAVGLSHSPLIGRNDPAPEVLAAVEDAVDTARTFVRAFDPDLVVLYAPDHYNGFFYREMPPFCLGTDANAVGDFGSSAGPLPVDADAARALARGVLDRGVDLTVSARMTVDHGFVQPLEVLFGGIDEIPVVPVFVNGVATPLGPVGRVRALGAALGEAAAALDRRVLFLGSGGLSHDPPVPVLEGAPPRVADALIDGRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0S1</accession>
    <name>A0A646J0S1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1990 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_28775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000333">
        <property type="protein sequence ID" value="MQS39434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014457">
        <property type="entry name" value="UCP010260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010260">
        <property type="entry name" value="UCP010260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1990" evidence="2">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="206" mass="22241" checksum="B89E23CEDBC8F6B9" modified="2020-04-22" version="1">MARAGLPTGARGRSGRAAAVRPAPVRRTLTYPEAGATRLGPMPDGYRHLHHTTRVGRGRAAFTAAGAAVLSWRMHRESGVRVRATAARAEPGVRVELSAGAGPLRIGAARCEVIWSADGRHRAGFAYGTLSGHPECGEESFVVDFRDDGSVWFTVMAFSRPGRWYTRAAGPLVPVLQLWYARRLGRTVRRLAADGDTGSDGVVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0S7</accession>
    <name>A0A646J0S7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_29465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000343">
        <property type="protein sequence ID" value="MQS39560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="430"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS39560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="910" mass="96688" checksum="1267F2B1B614EAAE" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0S8</accession>
    <name>A0A646J0S8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_18545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000206">
        <property type="protein sequence ID" value="MQS37553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024361">
        <property type="entry name" value="BACON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19190">
        <property type="entry name" value="BACON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BACON" evidence="2">
        <location>
            <begin position="358"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="1">
        <location>
            <begin position="458"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="572" mass="59244" checksum="BFFDBCA579424F38" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0W2</accession>
    <name>A0A646J0W2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric iron reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_23690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000264">
        <property type="protein sequence ID" value="MQS38492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF" evidence="1">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF_C" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="106" mass="11373" checksum="B6325F581596676D" modified="2020-04-22" version="1" fragment="single">YAHLVPLAEALRRDTPVSRRLLWGNAGSALAGAVRQLDEWARKAGRGDVAERAAALAAELFAHPDLSGAVHGPGMRRNTCCLYYRAPRGGLCGDCVFDRPPGRPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0W9</accession>
    <name>A0A646J0W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_24930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000279">
        <property type="protein sequence ID" value="MQS38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="208" mass="22076" checksum="7E73B99617526832" modified="2020-04-22" version="1">MAGLPPESTQQAVGYPSLFLLVALGALVPVVPTGALVSSAAVVALHQTAPPSLLYVFLVAASAAFAGDVTLYWLGQRGVRSKNGSRWLEELRSRAAPDRLQQAREKLDDHGVTVLVLSRLIPAGRIPVMLACLLARMPLRTFVRGDVPACLAWAATYQLIGILGGSLFDEPWQGVAVAVALTVVISGAPAVWRRLRRGRPDSPDGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Y8</accession>
    <name>A0A646J0Y8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_32585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000411">
        <property type="protein sequence ID" value="MQS40155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="130" mass="14249" checksum="8A492D974B498A82" modified="2020-04-22" version="1" fragment="single">LVYDLVVQPRQLLAAAEAASRRPGLTFVLDHLGKPPIASGRYEPWASRVRALAARENTVCKLSGMVTEASWARWTTADLRPYAEAALEAFGPDRVMYGSDWPVCLLAAEYPEVMATARTLTDALTEAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Z6</accession>
    <name>A0A646J0Z6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000316">
        <property type="protein sequence ID" value="MQS39241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="363" mass="41026" checksum="3CB1B41FA59B7193" modified="2020-04-22" version="1" fragment="single">MLLSVLVVAISLALFWMAAFTLWWQMHAWRTPETLAATSFDRPDSDVGLSFSLLLPARHEQAVLEHTIERLLESTHSNYEIIVIVGHDDPETAEVAERAARNDPLRVRVITDTHETKNKPKALNTALPHCRGDIVGVFDAEDQVHPELLAHVDHAFTTTGADVVQGGVQLINFHSSWYSLRNCLEYFFWFRSRLHLHAQKGFIPLGGNTVFVRTAVLREADGWDADCLAEDCDLGVRLSSAGKKVVVAYDSGMVTREETPDTLMSLLKQRTRWNQGFLQVYRKRDWRQLPTRRQRMLARYTLMTPFLQAYSGVIIPVNVVIALFLDVPVGAAIVTFLPLVTAMVTFVFEVVGLHDFGKQYGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J109</accession>
    <name>A0A646J109_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_29125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000338">
        <property type="protein sequence ID" value="MQS39498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="117" mass="11840" checksum="D9EFF6D20EDA6D3E" modified="2020-04-22" version="1" fragment="single">MTTTGQTTQTAQTTGQTAQLTGRTEQPEQPAEFKQPVTVIGLGNLGLALADAFLAQGHPTTVWNRTPAKADGLVARGAVLAATPAEAVAASELVIVAVLDQATAHDILLPTAAALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J126</accession>
    <name>A0A646J126_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TauD/TfdA family dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_29860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000359">
        <property type="protein sequence ID" value="MQS39637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS39637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="171" mass="18771" checksum="F134A8086700C47E" modified="2020-04-22" version="1" fragment="single">MTTAVDVSPISGSVIGAVVDGADLSGSIDEQQIEDIWAALDRHLVLVFRGHKDPSDEELMAFGRHFGHIPRTGLTTGANPDHNEILIISNVVENGQKIGVGNAEWMDWHTDYSFRPRVARLGFLAAVELPPGGGGETLFTDMYSVYDSLPDGLRERLHSYRARHALRSGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J142</accession>
    <name>A0A646J142_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFZ77_31405</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="VDEQ01000380">
        <property type="protein sequence ID" value="MQS39925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="299"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MQS39925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="390" mass="41024" checksum="00837754DF44D195" modified="2020-04-22" version="1" fragment="single">MSSERLAPLDLAFWHLESDGHPMHLGALAFFAPAEGAGGGERVLELLAARAAAIPRLRLRVRDVLLPVGGAAWAADQDFDIRRHVRRLSLSADDFAAAATAIAGELMERPLERGHPPWEMHLLTGGPDDDFAVLVKLHHALADGMRAVAIGAGVLDEIAGARSARPRRSRPAPQGAWSADPRRLLGFARDRIDDLGRAVGVGASVVRASRLDPRGLPALTAAPSGTRRLGTAVLDLEDVRRVRKAAGGTANDVLLAIVAGGLRRWAAERGERLPRTGPRALVPVSRRRPGTPSGPSGPGNTFSAYLLELPVAEPDARARLDAVRAVMDRNRAAGPLRGAGALAVLADQLPPLAHRLGTPLAGGAARMLFDLLVTSVPLPRSALSLGGCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J153</accession>
    <name>A0A646J153_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_12395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000126">
        <property type="protein sequence ID" value="MQS36374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="74"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS36374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="260" mass="28708" checksum="E19AC78DB5A2BB07" modified="2020-04-22" version="1" fragment="single">AVRHVVFTQPPGADAETSALLALFARYGCRVWLVDGGAAAGNLWRRATGHDHLWGFSVRPLHSAGHRPVARAVKRVIDTALAALALVFAAPVMAVCALAVRIADGPGVIFRQERVGLDGEPFTLLKFRTLCPVDEHESATRWNVAFDRRMSTTGSVLRRTSLDELPQLWNVLRGDMSLVGPRPERPYFVARFSRAHPGYQARHRMPAGITGLAQIHGLRGDTSIEERARFDNHYIETWSPWQDVCILARTAASLFRLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J162</accession>
    <name>A0A646J162_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_14260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="VDEQ01000145">
        <property type="protein sequence ID" value="MQS36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="241" mass="25530" checksum="80CCB4E0CCA81815" modified="2020-04-22" version="1" fragment="single">LDEVAGLIERFEGYGHVVVDEAQDLSPMQCRAIARRSRFGSVTVLGDLAQATVPWAARTWPEQLAHLGRAQAAVVSLTTGFRVPAAVMELANRLMTALDVDVPPARSLRHDGEVTVRRVTDTAEGTVAAVREALGREGSVAVITADAGLDRTAQALRAAGIETATVDGVGTAARVTVLPATLGKGLEYDHVVVVEPAAIVESEPRGLHRLYVVVTRAVSRLHVVHARPLPEPLDGWPPADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J175</accession>
    <name>A0A646J175_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_17205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000188">
        <property type="protein sequence ID" value="MQS37297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="58"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="314" mass="33829" checksum="4F4E5ACBF646B468" modified="2020-04-22" version="1" fragment="single">MRFRHPDGTTVHLAYCTNVHPAETLDGVLAQLRDHCEPVRRRLGRDRLGIGLWLAAPAAQALTADPAALRGLRAELDCRGLEVVTLNGFPYQGFGAERVKYRVYQPDWTHPARLAHTTHLARLLAALLPDDIAEGTISTLPLAWRTHFDTVAATTAHSALTTLAERLDALEDLTGNSIRIALEPEPGCTVETTADAIEPLTAIGSPRIGVCVDTCHLATSFEDPATALAGLAAARITIPKAQLSAALHAEEPHLPEVRAALASFAEPRFLHQTRTRTAAGLRGTDDLDEALTGHVLPDAAPWRSHFHVPLHAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J187</accession>
    <name>A0A646J187_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_19825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000217">
        <property type="protein sequence ID" value="MQS37793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="273" mass="31047" checksum="CC72AD7EB75EAF71" modified="2020-04-22" version="1">MAISDLHVAYPDNRRIVAGIRPRSDADWLIVAGDVAEIAEDFVWALTTLRERFAKVVWTPGNHELWTPPTDPVQLRGDARYRRLVEICRSLGVLTPEDPYPVWDGPGGPVTVAPLFLLYDYSFRAPGVTREQALAQAYAAGVVCSDEVLLHPDPYPSRQDWCAARLAETERRLAARDPRLPTVLINHFPLVRDPTRVLFHPEFAQWCGTERTAQWHLRFNAAAVVYGHLHIPRTTWHDGVRFEEVSLGYPREHRRRGLPDEVFRQILPAVGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1B5</accession>
    <name>A0A646J1B5_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="1">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GlcN6P deaminase</fullName>
            <shortName evidence="1">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">nagB</name>
        <name evidence="3" type="ORF">FFZ77_23155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="1"/>
    <dbReference type="EMBL" id="VDEQ01000258">
        <property type="protein sequence ID" value="MQS38402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="2">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="260" mass="27302" checksum="4EAF0AD7AC749611" modified="2020-04-22" version="1">MEVVIVPDSAAGGELIAEAMADLLRRKPDALLGVATGSTPLPIYEALAAKVRSADVDASRARICQLDEYVGLPSGHPESYRSVVLREVIEPLGLTESSFMGPDGTADDVAAACVAYDRALAEAGGVDLQLLGIGTDGHIGFNEPCSSLASRTRIKTLTEQTRQDNARFFDSVDEVPHHVITQGIGTILDARHLVLLATGAAKAEAVALAVEGPLSALVPASALQLHPHATVVVDEAAASRLKLADYFRATYASKPDWQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1C9</accession>
    <name>A0A646J1C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_25460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000289">
        <property type="protein sequence ID" value="MQS38813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="105" mass="11101" checksum="D7705F0388D2F888" modified="2020-04-22" version="1">MLVTEGRFSGSMPVVLTWISGPAFRPSTNLCNFTWGKGGGMSKGSSIHAATTLKPARTTVGHCRFVLLSDGVGVLTVSSPPVFAPLDLKIWPLMLESLLSAHTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1E3</accession>
    <name>A0A646J1E3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_27535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000307">
        <property type="protein sequence ID" value="MQS39194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="171" mass="19037" checksum="593C4647114C103C" modified="2020-04-22" version="1">MSAADGLRGLVTDETAARMITEVGIPDQVGGHVLLSDFSDGPVTVKEDVGPLKESEQIVENFVSLGTTGTDGEGLLLLDGRTGEVLVWEQERLSRVTPRLDVFVYFLTLIQEQINTAEDEMWDTDGEEVREAFDAIWAGFQSIDEPTVRESGEYWRRMMEDSFQSMGFHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1E6</accession>
    <name>A0A646J1E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_27780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000316">
        <property type="protein sequence ID" value="MQS39240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="47" mass="5292" checksum="19AF5A7AAB050425" modified="2020-04-22" version="1" fragment="single">IGGPFYQVLLAGAAVRAVWREQRGRNEWELTSHVGAHLTETREDASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1F6</accession>
    <name>A0A646J1F6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_28510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000327">
        <property type="protein sequence ID" value="MQS39382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molydop_binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="127" mass="13762" checksum="E2CBC20B6EB51378" modified="2020-04-22" version="1" fragment="single">MGMTGRPSVVHFAGVTHWTRTGEQLNGVRLVQIHPRTARASGIADGDPVRVESPRGSVTGTALLWEGIREDTVFVPNTFGPAQRVGDLFGAPRYEPANVLCDDGFYDNLSGQQAYKCFACRVVRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1G6</accession>
    <name>A0A646J1G6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_28800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000335">
        <property type="protein sequence ID" value="MQS39439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="213" mass="23179" checksum="577660ED321821DC" modified="2020-04-22" version="1" fragment="single">MNHPGDLAVFLRAKRAVLAPESTPLNGFGVRRRVPGLRREEVAQLAGVSVTYYTRLEQGHSRNASDEVLLALARALQLSVTEAEHLLDLARARRTATTTGSGTETASPNARALLALVAARPAVILGRRNDILAWNALGHALVAPHLPSGAPDHPGTRPSLPRLLFLDPQVRALYRNWDQEAADYVAYLRLISGKYPDDETLTSMVGELCVHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1H3</accession>
    <name>A0A646J1H3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YlxR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_02150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000018">
        <property type="protein sequence ID" value="MQS34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="91" mass="9923" checksum="96E8D4F332FB34B0" modified="2020-04-22" version="1">MSGRTHARARPERTCVGCRERAAKTDLLRIVAVGDDCVPDDRGTLPGRGAYVHPALVCLDLAVRRRAIPRALRAPGPLDTAGLRRRVEQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1I4</accession>
    <name>A0A646J1I4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_12100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000120">
        <property type="protein sequence ID" value="MQS36316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="165"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS36316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="435" mass="47216" checksum="C8E812FB93394CA3" modified="2020-04-22" version="1" fragment="single">LESPRGREWPLAPGAGPRSAHTAPPPATADVAIVGAGPAGLAVASALWHLGVRNVVLIDREGRPCGRFFDRIDMLRQRVLRSPYEHHPGVEGYRDCELLDFARLHWSLLTPVERREIRMAQSGHRSVVPVDVFEAYCEHVATLHHVDERTWRGAVREVRPTADSVTVRGDGFAVTAPYAVLCLGEERRAAPSEWWDGEAAPHGVGYWDEPVPREARSLVVVGAGLSAAHLISNALGDGRRVHWILRAAEERYQCADVNASFFRAEGRARFDGTDWDDRTTLMRGHRRASVMFEFRPLLQRAEAEGRLTVHRGRAVTAVTGERAGRASVRLADGERITGDHVVLALGTAVSNGGQLLPEGVTAPRDGWPDLDERTLAYRNAPRVFAVGAAAGMVLGPAARNIDGHRVATARVATAVAAQLETAAGAVRTGRAVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1I7</accession>
    <name>A0A646J1I7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000358">
        <property type="protein sequence ID" value="MQS39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="124" mass="13142" checksum="5FE63F5174B58DCF" modified="2020-04-22" version="1" fragment="single">LAGGLPARKAVLGVPSWGYGWTGVPAGAKNGLYQPATGMSPRGGGQLPYKAIKDLPGAVHTDRKHGAAWKYDGTEFWTYDTPATAAQKARYTQRNDLGGVMVWSLDGDDAQGSLIAALDRGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1J5</accession>
    <name>A0A646J1J5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_30330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000364">
        <property type="protein sequence ID" value="MQS39726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="118" mass="12294" checksum="9978DC6433D5050E" modified="2020-04-22" version="1">MLTAENADSTPYTSGAEKLVTPVQRLKSAMLSGAASSRTREPASSSAHTAASRRHWLVRRARMSAGTLSKPAMARSAEPAKNGMLIIGAALRSCGRDSSGRLLWAVEGCAGVAGRPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1K9</accession>
    <name>A0A646J1K9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_17215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000188">
        <property type="protein sequence ID" value="MQS37299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="185" mass="20052" checksum="F4963052F74AB585" modified="2020-04-22" version="1" fragment="single">RTALLTTALRIAADLGAHAVHCFSGTLPDHTTPHTAWKRLEESLTPVLDAAHTAGIPLAIEPEPGHLLATLDDFHHLRELLGDPEPLGLTLDIGHCQCLEDQPPADCVRQAAPWLRHVQIEDMRTGIHEHLPFGDGDIDFPPVLQALTTSGYQGLTVVELPRHSHAGPELARTSIEFLRANGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1L0</accession>
    <name>A0A646J1L0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_31715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000386">
        <property type="protein sequence ID" value="MQS39986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="67" mass="7502" checksum="A467351E19C52A82" modified="2020-04-22" version="1" fragment="single">REPVPHVAFGHGIHHCLGAALARMELRIAYTALLRRFPALRLAVPAEDVVFRVRSTAYGVERLPVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1L5</accession>
    <name>A0A646J1L5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inositol phosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_31835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000395">
        <property type="protein sequence ID" value="MQS40010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045977">
        <property type="entry name" value="DUF5933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19356">
        <property type="entry name" value="DUF5933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5933" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="83"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS40010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="353" mass="38418" checksum="68F6E193FAD40272" modified="2020-04-22" version="1" fragment="single">VGIDIAFALVRWAADAEQGYGNGALWVILGCAVIAVTRRTGQERVLLLKGVALGLLLVAGRKTGDTWLLITSKTRPEVLDQYVLTADQALGNPSWLVGRMVTATGPIGAHVLDWVYVKLAVAAVVFAVYQLRHVAAERRFPAHHLVRTFLVIGLLGPGIYMIFPVVGPIFAYGADGGQWAVANLWPDTPPQITTPQHMPFDEITPRNCMPSLHTAWAVAIFIHSRNAPRVLRLAGTFWLIATLGATLGFGYHYGVDLVAGVVFTLTIEAALRSLARGWDRSGTQLVAYGATVFVALLVSYRYLSMEMAAYPWAFGPLLILAMASVIYGYVRTTKRWDSPSAPAQRPAQQLEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1M4</accession>
    <name>A0A646J1M4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_19995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000219">
        <property type="protein sequence ID" value="MQS37825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="399" mass="42267" checksum="7AB49D58BAB0B47D" modified="2020-04-22" version="1" fragment="single">MGYVRQDEWEGHFARGEGFRPLGERERALLAEHVPAPAGGGRALDVGSGTGELAAHLASVGYRVDAVDYTDSAHTRARDEHPGDGQVSRIRLDIEHGDPAELDPGGYDLITLRLVYAFLTSRTGVVRGLGERLRPGGALVVITPTTADVPQDRRDIVLDEGEIALLTEGWETAERMDADGLTVLVLRGPRPAGTRAVEKGTPAGHALIGALAVVTDSTGRVLLGRSTQGMWELPGGKSQGSEDLAAAAVRELAEETGLVTAPGGAVVVAMLVDSIEQVPRLTAVVRVTAWSGTLTNPEPALFTRWEWHNPHTLAVLGPVFTPAAHALDAVWPGIIPGLPPVNSYPLAAGQPPVPGEPAEAVRLRHAMADAVTAGGWAPSEPVRRALRTVPRHRYVPEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1N1</accession>
    <name>A0A646J1N1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_20840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000229">
        <property type="protein sequence ID" value="MQS37975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="306" mass="31136" checksum="1A636A0C5AC02D5A" modified="2020-04-22" version="1">MSSPTGPASGLPVRMPRPRQSGRHRRPEPVAAPEGAPALVLAVPGTPGPAARGLAEETISIARSELPGLDVGIGYLYGDDHEYPSLEGVLAGTAARRTERYAIARAAGREVTEPEGPASVVVPLLAGPDHVLMGRIRQAVLDSGSAAELTDVLGPHPLLAEAVHVRLSEAGLARADRARLFTVATAADGIILATVGGDEAVQAAGITGMLLAARLAVPVMAAALDREGSVGAIAEQLRDSGSMQLALAPYLVGPELPEGLLEAAVKDAGCSASEPLGAYPAIGKLVLSQYTSTLGITPRPQGSPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1R9</accession>
    <name>A0A646J1R9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_25830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000299">
        <property type="protein sequence ID" value="MQS38885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="66" mass="7114" checksum="63E7689BC7D8282A" modified="2020-04-22" version="1">MEFVKTNPARLYALAVAVLALVAFYVPELPTELVLGVVAALLGTGEAVQRTENRKTARAYAEIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1T0</accession>
    <name>A0A646J1T0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000318">
        <property type="protein sequence ID" value="MQS39268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="113" mass="12449" checksum="7DC25AE1DF760939" modified="2020-04-22" version="1">MDAANGTRALAHPTREEILLEGVLHALSDPVRLRMVRALAASPERLSCSSFDLPVTKSTSTHHFRVLRESGVIRQEYRGTSKMNGLRRDDLDALFPGLLDSVLAAAARQERSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1V2</accession>
    <name>A0A646J1V2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000351">
        <property type="protein sequence ID" value="MQS39603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="173" mass="18949" checksum="63D656F76EF4A9CD" modified="2020-04-22" version="1">MYEEVLRCLPAPPARAADIGAGSGRDAAALARMGFRVTAVEPVREMREIAARLHPEDVVWLADALPELRGVEGAFELLLLSAVWMHLDQDERPVAMARLSELLTEGGRLVVTLRHGQPPRDRRMFDVSAGETVALAAECGLLLVHRGGGEDRLGRGDVHWSQLVFEKPGERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1V8</accession>
    <name>A0A646J1V8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_29865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000359">
        <property type="protein sequence ID" value="MQS39638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="187" mass="20726" checksum="CB518BDAB48B0E2D" modified="2020-04-22" version="1" fragment="single">IDAIVHDKGTAAALKPYYRLFCKRPCFHDGYLDAYNRPNVTLVDTEGRGVERLTPAGVVAGGREYRVDCLVFASGFESEFAVPYTARAGYDIIGRDGVYLSDKWADGARTFHGLQVNGFPNCFIMSKVQSGLHVNVPYMLNEQSKHLAYIVQSVQRLGKQVVEVSSTGEKEWVETILGLANQNLDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1X6</accession>
    <name>A0A646J1X6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetyl-L-homoserine sulfhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_31545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000383">
        <property type="protein sequence ID" value="MQS39953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="107" mass="11230" checksum="20AC58D09B6C1308" modified="2020-04-22" version="1" fragment="single">GNRWYEAAQRYLPNGAGAVLSFELRDGVEAGKRFVDAVELFSHLANIGDVRSLIIHPASTTHSQLGPEQLAATGTAPGLVRLSAGIENIADLKADLESGFRAAKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1Y7</accession>
    <name>A0A646J1Y7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000397">
        <property type="protein sequence ID" value="MQS40021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024808317" evidence="1">
        <location>
            <begin position="22"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="319" mass="34732" checksum="295FFF6E7CD28A2C" modified="2020-04-22" version="1" fragment="single">MPSKVNAVKIRRPLPPSVALVCVLALTTGCGLIPGSGSDTRTVKIWLMQDSVSEEFLDRFSKEYEEKHPSVKLEFTFQSWTGIGKKVNAALEGEDTPDIIEVGNTQVAQYAETDALEDLTLESVRDLGGEDWLEGLAKPGNIDGSQYGIPWYAANRVVIYNKDVFADAGIKKTPKTRDEWLAMTEQLNQDGTQGIYLPGQDWYTLAGFIWDEGGDLAVERAGSWEGMLHTDATLRGMDFYKELQELGQGPKDSDETKPPQGEVFAKGNVAQIVAPPSVASTILKANPELEDKLGYFTIPGKTADKAGAVFTGGSDLIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1Z9</accession>
    <name>A0A646J1Z9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_32570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000411">
        <property type="protein sequence ID" value="MQS40152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS40152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="348" mass="36723" checksum="BEEB3B6518547782" modified="2020-04-22" version="1" fragment="single">GNLYTPVEPDDALAAVDAAWECGIRAFDTAPHYGLGLSERRLGRALRTRPRAEYTLSTKVGRLLEPGGPGGDDLANGFAVPADHRRVWDFSADGVLRAVEESLRRLGLDRIDIVYLHDPDAHEDAAFRHGYPALERLRAENVVGAIGAGMNQTAMLTRFLRDTDVDAVLCAGRHTLLDQSALAELLPEAAARGKSVVVAGVYNSGLLADPRPGAPYDYTAADAGTLARALRLKDIAERHGVPLRAAALHCSLGHPAVAGALIGARSAAEIQDAARQLRTPVPAALWEELRATGLLPPGVPQRRPDPDPDRASGPEGAPRSPSEPAPSRPAPPAPSSPSSPSSPEGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2U2</accession>
    <name>A0A646J2U2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multicopper oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_12240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000123">
        <property type="protein sequence ID" value="MQS36343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024868753" evidence="2">
        <location>
            <begin position="25"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="91"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="285"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS36343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="355" mass="37300" checksum="CB738651E37BDA63" modified="2020-04-22" version="1" fragment="single">MRTHITRRSVIGASLAAAGTGALAACSGAGSDGHAGHGGSQNSGRGGNRSGAAEGFVSPDGKEVAAAEAERGKGPERKVRLTAAPVRLDLGGRTVRSWAYGDRLPGQEIRATAGDVLALTLANHLPEPTSLHWHGLALRNDMDGVPGLTQRSIAPGADFRYRFALSHPGTYWFHPHSGVQQDRGLYAPLIVEDPREPLAYDKEWVIVLDDWVDGVDGSTPDAVLDELRKGMSGGGGGGHEGHGMTGMMSRKEPEKTPAPGGPSRMMMGAASDLLGGDAGDVAYPHYLINGRTPDAPTSFRARPGDRIRLRIINAGGDTAFRVALGGHEMTVTHTDGFPVRPAKTDALLLGMGERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2V3</accession>
    <name>A0A646J2V3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFZ77_16510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="VDEQ01000171">
        <property type="protein sequence ID" value="MQS37167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MQS37167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="179" mass="18676" checksum="1E60EF728DD16063" modified="2020-04-22" version="1">MSTPHVVVVMGVAGTGKTTIGPLLADALGVPYAEGDDFHPPANIAKMSAGTPLDDGDRWPWLDEIGRWAHGRAGLGGVVSSSALKRSYRDRLRAAAPDAVFLHLTGARELIERRMSERKGHFMPTALLDSQFAALQPLEEDEAGVAVDVSGAPEDITARAAAALRALSGSAGAVPRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2V9</accession>
    <name>A0A646J2V9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_16940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000185">
        <property type="protein sequence ID" value="MQS37248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="347" mass="37754" checksum="FF594380C1381647" modified="2020-04-22" version="1" fragment="single">AFGPLSLLLEDDSVYHASEQRERDRAFWTERLAGRADPVSLASRSAPASDSFLRRTSSLSASAVAALRRAGQHAGSSWPTVMIAVIAAYLHRLSGERDVVLSMPVTGRMGSSGRTVPGMVANVVPLRLRVRPEHGLSALVRQTADEIGALREHQRYRGEDLRRELGRELGPGQSERALFGPVANIMSFYYHVEFAGLRATAHNLSNGPVEDLSISVYDRSDGTGPRVDFDANPALYSDAELTAHQERFLRFLDAVVTADPAQPIGRPDILTPGERHRTVVERNRTTHPLPPTTLPRAFAAVVARTPDATAVVFGDTVLSYAELNARANRLAHRLIAMGVRGESTVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J300</accession>
    <name>A0A646J300_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_23125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000256">
        <property type="protein sequence ID" value="MQS38397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS38397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="139" mass="15291" checksum="3B1AC4DCA1676B2D" modified="2020-04-22" version="1" fragment="single">TASGTISDRVEGLSIGADDYLPKPFAYAELVARIRAVARRSHRAVPPVLEHADLRLDPARRIATRAGERLALTPKEFGVLEYLMAAQSRVVSAEELLERVWDEAADPFTTTVKATINRLRSKLGSPPVIETVPRGGYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J306</accession>
    <name>A0A646J306_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_24660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000275">
        <property type="protein sequence ID" value="MQS38663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="132" mass="14561" checksum="4F537FA3E14A1200" modified="2020-04-22" version="1" fragment="single">MSEQDSSRPKRPKSTRTITVPYSGGAERRGPATMGQTNMIRCILRDDPVQINIHDVWPVPAGTRLESAVDALRALVVRHEALRTVFPHASGTAPCEQMVSAEGEFTVTVLDHEDLPREPARYAESVARQSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J327</accession>
    <name>A0A646J327_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_27530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000307">
        <property type="protein sequence ID" value="MQS39193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="92" mass="9930" checksum="1FFDBB7F0AC04CAD" modified="2020-04-22" version="1">MPDKTNEITGFARLLAPFGLTGIAVTADAPHTQREHIHFLTPDKQTHYLLVVKNNQPSLFTALCPLPWSRVAARHAPAAAGMAGVNCGSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J348</accession>
    <name>A0A646J348_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFZ77_28795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000335">
        <property type="protein sequence ID" value="MQS39438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MQS39438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="107" mass="10600" checksum="573A2CCCFB414DFD" modified="2020-04-22" version="1" fragment="single">MPLPIIALALTAFALGTAELVPNGLLPLISEDLGVSVSRAGWVTTSFALGATIGGPLVAAATMRLPRKPSAIGLTLAFLVANVITATTGSLLVVSVSRAFAGAMLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J355</accession>
    <name>A0A646J355_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000345">
        <property type="protein sequence ID" value="MQS39582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="110" mass="11826" checksum="38191C3F5D2B1AF0" modified="2020-04-22" version="1" fragment="single">MSHTRYQTVPMTEAVEYDVVVLGAGPTGENMADRLRAGGLSTAVVESELVGGECSYWACMPSKALLRPVIARAEARRVPGLRQAAEGPLDTDAVLAHRDEYASHWKDGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J369</accession>
    <name>A0A646J369_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excinuclease ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_30325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000363">
        <property type="protein sequence ID" value="MQS39725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="23" mass="2681" checksum="D2B11FDDFBB1EEA3" modified="2020-04-22" version="1" fragment="single">MLPFGTIYAEAQRRYFESVAPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J386</accession>
    <name>A0A646J386_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_31395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000379">
        <property type="protein sequence ID" value="MQS39923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024796464" evidence="2">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="254" mass="25469" checksum="F659F80E458277FC" modified="2020-04-22" version="1" fragment="single">MSSLVAAVVLSLVSAVAYAAGAIMQERVAATSPDQPYAPLHHAGWWCAISLNGFGAVLHVVALAYGPLSVVQPLGALTIVFALPMAALFAGRRAGATAWRGALMATVGLGGLLAVAGDAGSHTLGTGQRGMLTAVSLGAVALIFLVAQTINRPVLRSVLLASAAGVAFGIASVFTKTVAVDWEWSRPVAQWSSLVVIAVLALGGLLLSQASYRGAGLAAPLATVTVVNPVVAAAVGVTMFGEGFRFGALGTVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J396</accession>
    <name>A0A646J396_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_31830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000394">
        <property type="protein sequence ID" value="MQS40009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS40009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="432" mass="44279" checksum="EE87BEA6CD0C4C36" modified="2020-04-22" version="1" fragment="single">LEAHVNKVTKEKGVLFTVSAGNEGPGPGSVGSPGSAEAALTVGAVDEADKLARFSSIGPLADDGAIKPDVTAPGVGTTAASAPGSDIALAVGENPAGYVSISGTSMAAPHAAGAAALLKQQHPTWSGEWLKAALTASAKDVGHTVFQQGTGRIAVDRAIGQTVVADATTVSFGRQQWPHTDDKPVTKEITYRNLGAQEVTLDLTVQGTGPQGKPAPAGFFTLGTDKVTVPAGGTATVPFTADTRIGDADNGAYTAAVIATGAGQTVRTTAAVDREVESYDLTLDYVGRDGKPNLAFFTHLAQISGAGNASETDPGGRSTTTFRLPAGDYAIHASLSHESGESDRLVHPRLALTKNTTVTVDARRTKPVTMSVPDPRARMTAAGAAFSVGIGERSIESTSYLSTLDGFRTAQLGPEQPAGVKLKDVLLAQWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3D6</accession>
    <name>A0A646J3D6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_05885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000056">
        <property type="protein sequence ID" value="MQS35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="208" mass="22271" checksum="D608C9991ECE3674" modified="2020-04-22" version="1">MGDCGLIVDEAAGTVKWAEPERGGVVASSVLELYGRIAERFGELILNCPQDRWENPSPCPGWTARDVVVHVVSNHRRAVAGLDGSGYSAPGRGENLPHAWDAASEEIKAALRDPAKASALLGDEFGSIPFEEFVRRMACADTLIHGWDLARATGQDEVLDSEAVAVATEILVPEDGDIRMPRAFGAKVPAAPDADAQTRLLNFLGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3G3</accession>
    <name>A0A646J3G3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_16765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000179">
        <property type="protein sequence ID" value="MQS37217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="69"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="496" mass="52431" checksum="476055E500446B41" modified="2020-04-22" version="1" fragment="single">VGKTALALQLAHRTAARFPDGRLMIGLRGPQGRPLSWAQAGAALLRGLAGEPSGGPGALPALPADPQDLAELLGRTLRGRRLLLVLDDAASAEQIRPLLPPGEGSAVIVTCRRTPAALAGADHLVLEAVRADEAVELLLTTGGERMAEDPAATAEIAGLCGGLPLALRVAAAALTARPHTTAAALAERLRDERTRLAVLREGDLDLRATLLTGYQEAGPAQQRAFRLLTLAPAADFAGWTAAALLDLEPGAAGEVTEELVAARLLEARPGGRPPRYGFHSLLRVLAVELREAAEDAEGERTREAVERLCRASLTLARHADRQLAPGRDWRTRPVPSGAAVLDEAYDDGGGGRVDAAAVVGGAPLRWFRDEAAGLVEAVRQAHTAGLWSLAWELADSAAGYFHACAAWEEWEETHRLALDAALRAGNTAAEAAVRYSLGGLAWQRREAHRALAQYTSAQRGFDRVRDRIGSARCRIGVADILLGQGRPAAAARRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3I8</accession>
    <name>A0A646J3I8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_21700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000236">
        <property type="protein sequence ID" value="MQS38139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS38139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="180" mass="19610" checksum="A1DFA63BD0B529C8" modified="2020-04-22" version="1" fragment="single">MSYPQYETGEPIADAGAPDGPIAERWDRRRFEARLVNPANRRKHTVIVVGTGLAGGAAGATLGEQGYHVEQFCYQDSPRRAHSIAAQGGINAAKNYRNDGDSVHRLFYDTVKGGDFRARESNVHRLAQISVEIIDQCVAQGVPFAREYGGLLDTRSFGGVQVSRTFYARGQTGQQLLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3K2</accession>
    <name>A0A646J3K2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-dependent alcohol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_22885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000252">
        <property type="protein sequence ID" value="MQS38358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS38358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="355" mass="37379" checksum="B6C6CE71AE689B6E" modified="2020-04-22" version="1">MKALVFEGPGRTSWRDAPDPEVKDAADAIVRGDTVTICGTDLHIIKGDVPEVTPGRILGHEAVGEVVEVGAEVRTVRPGDRVLISCISPCGRCRFCRENRYGQCQGGGGWVLGHLIDGTQAEYVRVPFADLSLHPLTSAVDGADAVLLADILPTAYEVGVVNGQVKPGDTVVIVGAGPIGLATVATARLCTPERIIVVDLAESRLTAARAMGADATVLSTEDPERLVADLTDGLGADVAIEAVGLPETFDLCTRMVRPGGRVANIGVHGKPATLHLEDLWIKDVTITTGLVDTFSTPLLLRMTAAGKIPLTSLVTHRFELDQMEEAYDVFSRAADTGAMKVVLGGTPHDTVLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3M5</accession>
    <name>A0A646J3M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_25785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000297">
        <property type="protein sequence ID" value="MQS38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="118" mass="13423" checksum="3F554CF608AD829A" modified="2020-04-22" version="1" fragment="single">AGLLLDRGDHERAIGELDRAMSAYGTLGGERDAARVRARLRRLGVRRRHWTHAKRPVSGWESLTKTERMVAELVAGGLTNQQAARRLFISPHTVGFHLRQIYRKLGIRSRTALIRFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3P0</accession>
    <name>A0A646J3P0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_28435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000323">
        <property type="protein sequence ID" value="MQS39367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="60" mass="6744" checksum="CC7B3FD4D957C040" modified="2020-04-22" version="1" fragment="single">QVRPEDPCAEIPDVRTAHWQTPAHAAELGTEERRVVELLLRLPAKQRAALAWNLDGFTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3Q8</accession>
    <name>A0A646J3Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_29655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000350">
        <property type="protein sequence ID" value="MQS39598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="88" mass="8916" checksum="EC36854DAB647B0B" modified="2020-04-22" version="1" fragment="single">PREATMRMHAAGTLVSEGHGAACLGDPLNALLWLARTSRAYGDPLRAGQVVLSGALGPMVSVLAGVTVSAEISGLGTVRAAFTDKDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3S9</accession>
    <name>A0A646J3S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_30365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000366">
        <property type="protein sequence ID" value="MQS39733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="65" mass="6847" checksum="6DA82FBE7FB4B111" modified="2020-04-22" version="1" fragment="single">MSDIEALLEELRSLPATRASSARDIEALLAGVKSAAGRWADVLYEIHESAQGLVGPRAEAALEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-05-25" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V2P3</accession>
    <name>A0A6I1V2P3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">L-ectoine synthase</fullName>
            <ecNumber evidence="4 7">4.2.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">N-acetyldiaminobutyrate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ectC</name>
        <name evidence="8" type="ORF">FFZ77_00040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine</text>
            <dbReference type="Rhea" id="RHEA:17281"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="4.2.1.108"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ectoine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.108" evidence="4 7"/>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033990">
        <property type="term" value="F:ectoine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06978">
        <property type="entry name" value="cupin_EctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01255">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010462">
        <property type="entry name" value="Ectoine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39289">
        <property type="entry name" value="PTHR39289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06339">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="132" mass="14915" checksum="8D89396E03FD811D" modified="2020-08-12" version="1">MLVRSLKDIENTDRHVRAASGTWESKRLVLAREKAGFSLHETVLYAGTATSMWYANHIEAVLCVEGEAELTDDETGETHWITPGTMYLLDGHERHTLRPKTDFRCVCVFNPPVTGREDHDENGVYPLITEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V2Q7</accession>
    <name>A0A6I1V2Q7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="299" mass="31996" checksum="68A46D69690E2A7A" modified="2020-08-12" version="1">MTDALRAALADVVAIPVTPFAEDGAVDEKAQRALLRLLIDNGVTTLTPGGNTGEYYTLTPEERMRAVEVTVEEAAGRAVVVAGVGQEIPSAVTAARHAAAVGARLVMVHQPVHPYVSQGGWIDYHRAVADAVPELGVVPYIRDPRLTGDALAELGGRCPNVVGVKYAVPDAAVFAAFARDAGLDRFVWVAGLAELYAPAYWACGATGFTSGLVNVAPALSLALRDALRDGRYEDAMRRWEQIRPFEELRARDHSANNVSVVKEALASLGLCRRDVRPPSRTLPEDQRARVAALVRGWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V3G7</accession>
    <name>A0A6I1V3G7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">L-2,4-diaminobutyric acid acetyltransferase</fullName>
            <shortName evidence="6">DABA acetyltransferase</shortName>
            <ecNumber evidence="4 6">2.3.1.178</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ectA</name>
        <name evidence="9" type="ORF">FFZ77_00030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16901"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="2.3.1.178"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the acetyltransferase family. EctA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.178" evidence="4 6"/>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033816">
        <property type="term" value="F:diaminobutyrate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012772">
        <property type="entry name" value="Ectoine_EctA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02406">
        <property type="entry name" value="ectoine_EctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MQS34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="181" mass="19504" checksum="8F909B133A8EB628" modified="2020-08-12" version="1">MSVDTPRVEDGAALWRIARDSEVLDLNSSYSYLLWCRDFAATSLVARGPDGEPIAFVTGYARPERPRALVVWQIAVDRAYRGQGLAGVLLDALTAKVTAERGIREMETTITPDNTASERLFTSYAARQGAHVEREVLFDGALFPDEAPAEDPAEAVNSAAGGPPPGPHQPEVLFRIGPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V7S9</accession>
    <name>A0A6I1V7S9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="140" mass="14167" checksum="8175E001EB5E4098" modified="2020-08-12" version="1" fragment="single">MTAMTPGSNIPLSAARIAVDVAAPVRLDVSGLLLTADGKVRSDDDFIFYNQPAGPGVSYRSGGGAAPDAIVVDTSAVPPGIEKIVVTASPDAAGQTFQGIEPTATVRDAESGAVLATFTPPRLGSETALVVVEVYLRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2021-06-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V7Y5</accession>
    <name>A0A6I1V7Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_00070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="289"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS34077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="397" mass="40620" checksum="D484ACDCBEB2170D" modified="2020-08-12" version="1">MASVNRGPLVRPMVETADYLCDRATVDLLDDYLAGVRAHGAVFCNAVSTPPWGLRFTEPAPLALGAMLRGDAWLVPDEGAAVALRQGDVALIRTRLPYTVADRPESAPRVLVDGADRCVLTGDPADSGRNWRVTGRTVGDGGSGGSGAGSASGAGSALGGADGGSAGGGPGSGSASGSPASGASGSSGPGGGSGGGSDLLITAGYRVGGELCAPLLDALPAIAVVRPEPGLASLLDLIAAEVEHDEPGQQVVLDRFLDLLLVRVLRSWFARSDTTPPTGYRALADPDIGHVLRRLHEDPARPWTVASLADEAGMSRTVFARRFSALVGKPPLTYLTDWRMTLAADRLRAPGATITAVARGVGYADGFAFSAAFKRVRGISPSAHRASGRELPATRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V9D7</accession>
    <name>A0A6I1V9D7_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ectoine dioxygenase</fullName>
            <ecNumber evidence="6">1.14.11.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ectoine hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thpD</name>
        <name evidence="11" type="ORF">FFZ77_00045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate</text>
            <dbReference type="Rhea" id="RHEA:45740"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:85413"/>
            <dbReference type="EC" id="1.14.11.55"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. EctD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.55" evidence="6"/>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012774">
        <property type="entry name" value="EctD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02408">
        <property type="entry name" value="ectoine_ThpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MQS34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="297" mass="32491" checksum="A6F75DAFF5729382" modified="2020-08-12" version="1">MTTTARTDPYPTRGTGEVITPRQDPVVWSAPGAPGPMLPAELLEYERDGFLSVPEQITGAEVALYRAELDRLIADPAVRADERSIVEPKSRAVRSVFEVHRLSEVFAALVRDERVVGRARQILGSDVYVHQSRVNVKPGFGASGFYWHSDFETWHAEDGLPRMRTVSVSIALTENRDTNGGLMIMPGSHRAFLGCAGATPEDNYKQSLRMQDAGTPSDAALTRLADEHGIRLFTGGAGSATWFDCNCMHGSGDNITPYARSNVFIVFNSVENAAVRPFAAPSPRPEFIGARDFTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V9N0</accession>
    <name>A0A6I1V9N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_00075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="276" mass="28914" checksum="08DD38B006A658EC" modified="2020-08-12" version="1">MTEILVLGSTGKTGSRVAPRLQALGHTVRSASRTAAGPGAVRFDWADPVTWDPALAGVQAVYFVPTETLGLPERAAFVDRAKAAGVQRIVQLSVRGIDADGGVPDTESAVRASGLEWTMLRPCWFSQDFDAPDFFLAEVRGGALATPAGDGREPFIDADDIADAAVAALTGAGHAGKVYELSGPRALTFAEALALIGEATGRELVHRHRDPVAYAADLVGAGYSAADAEAIAAFMDGIGRGEDDYLSTGVQECLGRAPRPFEEYVRETAATGVWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J020</accession>
    <name>A0A646J020_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol mannoside acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_03375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000031">
        <property type="protein sequence ID" value="MQS34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="302" mass="33266" checksum="2D54A1CAD81C8702" modified="2020-04-22" version="1">MRDRLTDALYGLGWGAVRKLPEPVASALGRTIADTAWKRRGKGVLRLEANLARVVPDAGPERLAELSKAGMRSYMRYWMESFRLPVWSAERVRRHVTIDDAHYLTDGIAAGRGVIIALPHLANWDLAGAWVTRTLNTPFTTVAERLKPESLYDRFVAYRESLGMEVLPHAGGAAFGTLARRLRAGGLVCLVADRDLSSSGVEVKYFGETARMPAGPALLAQQTGALLLPVTLWYGDEPAMHGRIHPPVEVPETGTRAEKTSAMTQALADAYATGIAEHPEDWHMLQRLWLADLEPRPGEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J021</accession>
    <name>A0A646J021_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_02980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000026">
        <property type="protein sequence ID" value="MQS34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="92" mass="9343" checksum="349C4D072EB01588" modified="2020-04-22" version="1" fragment="single">ADPRAHALALEGLAGVEALDGDHAGAARLLGRAAALRSSVGVPLPEAERGDVDRIGAAARAALGDAEFGSEFRAGEREALKGAEAPRYPETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J035</accession>
    <name>A0A646J035_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_12225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000123">
        <property type="protein sequence ID" value="MQS36340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS36340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="78" mass="8109" checksum="830A91FD1EDB3893" modified="2020-04-22" version="1" fragment="single">MMFVTIGGVRHHVVAEGSGPVCLLSAGLTLGWFDWDPVVPLLTPHRTVVRFDRPGHGLSAAAVAPPSAAGEARRIAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J046</accession>
    <name>A0A646J046_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribosylglycohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_12745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000132">
        <property type="protein sequence ID" value="MQS36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="289" mass="29077" checksum="7615CF3BE3383364" modified="2020-04-22" version="1" fragment="single">TPGRRMRGAIDLAWNSLAGQVAAAADRAPEVESAVLPLRARISVRAGLGNLATGLRPPATGHDNPHYFDDAACVRAVVLAVVHPGDPASAATLAEFDARYTQDGDGVHGARAMAAAVAAALGGAGVDDAVDAALAQLPSATEIGRNGRHAVELARASDAAFDLVPLLEHQIVDHVYSYGIAAAETVPVALAVATAARGRVSEAVPTAACLSRVADSAPALAGALTGALGGGDAIPASWREACRTLAGCALPRLAGTDLVELAGLLAHTEPTPPGGQFRHDADNSDEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J056</accession>
    <name>A0A646J056_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IF2_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_02155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000018">
        <property type="protein sequence ID" value="MQS34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF2_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="58" mass="6198" checksum="237FEF8829F40738" modified="2020-04-22" version="1" fragment="single">MAKVRVYELAKEFGVESKVVMAKLQELGEFVRSASSTIEAPVVRKLTDALQGSGSAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J057</accession>
    <name>A0A646J057_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_16935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000184">
        <property type="protein sequence ID" value="MQS37247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="104" mass="11623" checksum="0CECFFDA2C4A6BB6" modified="2020-04-22" version="1" fragment="single">MYWRSSTRKGELPPSHEWERIRQRVIRRDKGLCQGVLSEGALCGHPGTDVDHIRPGNDHSMGNLQLLCGWCHKRKTQAESRAALAALPPMPKANIPLGVREPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J059</accession>
    <name>A0A646J059_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_16760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000178">
        <property type="protein sequence ID" value="MQS37216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS37216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="238" mass="26564" checksum="2495C59CD5A3EFCC" modified="2020-04-22" version="1" fragment="single">MGHRYAELVEAAENGARAVDGTRSPGLGHRPRRTDRGEVSGRRAEEKRGRVTVEPTAETTGLRERKKQLTRHALVRAALELFIAQGFERTTVDEIADAVDVSQRTFFRYFASKEEAAFAVQSLVESHFLEAVRTRPPQEGPFEALHNAALVAWDTLGEAIGEIIPFELHMRSYLMIESTPALIAAHLRRSLDLEEKLARLIAEREGLDLELDPRPRTAVAAFSGVMRVAGRRWGLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J072</accession>
    <name>A0A646J072_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_19695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000213">
        <property type="protein sequence ID" value="MQS37769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="55" mass="6294" checksum="A6A7D332D8EAD00D" modified="2020-04-22" version="1" fragment="single">RPASAAHGREQVKAPVRQPAMPLLQIRREAAVLLPGCSIRRLLFWRYLLVFRNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J078</accession>
    <name>A0A646J078_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_16725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000176">
        <property type="protein sequence ID" value="MQS37209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="113" mass="12745" checksum="CED4CE1C18691252" modified="2020-04-22" version="1">MAEPQQPARRMRPAPLLFEPSEAVADPEHFFDLESMDDPRELLARATELTLAFRAATDRAVEFQAMAAAQLADPRRFDRLTPGDVAARAGWTEDFARKMIEFGQRLLRDGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J083</accession>
    <name>A0A646J083_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase (AMP-forming)</fullName>
            <ecNumber evidence="4">6.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_17270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="VDEQ01000191">
        <property type="protein sequence ID" value="MQS37310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS37310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="210" mass="22384" checksum="3FBB5EA94C6183EA" modified="2020-04-22" version="1" fragment="single">MTARPPFELVPDPDGLGHVLDHHAVPGRTAVVMTMGALHEGHAALIRAARDRVGPQGFVVVTVFVNPLQFGAGEDLDRYPRTLDADLATAEAAGADIVFAPSAGDVYPGGEPRVRIAAGPMGELLEGASRPGHFDGMLTVVAKLLHLTRPDLAFFGQKDAQQLALIRRMVHDLDFPVEIVGVATVREDDGLALSSRNRYLSPAERETALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J087</accession>
    <name>A0A646J087_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_21695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000235">
        <property type="protein sequence ID" value="MQS38138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="16"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS38138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="245" mass="25248" checksum="769FE09531EF0AA5" modified="2020-04-22" version="1" fragment="single">MTQLRTVQVLGGGGAGSSAHVRSLAAGLVARGVRVTVCAPAELEHVYDFPGAGAHFAPVPGRSDPAAVGALRSVCATADLVHAHGLHAAVRAALALSGLRIPLVVTWHTRAPHGGARGQLLRLLERRSARAAEVVLGTCSELVDRARQHGARDARLAPLAAPVPPGRPGPSAALAKAGLGAADRPLVLAVGSLTPERGYTTLLDAAEWWRQLDPVPLVAIVGEGRERAALERRIAAEGLPVRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J092</accession>
    <name>A0A646J092_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate dehydrogenase cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_21705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000236">
        <property type="protein sequence ID" value="MQS38140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="239" mass="26257" checksum="83CA94B1A1342E7F" modified="2020-04-22" version="1">MALATRTRQRGTDRKPSPQRTFWGSTVGKKAVMAVSGLLMLGYLVAHVMGNLKVFFGPREFNEYGHWLRTMGAPVLHEEWALWIVRVVLLAAVAAHAVSAYQLSRRDIKARPVAYAHKRRRASYATRTMRWGGVIIALFIVWHILDLTTLTVNENAQPGRPYENVVATFSTWYGNVVYITAMLAVGLHVRHGFWSAAQTLGAGSASRDRALKAVANSLALVLTAGFIAVPVAVMTGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J098</accession>
    <name>A0A646J098_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_20005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000220">
        <property type="protein sequence ID" value="MQS37827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="268" mass="29643" checksum="0828749F200C6A71" modified="2020-04-22" version="1">MTVAETGEGPVLVMLHGGGPGASGVGNYHQNLPALARRFRVVMPDQPGFGGSYRPTEDDLGTRSITEITVDALYQALDALGIGDFHLLGNSLGGAAAIAMAQERPDRVTRLVLMAPGGGWLPFGPTPTEGQKEMFRYYNGGGPSEKKMAAFIRTMVFDHRQFGEDVVRARYEASLDESHIAFYHRYNAAFAQRGGMDPLWRDLHKITAPTLLLWGRDDRTITLDGAQLMLKQIRDVQLHVFGRCGHWVQLERRREFEDLVSGFLGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0A0</accession>
    <name>A0A646J0A0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2520 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_17265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000191">
        <property type="protein sequence ID" value="MQS37309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="152"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="306" mass="31161" checksum="43ACF6282C9A5872" modified="2020-04-22" version="1">MNPTAPHEPLDPRDRPARLTVGVVGAGRVGPALAASLQLAGHRPVAASGVSDASRRRAAELLPGVPLVPPAEVLARAELVLLTVPDDALPALVAGLVETGSVRPGQLLAHTSGRYGVQVLAPATRAGALPLALHPAMTFTGTSVDVQRLAGCSFGVTAPDELRLAAEALVIEMGGEPEWIAEEARPLYHAALALGANHLVTLVAQAMELLRAAGVAAPDRMLGPLLGAALDNALRSGDAALTGPVARGDAGTVAAHVAELRKHAPGAVAGYLAMARTTADRALAHGLLKPELAEDLLGVLAEDDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0A1</accession>
    <name>A0A646J0A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFZ77_21835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000241">
        <property type="protein sequence ID" value="MQS38165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MQS38165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="124" mass="12070" checksum="8FE0053D1764EB28" modified="2020-04-22" version="1" fragment="single">MTADTAAGTTSAGGARALRRVLLDHGALTALAVLTVALSLLSDDFPTTRNLLNVGVQAAVTAILAFGVTFVVVSAGIDLSVGSVAALSATVLAWTAAADGVPVWLAVLLAVATGVGCGLVNGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0B1</accession>
    <name>A0A646J0B1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_21735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000238">
        <property type="protein sequence ID" value="MQS38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_8_C" evidence="1">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="151" mass="16052" checksum="67A872AAA32E013F" modified="2020-04-22" version="1" fragment="single">TLWFDHGTDPRAASYAYLLMPGASRRAVAARARDHRRLTVHANSADRQSVSIPSLGLLAANFWRAGTVGALTASAPASILVRRSARTRTAALHLADPMRGGEPLEIVWRHPVGRVTGHDPGIEILSAGRALRLRLTGGTAGASHHCEVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0B7</accession>
    <name>A0A646J0B7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Condensation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_24655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000275">
        <property type="protein sequence ID" value="MQS38662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="252" mass="26658" checksum="B918F70B041487A6" modified="2020-04-22" version="1" fragment="single">RISVVALAGAPVYVALAASHAATDGSALAVLREEWLLLLAGEPLPPLTALAPLDLAAEEAAPAGLRKSEASLRYWERIIRTGPQAMFAEPGATGTDVRVPQLTLRSRRGARALALVAERTGSLPSTVLLTAWCALIAHRTDQTACVAAVPTSNRYTPRLARSVNTVSQDALLSLDVQVPSFDALLSKAWGAALNAYRHSQFDSLSLWEMIGRTTVERGSHFARDIVFNDVSTLPATLATATAQDAGPEPGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0B9</accession>
    <name>A0A646J0B9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_22745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000250">
        <property type="protein sequence ID" value="MQS38334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="8"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS38334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="221" mass="24550" checksum="EE1FF7A35FF9CC52" modified="2020-04-22" version="1" fragment="single">ALEGFTMFALNQGEVCTCPSRALIQRGHYSEFLEAAIARTERIVRGHPLDTDTMIGAQASNDQLQKILSYLDIGQQEGAKILTGGQRIEYDGDMAGGYYVQPTIFEGDNRMRVFQEEIFGPVVAVTSFSDFDDAIKTANDTLYGLGAGVWTRDVNTAYRAGRAIQAGRVWTNCYHAYPAHAAFGGYKQSGIGRENHRVMLEHYQQTKNLLVSYSPKKLGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0C6</accession>
    <name>A0A646J0C6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_25130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000283">
        <property type="protein sequence ID" value="MQS38752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="161" mass="16605" checksum="FF253DB703807411" modified="2020-04-22" version="1" fragment="single">MTDSPEQKPAARGRVRRLLGRIIPPLRWWILPVCVLAGGAGGTAYGVLVTPRYAATSYVVAVPGKDSPPGAALGFAQAYGRIATSDSTIAYARVAAGIPARALRRQVSTETSPDSPMIAITGTAKRPSAAADIANAVADAVFVSSNQVAKSTGVRLLSFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0C9</accession>
    <name>A0A646J0C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA carboxylase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_21730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000238">
        <property type="protein sequence ID" value="MQS38145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="527" mass="57212" checksum="FAA5DB962C9618C2" modified="2020-04-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0D5</accession>
    <name>A0A646J0D5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Streptomycin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_25110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000282">
        <property type="protein sequence ID" value="MQS38748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="333" mass="36598" checksum="8E907597F7BF0AC2" modified="2020-04-22" version="1" fragment="single">MNIEEQSVVEVELGSLNSAGSPRLSGESPEHVHVLAAAQSPLPPIVVHRATMKVIDGFHRVKAARLRGAETIEARFFDGDEAEAFVLAVRLNVRHGLPLALADRKRAAERIIASHPQWSDRRVATVTGVSPGTVGDIRKRTVPGRTPESRRVGQDGRVRPLDGSAGRMLAGELLAANPGLSLRQVARAAGISPETARDVRNRLHNGDDLVPRQCRRKTPAVLVAAREDFTEDLLARRPELVAQGPSQRSGRSRTDIAPDRAMLVKRLKADPALRFTETGRNLLRLLALHTLRKEEWDAIINNVPPHCTDIVADLARQFADLWSEFAVRIKDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0D8</accession>
    <name>A0A646J0D8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S1 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFZ77_05470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000052">
        <property type="protein sequence ID" value="MQS35095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_Al_protease" evidence="8">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="68"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MQS35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="254" mass="25368" checksum="171B5E0E7BBDC7D7" modified="2020-04-22" version="1" fragment="single">ASAGDAVLGADIAGTAWYADTATGKLVVTVDKTVSAKEIAEIREAAGSQAGSLEIKRTPGVFSKLIAGGQAIYGGGSRCSLGFNVRSGSTYYALTAGHCTELGSTWYTNSANSVTLGTTAGSSFPVNDYGIIRHSSATAADGRVSLYNGTYRDITAAGNATVGQSVQRSGSTTGLHSGRVTGLNATVNYGSGDVVYGMIQTNVCAEPGDSGGALFSGTTALGLTSGGSGNCTSGGTTFFQPVTEALSAYGVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0E1</accession>
    <name>A0A646J0E1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000307">
        <property type="protein sequence ID" value="MQS39192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032806">
        <property type="entry name" value="YbfD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13808">
        <property type="entry name" value="DDE_Tnp_1_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1_assoc" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="83" mass="8779" checksum="17D3E3FA134B5599" modified="2020-04-22" version="1" fragment="single">MGRQSAMPCPVKTLPPLRAAGRSLTERLVRLPDPRRRRGVRHPSVSAVLIAASAIVAGARSYTAIGQWAAAAPQTTPARPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0E6</accession>
    <name>A0A646J0E6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_25550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000293">
        <property type="protein sequence ID" value="MQS38829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="334" mass="35382" checksum="388ED6014272E134" modified="2020-04-22" version="1" fragment="single">MTDDTTSWDAIVVGGGLGGLTCAAYLAVAGRRVLVLEQHDRAGGNSHVFRRRRVYEFDVGVHYIGDCGPGGVVPAILNGLGAGDRVRFHELDPDGFDRIELPGLAVDVPAGWAAYRDRLHRALPGDRAGLDVFLGVCRAVAGERRGSLLAPGGLPGGDWTSGTAALREWGRRPLGELLDHCALSVRARTVLAAQSPNYGLGPGEATVSTHATVTDHYLRGAYYPVGGGQMLAAALVEVVEAHGGELRTRSRVARIDIAGRTVTGVTLADGRSLGASLVVSNADYRRTVLELAGPGHFSAKVVARTRDAAMALPFVTLYVALDRELPPRREANLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0E7</accession>
    <name>A0A646J0E7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000312">
        <property type="protein sequence ID" value="MQS39209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="89" mass="9499" checksum="CAFB027977BF48BB" modified="2020-04-22" version="1">MAETERGRDKYTGTREEVVTELEERALGKYLMGGSDASVDRVLEAAQGVRSGADSAQTASTDFTVTEQNDIPATRSPGDKNADSTDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0F2</accession>
    <name>A0A646J0F2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_24940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000279">
        <property type="protein sequence ID" value="MQS38714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="99" mass="11052" checksum="BCFDF25BFC2B5A66" modified="2020-04-22" version="1" fragment="single">MNGLRVATIASLTPLEELDREPFLVDTRGQQAMCARWAAEHGHTVTRQLLFYGLRPDHRGLWADVDDGQVELFVAASERVLARALTSVGEFVAECERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0G2</accession>
    <name>A0A646J0G2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_28780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000334">
        <property type="protein sequence ID" value="MQS39435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="87" mass="9565" checksum="166DA328B2849F7E" modified="2020-04-22" version="1" fragment="single">RAYDAPAEEREALVDLAKNSKVKDGWWVPYATKLAEPMRLLIAVEDEATRISQHTVGVVPGLLQTMQYARAIKATPGNELTDEALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0H2</accession>
    <name>A0A646J0H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol reductase thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_29570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000345">
        <property type="protein sequence ID" value="MQS39581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS39581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="76" mass="8583" checksum="AEE6BFF9EE8FE80E" modified="2020-04-22" version="1" fragment="single">MSTVELTKQNFDQVVSENDFVLIDFWASWCGPCRQFAPVYEGAAERHPDLVFAKVDTEAEQELAAAFEIQSIPTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0H5</accession>
    <name>A0A646J0H5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase maturation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFZ77_28770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000333">
        <property type="protein sequence ID" value="MQS39433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="PTHR14463"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MQS39433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="469" mass="53648" checksum="48E50EA075576691" modified="2020-04-22" version="1">MEWFGDGDYWLSRLVFQRALAAVYLVAFLTAALQFRALIGERGMLPVPGYLRRVPFRAAPSLFHLRYSDRLFALCSWTGVALSAALVAGAADRIPLAAAMACWAVLWVLYLSIVNVGQTWYAFGWESLLLEVGFLAVFLGNERTAPPVLILFLLRWVLFRVEFGAGMIKMRGDRCWRDLTCLYYHHETQPMPGPLSWFFHRLPRPLHRVEVAASHVTQLVLPVLLFTPQPIASAAAAVIVATQLWLVLSGNFAWLNWLTIALALSVVDGSPIARPPGQPGAPLWYEITVIAVTAGLLALSYRPARNLLSRRQRMNCSYDPLHLVNAYGAFGTVGRVRREVVVEGTDETRLHDGTVWREYGFRGKPTDVRRLPRQFAPYHLRLDWMMWFAALSPVYAHSWFGPFVERLLEGDRDTLRLLGHNPFPDAPPVHVRARIYRYRFTTWRELRATGQWWRRTPDGEFLRPIRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0H8</accession>
    <name>A0A646J0H8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase ArsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_27550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000309">
        <property type="protein sequence ID" value="MQS39197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="144" mass="15279" checksum="6F0ABB4CD12CDA76" modified="2020-04-22" version="1">MTETSGRRPSVLFVCVHNAGRSQMAAAWLADLAGDRVEVRSAGSAPGAAVNPAAVAAMAEVGIDISAETPKILTVDAVRESDVCITMGCGDTCPVFPGKRYLDWTLEDPAGQGLDAVRPIRDEIERRVRHLLHELVGDGRTAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0I6</accession>
    <name>A0A646J0I6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000348">
        <property type="protein sequence ID" value="MQS39587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="115" mass="12646" checksum="06BD4D1B2D80C470" modified="2020-04-22" version="1" fragment="single">MSQTPRQSAERSVPTSADVARLAGVSRATVSYVLNNTSSVRISEPTRRRVREAAEELGYVPHAAARSLRAGHTRMVLLPASASSVGPLYLQFFNELQWALRRLDYTVVQYGSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0J3</accession>
    <name>A0A646J0J3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-(Cis-5,6-dihydroxycyclohexa-1, 3-dien-1-yl)propanoate dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hcaB</name>
        <name evidence="3" type="ORF">FFZ77_20010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.87" evidence="3"/>
    <dbReference type="EMBL" id="VDEQ01000220">
        <property type="protein sequence ID" value="MQS37828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="278" mass="29367" checksum="D5AAB15598BE370A" modified="2020-04-22" version="1">MSGGWLEGYAALITGGGSGIGRAVAERFLAEGASVTVLGRDRSRLEEVVDCAADRSRIHTVTGDVRDSDTLHTAVQETVDRFGKLDTLVANAGVWDYQRQLTRLTADELDTAFDEVFSVNVKGYLLAAEAAWRELVKTRGSIVMTLSNASFYVNGGGPLYTASKHACLGLMRELAYELAPKVRVNGVACGGMNTDLRGPRSLSLADRSIAASFARRGPDTPPPPIPLHDSSTDPRDFTGPYVLLASRAQSGPVTGHAINADGGIGVRGFAHAAGGDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0J4</accession>
    <name>A0A646J0J4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_30235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000361">
        <property type="protein sequence ID" value="MQS39708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="59" mass="6373" checksum="2784ED1AD72BEDC2" modified="2020-04-22" version="1" fragment="single">AKGTYAGILLATSDLDGAFDRLQAGDAEIVQEPTEQPYGIRDCAVRDPAGNLIRIQELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0K0</accession>
    <name>A0A646J0K0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recN</name>
        <name evidence="8" type="ORF">FFZ77_21690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000235">
        <property type="protein sequence ID" value="MQS38137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS38137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="514" mass="53996" checksum="D6744752C6444B61" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0K3</accession>
    <name>A0A646J0K3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_30360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000366">
        <property type="protein sequence ID" value="MQS39732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="91" mass="9850" checksum="06752A49835DAAA1" modified="2020-04-22" version="1" fragment="single">MPAEQRPRREVVTGVPRGARRAPGHAHARFEISEQTTLGTTYVRSLMRSQLRAGLSALAALALFIGTLPLFFVLPAALDCGFTTPGFVVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0K4</accession>
    <name>A0A646J0K4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excinuclease ABC subunit UvrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_30225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000361">
        <property type="protein sequence ID" value="MQS39706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="83" mass="9385" checksum="447238631076C3B2" modified="2020-04-22" version="1" fragment="single">DKPIRDFTEKEMHDFLHREPTKVKVEGVNLTYEGLIPKVRKSFLSKDKEALQPHIRAFVDRAVAFTACPECGGTRLSEAARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0K7</accession>
    <name>A0A646J0K7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_30370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000366">
        <property type="protein sequence ID" value="MQS39734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="4">
        <location>
            <begin position="118"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS39734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="224" mass="24429" checksum="044801BFBBAC83F0" modified="2020-04-22" version="1" fragment="single">GDDGIDVVFLDIHMAGLTGLDVARLLARFAHPPLIVFVTAHEGFAVQAFDLKAVDYVLKPVRRERLAEAVRRAGDLVHTAQEPRQPGRPPHPASAQPAQPAHPASAAQGPVHSSAEQIPVELGGVTRFVPIDAITYVEAQGDYARLHTEHGSHLVRIPLSALEERWASRGFVRIHRSHLVSLARIDELRLDAGTTTVRVGTAELAVSRRHARQLRELLMRQAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0L6</accession>
    <name>A0A646J0L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000378">
        <property type="protein sequence ID" value="MQS39922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="79" mass="8306" checksum="A4D58B46EBC1B4A3" modified="2020-04-22" version="1" fragment="single">MTPAPGAPGFPGAPEVSGKKVYVTGTHRARLPAETWDTIRPLLPRFGISRVADVTGLDVIGLPVAVAFRPLSRTLAVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0L8</accession>
    <name>A0A646J0L8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RICIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_22750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000250">
        <property type="protein sequence ID" value="MQS38335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="91" mass="9861" checksum="A0C94E5F27423DB9" modified="2020-04-22" version="1" fragment="single">SGKLTEIRNHHSGMCLDAANGSTADGAIIAQRTCNGMKWQKWRAFFDNSSGAYQIVNEHSQKCLEVLGGSTADGASVVQSSCYGTPPQYWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0M0</accession>
    <name>A0A646J0M0_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nusA</name>
        <name evidence="9" type="ORF">FFZ77_02145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000018">
        <property type="protein sequence ID" value="MQS34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MQS34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="334" mass="36761" checksum="F6651EE117431AC8" modified="2020-04-22" version="1">MDIDVKLLKGLAQEKEIPFDLLVEAIESALLIAYHRTEGSSRHARAVLSRDTGHVTVWAKEDPADLEEGQEAKEFDDTPSDFGRIAATTARQVIQQRLRDAENDVTFGEYARREGDVVSGQVQQGKDPKNVLVRLDDKLEAILPVQEQVPGEEYTHGLRLRTYVVRVARGVRGPSVTLSRTHPNLVKKLFALEVPEIADGSVEISAIAREAGHRTKIAVRSTRSGLNAKGACIGPMGGRVRNVMAELHGEKIDIVDWSDDPAEMVANALSPARVSKVEVVDLGARSARVTVPDYQLSLAIGKEGQNARLAARLTGWRIDIRPDTEQDDRESDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0M5</accession>
    <name>A0A646J0M5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_24640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000272">
        <property type="protein sequence ID" value="MQS38659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="113" mass="11060" checksum="DE0B4C56B37AD807" modified="2020-04-22" version="1">MLIVVGVACIAGTPMVWLLNSPGTGELVGVSLQVGTGVAALVWAWLQPRQGDSAMDTGKAEASGGGSVHTGIRRPGGAGTGSARADRTGDATADGSGSSAGTGIDYSWSWSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0N0</accession>
    <name>A0A646J0N0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_04090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000038">
        <property type="protein sequence ID" value="MQS34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="273" mass="27445" checksum="258828A8C7A97925" modified="2020-04-22" version="1">MNDTMVTVVGNVATQVEYRETVTGGMARFRIAVTPRRWDRQRESWVDGPTGFYTVFAWRALAANLAGSVSVGDPLVVRGRLRVREEERDAQRETADGGGQRRTFVDIEAVTAGHDLARGTSAFRRMVRAAPPPVPESRPGWSPGRPPGWGAPAEEAAMRAGRSGSAPSAPGDGLPEERTGLADPGPGPGAAPGPGPASGPPSMAGPTAASMAGPAPGAALGAASGPAPGAAPGAAPEDEPRAAPDAGPDAGPPSGPGPRPVVAAEAALAAPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0N6</accession>
    <name>A0A646J0N6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_31910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000400">
        <property type="protein sequence ID" value="MQS40025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS40025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="101" mass="10771" checksum="4C2E6D76D588A4EC" modified="2020-04-22" version="1" fragment="single">MGRPRGFDEAEVVRSAARLFAGRSYDGTSIDDLVTHLGLHRNSLYKTFGSKRGLYLAALRWSLEHEVAPLIDRVAEAAGPAEALRAALGPPDGGGGLDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0N7</accession>
    <name>A0A646J0N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFZ77_11075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T-272</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000106">
        <property type="protein sequence ID" value="MQS36124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="352"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MQS36124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="884" mass="94002" checksum="D8FE038B4E2A8BC4" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0P3</accession>
    <name>A0A646J0P3_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">FFZ77_25775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EMBL" id="VDEQ01000295">
        <property type="protein sequence ID" value="MQS38874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="9">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="8">
        <location>
            <begin position="174"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MQS38874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="364" mass="38852" checksum="4D8144ADD412FBB9" modified="2020-04-22" version="1" fragment="single">MSEAASTRTSVGLLPSLAPLLHSWLPRQRWFAGKDQPVTGFSLVSATELLPVRGPGPGLLHLLVAVHRPASADELAHDCYQLLLGVRRTLPSHLAGALIGRPATGPLAGRTVYEGLHDPRLAELILERLRTPGVLGPLRFDRFDGIDRFSRYSEFSGFGTGPGMSGGGLTARPLDAEQSNSSLVYGDAYILKFFRRVQPGPNPDLELPLALARAGCTRVPAPVAWYESAGPQPYTLGVLQPYLRGSRDGWRLALEALAAGAPFTDEARALGRVTAEVHTALAAELPTAPLSHPQTERLAAGMIRRLGEAARAVPALLPYAPRLRVAFDAVAALGREGRAWRAQRVHGDLHLGQALYEAAPAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0P4</accession>
    <name>A0A646J0P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_32540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000408">
        <property type="protein sequence ID" value="MQS40146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS40146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="73" mass="8190" checksum="B549A62D143107B0" modified="2020-04-22" version="1" fragment="single">MSEIFPWTPAAVVFDCDGTLMDSERHWEDARDLVLREYGVIPDEEFAELSKGVHYTECGQLMAVTAGRPELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0P6</accession>
    <name>A0A646J0P6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_12400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000126">
        <property type="protein sequence ID" value="MQS36375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS36375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="470" mass="48100" checksum="04B648BA6B33F27F" modified="2020-04-22" version="1" fragment="single">MWGTGGIGADRSGRGPAGAEAGHWRAAAFRREANSRRPETSRRAAASRRAAAGHWLPLLPLIATVLLLAAPLPKGTEAGTGGIAPADLASAALVLFCLARAARARRRPLTPAAALVFALPAVAVAVTTVTAADPVAALPGLIRYLQVFVLVPVAVLLLIRDARDFRVIAGCLVVLALAQGAIGVRQYATGTGASYMGEDIRAVGTFGPTDVMGMATVVAYGLLAAAAIALRPPPGAPRWLRPAAVVAAGALVVPLALSFSRGAWIATGLAALVMIALTGLRQAVRALAVLTAVAVVLVGGFGVGSQLISERLSSITRVTAAPDRSVSDRYTMWAAAVSMWREKPVTGVGPKGFPAHRDGHASIGLSSGGDTAGAGHAFLRQPLLSPHNMYLLILSEQGLIGAVAFTGSWAAILARGVSGLTRSRPRPARRRAADCGLLAVALTLWQTVDFLYADIGGPSTVLTGVVLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0P8</accession>
    <name>A0A646J0P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fpg/Nei family DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">FFZ77_32530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000408">
        <property type="protein sequence ID" value="MQS40144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MQS40144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="243" mass="26069" checksum="8742D9488B94189E" modified="2020-04-22" version="1" fragment="single">VTAVDRYGKWLGVTVAPPSGGELHLAVHLARAGWLRWRDEFPAAPPRPGRGPLALRTVLASGAGFDLTEAGTAKRLAVHLVRGVDEVPGIARLGPDPLAPDFDRAAFAALLAGERGRIKGVLRDQSLIAGIGNAYSDEILHAARMSPFKPVGRLTEDETTALYQALRATLEEAVERSRGIAAGRLKAEKKSGLRVHGRTGEPCPVCGDTIREVSFRDSSLQYCPTCQTGGRPLADRRLSRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Q2</accession>
    <name>A0A646J0Q2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoenolpyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_32590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000412">
        <property type="protein sequence ID" value="MQS40156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-utilizers" evidence="2">
        <location>
            <begin position="268"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS40156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="372" mass="39675" checksum="F564963D7DEE6BE2" modified="2020-04-22" version="1" fragment="single">RGLPHNVTTEMDLALEDLADAIRADPAAARAFQDPGGEAGEQARAYRDGELPPTAQRGLAAFLDRWGHRAVAEIDIGLPRWSEDPSYIIGVIANLLRADDPAARPDAVFARARADAETMIERLARRAGPRGPLVRFALRRTRLLAGLREYPKYLAVRVFAVVRERVAERGAQLHAEGRIDAPQDVFFLDFDDMDTEDGDLRRTVARRKESYARELRRRPVPRVLLSDGTAPEAHRAPAAPGSLTGTPASAGTATAPARVITDPVGARLEPGEILVAPSTDPGWTPLFLTAGGLVMEMGGANSHGAVVAREYGIPAVVGVRGAMEAIRTGQIVTVDGGAGVVSARDDGPRPHPGRRCGPGPLGGEGHPGRRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Q6</accession>
    <name>A0A646J0Q6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000398">
        <property type="protein sequence ID" value="MQS40022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="100" mass="10618" checksum="3EA4AD9A22553D0E" modified="2020-04-22" version="1" fragment="single">YDALTSDGSDWDEDGMTSGSAKGGWIWPGRGLFRVQSRGVHTAYASEYAAAPANRRDLFEGTVNVHWKSGSKLRDKPGDTGFAARTGDTVVHLAASGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Q8</accession>
    <name>A0A646J0Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_27610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000312">
        <property type="protein sequence ID" value="MQS39208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="69" mass="7779" checksum="6EAED8053C5B019E" modified="2020-04-22" version="1">MTTSERLDTGPALAPDAERYEYTTYAPDGVTCRKCGVPIKRFERVNRVVHDALNSGPREVGYQHPECPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0T2</accession>
    <name>A0A646J0T2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_19990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000219">
        <property type="protein sequence ID" value="MQS37824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS37824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="84" mass="9309" checksum="A1A1B66E55053C11" modified="2020-04-22" version="1" fragment="single">RAQEGPAVRDFVRLADSWTGRPDLHEAFTAGYGRPLTGAEEQHLTVESLLDAVSGIQYGTRHHDPELAERGLRTLARLRTGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0T3</accession>
    <name>A0A646J0T3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system PemK/MazF family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000348">
        <property type="protein sequence ID" value="MQS39588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="152" mass="17050" checksum="53E4FAA4A4BA25E5" modified="2020-04-22" version="1">MTTFPGASDPADLPGRTGAGATTEADPAAVGPVRTSYAPDRDGDPDPGEIVWTWVPFEEGDGRGKDRPVLIVAREEPGTLLAVQLSSKRHDRDREWVPIGTGSWDREGRDSWVDLDRVLRVHERGMRREACALDRPRFDTVAERLRERYGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0U3</accession>
    <name>A0A646J0U3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_20835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000229">
        <property type="protein sequence ID" value="MQS37974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="348" mass="35531" checksum="3C80F962CDEA5C70" modified="2020-04-22" version="1">MGHKTTGRAFIGSFTSAGGRGVIAAAVDGETGALTETGASDAIADPSYLALAPSGGAPVLYAVSETEEGAVAAFDIAGAAPRPLGVPAPVLGASPTHLAVFAGSLLTANYGSGSLSVLPVRDGGEPGAARVVQHHGQGPDPDRQRGPHAHQVLPDPSGRWVLGVDLGTDSVHIHALDAASGELTPHGETALRPGAGPRHLAFHPAGTHAYVLNELEPTLTVCRWDAVAGVLEPLGESPVLPDGTDGPCYPSEIVVSHDGRWLWAANRGHDSIAVLSLDGTGERAELITTVPCGGDWPRDLALDPAGRRLYAANERSGDVTWFDIDPATGIPRRAGSLDAPAASCVIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0U6</accession>
    <name>A0A646J0U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excinuclease ABC subunit UvrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_30230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000361">
        <property type="protein sequence ID" value="MQS39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="227" mass="24405" checksum="E00E4A8F3D30B16B" modified="2020-04-22" version="1" fragment="single">MAPRTDTQSPEPRDADSHGLIRVHGARVNNLKDVSVDIPKHRLTVFTGVSGSGKSSLVFDTIAAESQRLINETYSAFVQGFMPTLARPEVDVLEGLTTAIIVDQQRMGADARSTVGTATDANAMLRILFSRLGQPHIGSPNAFAFNVPSVRASGAITVERGAGSRTVKQTFTRTGGMCPRCEGRGTVSDIDLTQLYDDSKSIAEGAFTIPGWKSDSWWTVRTYAESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0V1</accession>
    <name>A0A646J0V1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_30355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000365">
        <property type="protein sequence ID" value="MQS39731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="88"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS39731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="261" mass="27813" checksum="C65C00A1CFE329AC" modified="2020-04-22" version="1">MGRLADEDSAARRRRRLPGAANTADFSEALARGLSVLAVFNGERRRLTQADLARELGLSRATVRRAVLTLEHLGYLVADGRTYGLSPGVLRLADAYLTSNPVSAVTQPVCERIRTRVDEACSVAVLDGADAVVVARAVPRRLAAVGSGIGYRTPAAVSSLGRVLLAHLPPGERAACLGTEAAASLDHDALDRVREDGYAYVAHDIEAGAHSIAVPLHRWDDRVTAALHVGCSLERISPQAMHDEVLPLLREAAGELRGQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0X5</accession>
    <name>A0A646J0X5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000399">
        <property type="protein sequence ID" value="MQS40024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="109" mass="11786" checksum="35960E00499C03EF" modified="2020-04-22" version="1" fragment="single">PGTAILFSPYIIHHRPDLFAEPERFLPDRWAAGGSAAGLPPGACVPFGVGARKCIGDDFATTEAVLALASIAGRWRLRSVPGVPVRPAAEQILHPERMPMRLHRRSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0X9</accession>
    <name>A0A646J0X9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_25465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000289">
        <property type="protein sequence ID" value="MQS38814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS38814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="153" mass="16186" checksum="F7E0638D5A989557" modified="2020-04-22" version="1" fragment="single">MLDDGRYVVAWTDDPSGIEGGRLTFRVFDLDGSPLGGEKICTRTRGFFPGANAMTLLENGRFVIASIETIAESDIGVPQSTVVAHVFEADGDGTEVIDLSAGNPKGFNRSWPALAPLPGGRFLFAWVEKSATTFDTVPAVMAKVCSDSQGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0Y0</accession>
    <name>A0A646J0Y0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_32535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000408">
        <property type="protein sequence ID" value="MQS40145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS40145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="116" mass="12418" checksum="AAFBCA983CDC76AD" modified="2020-04-22" version="1" fragment="single">ASNCPRDVVEDCLDTAGLLQHFAHVIVPEKQVRPKPHPDVYLSAAAACGAEPVDCLAVEDSLCGIRSAVRAGLRVLGVGPGPDRESLAMADHWVRSLEDRALLVWARSRALSGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J102</accession>
    <name>A0A646J102_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_28715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000330">
        <property type="protein sequence ID" value="MQS39422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="89" mass="10125" checksum="D069657B83539CF4" modified="2020-04-22" version="1" fragment="single">RAAYAEMAEAANRWERADVRADGVRVRSYRLADDARDTDVRLTFLDLHDGLPRGQEPDSLLRLFDGNRKSIEPFQSTGSYTEDRLLAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J119</accession>
    <name>A0A646J119_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-2-oxovalerate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000350">
        <property type="protein sequence ID" value="MQS39602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DmpG_comm" evidence="1">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="70" mass="7346" checksum="D9AB1D33DF30B534" modified="2020-04-22" version="1" fragment="single">PVQVDRETLTLGYAGVYSSFLRHAEAASAQYGLDVRGILLEVGRRGLVGGQEDMIVDIALDLLGSSPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J130</accession>
    <name>A0A646J130_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_30335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000364">
        <property type="protein sequence ID" value="MQS39727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="252" mass="27619" checksum="80A49AB3269DC5D7" modified="2020-04-22" version="1" fragment="single">MIVLYLLAHGFASSVMVVLCQRWAAHVDGLLRLGLRLLVVGYGLDLAYDIAKGLAVAARWAGGNWDDLSTMVAPVFALLSTLMVATGFILPFVGLRLRSSAIAFQQWRRMAPLARLVVTHSDMAKVSRSRIGWAPELRMMQRQAACHDALLELRPFMDPRIREFVREQAADRGPRAELEAMAAMVAVAADTSSLYRTAHRKALTAATARGARSPEEEAKNEGRRAVLDAGRYMSGADDSHPYSSLPDLAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J136</accession>
    <name>A0A646J136_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimP</name>
        <name evidence="6" type="ORF">FFZ77_02140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000018">
        <property type="protein sequence ID" value="MQS34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="165" mass="18343" checksum="726E99B91D766024" modified="2020-04-22" version="1">MSTTQSERLRGLLEPLVSAADLELEEIEISRAGRRRQLRIIVDSEDGATLDACAELSRAISAKLDETDAMGEDEYVLEVSSPGADRPLTEHRHYARAVGRLVRFQLQDAGELTARVLTVDDEGVDLEVPGVKGRKPTARRIAFAEIAKARVEIEFNRKDKKEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J137</accession>
    <name>A0A646J137_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_30925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000368">
        <property type="protein sequence ID" value="MQS39838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="157" mass="17233" checksum="9E78141BBE73FFE2" modified="2020-04-22" version="1">MVSVADRSSGHGPTADLAERVQRLIELRTPAGSRRPSYDQIARSINDTAGRNVISGAYIWELATGKTTNPRIHHLEALAGWGGTDVRYFFDDAYASRVEPQLNLLWRLKASGVLNVALRAQGLSHSSREQVGTMVDHLRSLEGLKEPDDAPDLPAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J141</accession>
    <name>A0A646J141_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TQXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_04085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000038">
        <property type="protein sequence ID" value="MQS34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TED" evidence="1">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="351" mass="35805" checksum="446C2730D66B419A" modified="2020-04-22" version="1" fragment="single">MTGAGTAVADDGAHHQSGAVATLDGLKTFDSAVLRANGKSHSIPAGLFEMTVDGGGRLKTYCVDIHNPTQDQAGYLETPWKQTSLGANRDAGKIRWILQNSYPQVDDLAELAEAAGTGPLTQKTAAAGTQVAIWRYSDGADVAAADPAAEKLADWLHRKARRVSEPKASLSLEPSAVSGKPGGLLGPVTVRTGAGRVSLTPPVGAAADGIEVTDAKGKPVTSAVDGAELYFQVPSDAPDGSATLTAQMATSVPVGRTFTSTTRSQAQILAGSSESTVSAHATAAWAASGAIPALSAKKNCAEGGIDITAGNTGDAPFTFELAGAEHTIPAGTRRTITVPVGEDQPYDFTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J148</accession>
    <name>A0A646J148_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_11070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000106">
        <property type="protein sequence ID" value="MQS36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="383" mass="42955" checksum="2BBDFEBBA17E8516" modified="2020-04-22" version="1" fragment="single">MTIAALETSALVDPRFHATDGPHAVWRRLREDDPVHWHEPGQYPGFWSLTRYDDIRAVSMDAGTFSSARGILLRPSAQGEDIGGGRTLALTDPPRHKALRALVSDWFTTRSVRDLEEFMRGAVRDVVARALERRECDFVTDIAARLPLYVICRLMGVPPAEQELLFSLTRQAFAAGAPEARSAAHQQIMQYFIELMYRRMDEPADDLVSALVSGTVDGELLTEEEILLNCDNLLVGGTENVRLAVSSGMSAFLDHPGAWEAVRADRELLPGAVEEVLRWTSSATHLLRTATRSVVLHDREIREGDRVVLWIPSANRDERVFDQPDRFDVARRSNRHLALGIGEHFCLGGMLARVEMRLMFDELLDSVRRVERTGPPVPVESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J155</accession>
    <name>A0A646J155_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol phosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000395">
        <property type="protein sequence ID" value="MQS40011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045977">
        <property type="entry name" value="DUF5933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19356">
        <property type="entry name" value="DUF5933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5933" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="46" mass="4795" checksum="7DE368FCDB5B1F82" modified="2020-04-22" version="1" fragment="single">MWAAAGVVALGFLIALEIAARNYHLPGPIAHQAREAIFVPASGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J164</accession>
    <name>A0A646J164_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000403">
        <property type="protein sequence ID" value="MQS40030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS40030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="71" mass="7682" checksum="490368CE7732ACB0" modified="2020-04-22" version="1" fragment="single">QESAGRAGQMHASRVSEAKARRDEAGRALREEQRLTLELPDTQVPAGRNLFLGEGMQVHHASQVVFADGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J194</accession>
    <name>A0A646J194_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">FFZ77_20710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="VDEQ01000227">
        <property type="protein sequence ID" value="MQS37963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="180"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="249"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MQS37963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="455" mass="49279" checksum="EBEC3E52ED3029D3" modified="2020-04-22" version="1" fragment="single">ALLMCAIVVACTVSLMGMRHFFLDTIDEQLTSTRDSIAESNLTLQQIEALSTLGIALDELSPGSGERGLLPHSDFQFVAVDASGTAIRVAGLEPTGRQRDLAAAVDDAGRLARSDRPVDVTLDDEPFRATAATLDDGTTVVLAGSTEFVHTNIRKVVKFDLGLSTVLLGLLAVLTMIGAHHRLRPLEDMVETASAIADGDLTRRVPSSRHPATEVEQLRIALNSMLQQVETAYSTRERSAEQLRQFVADASHELRTPLSAIRGYLQLFDRGMLNAPEDRDRAWSRINSEVDRMHRLVDELLMLARLDQRAELRLRNTDVCALVRDAAADLRAQQPERPVTVRADGVLLVHADESGLRQVLGNLVGNVRVHTPRDAPVELSVRRTDETVTVVVADRGPGLAEEDAVRVFDRFFRAGGGAGSGLGLAIVRGVVDAHGGRVTVRRRSGGGLAVMVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1A1</accession>
    <name>A0A646J1A1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_21715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000237">
        <property type="protein sequence ID" value="MQS38142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024883650" evidence="1">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="281" mass="30379" checksum="9AF4292DE7395025" modified="2020-04-22" version="1">MVLGRGTRWLAGAMTVACMALIGPSASAPGDALVARPLPAGAVGDIVPNRVMTWNICNPCKESNVDRAAEIATYAPQVIGLQEACVGDVEKIRHQLESLYGLVYHVEYGMVLRNRGRCGGLPWHPGEFGQAVLSAAPMTDRVSVEYPDGGSEDRGYMAVTTMVGGRSVRVFNTHLAHLRQEAVRADQVGVLATEVARHDRAIVLGDFNAVPDAPELTGIWALATDTDPMCRPSPTGACEPTTDWHSKFDYIFLRGIVPLEHGVHPTPYSDHHLLHTDLRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1H2</accession>
    <name>A0A646J1H2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_29580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000346">
        <property type="protein sequence ID" value="MQS39583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS39583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="276" mass="29236" checksum="39E51B8F74E61597" modified="2020-04-22" version="1" fragment="single">MNHTPQWYPKGRTPGHEVAVEVTGLTIATADGRPLLDRAGLRLAPGMVTALTGSSGSGKTTLLRAIAGALPHEARRTAGRVEIDGQDVLDLGPEELRALRRHRLAYVGQDPASGLNPRMRVRALLAETAVDRSTPALVALLEELRLPATRAFLSRRPGELSGGQQRRVALGRALARHPSILLLDEPTAGLDPALRDEIAELLRHLARSHRLAVALSCHDGDLVSRLADEVVALSPALGAEAGPRVRPAVRAAPSAGAPVLSVTGLQAAFRRRGTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1I3</accession>
    <name>A0A646J1I3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-hydroxy-2-oxovalerate aldolase</fullName>
            <ecNumber evidence="4">4.1.3.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dmpG</name>
        <name evidence="4" type="ORF">FFZ77_29670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="4"/>
    <dbReference type="EMBL" id="VDEQ01000350">
        <property type="protein sequence ID" value="MQS39601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS39601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="213" mass="22616" checksum="D972FD9BC000DC51" modified="2020-04-22" version="1" fragment="single">MTADLYIQDVTLRDGMHAVRHRITPADVSRVVAALDAAGVDAIEVAHGDGLAGGSVNYGPGSHTDWEWIEAAASVLERATLTTLLLPGIGTIAELKHAYSLGVRSVRIATHCTEADVAAQHIATARELGMDVSGFLMLSHMAPAGELARQAALMESYGAHCVYVTDSGGRLTMDGVRERVRAYRDLLEPETRIGIHAHQNLSLAVANSVVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1J6</accession>
    <name>A0A646J1J6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_14735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000150">
        <property type="protein sequence ID" value="MQS36828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024973442" evidence="3">
        <location>
            <begin position="41"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS36828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="342" mass="33883" checksum="50A24D56A1BBD545" modified="2020-04-22" version="1">MLTGNGRHRRPRQAPALIVAAGVTGSAIAIPLLGAGSASAVESSTWDRVAECESGGGWSADTGNGYYGGLQLSQQTWDAFGGAEHASRPDLASRAQQIAVAEKVLAAQGAKAWAACAEIAGLTAGGGKSGEEAPSDERDARSTRSAQGAEDTPKRASKGSDAPAPAATQSVGSGGDRTAGGGKHRGEPADEPAATDRSAAPTGSGERSTSDDAPPKKPDASGTSGKSDTPAGSGGAEAPRESADGRPSRGDAPAREAGIGTEKTSADTGAGAEAAEGAEGAVADTSPGAYTVRAGDSLSAIAQERELDGGWNALYEQNRDTVGTDPDLIHPGQSLDLDAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1L6</accession>
    <name>A0A646J1L6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_18550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000207">
        <property type="protein sequence ID" value="MQS37554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="357" mass="38424" checksum="C81B3079C0E9D23F" modified="2020-04-22" version="1" fragment="single">MDDYAGRVLADRYRLPLTPSDEYELVETRAFDTYSGQEVLVRQVPLPEVVEAEVVDADGPPGTAPYGRTASHTPRRRTDPAVLRAVEAAQAAARIPDHPRLDQVFDVFAEAGSLWIVSERVAARPLAALLAEKPLTPYRAAEVASDVLTALLVLHAHGWTHRNITSRTVLVCDDGRIVLTGLAAGAAEEALCGYAPVPVEAPEELPPYDDEDGYHPYGGQGSGDPDHEDPDGDDDGEFFDEDEDHDEDDDGYGTEDEEGGEEAEADPEYGHQDNTGPGPVRPYERPVLPGAGVPDSRAARAGAIAAYRAGARAAARDGGDDGGSPVQTGHDPDWWARGPFWLWSRKALIAIFLARST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1M3</accession>
    <name>A0A646J1M3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000402">
        <property type="protein sequence ID" value="MQS40029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS40029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="107" mass="12599" checksum="342C64BA7B8422C8" modified="2020-04-22" version="1" fragment="single">MTLDIRADDRPSYDYKLLVPEQGRIPESLSRRYRDGDLASYTSKFFAQYPGQTSAWTVSGFRPYEFGEFTYFLESRPGHRARHFFLPDADNLYGQTGFNQWPYSRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1N7</accession>
    <name>A0A646J1N7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA carboxylase subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_21725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000238">
        <property type="protein sequence ID" value="MQS38144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="68" mass="7569" checksum="5EE3096D93EDE6EE" modified="2020-04-22" version="1">MNSTLESSLLRVEKGNCEPEELAAITAVLMARAASQPERADAELSRSTAGWRRLERQRGFQPSHSWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1R2</accession>
    <name>A0A646J1R2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_25470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000290">
        <property type="protein sequence ID" value="MQS38815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="131"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS38815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="530" mass="57587" checksum="7B25EBD9FE2534DD" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1U1</accession>
    <name>A0A646J1U1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AfsR/SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_29130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000338">
        <property type="protein sequence ID" value="MQS39499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS39499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="289" mass="30605" checksum="90F781C737E3FF0E" modified="2020-04-22" version="1" fragment="single">RLLIAPGRPVSTDRLVDDVWGANPPDHPHHPRNTLQGQVSRLRAVLERAQPGGRELLVNGPAGYQLRAGPDAVDAARFTALLQRSRSAGPRERAALLSDALGLWRGDAFAGFAEEPFARPAAGRLEEDRLTALEDRLALRAELGEHGEIIGELDELVAAHPLRERLRAVQLRVLYRAGRQTDALTGYEDLRRRLDEDLGLEPSGELAALHQAILRQDPALDLVPDPGPGPGPAPGREADHAPDPASDPASGRPPATGAGPARGADPRPGSGGTPRPAPAGEVGLFGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-06-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1W4</accession>
    <name>A0A646J1W4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_30340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000365">
        <property type="protein sequence ID" value="MQS39728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="114" mass="11790" checksum="BB8FBAE707235623" modified="2020-04-22" version="1">MGGRTRSASVNSHTVPGPGPADSSTTCAPPISPVTVDFQSSTGRYARTAPVSGRGSPGLPIPTTRPNRLKRRTRASSWVSPEAKKALSPQLPPGTSMGSEAISGSVENGRRYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1W9</accession>
    <name>A0A646J1W9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000370">
        <property type="protein sequence ID" value="MQS39868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="215" mass="23399" checksum="BD152CF6F1810462" modified="2020-04-22" version="1" fragment="single">GQADPTAATLDELQALTVCDPACGSGHFLVASARRIAKQVAAVRERNPEPTPDAIRRALHEVIARSVYGVDLNPMAVDLAKISLWMEAMEPGRPMSFLDAHIKHGNALIGATPKLLRGGIPNKAFKAVEGDDAKHAASLAKRNNEQLNGQGEIFSLDQEERVSNASFARGLRRIISAPANVLRQVREQSAAYRQWREATAYTEALHHADTWCAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1Y2</accession>
    <name>A0A646J1Y2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000387">
        <property type="protein sequence ID" value="MQS39988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="87" mass="9013" checksum="063A2FD5B1885EC2" modified="2020-04-22" version="1" fragment="single">MGLNEEARTVRVDIGELVLDGFGPLDPDGVSAAFRTELTRLVRERGVPLAVDGGRVVDALSGLPPLPATTSPSRLGEALARAVHAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2S3</accession>
    <name>A0A646J2S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_00005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000001">
        <property type="protein sequence ID" value="MQS34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="157"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="272" mass="28959" checksum="C49C6A812FF98B96" modified="2020-04-22" version="1" fragment="single">LVRGDGLLPRMEPFVGEYVADALTAAGAEVRRNTSVASVERPDTGGPVTLVLENGERIEADEVLFATGRAPRTEDVGLESVGLRPGSWLPVDDSCRVEGSEWLYGVGDVNHRALLTHQGKYQARIAAAAIVARAQGVPLLETDRWGAHAATADHAAVPQVVFTDPEAAAVGLSLAEAETAGHRVRAVDYDISSVAGASLYGDGYRGRARMIVDLDREILLGVTLVGPGVGELLHSATVAVVGEVPIERLWHAVPAYPTISEVWLRLLETYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2W4</accession>
    <name>A0A646J2W4_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_18445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="VDEQ01000204">
        <property type="protein sequence ID" value="MQS37534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Melibiase_C" evidence="7">
        <location>
            <begin position="391"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS37534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="508" mass="54665" checksum="5D1D9DA5FD283BC0" modified="2020-04-22" version="1" fragment="single">MPRPPGSRTPFPRPLSRTAGARRTAPLRCALALALALPLAAAGQLTDPPPAAASDNGLSIRPAMGWSSWSFVRRWPTEAKIKAQADAMLSSGLKDKGYIHINLDDFYQKCDANGFIVDDYGRWAVDEKKFPSGIKALADYIHDRGLKFGFYVTPGIAKNAVTRNTPIEGTPYRAKDIADTSKQEKNYNCKNMYYIDYSKPGSQEFVNSWARQFASWGVDYLKIDGVGSHDIPDVRAWDKALRATGRPINYALSNNLAIADAPTWRQLANSWRTQGDVECYCGPGPNGSGYPLTDWGHITSRFTSAANWQQYAGPGGWNDLDSLQIGNGDQVGLTADQRRSHLTLWAMAASPLLLGTDLTALDATDTAMLTNERLIAVNQDGVAAKRIVNSGAKQVWSKREADGDHVIALFNTGASGNQTVSVTWAQAGFTGTAQVTDLWSGRDGGAVADSYSVTLRPGETRLIRAAPAAGNTVRHEAENASYTAGSTVDSNHGGFSGSGFVNTPNAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2Y5</accession>
    <name>A0A646J2Y5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_21710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000236">
        <property type="protein sequence ID" value="MQS38141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS38141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="205" mass="22560" checksum="3058A67C844C4CCB" modified="2020-04-22" version="1" fragment="single">MQFQQLLYFVAVAETRHFTRAAERVHVSQPSLSQQIRALESELGAELFSRARGNIALTEAGAALLPLARRILADADTARLEVQELAQLRRGRVRLGATPSLCTGLLPEVLRVFHDRHPGIRLLIEEGGSHDLVRQLARGALDLALIVLPLPPGSPALTTVELLQEDLVVVSAAAGKAPRRPVRIADLRDQPLVMFRHGYDLRELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J323</accession>
    <name>A0A646J323_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate thymidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_25795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000297">
        <property type="protein sequence ID" value="MQS38878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="246" mass="26612" checksum="591F41F77DF9A8D1" modified="2020-04-22" version="1" fragment="single">FIVGGISALVRRFRADRPDAQILLTRVADPRPFGVAELDPRGRVIGLEEKPEHPKSDLALVGVYLFTARVHDAVCRLKPSWRGELEITDAIQELIDAGCRVNSTVVSGYWKDTGSVADVLEVNRLVLDGVEADCSGEVHSSELIGRVVIEKGATVTGSRIVGPAVVAAGSRIRDSYIGPFTSIDSDCAVIDSEVEYSIVLRGASLIGVRRVERSLIGREVEVVSTPRILRAHRLVLGDHSKVQVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J389</accession>
    <name>A0A646J389_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">FFZ77_31710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T-272</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000386">
        <property type="protein sequence ID" value="MQS39985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MQS39985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="83" mass="8461" checksum="E3956BDAC784355F" modified="2020-04-22" version="1">MEVRVDRDRCAGSGLCVSYAPEVFDQSEDDGKVLLKKPLPGTGAAGAVRAMAARCPTGAITVHGHGHGHGPGEPSAPREPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3C9</accession>
    <name>A0A646J3C9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_03370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000031">
        <property type="protein sequence ID" value="MQS34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="397" mass="42243" checksum="D11C98A752775F8C" modified="2020-04-22" version="1">MKIGIVCPYSWDVPGGVQFHIRDLAEHLIRLGHQVSVLAPADDDTPLPPFVVSAGRAVLVPYNGSVARLNFGFISAARVRRWLHEGTFDVIHIHEPTSPSLGLLSCWAAQGPIVATFHTSNPRSRAMIAAYPILQPALEKISARIAVSEYARRTLVEHLGGDAVVIPNGVDVGFFERAEPKAEWQSRSAAAADGSDGGVIGFVGRIDEPRKGLPVLMKALPAILAARPGVRLLVAGRGDEEEAVSGLPKEMRANVEFLGMVSDEDKARLLRSVDLYIAPNTGGESFGIVLVEAMSAGVPVLASDLDAFAQVLDQGGAGELFANEDAGALAAAAIRLLGDPARRAELRRRGSAHVRRFDWSTVGADILSVYETVTDGTSSVAADDRPGLRARFGLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3H0</accession>
    <name>A0A646J3H0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_18015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000200">
        <property type="protein sequence ID" value="MQS37452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS37452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="139" mass="15312" checksum="4B9A00F6B256F6AD" modified="2020-04-22" version="1">MTTAKDIMHAGAQWIPMHETLDRAAQLMRELNVGALPIADADERLCGILTDRDIVVGCVAMGHDPAKVTAGEMAQGTPRWIDAGSGVEDVLQEMEVHQIRRLPVIENKRLVGMISEADLARHLSDEQLAGWMERVYARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3I1</accession>
    <name>A0A646J3I1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_20695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000226">
        <property type="protein sequence ID" value="MQS37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="80" mass="7181" checksum="457479C49A73B231" modified="2020-04-22" version="1">MLVIRHRPSAGRAGGFGGGPCGPRASAGSGGGSGGGSGGLPADAGSGGGAGGPRAGAGLSPAHRDRPGRRGSGPRGRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3R8</accession>
    <name>A0A646J3R8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">FFZ77_29705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000352">
        <property type="protein sequence ID" value="MQS39608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="92"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MQS39608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="198" mass="20361" checksum="5872849B2FF29D53" modified="2020-04-22" version="1" fragment="single">MTSANPLESTAPTAPTASAASAVKRRANRSYTLITGCTVAGLIVLLALVSFLWLPYAPDDTSGGRLAPPGADHLLGTDKLGRDLFTQVMTGSRIAVEAGLGSVLIAATVGVTLGVLAAFAQGWLDDTLSAFLDILIAFPTLLLAMLIVAARSATLESAILAIGLAQSAVVGRVVRVLAKRVLAQDYITAARTSGTSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3S2</accession>
    <name>A0A646J3S2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_30240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000361">
        <property type="protein sequence ID" value="MQS39709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="108" mass="11768" checksum="DA13F101247970B0" modified="2020-04-22" version="1" fragment="single">EALARGVHMSAGHLSREFRAAYGESPYSYLMTRRVERAMALLRRGDLSVTEVCFAVGCASLGTFSSRFTELVGMPPSAYRRLAASATAGMPPCVAKQVTRPVRNQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3U6</accession>
    <name>A0A646J3U6_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000390">
        <property type="protein sequence ID" value="MQS39993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="475" mass="52780" checksum="896C7DC17CF18A5B" modified="2020-04-22" version="1" fragment="single">MAALPRERELLSAVQTVGGLIPQDMLVRISEGKEVNGSAPADYHVIGSRSVQEEAERHWGYLKSVWSELRRRLPVAPEAEAPADPTGVAIARWLEPLFGELGFGRLPALPAPGITADDGTKSFAVSHRWNHVPIHMTPWHTGLDKRPGGPGGPGGLGTVPPHSLVQECLNRTSGHLWAVLTNGRRLRLLRDSSALATASYVEFDLEAIFDNELFSQFVLLYRMLQVSRFDIADGATLSSCWLERWRTEAIESGTRALDQHRDGVQRAVTVLGTGFLRHPANAALRQNLDTEAFHSALLRLTYRLIFLFVAEDRDALHPPDTDDRTRQRYARYFSSARLRHQATRRRGTAHTDLFQALRLVLDALGDEDGRPELGLPGVGGLFDDTEADRPLHGLALANEHLLEAVRSLSRVRDTRSGRWRTVDYLHLGSEELGSIYESLLELVPKHNGTDGTFELVNRLGNNRKKTGSYFTPGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V0N3</accession>
    <name>A0A6I1V0N3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DsbA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_00055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="244" mass="26593" checksum="83F0B7BB88A39ED2" modified="2020-08-12" version="1">MRVEIWSDIACPWCYIGKARFEKGLADFAHRDQVEVVHRSFELDPGRARGDVGSVVDMLALKYGRTREEALAMEEHVAGNAHAEGLGYRTGDRDHGSTFDIHRLLHLARARGRQNELLDLAYRANFAEERSVYDPETLAALAVEAGLDEAEARAVLADGAAYADEVRADEREAAELGATGVPFFVFDRRYGLSGGQPAELFTQALEQAWRDREPVPAAPAVPAVPAGADAPGCDTDGSCEVPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V0P4</accession>
    <name>A0A6I1V0P4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_00110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="274" mass="29919" checksum="CAFF9E55274CD91A" modified="2020-08-12" version="1">MPAPRTVLLTGAAGGLGTLMRGLLPAYGYELRLFDARPIEGEPTAITAELADTWALREAVRGVDAIIHLAGISLEAPFAKILRSNIEGTYNLYEAAREEGVRRIVFASSNHAVGFTPRPRGEPPFGPGELIPVDTPRRPDTYYGLSKCFGEDLAQLYWDQHGTETVSVRIGSCFMEPSTVRMLSVWMSPGDGARLFHAALTAEDVGHTVVYGSSANTRLWWDLSSARALGYEPRDDSEQYAPGLIAEQGELDPDDPDHACLGGHFVTRPPMWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V3H9</accession>
    <name>A0A6I1V3H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_00080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026267986" evidence="2">
        <location>
            <begin position="29"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="486" mass="50780" checksum="FE704BF892806873" modified="2020-08-12" version="1">MNKTIRHTAVFSLLLVLALLVRATWLQAFEAKALAENDRNHRTKIAQYAQPLGDIIVAGSPVTGSAPTAGGDLAYQRTYTDGAMYAAVTGYSSQLYGATQLEGIYSEVLDGTDSRLKNPAEAITGRQQKPGDVLTTIDPAVQEAGYRALGDTKGAAVAIDPETGAILGMVSTPSYDPTAIAALSDPDAAATWQKLLDDPDKPLVNRALRQPLPPGSTFKLVVAAAALEEGRYDSVDEKTDSPYPYVLPGTTRALPNDIPGAPCENASIRTALRYSCNNVFAELAADLGQDTVRATAERFGFNDEELDVPVRAYASVYPTGMDDAQTALTGIGQFEVTATPLQMAMVSAAIANDGVMESPHMVSEVVDSAGETLESPGDGSSKRIVSSRTAEQLRSAMVTVVEDGGTGSNAQVPGAEVGGKTGTAQHGENNSKTPYAWFTSYAEDAESGEKVAVAVLIEDAGGPRSEVSGNGLAAPVAQRMMAAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V5W1</accession>
    <name>A0A6I1V5W1_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_00085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS34080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="555" mass="59710" checksum="D2216D9E39F77E09" modified="2020-08-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V784</accession>
    <name>A0A6I1V784_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_00015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5026207723" description="GRAM_POS_ANCHORING domain-containing protein" evidence="6">
        <location>
            <begin position="40"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="307" mass="30895" checksum="C972DB050BFB5293" modified="2020-08-12" version="1">MNSDTLRMPARRRAAVLTSAAASVALIAAPSALTGPAHAAGGGAEGRADAVVLRTGLQISLLDKTVQVPLTASLNAVKAPASADSTTLSVRLDGVDQGRPFQVLRADVAEAKATADKRRAEGHAQLVRARVRVPGLPLLSLVEVEKVVSKAVCAVGERPVAESNLLGGVKVLGKQVALSAGGRTNVAVPGVGEVTLDLSRTRTTSRTAAATALELKVAVNPLSLNVAEVNGTVTLAEATCESPRAGQRPAAASTSGVKPQTGPAENLAETGGSSTTPYLAAGAAALLGLGGTALLLARGRARSRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V7Q9</accession>
    <name>A0A6I1V7Q9_9ACTN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_00010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="353" mass="37798" checksum="D4B2DEBAC1D93F6A" modified="2020-08-12" version="1">MHMHTDGSHDLRHHGDAEIRDAGAGLIDLAVNVRTSTPPEWLRECVAGSLTSLAAYPDNRAARAAVAARHGLPAERVLLTSGAAEAFVLLARALAVRRPLVVHPQFTEPEAALRDAGHTVDRLLLREANGFRLDPREVPESADLVVIGNPTNPTSVLHSPEDIASLARPGRLLVVDEAFMDAVPEEAGTLAGRTDVPGLVVLRSLTKTWGLAGLRIGYVLAEPETVSALARAQPLWPVSTPALTAAEACMAPAALKEAEQAARLIALERAHLLAGLAEFEETRVVQSAEASFVLVHVRRGAEVRERLRSLGFAVRRGDTFPGLGPGWLRIAVRDRATTNRFLQALDQALAMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V9F0</accession>
    <name>A0A6I1V9F0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_00095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="224" mass="24043" checksum="53B9BE4867628968" modified="2020-08-12" version="1">MTFAPAPVPSRTQYVLEAIRHAVLTGRLRPGQALVEVELAAWFGVSKTPVREALKTLAGSGLVVLSQYKGVTVRTVDTAMAHEVYDVRLLLEPEALRRTVVRSASSAPARAVLESAGEALARAEQAAGPAERSLANREFHRALYSSCGNPLLVRTLDELRDQAALVSAVAWAADPSWRQEAAEHRETLRLALDGAAEAAARALRRHIAGFVHRAFPVATPGDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2022-01-19" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V9M2</accession>
    <name>A0A6I1V9M2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine--glyoxylate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_00025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="17"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="366" mass="37580" checksum="5CD37875AF070E4B" modified="2020-08-12" version="1">MTHPLLDLPPLTAAHFAGVERRVAALLDTEQDVVITQGEALLPLEGCIRGGARPGSTALNVVTGPYGQTFGNWLRDCGAKVVDLEVPFHTAVTAEQVERALAAHPEIDFVSLVHAEAATGNTNPVAEIGEVVRRHGALFMLDAVASVAAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAVSVSARAWERFAANPAAPRRSYLSLLDWKERWIDGGRKALLHAPAQLEMLALEACVERIEAEGLAALMARHASAAAATRAGATALGGGLEPYVHDARDAAPVATTLRAPAGVDASELVAKALAADPSLPLIAGGGALSKEMIRVNHYGVDATRGAVRSSLAALGGALAETGASVDLEAAGRAVSGVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J034</accession>
    <name>A0A646J034_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_06580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000063">
        <property type="protein sequence ID" value="MQS35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="232"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="309" mass="33583" checksum="16203EE5EF50FD6A" modified="2020-04-22" version="1" fragment="single">MLVTDAGVKTGSGRNRFGRFGAVTELWRSAGRCPDDQDRQSHPDHSVHPDGGHGAAAKASPPGGPRRTAPDCPRLEIVRTPRLVGRGDPDVHQILCLLHGGTGSLEQAGRTARLRAGELVVVDGSLPCRGWLQGPPELLRALVVHVPRALLPLPPGAVRELLARPVALDRGLGGALSHWLTDVCARADEFAPADLSALASVTVDLLVPLLGRSHRAGGRPESTEDRRGALRQQIQDHIRRHLADPELSPASVARAHSISLRYLYQLFREQEVTVAGWIRQCRLERCRRDLADPGQSFRTIHAIAARWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J091</accession>
    <name>A0A646J091_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_19625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000211">
        <property type="protein sequence ID" value="MQS37755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="75"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="246" mass="26293" checksum="94291D612A1F1553" modified="2020-04-22" version="1">MSADTATTPTAAPTASAAPWILMYHSVADPSDDPYGITVAPDRLGRQLRALRRLGLTGVGVGTLLRAHALGRTRGLVGLSFDDGYADFTEAALPVLRHHGCTATLFVLPGRLGGGNDWDPEGPRKPLLDERGIRAAALAGTEIGSHGLYHVDLTAVDDDALRQETGRSRAWLHELTGRAPDGFCYPYGTVDRRAADAVRAAGYAYGCAIRPPAGLTGPYALPRTHVSQADRGVRLRVKRLRHRLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0B5</accession>
    <name>A0A646J0B5_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-phenylpropionate/cinnamic acid dioxygenase subunit beta</fullName>
            <ecNumber evidence="2">1.14.12.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_20000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.19" evidence="2"/>
    <dbReference type="EMBL" id="VDEQ01000220">
        <property type="protein sequence ID" value="MQS37826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008695">
        <property type="term" value="F:3-phenylpropionate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="158" mass="18321" checksum="7C8CDD40E65ADC75" modified="2020-04-22" version="1" fragment="single">LLDSGRYADWLELLADDLDYWMPTRTNRLRRQQALSIAARGEAAFYDETKDSLAWRIRRFDSGMAWAEDPPSRTRHLVTNVMARHVDPAEQDGFTADDLWVRSSFLVHQNRLEREVNVFAGSRTDILRRTADGRLQVARRAILLDQNVLLAKNISTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0F3</accession>
    <name>A0A646J0F3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_12420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000127">
        <property type="protein sequence ID" value="MQS36379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS36379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="225" mass="24199" checksum="B356B01549822163" modified="2020-04-22" version="1">MSSDAPVILDHRHGPHGEVVLRRRGEHHEIIANGCFLMDTSDGRSERHLVDAAYAALAANGGRPPSLLIGGLGVGFSLAHAAANPHWRHIAVVEREQAIIDWHFSGPLAPISSAALADPRSVILSTDLLTHLRDTDDRYDALCLDIDNGPDWTVTEDNGDLYSPTGLALCRRVLEPGGVLAVWSAKPSPAFEETLRNAGFKGVRTEEIQVARGVPDVVHLAVEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0K8</accession>
    <name>A0A646J0K8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3459 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_21820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000240">
        <property type="protein sequence ID" value="MQS38162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="14"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS38162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="480" mass="53823" checksum="9D0F56A780287437" modified="2020-04-22" version="1" fragment="single">PLPLLVERRRALFGSWYELFPRSEGAVLAPGRPPVSGTFRTAAERLPAIAAMGFDVVYLPPVHPIGATHRKGRDNALSAGAHDVGVPWAIGSRDGGHDALHPDLGTFADFDRFVAAARALRMEIALDFALQCSPDHPWVSEHPEWFRRRADGSIAHAENPPKKYQDIYPIAFDDDMRGLVRETLRVLRFWMARGVRIFRVDNPHTKPVVFWEAVLADIARTDPDIVFLAEAFTRPAMMRTLAAVGFQQSYTYFTWRTTKRELTEYVTELVGDSASYMRPNFFVNTPDILPDHLQHGGRPAFETRAVLAATLSPSWGMYAGYELCENTPLRAGGEEYLHSEKYELRPRDWASAERTGRTIAPLITALNRIRRRHPALQQLRDVAFHPTDNDAVIAYSKRSGRDAVIVVVNLDPHHTQEATVSLDMPRLGLAWHETAPVRDELTGETYHWGRASYVRLEPGRTPAHIVALRPSPPIGGSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0L2</accession>
    <name>A0A646J0L2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_31355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000376">
        <property type="protein sequence ID" value="MQS39916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="109" mass="11973" checksum="B4D45DE53250D78F" modified="2020-04-22" version="1" fragment="single">IAERLRDEAAHDDLLSTLLAARDGDGAVTPRLIHDQVVTLLTAGGESNAAVLSWAFHLLSAHPEAERRVHAEVDSVLGGRLARWEDLPRLEHTARVVTETLRIYPPGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0N8</accession>
    <name>A0A646J0N8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_31550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000383">
        <property type="protein sequence ID" value="MQS39954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="63"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS39954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="220" mass="22348" checksum="74146A616CCBAC3D" modified="2020-04-22" version="1" fragment="single">MTRAAGPSSLLPPATGGWQEGDPVGGRRWARLEQPLPLEAGGELPGVRMAYETWGRPAADGSNAVLVLHALTGDSHVAGPAGPGHPTPGWWDGLIGPGRALDTDRWFVVAPNVLGGCQGSTGPSSFRNAGDGGGDGDGGDGGDGGGHGNGGGHGEAAVQGRRWGGSFPFLTTRDQVAAEARLADLLGIQRWALVIGGSMGGMRALEWAVSHPDRTEALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J0P2</accession>
    <name>A0A646J0P2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_31920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000400">
        <property type="protein sequence ID" value="MQS40027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS40027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="131" mass="14699" checksum="41283262C4C05ECE" modified="2020-04-22" version="1" fragment="single">RVQLGESTEVRRLLPNLGRRMVGAWAFVDHYGPDDIADEPGMQVPPHPHMGLQTVSWLHEGEVLHRDSTGSLATIRPRELGLMTSGRAISHSEESPRPHARFLHGAQLWVALPDAHRGVEPHFQHYTELPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1D7</accession>
    <name>A0A646J1D7_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_25820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000299">
        <property type="protein sequence ID" value="MQS38883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="586" mass="59949" checksum="B7FC2A47D9F53FDF" modified="2020-04-22" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1H9</accession>
    <name>A0A646J1H9_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">FFZ77_05455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000052">
        <property type="protein sequence ID" value="MQS35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024801693" evidence="4">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MQS35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="217" mass="22250" checksum="84EB65986244B3D4" modified="2020-04-22" version="1">MWTCVARGSVAALLAALAVVAPARAVSPTALPPTALVDATAVASCDEARERQQAGELDGAQETYTAIAVKGGDAERACAVAGLKSVAAQREQAAAVVTAGEDLVKAGDLDKAGNVFRSALAMDQSNPGATAGLAQVHTAQDRPGASSNWERFSAYWVVPLVQMLLFSAVGFAVLYALAGLSTRLFVPVDTISWPRGRARPGASPSRGMTPVMVTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1P8</accession>
    <name>A0A646J1P8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glgA</name>
        <name evidence="4" type="ORF">FFZ77_23695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000264">
        <property type="protein sequence ID" value="MQS38493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS38493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="247" mass="26376" checksum="4B47C25EBBFFBD5C" modified="2020-04-22" version="1" fragment="single">MGLLTRDFPPDVTGGAGVHVEFLARELRTLADLEVHCWGDGEAEGVLRHRPAAGLAGADDALRALSVDLAMAAELAGRELVHSHTWYAGLAGHLAKLLYGVPHVMTAHSLESLHPWKAERAGGGYALSSWAERTAIEAADAVVTLSRRMREEVLAAYPALAPGRVRVIRGGVDTLVYRPDHETDARDRIGLDPRRPFVLFAGRTSRHKGLPHLLRAARTFDPEAQVVICAMPGGQAGAAGSEGEPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1Q8</accession>
    <name>A0A646J1Q8_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_24935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000279">
        <property type="protein sequence ID" value="MQS38713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS38713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="256" mass="27256" checksum="CF84432444BE472E" modified="2020-04-22" version="1">MPVEVTWWGHATCTVEDSGVRVLTDPLFARRLAHLRRRRGELPPPEAAVADAVLISHLHNDHLHLPSLARLSAGTRLIVPRGATRAVPGLARLGLRVTEVAPGDETAVGPLTVRAVPALHDGRRLPVGPRRSPALGYVITGESRTYFAGDTGLFDAMADAVGQVDVALLPVGGWGPYLGPGHLDAGRAAQALAALAPHRAIPVHYGTYWPIGMDGVRPHEFYSPGDEFVRQAARLAPGVSVHRLGHGERLGPEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J1S3</accession>
    <name>A0A646J1S3_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">FFZ77_27545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000309">
        <property type="protein sequence ID" value="MQS39196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MQS39196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="27" mass="3005" checksum="87DCD977126BDB74" modified="2020-04-22" version="1" fragment="single">MLTSVDPDVIRVLGDPLRLKIVTLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J2X2</accession>
    <name>A0A646J2X2_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_19820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000217">
        <property type="protein sequence ID" value="MQS37792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009366">
        <property type="term" value="C:enterobactin synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003542">
        <property type="entry name" value="Enbac_synth_compD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38096">
        <property type="entry name" value="PTHR38096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01399">
        <property type="entry name" value="ENTSNTHTASED"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS37792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="74" mass="7924" checksum="88C590B569B2AFAD" modified="2020-04-22" version="1" fragment="single">MLPHDVASAWAFDDTADIPLFPEEEAALARAVERRRREFTTVRGCARRALAGLGLSAAPLVPGVRGAPVWPDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J344</accession>
    <name>A0A646J344_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ergothioneine biosynthesis protein EgtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">FFZ77_28445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000324">
        <property type="protein sequence ID" value="MQS39369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="2">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="169"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MQS39369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="389" mass="43161" checksum="9BBBA441D0E40C6F" modified="2020-04-22" version="1" fragment="single">MTEDLRSRALDALTTARARTAILTGCVDDHELTAQHSPLMSPLVWDLAHIGNQEEQWLLRTVGGRTALRPEIDSVYDAFAHPRADRPSLPLLAPAEARGYASDVRGRVLDVLDATPLEGGPLTDSAFAFGMIAQHEQQHDETMLITHQLRKGPAALTAPEPPRGGAEELPAEVLVPGGPFTMGTSAEPWALDNERPAHQRVVPAFHLDTVPVTCGAYLSFMADGGYREPRWWAAEGFEQVRRNGIDAPLFWRRESGQWLRRRFGVTEPVPLDEPVLHVSWYEADAYARWAGRRLPTEAEWEKAARHDPVSGRSRRFPWGDEDPTPAHANLGQRHLRPAPAGAYPQGGSPLGIRQLIGDVWEWTSSDFGPYPGFAAFPYREYSEVFFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J361</accession>
    <name>A0A646J361_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylating acetaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_29665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000350">
        <property type="protein sequence ID" value="MQS39600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcetDehyd-dimer" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="186" mass="19482" checksum="3814D1211967CD56" modified="2020-04-22" version="1" fragment="single">CGGQATIPVVHAIARKTPVPYAEIVASIASKSAGPGTRANIDEFTETTSAAIESVGGASRGKAIIVLNPAEPPLIMRDTVFCLIGDADHDAIRSSVHDMVAEVTKYVPGYRLKQEVQFTPVPADEPVHTLLPAGVPKATTKVSVFLEVEGAAHYLPAYAGNLDIMTSAALRTAERIAQHSRQGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2020-12-02" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J367</accession>
    <name>A0A646J367_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron chelate uptake ABC transporter family permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">FFZ77_29850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T-272</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000357">
        <property type="protein sequence ID" value="MQS39635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MQS39635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="320" mass="33760" checksum="85E3D34D94A292BD" modified="2020-04-22" version="1">MRRLPLLLATLCVLALVTASLFIGGYDIDLRALFTDPEARRMFLISRVPRTLALVLAAAAMAVSGVIMQMLVQNRFVEPTTTGTSEWAALGVLLLTLLVPGASPLLKMGAASAFAFAGALVFLVVLGRIGLKSQVIVPIVGIMLGALVSAVTLYIASSTQLLQMLATWRSGGFSSVVRGNYEPLWVVGAIVAGLYLLADRFTIAGLGRSTATSLGLPYRRIMFIGLVMVALAAGVTTVVVGFIPFLGLIVPNLVSMARGDDVRGNLPWVVLSSVALMIVCDLVGRLIVFPLEIPATVVLGAFGAVVFVAMILRQRGKAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-04-22" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A646J3T4</accession>
    <name>A0A646J3T4_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">FFZ77_31360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000376">
        <property type="protein sequence ID" value="MQS39917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MQS39917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="311" mass="35855" checksum="3042D3F111DC71E7" modified="2020-04-22" version="1" fragment="single">MRRPRSSEYPGPRRELRVRPFRARQFSARQFSARRIRRRQVRVRRSLGRRFHPPCAAVRDLPAVRRRRSGGRPGRTRRISAKLGRATCADPRSWHPVAEPRTLHGTFPRWRDRPFEPRTDTITDKRSPTPGISLRTGIAGGALPVLGHIPMFHRKPLEFLSSLPAYGDLVGIRLGRRRACVLCHPHLVQQVLLDGRSFDKGGPFYEKLRPLGGDGLGTSPRDEHREQRRLMQRAFQRHRMAEYATVMGDVVEEQMDRWHDGQEVDLHDDLHQITVQVVARSLFSQGIPPAVITEMRASLAVFVRGFYRNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-08-12" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A6I1V7S0</accession>
    <name>A0A6I1V7S0_9ACTN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase (NADP(+))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">FFZ77_00060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces katsurahamanus</name>
        <dbReference type="NCBI Taxonomy" id="2577098"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics and metabolomics analyses of clavulanic acid producing Streptomyces species provides insight into specialized metabolism and evolution of beta-lactam biosynthetic gene clusters.</title>
            <authorList>
                <person name="Moore M.A."/>
                <person name="Cruz-Morales P."/>
                <person name="Barona Gomez F."/>
                <person name="Kapil T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T-272</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VDEQ01000002">
        <property type="protein sequence ID" value="MQS34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000460558">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07129">
        <property type="entry name" value="ALDH_KGSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044151">
        <property type="entry name" value="ALDH_KGSADH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="8"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MQS34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000460558"/>
        </source>
    </evidence>
    <sequence length="512" mass="53109" checksum="6C8E97E5C70F8912" modified="2020-08-12" version="1"> </sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>