<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QLL9</accession>
    <name>A0A328QLL9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000016">
        <property type="protein sequence ID" value="RAP22843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP22843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="170" mass="18636" checksum="52428DA45D393B5B" modified="2018-10-10" version="1">MTDIKKVDQAIEIAKKAGKNILSPELLGEFNSIFKEASAAAANIDTNEWAIKEKKKKKKDEIDSITLDKVDKASLAQLSQGVVANAANAKPQNINIVPLQIFLDNAIRSLENVSKQESKVNNLMDQFIKGTISEDEVVVETAKLNLSISMVTTIVQSAVQTFKEIQQIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QML3</accession>
    <name>A0A328QML3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000014">
        <property type="protein sequence ID" value="RAP23054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="425" mass="46131" checksum="208CF1A55E870577" modified="2018-10-10" version="1">MFNTDMMPNLIERSNASLSNVLSHATQLQIERGEGSYLIDYQGHRYLDFGAGIAVNSTGHCHPTVVNAIQQQSQTLLHGCAGVVYYDQNISLAERLGKMSGLNSVFFTQSGTEAVEAALKCAVYVKNKQGIIAFNGSFHGRTLGALSVTTSNQKYLDRYPLAFSNRVILEYPNFYRNPAPMNNEDGYLDYLSKKLATIDTSTIGAIIIEPFMGEGGYVPCPGSVLKYLREWASDNDVFLIFDEIQSGIGRTGQWFYYDHFGITPDILTTAKGIASGLPLGACLSSKTIMDQWTTGSHGGTYGGNPLSCAAATATLNVLEPLLPKISELGQIAKDRLIKELESLPLIGHIRGEGLMIGIECMDSSGEPNPTAIKAIISRCLEKNLLILPCGKDGNVIRLMPPLTISPDELNDGLSILIESCHHVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNY9</accession>
    <name>A0A328QNY9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="109" mass="12720" checksum="ED92B0CB8C460AC1" modified="2018-10-10" version="1">MKLWLIIGLVFLGCQAANCQVEMNYELLHYMAAKEPDPDPNDREQIKKQFQTYFIKQVFLNSVFKSNHLYYGEDNPSDYGLVNQLMINQFAEQLVETDVIDLSHISLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QP45</accession>
    <name>A0A328QP45_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DID73_02120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP23564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="287" mass="32014" checksum="356D95D28CA6BDF3" modified="2018-10-10" version="1">MRIGYLGPQGTFTHFACEKAIESSAFTDILPVEYQSLDRLFDALNDGNVDAIFSPIENSIEGPVNRVLDALTHSNEAFIDTTYSMPINQSILSFNPTIVPNHISDIVSMPHAIAQCYAFIKEHCPNATLHHAPSTAGSVPMVEALNLPQESTVVIGHQGISKFFPIHVIEKNIQDQKKNTTQFSLIKRAINIDSQPPAEAHCLLAFSTPKDAPGSLLNVLEIFKSNQINLSKILSRPEKSDMGSYIFYIEFPTNFDTLSMNDLFSQIKKKSLFFKHLGFYRSHIIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QP54</accession>
    <name>A0A328QP54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="240" mass="27816" checksum="39A1C6E63FB5DED0" modified="2018-10-10" version="1" fragment="single">VNLTTNHPNIFNVENLFSLNQEDEYDITIDLDNVYEKNPKQHILITYINEVKKILDEDIQFRSPEIKFTEEENELIVKLKKDPFVIINIDPSGYYNSTRKVYGINIQELAKRIQEEHGVKVVEVGLYEDHGLPKVTLKNEREAMILIAASRLFIGLDSFFLHIAGALSVKAIGFFGGVNPEYRLFETYGIKVFQNYCENQHCYHNEFHYGDKECELNMDIPKCASHDIKDVISVIKDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQB2</accession>
    <name>A0A328QQB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">DID73_01730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="G" evidence="9">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="9">
        <location>
            <begin position="177"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="KH_dom-like" evidence="10">
        <location>
            <begin position="353"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="439" mass="50896" checksum="983B84DB9CF6B8B3" modified="2018-10-10" version="1">MKKVVIIGRPNVGKSSFINRLLGKKTAITAREEGVTRDIRYYEQTWNGKTFEICDTGGVIFSKNTDNPYQDKINGMIEEELNGAHKILFMVDFNHPDHPEDLIIKDHLKRHLKKLFLIINKVDNFERQSELYPFFAYGIDQSYPVSALQGNGIGDVLDDIVENLSVITEEDEDENINVALIGKPNAGKSSLYNAIFNQNKAIVDHKMGTTRDINESIIKVNNNPINFMDTAGLRRKRKISDTIEYFSIVRTERAIEKADVIVFMIDAEELLTDQDKKILNHIFSQHKNCMIFVNKWDLLERNEHTRNDIIKILEYEVPQLSHYPIIMGSAKEKHNIQAFLEQIIHIYDASKYRVPTGPLNKFLERFFEINHPPSKKGKQFKIFYATQVGSIPPQFIFKVNDAKLLTKPFLRNFEREFRNFFPESKGVGMRFDFRSKTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQN7</accession>
    <name>A0A328QQN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024423">
        <property type="entry name" value="DUF3050"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11251">
        <property type="entry name" value="DUF3050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="248" mass="28188" checksum="7556E09C7F016638" modified="2018-10-10" version="1">MNIHQSLAPLHHQLKEHPLYDAIQTIDHLGIFMSHHIYSVWDFMNLLKTLQLQLTSMSVPWVPVQDVDNVRLINDIVLEEESDIIDGQVTSHFLYYVKAFNSIQSNHSMGQFLDDLNRPDMSYANLIAQPYIPSSVHGFLRFTHDVIQSSLIETAAAFAYGREILVPVIFEPLLKQADLDPAVMGFISYLERHIELDGGEHGHKAEQMVANLCNSDADWQLVLKTAEAALQHRIQLWDGILAEISSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQU9</accession>
    <name>A0A328QQU9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DID73_02530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000014">
        <property type="protein sequence ID" value="RAP23056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="284"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="412"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP23056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="651" mass="74128" checksum="C10069C38C1B9C5E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQV9</accession>
    <name>A0A328QQV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00282 family metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="270" mass="30774" checksum="9497144492844D4A" modified="2018-10-10" version="1">MPTNETFNILCLGDIVGQPGRHILQEELEGIREEFNINFTIANIENSAAGFGFSNKLYHEFIHMKMDAFTSGNHVYAKREVIEKFDIYDRLVRPVNFPKSHPGKGVRYFEKDGKTIALINLIGRVFMTQMPYCPFETMDEVLNDIDADIIIVDFHAETTSEKQALGWYLKDRVSLVFGTHTHVQTNDYRKLSNKTAYISDIGMCGAFDSVIGMDKTISIHKFLDQLPSRHQPVKSPEQFLIGAVMIAVEPKSNHIKSIETIHRVYDNEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QR20</accession>
    <name>A0A328QR20_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_01580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="18"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="398" mass="44367" checksum="9467A94A4FF87591" modified="2018-10-10" version="1">MNLKSDFPIFNAHPELTYLDSGATTHKPKIVIDEITNFLSNHYGTVHRGVYELSVTSTEMYNKSRKKIQEFINAPSEKNIIFTKGTTASINLAAFGYVKHIIEENDEILITEIEHHANFVPWQQIAKEKKAIVKYAPVNDNGELDIQAFKQLINKKTKFISVTHISNVLGTILPIKTILNLAKENNIPTLIDGAQAIAHESVNIEELEPDFYCFSGHKMYGPTGIGVCYASNRVLNEMKPISFGGDMIESVKKEGTTFTEAPLKFESGTPPIAEAIGLCKAIEYIESVGIDKLKQIDQSLTEKTINSFKKYPWIKLIGNAKERSSSISFEIDGIHPHDIGSILDSENIAIRVGHHCAQPTMERFNVPATARVSFGAYNNENDIEKLMAGIHKSKEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QR65</accession>
    <name>A0A328QR65_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nadC</name>
        <name evidence="12" type="ORF">DID73_02405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="105"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP23169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="280" mass="30877" checksum="76DC9B56D4E4C92F" modified="2018-10-10" version="1">MDIIDCIKNALNEDKPTIDVTSALLLNESRHAEAHIIAKAPGIFFGQPIVDGINAMTPTITCDLLVQDGDAVAPNDICVIIKGDLRTIVEVERTLLNFLQRLSGVATITNQFVSALDDNSIAILDTRKTTPLLRELEKKAVCAGGGMNHRFGLHDMVLVKENHLHLYLKDYGIDAFNEKIRAHKNEHPTIPIEIEISSIDLLKQIDLSHVDIVMFDNMSIDQLSDCIHYLNSQPKKPLKEVSGNISLDTISLYKGIDIDRISIGSLTHSVSALDLSLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRM9</accession>
    <name>A0A328QRM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="382" mass="42398" checksum="D02D5DAF23054502" modified="2018-10-10" version="1">MSKKVLLAAAATIPMRSGHGQPYGPTAKSVDPTQGKLQFNCGKKHTSKDIYETNGQINIGHVNDFCDADPDLLGLKTSYSRKIIDVLLSGYRLESNMDNPNPSATLAFNPKKIAFQESKKVQDIRNQTSANSILPKEVAVFWGGCFDKDPEILPINRQRVITNETNALGNREEVSSTYMTVDHQSIMKTKQDCAELMPYQKPGNPQQTQDDVYYVILAAKLFKESHELIGVMIAIPPRSFLKETWIGVGSTFALTILYVILRCCWEDNRHSRELAADPTLQDQGEGDIELEELERGQTNQERDAVEGAPDADEGAPDADEEAPDWPSVEELAEIQNPRASDADSDEERDQIGIEIQQAPDWPSEEEASDADEGAPDAEFNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRQ1</accession>
    <name>A0A328QRQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide peptidase SppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sppA</name>
        <name evidence="4" type="ORF">DID73_01500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="109"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="297" mass="32526" checksum="4B53B4BACD91E82B" modified="2018-10-10" version="1">MTSESKKVSLIIGLIIVSTFVGFYDRIQPKANQTASVIPKASVMVIPIEGVITSVGTEWDGNIVDVVSQQLKEAKDAKTVKAVVLRINSPGGTVGASQEIYDAIMRFKADSKKPVIVSIMDIGASGAYWIAMAGDYIFSHPGSIVGSLGVITQTFDLTSVPKKYGIDVRTYKAGPHKDLLNPWRKPSKDDEWLINKMLTTVHEQFKSTLVERRKVSTDRAQILADGRIYAGQDALAEQLVDELGGIYDAIQYAGKLVNLKDPKVIYPNRGFKDWVQSLRASSFGALNSAMAGQVWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS11</accession>
    <name>A0A328QS11_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016296822" evidence="1">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="325" mass="35322" checksum="0ABE7C38DBB1550A" modified="2018-10-10" version="1">MLKHCLILLMACMPLFADSYSMNRPDAHGPIGVMADHKHHQNNVMVSYRAMPMTMSTLVNGKETVSLDSVQSNYMMSPKDMQMTMHMVGAMWGYSNNITLTAMLGYSENGMTMINKMNQTSEMNSSGLNDLNVGAIVDLNKTKNSKTIANIGVSLPIGSIEKENADGVHLPYGMQLGSGTYDVNLGLTRTYQFNDISVGTQISGLVRLGRNKLDYRLGNKYQGTSWVQKVWSRELSTSARIAITGTTDITGSNNTLTAMQIGMSPMYNTNSGSLVSSLGVGVNYSPSFLDKTRIAGEISTPVSKDTNTLALIADTSFTFGIQQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS43</accession>
    <name>A0A328QS43_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="66" mass="7478" checksum="77D027065C6334F7" modified="2018-10-10" version="1" fragment="single">MGIRLKGYSLLEIILVTTFIIIFIVVINPGTYIDRFSKILLKMNVLNESELMINKFNSLANSQCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS46</accession>
    <name>A0A328QS46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="120" mass="14145" checksum="1724DFF6BC3133FC" modified="2018-10-10" version="1">MSIIRNVLGELIVFFDWLFKPTQVKRSSDVQASLDNQCQSLAVYEFRRCPFCVKVRRHMRRLNIHIERRDIKKNPNYRSELMDGGGRTMVPCLRIESNNGVEWLYESTDINDYLTSMVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS53</accession>
    <name>A0A328QS53_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000017">
        <property type="protein sequence ID" value="RAP22837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP22837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="181" mass="20800" checksum="585C7249B8A129C3" modified="2018-10-10" version="1" fragment="single">PEEMIKFLEELRKRINKQIIHRAKAWIPIPLTTPPDQEGINIKKEERFNSSGFKTITDKFMEFQISNTKITSGDLDFAIQQWRDQLEGGENSSAQANVTSTNPSALRRRDLLIQKLKDDQLVGRGSSSTQANEKCCENENCTKNKRKQRATKKLVKKTFRRRVTHSPDVFPQVLNFGLPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS66</accession>
    <name>A0A328QS66_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">DID73_02205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="776" mass="81113" checksum="B3B2098CD2F8E4AD" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS84</accession>
    <name>A0A328QS84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotase</fullName>
            <ecNumber evidence="7">3.5.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="7"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="51"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="450" mass="50178" checksum="9E4C469B4F5206CE" modified="2018-10-10" version="1">MTESTLFKDIQLVLPEGIRQGDLLVKAGKIVKIAPSITEPADQVIQESGLTLMPGVIDTHVHFREPGPTQKETIASGSKAAVSGGVTTFFDMPNNQPATITVDALNQKKQIAKQTSYSNYNFYIGATLDNLDELIKADNCPGIKIFMGSSTGNMLVDDQQILDDIFKHANKPIVIHSEDETMVRENMDRYKGSSDVSDHMNIRTPEAALACTKRAVELAKKHQQRLHILHLTTADEVDWLLSQDLPPYITVEVCIQHLLLHAPEVYDRLGTFAQINPPLRTESHANRLWFGLQNGLISSIVTDHAPHLIEEKNQPFGQAPSGMPGVETLLPLTLQFFHDQRATLHDVSRWLSGAAQRLFNIDRRGQLLDGYFADLVLVDLNTEWTIENKATVSQCGWSAFDGWTVKGRPIMTFVNGQMVFREGEFFQFPDVADEVVLSSYTLSEKNIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS94</accession>
    <name>A0A328QS94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA internalization-related competence protein ComEC/Rec2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_01295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004797">
        <property type="entry name" value="Competence_ComEC/Rec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00361">
        <property type="entry name" value="ComEC_Rec2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="441"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="677" mass="76679" checksum="D7FCC5BB8288AB16" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSI8</accession>
    <name>A0A328QSI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3286"/>
            <end position="3406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3564"/>
            <end position="3591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3627"/>
            <end position="3703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="3940" mass="438868" checksum="97F921BCEA02402B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSQ1</accession>
    <name>A0A328QSQ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="461" mass="52084" checksum="AB28E7A2A8AF844E" modified="2018-10-10" version="1">MSIGKHSSEVNQQRKRTSPTFDSSQMNSLLKASTLPRSYSPEQTKLQESHQSLQVPSAVLMINQGEVQMESYTGSYNADTQFELASLTKQFTAMAILTLFNQKKLDISTSLSELKDGSGQSFLANLPNASKVTVQHLLEMASGYPQIPHDDKHPMTRRELLETINKKLHDASKEIKEPGNYEYNNINYYLLTIILERLSNQTYDDYLQTTFFKHLGMTKTSTKQSQPFAHPLMIGETKTFSKLDHQKYPRHHEDVLSGAGALKSTPNDLAIWTTELQKALMEQSSILPDVPIQEKNTSVMYGLFNVNKSTGNFEAAGSITNQVQSHIKASSNGIIIAISPQFNIMSNKLIEQAERISSTKIDPQTPLEYHMDTIQMEFDVAKDLGDLSITSKTIDHYLFCLNHIKMSNDEKNQFINHCLNIYNKTLQKLGNLPGNHQELINTIDQVTDKNKKEQLNTIFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSQ6</accession>
    <name>A0A328QSQ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exodeoxyribonuclease VII large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xseA</name>
        <name evidence="7" type="ORF">DID73_00020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="6">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="5">
        <location>
            <begin position="125"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="380" mass="42625" checksum="36999AC12D3E3D69" modified="2018-10-10" version="1">MNHLHLTVSEFNQILADIIHHQLQLNKLCISGEITQFNYYGDKKHLYLTLSHEGAHLQCVIYNQHLKNIPVINKGDQCEIIGQCKYLKNKGQLIFSGVNVLLNGKGKKQHAFSKQLNKFKETGKFAQKTEAMIPRIIEKVCIITSNQSAAHHDIMSILTKTEHTFESMLIPSSVQGLLAPSELQQALSIAESLSPDLICITRGGGAEQDFDCFFDETLANQICESNIPIITGIGHEINTTLSCLCANKNFETPTAMIQWLANHSITPVKVIMNDLAILKQELEFNAQNIKSLIQQLKETASITINDNHSKLIKSIEHLNQQIVEANPIAKLNNGFIYCETNNKLPIKTVQQLKKNDTIYMTLANGKAEARINHVHKKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSR6</accession>
    <name>A0A328QSR6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1752"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1753"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1845"/>
            <end position="1859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1879" mass="204323" checksum="065C285691F31AD1" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSS3</accession>
    <name>A0A328QSS3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_02540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000014">
        <property type="protein sequence ID" value="RAP23057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="133"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="372" mass="41468" checksum="E46741E102ACE006" modified="2018-10-10" version="1">MGHDSGAHLMYIPLSILPFIIFNHGEQKWLKWVSYICIYVSLSIVTIIQHTMPELAISLPPQSMKIIYYIAFSTTFCLVIPQIVVFYQAELNAKDLLKSANDQLSSTLVKLKESRDAQVMLTQHSDYAKLVQSIAHEFKNPLQMLQGTAEIGLLKDESNKELFGTIISSVERLNNVIQPLLLYLNKKTQYSFEAINLEKVVEEIMVLSKANCKAKSIQLSFDNQAENSEIMGDAQFIGQVIINLITNAIQAIPNQGGAITIQLLEDPMMLNNDTIPAVKMNITDNGCGIPEGKINSIFMPYESDHSSENNLGLGLSIVAKIVKDHQGLIKVSSSEGAGTTISVWFQMAKKEDIQENTESEDIFQLDDSFFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSU3</accession>
    <name>A0A328QSU3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="117" mass="13384" checksum="7BFE4F36C3FB2072" modified="2018-10-10" version="1">MSQYIEEFEKKQLVENDYPQVGVGDTVVVHKQISEGKKTRIQRFQGLIIKKTGQHSRESITLRKIVDGVGVEKSFFICSPLVKNIEVVTKGKGRRARLNYLRDRKGKAALRVKNIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSX7</accession>
    <name>A0A328QSX7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="367" mass="39034" checksum="7EB60FC6BA497238" modified="2018-10-10" version="1">MDANLNPVRKPSTSAQTQKAEQATGKGAAKKTTSAHKSQVKACLSKLSQMRFPTNISFRIPQTLKETGAAVLKRGQNMLDRAFSKSTKAEINQTAEQAKKLLVNLQKGMRQKVDQGAQSMSEKMGQGAKSMRQFASQVNVNARAFASEAKAAGAEMLGKATTAGSGMLDKAKQRVAGALPETMKDQMMAMKEEFQHLKNMSPEDRQAMLNNMLDAHDDFVGKVDQWMDGLANSAQDWMTTLKSDVITWVDSQRAPAQVSDATLKELSSVADSIKGVGNKIDLKGVMVGNRHMISPDDSTGGLIGTDMGQEVVNDVVDVIEGGVEVVGDALDLAEGVLDAAKNVAETGHAVANGAQGGVEILKCLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSZ0</accession>
    <name>A0A328QSZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1141" mass="127817" checksum="4707845A819BD950" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSZ9</accession>
    <name>A0A328QSZ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP25033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="62" mass="7328" checksum="BFD415F125F8E322" modified="2018-10-10" version="1">MAIEFYNVKKRKKVQIDESNIEKVEYKRDTTKGTQIRYAFKAQDDDGTNLTKFCSKADYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTF6</accession>
    <name>A0A328QTF6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TIGR01777 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_02020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="3">
        <location>
            <begin position="11"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="4">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP23966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="450" mass="51164" checksum="E55D081887212A18" modified="2018-10-10" version="1">MKISHASTVLAPAEFIYDWHTREGAFERLTPPWENVEMLGFDGAFEHRSVHLKVKRFGVPLYWTSHHKEVIPGRQFVDEQVKGPFKYWRHAHVFQPLADDRTKLMDDIEFKLPLSLISHLVGGKPIKKDIARLLMYRQAIIKHDLQLQYALPLEPQVIAITGASGLIGSHLVPFLTAAGHTVKRLVRKKRPDWTYELCWDPEVGILDDFSDVTMIIHLAGESIASPLRWNDQKKNRISRSRIRSTQALVQQLRDIPNKVSTFVCASAIGIYPSSQQLMMEDSPHGDRFLSRVVSEWEAECDPIRDKIRVCNARFGTVLHPDGGIIKRLKPLMSLGVLGRIADGDQYMSWVSLDDALRAIYVMLANQTVSGPVNVVSPHAQHQHDWIKEWAKSAFRPSVAPLPKTVVEDVMGEMGEELLLQSQRVSPKKLKDLNFQFQCNSMTDVCKLYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTG1</accession>
    <name>A0A328QTG1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1765"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1839"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1765"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1861"/>
            <end position="1887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1911" mass="206384" checksum="715B280A79007C1A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTJ4</accession>
    <name>A0A328QTJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="100" mass="11678" checksum="B22A1BE5E9747DFE" modified="2018-10-10" version="1">MQKIIRSNQPNVVHEGRLPRQVQLSRHKRVTPPRLSRSVNGLPLNSTQYWVKTINYQLDETGVNIRRNPQGQPVLETTWTYTRGLWRPGCTCVDLRDPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTK4</accession>
    <name>A0A328QTK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mur_ligase_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="78"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="378" mass="41666" checksum="E0EBF748A5CEFDBF" modified="2018-10-10" version="1">MNKVGVLGDGITAKAVRRFLDQSPDHCVSSVDGADFIVTSPGIPPREWPETATEIISDIEFAYRILKAQKKSPTIIGVTGTNGKTTVTAGIAHALEKTPYGNIGTPLITEVNDILDDDIVVIELSSFQLFSSPTLYCNIAIIMNIESDHLDWHGSFENYKAAKGNLIKIDGGQSIYVPQNLRGDIHGEEVKEIEQLPVPGWRQFCGQHNEWNAAIILDVLKSLGQSVDEINRIMDQFKLPPFRCESVFSNDDLTIINDSKATNMAATLAAVNSFSGEKLLILCGEPKSDYSKEWMLGILKECHTVYAAGYLNNHKDVFPSEMLEKVTFFSNLKDATSSAIKTTQKGTILFSPSGASFDEFDNYLARGEAFNQYVKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTL3</accession>
    <name>A0A328QTL3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LPS export ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lptB</name>
        <name evidence="5" type="ORF">DID73_01825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="242" mass="26785" checksum="D13DCACA2EB07CCC" modified="2018-10-10" version="1">MKEIRTESIVKQYKGRTVVKGASLHVSEGEVIGLLGPNGAGKTTTFYMIVGLVRPNSGKVYLNGKDVTVLPMYKRARLGLGYLPQEPSIFKKLTVEDNLRLLLEVVEPIPPDQFESRINELIMDLGLNHVRKSKGYQLSGGEKRRVEIARSLSLNPSFILLDEPFAGVDPIAVNEIQGIIKSLKDKGIGIIITDHNVRETLAITDRSYIIHEGEILLSGNPNEIANSDIAKKYYLGESFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTP8</accession>
    <name>A0A328QTP8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP25035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="136" mass="15170" checksum="7150A6EAB139BA05" modified="2018-10-10" version="1">MGAVSRPPIFPFQLPQIQLPQIQLPEPDLINRIVDESTTIVNQLLDEINHSANNIIQSQIQLPEPDLGKQIVNEPTTVAKKLLGEINDPANNMPQVLLTTIEMPQASQLPTIELTVRTNQPNGCCCLPRCMTLWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTT8</accession>
    <name>A0A328QTT8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="1">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="123" mass="13362" checksum="2FA432639833EC97" modified="2018-10-10" version="1">MTTQQQDRTILPLDMTSIIGLLQPTGGGFAPLHYDITQPSPETTEIHVNIQQCNPESIAINVTPHSVSISADASFTFQESQEKDGIDLKRHVDTHIPMAPGVDVSGIRSQLTDDTLILTIPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTU1</accession>
    <name>A0A328QTU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">nth</name>
        <name evidence="12" type="ORF">DID73_01695</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP24106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="217" mass="24274" checksum="596B025CC1FC6224" modified="2018-10-10" version="1">MPESIKESIKRSVSIFDVLKSTYPPVTTFLTHKNDFELLIAVILSAQCTDARVNMVTPALFDHLPTPQAFVDAELDDIKELIKSINFFNNKAKNIQATAQVLLEVYNGQVPADLNKLVELPGVGRKTANVVLGQAFDIPGITVDTHVKRLSQRLGFTKNDDAVKAEMDLIKRWPEEIWIDMSSLLILHGRQICNARKPKCQECSISSLCPSFPIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTW8</accession>
    <name>A0A328QTW8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">DID73_01550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="427" mass="48917" checksum="009107CA37CC62A6" modified="2018-10-10" version="1">MTDMSFSIPRGTQDILPEDIKKWHLIEETARNLFSTYNFSEIRTPIFENTDVFARGVGENSDLFNKEMYTFEDKGGRSLTLRPEGTAAVTRSNIMHSLYKRMNPLKLYYIGPFFRYERPQAGRYRQFHQVGVEYVGESSSYADAEVIALGYHLFESLGITDLKVHINSVGCNVARPVIEEMVKQFLSSNLSKLPQYIQDKFNENPLRILDSKDESVQAYIAGMPDIKEALTQESKDHFFSVLQHLDEMKIPYQVTNTLVRGLEYYTETVFEIVSDHLGAQSTVCGGGRYNNLTKELGGPSLPAFGFGFGIERTVMLLDHIKKEFSMSIDVYFIPLDTLSRDILFYTMNRLRGYNISCEIGYTDQLKSQLKKANKLNAKRVVIIGEDERESKQAQYKDMMNRSQELVPYDQLVDIIVNDFAVNELSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTY7</accession>
    <name>A0A328QTY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_02400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="276" mass="31054" checksum="59EF671E585E1B3E" modified="2018-10-10" version="1">MDKKNRGNEKLSVTAIQLSSGEDVQKNLDEVNSQVDQLEESPNILVLPEVFNYRTESNHEDPYSEELDGKSIQFLKQLAKGRGMHIIGGSITETGPNNKAYNTTVVINDSGQVIGTYRKMHLFDVSLGGKSIRESNRYMSGNQPEIVDILGWKVGLSICYDLRFPELFRWYFKAGVDMVVIPSSFTYETGKKHWHILCQARAIENQCYVIAPNQCGIGANNTNTFGHSLIINPMGEIMAEADDASNMSISAHLIKSSLDNIRRQFPIQEHQRKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QU47</accession>
    <name>A0A328QU47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2721 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021279">
        <property type="entry name" value="DUF2721"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11026">
        <property type="entry name" value="DUF2721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="131" mass="14781" checksum="908671E94FD22C62" modified="2018-10-10" version="1">MQINITTPAILFPAITLLMLAYTNRFLALSQLIRSLHKEYKENQSLNILKQIQHLKYRILLIRFMQAFGALSILVCALSISFIFFGVDQIGAVLFFCSVILFILSVISSFIEIVLSTKALAVLLSDIENKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QUP7</accession>
    <name>A0A328QUP7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folP</name>
        <name evidence="2" type="ORF">DID73_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="254" mass="27437" checksum="71416CC949B7B17F" modified="2018-10-10" version="1">MMGIVNLSPDSFYDGGTSSDALSQQIDEFNAANVDIIDIGAESSRPGSSPISSNDEINRLRDGLAHISSHSPALISVDTYKAATADFALSNGATIINDITGGESDDLLRVVQQHNASIVLMHKQGSPDTMQNAPHYTHVIDDVKSYLSNQIDKARSFGITSIIVDPGIGFGKTLEHNLLLLKHLNEFQSLGCPILIGTSNKSFIGHLTNADVHERVPGSIASALATYEKGARIFRVHNVKETQQAFQVYRAIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVG5</accession>
    <name>A0A328QVG5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purD</name>
        <name evidence="10" type="ORF">DID73_01255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="430" mass="46363" checksum="2DB71269107F47D2" modified="2018-10-10" version="1">MKILLIGSGGREHAIAYRLSVSSKCQELYIAPGNPGTFQCGTNVDIPADDVPSLLNFAKDTGIDLTFVGPEQPLALGIVDAFQAEGLVIVGPNKEAAQLESSKAWAKAKYEEYGIPTAAYQECHDYDSALAYIQQKDTYPIVIKADGLAAGKGVTIAQSLDDAKKALSDCFVDQVFKDAGDCVVIEDFLQGEEASLFAFTDGTTVLPMISAQDHKAIFDGDKGPNTGGMGAYSPAPIFTSDVQQKVMDRILTPLVEGFQRDGITYKGILYAGLMIDDQGDPYVVEFNIRFGDPETQIVLPKLTTDLLDVLIAISEDRLNEISLDWNDGYSVCVVMAAKGYPGSYDKGQVITGINDSSDPQSFVFHAGTKQTDSGEFVTNGGRVLNVCADGDSLDDAISSAYQRCKRIQFDGAYYRRDIGQKGLARLKQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVM9</accession>
    <name>A0A328QVM9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000016">
        <property type="protein sequence ID" value="RAP22840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016460706" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP22840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="80" mass="9254" checksum="A785E29C2311D6D2" modified="2018-10-10" version="1" fragment="single">MISRLVLISIFILNSIAFSQTKSTQLDLDNLTPEQITMGQQFFDKSSKKNRATKNSRRKPIVNQKKVQLKQNNKSNILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVP0</accession>
    <name>A0A328QVP0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="550" mass="63249" checksum="F65EE77AF199844C" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVR7</accession>
    <name>A0A328QVR7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000015">
        <property type="protein sequence ID" value="RAP22880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="143"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP22880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="409" mass="45943" checksum="72558D27F97DDA00" modified="2018-10-10" version="1">MTKKNIKFSKMKFIQLINQVINLNEVSIIHYVNEDNHRHTLIAHSPHQTIHQTNPNENPTVTLQQSLKKNDTIWVIATSYEWGCNQLGLPTPHTNAVFIEYNNYLIFNHHTELATQTGMPLPERNHFESTPPSIPSLSPLWNESDFSNAISSAQHAIKEGDIYQINLSYPATIQTNHSIQDLYQHTQSLNQSRHGALIQTNHWGIASASPEELFYLKNGRIRTRPIKGTIGRHDDPIDDQLALNTLKNSTKDHAELVMITDLMRNDLSQFSETGSVQTTKLCDLVAFPYVYHLVSTVEAIVPTTTSPLDILKKLAPGGSITGCPKISACKQISGIEHHPREFYTGHIGFISSTGEASFNVAIRTCYQLNQNPIMTHAGCGITIDSNPIQEYQESIDKFRFLTNKVIVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVU2</accession>
    <name>A0A328QVU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_00680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="219" mass="23850" checksum="5E9C08775644EF9E" modified="2018-10-10" version="1">MIQLNDIHKTYQGPNGNIDIIKGISLSIAPKSSIAITGPSGSGKSTLLRILAGLDEPTKGRVILNNQNIYDLDDDERAQIRSQTFGFIFQSFRLFPALTVLENVSLSVDIKGDLNSTDIAKEWLNHVGLSDRYSHLPEALSGGERQRVAIARALAPSPSIIVADEPTGNLDQKNSDSLQTLLNDCIEKSNAALVLVTHDSQLATMCETRHELSNGQLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVV5</accession>
    <name>A0A328QVV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021253">
        <property type="entry name" value="DUF2796"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10986">
        <property type="entry name" value="DUF2796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="216" mass="24872" checksum="F4A9399CD4FD0341" modified="2018-10-10" version="1">MFNIKHLIMKNQLITVILLAIVGTLPLQATQDIHVHGKGAVNIVLNKNKIAIELKIPAMSLVGFEHPPSTKAEKKAIELAKKKLQKTQLFSFYKTNGVFKKRSNLNLAPSKKIVELHRDKKNHDDHDDHKKESHSDHDTHHNHHEKQHKKHQAHSEKNEHSEFHIVLEYTKSNDISIISTTLFEHFDDIHDLNVNIISDNNQTNQVLNKHKNQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVV9</accession>
    <name>A0A328QVV9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="119" mass="13645" checksum="2255527AE76D0D81" modified="2018-10-10" version="1">MPPPKKVVEEFNIINFHLTAYPCSMYVFTGTCWQCNHLFEINTNVTLLIDFNTPCPSCFNFCQLNSLMVQAFLSRPTINSAPLNPRPFSIPQSLMPIVPRLMYSYGDFLASLLFLEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVX6</accession>
    <name>A0A328QVX6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="217" mass="23825" checksum="11C28AB9EC19F778" modified="2018-10-10" version="1">MLKIITIPVTLYEQNARILIDDSSKEAVIVDPGGDVPNILAQLPNDVTLKAIWITHSHIDHVSGVGALLNEFDQGSIDVVAHAEDKINRENLPLQSQMMQFPYSGEFDTTQDCGHEDVLSLGQYNFKVLHTPGHAIGHVSFYCDNMTNEFNVPICIAGDALFRGSIGRTDLPGGNHQQLLDSIQTQLFVLPENTLVFSGHGPNTTIGEEKESNPFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVY1</accession>
    <name>A0A328QVY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="239" mass="27634" checksum="431AF032A32C3B9B" modified="2018-10-10" version="1">MKKRQPNLLIIDDDPNVFEMLSPTLDFCHVQPVFSKKSLPHALKNNIDGIILDYKMKQDNGLTFIPTIKNAYPNAFIILITAYGSKKLVIEGLQNNIDDYIEKPLNLKQIKESVLGHLKTYFGDAIEELNYHSEISAIQNDLNSININSSNQNLVSYSREKKLNYKYTSRLFKEKTGKNFRSFKLEKKVKLAKELLENTPLKIAEISNRLNYMNPSAFMKMFKSETGLTPSNYRKKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVZ3</accession>
    <name>A0A328QVZ3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="242" mass="27871" checksum="DAA64BF6BD4E2300" modified="2018-10-10" version="1">MNLIILAAGKGERLYPLTRNTPKSLLDLGNGQSILEHQIEWAKSTNEIKKIIIITGYLSDQIESKIKALKKQIDIEVVYNPYYNITNNLMSLWTISNIKFDNDILISNGDNIYKSPFFKKPTDNGFYLTISKKESYDEDDMKVSLSNNLVQKVNKKIKLENTDAESIGLFQIIGEKEQAIFKKKLISCAKDEAFHQVFWLEVINELIKDGIPISTFEIEANQWSEIDYHPDINNIKQHIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW03</accession>
    <name>A0A328QW03_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M15_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_3" evidence="2">
        <location>
            <begin position="76"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="214" mass="25297" checksum="6A496005F46EB675" modified="2018-10-10" version="1">MSTEEPQKKSNRRRSRRRPNQQKDQNKDQPRNQQRSRSSQRNRRKGNQKSGQRNSKWNRHRISDHFMKRDFDSRKKDCSCGSSLRISLGLVGIIEALRAKINKRIEIVTGYYCPDCRERQYGIKRDFHHAGVAADIRVTDMPVVDLFLIAETYPELKGIGINFDDNHLHIDTRKEDDRQTWVEINDEWIELTPENRDEYIKQPVLTNESSDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW69</accession>
    <name>A0A328QW69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="929" mass="98919" checksum="1F368D7F6E1084EF" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW78</accession>
    <name>A0A328QW78_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="8" type="ORF">DID73_00135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="354" mass="38164" checksum="E39E4F4BA5C28CF0" modified="2018-10-10" version="1">MMAKDLYDVLGIQKGANEQEIKRAYRKLAREYHPDVNKSAGADDKFKEVQSAYDVLSDPQKRARYDQFGITDDQAGAGGFGGGGFEGFSGGAGFEDAFGDIFESFFGGSRGGGGGRSSGQHAGEDLRYDLTITLEEAAKGFKKNIELFYLDVKSGSTRSCSQCNGVGYVEVVQRTILGSISQRTTCPVCHGTGGIEREKKKKKIDIKIPAGVETGMKLRVSGEGNAGIGGGPRGDLFVVVTVKDHAVFHREGNDLFLEVPIPLSQVVLGATLRIPTLEGKSDLKVPSGTQPGTRFRLKGKGIKNIKGFGHGDMYVVVNVDIPTNLSKDEKACFEKISQLRDDEKRLAKVLDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWB2</accession>
    <name>A0A328QWB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">DID73_00335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="80" mass="8574" checksum="F44EEB57CAF1CCE6" modified="2018-10-10" version="1">MKELVDYIVRSLVDNPEFVEVNETAGSSVIILEISVGSTDIGKVIGKEGRIANAIRTIVKAAAAKSDKKVTVEILTNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWC2</accession>
    <name>A0A328QWC2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">folE</name>
        <name evidence="7" type="ORF">DID73_00635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="191" mass="21443" checksum="0FD1A28660160F97" modified="2018-10-10" version="1">MTEKPSLEDALAAVEILIRYAGDNPNREGLKETPKRVVKSYEEFFSGYAKNPDEILAKTFEEVEGYDEMVIVKNIDLESHCEHHMVPILGVAHVAYIPNNRVVGISKLARIVDVYAKRLQTQETMTAQIADTISRVLEPKGVAVVIDAAHQCMSTRGVHKRHSSTVTSRMLGLFRSDPRTRSEFMDLIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWD0</accession>
    <name>A0A328QWD0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="485" mass="54669" checksum="91E0768D78502672" modified="2018-10-10" version="1">MSFEDHDKTIEDIVKKDYEFGFQTDIEIEKFPKGLNEDIIRRISEKKKEPEYMLEYRLKAYKHWLTMEEPHWSLSEYPEIDYQDLHYFAAPKSMEEKPKSLDDIDPELKRTFDKLGIPLLEQKQLAGVAVDAVFDSVSVATTYKEKLKEHGVIFCSISEAIIDYPELIKKYLGSVVPHTDNFFASLNAAVFTDGSFVYVPKGVTCPMELSTYFRINEENTGQFERTLIICEENAYVSYLEGCTAPKFDSNQLHAAVVELVVLDDAEIKYSTVQNWYPGDKETGKGGIYNFVTKRGKCLGERSKISWTQIETGSAITWKYPSCILIGKESIGEFYSVALTNHFQQADTGTKMIHIGENTKSTIISKGISAGKSNNTYRGLVQANKSAKNARNYTQCDSMLIGDICSANTIPYITIKNKTAVCEHEASTSKVGEDQLFYLMSRGISLDDALATIVSGFCQDVFDKLPDEFALEANQLLSVQLEHSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWE2</accession>
    <name>A0A328QWE2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016341561" evidence="1">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="265" mass="29917" checksum="9F73FF0C6A23A397" modified="2018-10-10" version="1">MRKTIITLLIFISPLFAADSLYSDDIQEAVDLEKQQLQEAYDYSEDTTKKNQSISYFLDNYMTSIFTLSQLTSGLAHITDESKIYSDINRLDRICMELTQLLDGQSINFKFKPVGTLSKIQSYYQQTLYKLHVISPYMPTLLDADQKKASYYVEYIYRITNQIQSNIQKMIAIKQQLNQGTQSPLPFSPQTPQQLSFALENQLSSSLINMINSDSGPAESGMPFSSLSTPANADMFNQSAVPQGLPNVPSPNASPLQMMNYMPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWE4</accession>
    <name>A0A328QWE4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="105" mass="12122" checksum="043B31F20F217F31" modified="2018-10-10" version="1">MDSQDHVKLNRLSGNYIAAVNEILKLSDHNRTPYLLDLAFIKLTYQQYEESLTFFLTYLSRTKPKTLNKMGQFIASQLFTVFPDSTPLNQITHYYLCDAPPKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWG8</accession>
    <name>A0A328QWG8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YscJ_FliF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_02580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000016">
        <property type="protein sequence ID" value="RAP22842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="4">
        <location>
            <begin position="137"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP22842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="594" mass="65734" checksum="3F79B6F4ECAE3683" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWK0</accession>
    <name>A0A328QWK0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="332" mass="37598" checksum="275BFD7C9B261AB9" modified="2018-10-10" version="1">MRLIVLNQLSVKSRTFLVRLFISIFLISVVGIMLLLRAMYYMPVYYEDDWLESDTTIDPAIHDVQLRVSTRLLSPTQEQKQQPVCVLVHGFSASSFELEAFKASILAKDPTVLFSTIVMGGHGRSYDAFKSASYHDWIQPIIDEVSTLNDQGFQDIRLFGVSAGAAGIVHLILNGELKHTPIRQVVLMDPYILPTNKTLYLVPVLKYVITNTRLEDIRSIGTQNWYTNRPASALHELLKLVKSVQHDLTTYDGKIVPPMTIYTANNDPTADTKGVDMVLDALGSDVVTIKRYDSDRHVIIEPTSKDDWAEKDQAHYDRIIDEIYGLIQLDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWY8</accession>
    <name>A0A328QWY8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proton_antipo_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_02050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="133"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="462" mass="51870" checksum="9A2512DE768DD4B2" modified="2018-10-10" version="1" fragment="single">MITQAPFLVVGIPLFTALIMGMFGLMFPSLVTLIGFIGISFASISAIVLFNNVSLNGVQEYFFGNWPAPIGIEYSVDHLNALMILLIYVVAFFAYIYSLKSVPLEINKSKHSFYYTLYFLLITGLVGITITGDAFNLYVLFEICALSSYALLASGGKRTYLATFYYLLIGSIGACFYLIGVAYLFIKTGSLNMAHLLELIPPIYFTKSVLVAFIFINLGLFIKMALFPVHSWMPNVYTKAPISTTCLLAPLGTKLTIYILIRFYFDIFTPEYVYQVLNIQNFMVWLSTIAIIVGSLYAIFHTSYRKIIAFIVVAEIGYIVGGVWSGHPDSLMAAIYHIVADSLMTLSLFMIGGMILFYIKSERVSDCSNIFRRLPFTAVALIIVFASIVGIPPTSGFFTKMYLIKGAFQMGYYQFIVALIFSSLASLFIFFRLFESYFFNKSEEYGVTTRIKESRLLTIPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QX07</accession>
    <name>A0A328QX07_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycos_trans_3N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_02155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="3">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="458" mass="51384" checksum="8C145DBE69737926" modified="2018-10-10" version="1">MPIHFFIFLFFLLFLTISDFLLVKMPIFLNTIDMSNIEQFKKILKGKGTGKTMSKHMALDDISFVLSHFNSPDIPMAMKATLLTAWLMLDATDEEAVALNQLKNNINDILPNDLHFLFNKGSSLLIDQQVSMLLNHQSLSRKDLMECLSTFHSGDVPDYKIAALLEGLRLKEETFEENSAVYDFFKSKAKSVNLNIPLIIDMATPYDGFNRHYFLQPFLAALLASIGIPSILHGVQTVSPKNGMNTHKLFLNAGKHPLKSLDNVAKDILDPTIGWGYIDQSIFCPPLHDLIPTRIAMVKRPVLATIEKWLQPISANRTVCLTGFTHPPYKQKTIDMVHHAGIYDDLMLIRGVEGSTLLPYDRRAPFIISHNNQEPTFDFISPTDVSHEPCDLGEQNPDETLIKGIDALTGNNQQLSDYLCYQALAIGTVIGHDINKMTNDLMASIDSGKALSHWENIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXB5</accession>
    <name>A0A328QXB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="334" mass="37693" checksum="EE84CD0EC39AEBD4" modified="2018-10-10" version="1">MRNLSSVWDRIPMCFNRQKTNTDQSMILKSPQTIFSGGICLFILCFVLALSSSILAAKKINIVTVNDDFASIASSVGKDLVNVQSLVHGSKNMHDINPKPSMVMKVKKADLIIRLGMSQDSWVDGLIQVARNPNLFSNQNGYLDASKNINKLEVPTEDIDGSQGDIHKEGNPHYWLNPMNGIIIAKDIRDHLVVIDPKNKSFYDQNFNEFSKKITDKMNIWKQEMAKVEKAEFVTYHKVWAYFFEAFELSDAGTLELFPGVPPTIKHLKHLKDNLVNQNQDVIILTANFYPKNIGESFSKDVNAKFRHISTNVGEGGISSYTDLFDYLVAEITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXD6</accession>
    <name>A0A328QXD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="128" mass="14860" checksum="2AD1B6E285E6A91A" modified="2018-10-10" version="1">MFKTVAVAQRIDLSINNYNVCWNELTKDVRNKISKKTNEAYNRVPGWSPYYPEWVINAIDVIINNRKTNCEDMDITFSRLKITESFKVCVIDGGVKNTEDKRYFSIFGVTFTERNGLDFDTFIVPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXH0</accession>
    <name>A0A328QXH0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="295" mass="35168" checksum="E3DA208987B79179" modified="2018-10-10" version="1" fragment="single">MNITILNKLFKVLLFIGVSSLLFLFYKNKANAAFYLDYLSVYGYFISLSIGATFLILLMNLTRAGWGVVIKRVPEHIMSLLPIYALLFIPILFGLDFIFEWLDPSHIEHDPLIQQKLPYLNLPFFVARNIIYFIVFSVISTYYWKNSIRQDNSNKDDAILIAKNLQRRSPIALLLMSLITSFASFDWLMSLYPHWFSTIFGIYYFSGCMVFIFSVTILVYEILLRYKVIENYPNTEHFHDLSKLLYGFIIFWSYVSFSQYFLTWYANIPEFTQWYYPRIHGEWKILFYMLIIFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXU2</accession>
    <name>A0A328QXU2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="280" mass="32480" checksum="16C5F806847A9749" modified="2018-10-10" version="1">MIDAMVLAWFIFGVFGTVLRCVKFRQPISFRFQIFILLYCGIPFLIPFTFKAIGIVAIFIPFLIHRYFYNSPYLNLFSLFGLWLPFEMGLLSVSFKSSLPVDYAIILLTFFSTFISFSHSRSLTLFLASFRMSLSDLKVAIKIYVLLLLIIIPLGHFTGFLSFQFFEPSIMFFVQTIVVGYFLYALPEELLFRFLMFDFFRPFFASDRAQWFITSVIFGLAHINNRTADMVGYNWSYVLLSTIAGLGYGFVYMRTKKVSASALTHALINMIWGMFFNSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY00</accession>
    <name>A0A328QY00_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="7" type="ORF">DID73_00965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="540" mass="60125" checksum="E1E65872A25E0317" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY05</accession>
    <name>A0A328QY05_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="381" mass="43865" checksum="B7D028A9CB96CA1B" modified="2018-10-10" version="1">MHKFIAYNPETRKIQFENNQFEIEQNPFDKGKSARVFNLIGTTKLIAHIDTDSDPNNIPFRAGVILGLIMSSNQLNVNAGELLDNEEGTLTIRKRYEGISTGNIIYKPKTEEIAIEAERVTQELNKLTANEKRTLLFKWFDQIIDQCKLLNDQGIHLNDITPDNIILNFEEKTVRLVDTGNATHKDTLLKVYECTGERFYTIQQAPKKPSLSSDITAGFISLTKILYPEITTINFYKIVFVSKKRTRKMCIKWKDFIQALSTIDPQIIVSLQAYERILPKSRYMQQKKTLKFTETAQEKTEYPYEYTLRTNNKLKDLIRIQHIFAINGMATITKIEADQVRGELTIKSKRDIRHTLNGYISPSPQQQTQAITNKKGCCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY15</accession>
    <name>A0A328QY15_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="248" mass="26696" checksum="5E16C87417B6026A" modified="2018-10-10" version="1">MQQRKYYSWLIGGLVLTQSIFGSDEGLVNQMKRLTYQEIKGINHEVSETIHQHAEKTGYIDFAPIGGHGGVIVIQPSSAINDVNQTKSGGIKHLSGGSGGFIINLAPEWGIGATFGSVSGFTSKKVNGHFHETLVLNQFSMLTVQYKPLITERVIIDIEAGLGASMAGVKNEITDETAPSLSSIRHNTGLAYQLGVGIRYRISSLFFVGISSGYFNGSVNNIKRGNHSDATDLTIEGSYARISLGGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY23</accession>
    <name>A0A328QY23_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_01985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="167" mass="19141" checksum="89F7256F3DB60F30" modified="2018-10-10" version="1">MYYFLAVFGWPIPTSNQLSQNEFMMGAICNLFVSFLLIYRHYRHQSNASLANGLIIALFNGGIIVGVCWWMGMLAFIMNLFFFIISILMPVSCVIAIALSKRQPSAIAKQTQLTEREKEVMHLVQQGLSNKQIADQLFISESTVKSHLKQIFKQLNITSRFQLIRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY58</accession>
    <name>A0A328QY58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003832">
        <property type="entry name" value="DUF212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31446">
        <property type="entry name" value="PTHR31446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02681">
        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="145" mass="15658" checksum="FB807103B4F2CC1D" modified="2018-10-10" version="1">MLNDILFNFFPLIASLSSMTISQSIKLLCMILTGKKINLVSLTRSGGMPSSHSALITAITLSIGLKNGFSSSHFFLSVVLSLVVIYDARGIRHTVGNHAQILNNSVLSTTEKKLNEHVGHTFPEIIAGISIGIIVSLAMYNVINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY87</accession>
    <name>A0A328QY87_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_00240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="647" mass="71688" checksum="EC56E33FE0B06D91" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYB9</accession>
    <name>A0A328QYB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_01560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="8"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="397" mass="42973" checksum="C10606F98E894977" modified="2018-10-10" version="1">MNILLLFGVTLFITILTSFLFIRLRLPQVIGYILAGIVLGISGFQLFDAHDVQSLTMVTYFALGMIGFTIGGELRWARIKRFGASILIITFFESSFSCLAVFFAVYLLTFNLPLALLLGGLACATAPGGTTNVIQEYKARGQLTSTLYGVVGADDAFAIIIFAFLSGISKVLIGASESINALSMLAHIISDIGGAFLLGLILGGIVSTWMLYVRSSDVRHLITLTSILICTGLSVAFNVSLILSTMVMGIVVGNIRPHRSRSCFVSLHAISTPLYMLFFVLIGARLDYKLLLTMGSVGMIYFIFRLFGKYFGAFTGSYIANVPDKVRKNIGLCLFSQAGVAIGLALSTDIEFSKYNLEAQQLGASIVTIVTASTLIFQIIGPIMTKYALFKAKETHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYD6</accession>
    <name>A0A328QYD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="149"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="335" mass="38354" checksum="97D47AE93E2B7302" modified="2018-10-10" version="1">MNKLKIHVIAEKFVGEANGVTTAILELIDSLKKDSFYDLQENPKNAEVVHAHTIGLDYVRQSFRFKKKMIVHAHVVPDSYLGSLIFAELWRPFAKMYLKFCYNRSKEVIAVSPFVKIELERIGVKSKIHVLCNAVDRQKFKQDDTLRAKFREKLNLTNEFVVTCVGQIQPRKGIYDFIETAEKCPNVTFIWVGGTPFKALTAEYKKLQEVVKQAPKNIIFTGIVDFEDMPGYYAASDAFFMPSFQENFAFATIEASSVKLPLILRDNVEYPSSLFTHYLKGKTADDFAAIVKQLSEDSEYLSKWQNESETLASKYSLKAYMQQLKEIYLGVLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYE1</accession>
    <name>A0A328QYE1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpS</name>
        <name evidence="9" type="ORF">DID73_02110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP23562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="334" mass="37797" checksum="61E447BA50420F0C" modified="2018-10-10" version="1">MASNIILTGIKPTGEPHLGNYLGAIQPAVEMAKKNPNEKKYFFIADYHALTTIKDPQKMMEYRYQVAATWMAFFSGIDNCYFYFQSQIPEIFELYWILSCFCPKGLLNRAHAYKAIVAKNSENGHDQDRQINQGIFSYPVLMAADILLFHATKIPIGPDQKQHVEIAIEIVKSLNNILTNKIPVPEPMIDKANDIIIGIDGQKMSKNYNNTLPLFANEGDLKKRIGKIQTDSTPLGEPLQPDGCNVFKLFSYISSTSRQDELKKEYLSGDIGYGHAKQYLLEAYQTYFEAPKKQFDVFMCDKSTLDNRLKRSSKEVTAIAKGHLEDIKKALGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYF0</accession>
    <name>A0A328QYF0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="240" mass="25906" checksum="C80B1B7BB77B23EA" modified="2018-10-10" version="1">MKTANPALNAKIFNQVRQADTTTGMTIQGTVNKTYISLGILILAATFTWSNPSPGLMLLGGIGGFITAIITAFKKEWAPTTTPIYAALQGLLLGGISVMFNQQYPGIVIQAVYLTFGTLFALLCAYASGKIRVTENFKLGLIAATGGIFIFYMINFILGLFGMGITSVYGNGIIGIGFSAVVVVIAALNLVLDFDFIEQGAQQGAPKYMEWYGAFGLMVTLIWLYIEILRLLAKLQSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYZ3</accession>
    <name>A0A328QYZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="316" mass="35161" checksum="1C5811E75AECB0C1" modified="2018-10-10" version="1">MLKVAVIGCGNMGQHHAKAYTVLDQVQFVAACDSNIERFEAITKEESTTYYSTVDEMLENEPIDAVSICVPTSQHYNVAKVCIDRGIAVLVEKPIAESVKEAKALVQYAKEKQVVLTVGHIERFNPAILKAKEYINDGKLGQIHAIQCKRYGPFPKQIKDADVLVDVAVHDIDIVQFLVDSNLVSTDVYTHNIHCDDRADYGHLMLQFESKLMVNIHVSWALPFKHREVEIVGDKGIAIIDCIQQSMTYYEVDVEKGPDFVSLPLTDPQAVTIDKKEPIIEECRAFSNAVINNTAPFICPEQATEALSLALCTPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZK4</accession>
    <name>A0A328QZK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="464" mass="54542" checksum="F6A403F0371E4A85" modified="2018-10-10" version="1">MGERMYIFYDFETSQKDFLGQILSYYLVLMDERFNPMKECDGLIQPNRLELPACGAIQVNKLSINECITHGLTEFEAANKIYTFLQGCTNDHGHVPLVGFNSARFDFKHIEKLLLKHGLSPTFYGKISSLDIYQFSKYCALNHTETFPFIRKKRQETDSFSFRLEDLANAFGCLKEAQTHDAKDDVLLTIELTKQLETKFEISLKSFYTMQHDVQTFNTSNHYLKEPVFQFEQPSDTPIIHYNEWLVIGKASKSTFILLDINAYEREPKDNFNDYSTMTKYVNTRANAILCSTHQQTDQHKAILKDPNIQKIAENALQYFKLFPVDWDIEYRPWAMGFEFIQTLREYIERLQTNPAEYEAIISEWKQLRKRTTNRAQELNFMITLFNRFYLNHHPSPNPKHIQKYIEPRYVTGSMHRNIMDQISPETEKNTIEFHLTSAEPGSRDHTVLSELNDYTKQFIGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZL8</accession>
    <name>A0A328QZL8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="679" mass="77465" checksum="F62DB3339678E5B4" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZP2</accession>
    <name>A0A328QZP2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="67" mass="7171" checksum="03D3303E881372B4" modified="2018-10-10" version="1" fragment="single">SYEPMGDIQVIPGSPLTNVTVPLPLIPNVIDELPILSILATASNGVFQVRGAKELRVKESDRIDGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZU0</accession>
    <name>A0A328QZU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide oxidoreductase DCC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="135" mass="15716" checksum="7EC7F8C0471E1C5F" modified="2018-10-10" version="1">MSNGSPVLFYDGVCHLCHGLVQFILKYESRPSIFFAHLQSSLAQQKLQQSLIDDLSTVVLFDPNRNKVWVKSAAIVRVLFLMGGWWRLLAAILWLIPFPIRQLGYFLVARYRYKWFGHSNECMLIDDTDRFFVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZV4</accession>
    <name>A0A328QZV4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ybeY</name>
        <name evidence="8" type="ORF">DID73_01905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="144" mass="16454" checksum="2F62AF600EA49E4A" modified="2018-10-10" version="1">MKNNAMIPNMEINNQQTTVDISLDIESYVITLCTHLGLQFDHLEITLLSKEAISKMNLEYFDLDTPTDTISFNLTPEAAITGDIYLCPDIILANATTYLSDFNEELKIVLIHSMLHLMGYTDDTPENYSHMKNTQEKIYQELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-02-10" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZY5</accession>
    <name>A0A328QZY5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="225" mass="26046" checksum="D3774F0DE5888CA2" modified="2018-10-10" version="1">MMFDKYFGFLRSHDEESIIQSLLEHSKIDSEELHILSKMLFVLMHQESGDLDSMHSQINQINDENVKIFETVSDHIIQSNFDFQKQYDLLRLQQRIDSVSGLIIATSKRIIITKNIGAEVPNDLFPFLKKLSNLVIESQETFIEAIQKFQTSRKEVIKLIHKVEEQENLVDNTRSESLEVLYHLANQNQLKMGDLASIEGIIEYYEDISDAIKAATTSLDWLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-12-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R005</accession>
    <name>A0A328R005_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_rhamnosid6H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="1">
        <location>
            <begin position="59"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="403" mass="46422" checksum="82EBFA3C0C96E4A5" modified="2018-10-10" version="1">MLDLKTLQSWELNQNSEEMDVKKMINTINKAFEISKRVLREAYNEKGINAGQTHFSDVWVRDSSFAGWGALSLGDTTIVQNFLLHTLDNMNEKGQCPLRIGQKYFLLKYIGLKGPQGPTYIEDKYVSIPMDSNALIIILFLKYINETGDQNLAGKYYYKLKQAIAWYENYLKNDLINEGPYAGWADSVKKRGHVLYSNALYFEALVSMQKIATTLGNNSDIRQFDESSKKVKDAINKTFWNGTYLNDWVDGKKTKTTLSIEGNMLAILFNITDADQTKKIINYILENNVITEFGCPVVHKNYDWNDVYPPFLFIGLKDYHNGLIWFWVSCIASIALYNSGYKEDAVELLNKISQKINRDDSVYEVYTKKGNPVKRLFYKSEEGFAWSAGLFVWAYQELFKTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R082</accession>
    <name>A0A328R082_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="215" mass="25150" checksum="7EED4BCE7C57F4A8" modified="2018-10-10" version="1">MSYLLPFRFNYFYPKFKKQPITILDVGCGNQSPTVTKKYFPQCIYHGVDRGNYNNSGRDMGLMDAYFELDLEESLLDELSDCYYDLIILSHVIEHLDNGLDVVERLSKKLKPGGHIYIEYPSLKSLQLPSADGSLHFCDDVTHKRLYHMMDIANELMSNDCMIIVAKTRRSRLRIMLSPIGFVFNLFYYLFKRKIHSMLMWDILGFAEFIIAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0B1</accession>
    <name>A0A328R0B1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016468766" evidence="2">
        <location>
            <begin position="20"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="425" mass="45727" checksum="93F57A9C51198721" modified="2018-10-10" version="1">MKKYILGLLCFLLVGCSSSDPKGSFSTTGRGTVKSFSDLPTLSCTDGSNMLIKSYKLIYETVGIDGESKVQASAAVLVPANILGGNGNATTLLYLHGTIFKRSDAPSQFTTSNITPLELAPDSACNSLVTVVPDYLGLGEDTTQMHPHSHAKSLATASVDALKAAQEFLKGELGITINKSNIIISGFSEGAYATMVTHREIQENHASDFIVKASYPLAGAYDLSDTMYNALFKSNTPYVDIMSNGQPLTGVSFVPYIILTYMRTNNITDSVSDIFISGLSDIETKYDMNTSMADITTYINNALPSGKDNILKEMINSDYNTAIDNDSNHPIRKALVENDAYKWKPETKMLIIACDGDDITPSTNATVAHNYMTNTLGSTVVSKQIVSADSHADCLMPGAQAIMTDLTNLLSPSSPMKVYSTQIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0B8</accession>
    <name>A0A328R0B8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="113" mass="12813" checksum="A55261137044239A" modified="2018-10-10" version="1">MGLSRIQYQMTTVARQPRSDKTFIGNKVNTNSIAFRNMMRKIEIIVLDTNINNKNKAEQILEIRNKFPGDKIHVDKAMRSLGSINEVLESILKKKGALSNSQSCCALIYQLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0L7</accession>
    <name>A0A328R0L7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="461" mass="53093" checksum="CDCC15F178BF701E" modified="2018-10-10" version="1">MSKKSVLLTISIWDDHVRLSLIGKTMKALDHVSFRFTLTVNDIGIRQMDSFELVYFIRTGIQQLLSRQSVMISSIGVSIMPGYIMAWDRDSCTPLTPCLVPNNSLPPHQYQEFKFSSFFSLLKDADQQSVNPNCALNLWVLSKRLKKPFAKGLMISGLDTWLNYLMSGYSDDSLIASPDIMSELTFSDNDWDDPLLQSVGFNKELFPGLGDCQELVTKNFSPLEDGIPIAYSTSTNRLISNMLRQYTNEPIACIHLSDINHMYIDNMSIQSSGSQNHWVRFSSWNSLYHSFNLTNGTPSTVDVTVDDIKDDIVVPLDPFRSYHNQTYHMLNMASFEPQNIRKLGVLQTLFLIKYLLSQYDHRSQSGHIQKLVISMSEWQPSVVQLCVDLCQIHGIDFNIAHWLDLIHVCQFSGMNVFFSQSTKQDLFKLNEQLIPTLDPLTCYSLYQEWEHWFNTLYDYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0N6</accession>
    <name>A0A328R0N6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ORF">DID73_00260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="366"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="459" mass="51161" checksum="630121E11775277A" modified="2018-10-10" version="1">MTKQQLWGGRFEKSLNPAAVDFSYSLSFDQVLLPYDVALNKAHSSALVKAGVITKKECQKLHKALDDVLKDAPNVLETLPDDEDVHSFVERLVVEKVGDLGKKMHSGKSRNDQVATDVRLYVKDKIEDINDLMHGCFKALFNFAEDHKDTVFPGFTHLQIAQPVVLGHHVLAYFEKLKRDQNRFVDAYERADFCPLGSAAMAGSNYDIDRHAVAEALGFSDITLNSMDAVSDRDFILDVLYAASMVTMHLSQFCEELIFWSSSVVGFITIGDEFTTGSSIMPQKKNPDIAELIRGQAGPVMGQFVALHEMIKGLPLTYNRDLQDDKKLLFTAMDITVSVLDCFARMIPTITVHQDRILTAMNTGHILATEIADYLAMKGVPFREAHEQVGQLVQLADDEGCQVHELTVEQLQSVASAIETDVVDRLSFKAAINQKNGIGGTAFDQITERLEQLKEAFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0S5</accession>
    <name>A0A328R0S5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="767" mass="85536" checksum="D8B768C822D85D28" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0U8</accession>
    <name>A0A328R0U8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="338" mass="38090" checksum="22CF02C5F6172977" modified="2018-10-10" version="1">MSQKKMLIIKMASLGDIIQISPVIDALSEHDDVVIDVLTFEEHRALFQHHPKIRQVIGLRRSVFSILKTTIRIIFNRYDIGFNFHRSTLLDALMFFCRIKCRFGFSSPEKTSLFLNESVSFDLNKSRHQRYLSIVKSALGGAIDASSYGLSYYKSPGAVCALPVTDAPYIVIAPYGGENRYSSMVSRVWGGYPELIQQILQDVSTHHVILTGGPSDEDNLLKLKNSFDDRVHVFVGNYDELALLLESAVCFIGNDSFPLFMAIASKCKALAIFGPTDARLIVEPYKNTYFIQSDVDCSPCYNPLEGIRNIAYNCPYDIKCMTSISIQKVFNKLKDICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R148</accession>
    <name>A0A328R148_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016330679" description="SLT domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="69"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="192" mass="21890" checksum="E11AFFB85297E4E9" modified="2018-10-10" version="1">MATVIFASAFVWFLFLSPPDSAPLQPYHPTVQKIDYESARGTKKKLVSYIKTNNPSLPDNDAKEIAYWIDEYASKEDIDPMLVAALIGRESSFNKTAVSKTGAKGLGQIKDFNFDSLDIKDPYNVKQNVRGTVKYLKHLFGMWKDSKDSTRMALASYYQGPNETKRKKNNFPDHVSNYVDDIMKKYRSLNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R170</accession>
    <name>A0A328R170_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP25010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="221" mass="25629" checksum="020F690EFFF17CDA" modified="2018-10-10" version="1">MDNLYGIEYPMIIEGGIMIKNIVFDIGNVLFGYDPTYILQQLLPENRFHDEYLTHFINSKLWQDLDRGSLDESSLVDLLMTKIPDPNLEDNLQLIIQNFIYHLHLINESRELFLTLKRIYPIYLLSNFQAVPYSKLREINPFLYQADGAIISAHHQLMKPEPEIYHKLLDKYRLIPEETVFIDDLPENIAAAKTIGMHGIVFTSADSTQTALRDLGVEFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1A2</accession>
    <name>A0A328R1A2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="2">PNP synthase</shortName>
            <ecNumber evidence="2">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdxJ</name>
        <name evidence="3" type="ORF">DID73_01380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="3-amino-2-oxopropyl phosphate binding" evidence="2">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="250" mass="27200" checksum="EC9FA1FA53E0E234" modified="2018-10-10" version="1">MVNLSVNINKIALIRNARGGDRPSVLHFAELALTAGAAGITVHPRPDQRHITAADAIELGAHLSNKHQEFNIEGNPFEGDMGTFPGFMTLVKQIRPDQCTLVPDAVDQKTSDHGWDFDRDGDRLKPIINELQSLGIRVSVFVDPVEDALNGAKACGVDCIEFYTESYAIAHANGQGSESFQIYADLAEKANQMGLIINAGHDLNLDNLPLFATLPHLKEVSIGQALVTDALEIGFELTVKAYLNCLRKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1L9</accession>
    <name>A0A328R1L9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallophos_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_01135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="307" mass="35112" checksum="65E4A8415910F086" modified="2018-10-10" version="1">MISLNLGCLIVCWILIFCVLFNVVIRLEMRFLLEFNDGAPGTVSPHLILRRVGVDGMSCWHSQSVSQQQFSKAKSDSMANICKLLIVIAKQTINDSHLFFITCILTELKFFVSFIYTRTMEILMISDTHGNRDMIESMLPVTDSVDLLVHLGDDYRDALPFIEAGFPTIRVPGTWGAEYQDPLIDNRRFEDFLGWRFFLTHTPTKDSHDLPNDMDPNLVIHDQECHVFCHGHTHEPKISKYNDVVILNPGHLKSHYDRGFDASYAKITISELICHIRIIHQQTTQVIDELKIERNQPIAASDGKETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R2A1</accession>
    <name>A0A328R2A1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name evidence="3" type="ORF">DID73_00315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="348" mass="38128" checksum="61F54A55E589906B" modified="2018-10-10" version="1">MTFVIVKEKRLYALKILTINAGILGVSGYTGQELVRLLALHPIFEISALLSTSFEGSYGDLVPEFSAVDLPMVQAYDVSKCADLDVVFLAVPHTKGMGIVHDLMTTYDSLKIVDLSADFRLSNVDQYESYYNVSHAATSLLSEAVYGLPEKHKDALSSARLCANPGCYATSMILGLLPLANHIDLKTPISMDAKSGVSGAGKGLKESSLFCEVHDQLSAYATGEHRHMAELIQEVGFTNVLFSPHLVPMHRGIESAIYIHYPDMDESSLSSLYLDFYKEHPFVTVYSSSTMPTTRLVNHTNQCAIIPKKKGEWLVIFSLLDNLIKGASGQAIQNANIMFGLDETDGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QMR1</accession>
    <name>A0A328QMR1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="8"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="178" mass="20049" checksum="38BA3AD48B5EBF00" modified="2018-10-10" version="1">MIETIEFETIDSTNETAKRLLSFGRKSSVAIISKKQTNGKGQYGRVWESSSSDGLYYSLLLKGSRFPKDLSGAENRVIVSNIQNIISLISGEKTEFKEPNDIYLDDKKLGGVLIESFPNHKNEYCDAVIIGIGLNINQKEFSGELEKKAISLYQKTGKIFNKYKFVGLLNEYLSLQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QMZ6</accession>
    <name>A0A328QMZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="303" mass="35539" checksum="28CBA90B686F60E2" modified="2018-10-10" version="1">MPGILSDKQMDCIDRCIKFVNTNNVPIQNIGLLMTYNEVDIIREVMDNNLKFFDKIFVLDGSVDGTTEIIQEYSNVKYLLHDKDIFPKRKIRDGARQFLMEKAQEMYPIEGWFTILCGDEILVDDPNKIAEKADKVGAEIVNWHPLNFFLHTSEKDKELDLTAPLQDQIKHYSPGGLEVRQFKNKPNIFFNINNHRKVYPEGVKAKPLFDYPILKHYVVRGPQQFIHKSSTGTQGVREATTETQKIYFDQINSFGKQVRIYDGSFHEFEPENRPSFIIQYLNWHKYRTIDWGMFSFLKKILPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNF0</accession>
    <name>A0A328QNF0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mltG</name>
        <name evidence="9" type="ORF">DID73_02280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016235115" description="Endolytic murein transglycosylase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP23433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="318" mass="35794" checksum="052523127E1B51D8" modified="2018-10-10" version="1">MKIFLIVLCFVSQLFAVPVTIPSGANATWVSQKLQEKGIIKSPRLFYLYLRTNKLSTQLHTGDFDIPAGGSYKDISDILIGKKQQFISVTIPEGFTINEIASRLEKKAIISSAADFLTYIQQQPSSTINPLLSKETIQSFEGILFPDTYYFSKNSSFNTVYRAFIKRFNDVFLTEYQNTSSPKLPFYDTLILASIIEKEAGTISEMPIISGVFHNRLRKRMYLASCPTVGYAMGQPRKTSLTYKDLEVKSPYNTYKNKGLPPSPIASPGKRAFKAALNPDKTPYLYFVSKNDGSGTHIFSLTLNEHLRNQKKILSKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNG4</accession>
    <name>A0A328QNG4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="254" mass="27756" checksum="A21A90538F834B74" modified="2018-10-10" version="1">MSKVAIITGASSGIGQGLAKLYAESGYSLGLIARRESKLHQLKTDLESSTSAKIMIGVCDVSNKSDIFSCIEGMIDHFGRVDVLVANAGVSLASPAYNSNADHLTETIEANVLGAGYSAYAVIPTMIQQKSGKIAVISSLAGYRGLPEAGVYCASKAAVNALFESMRLDLKKFKIGVSIIRPGYIKSPITDRNDFYMPFLQETDVGCKKIFNAIERKQKIFSFPWPLAIIVKTLYFWPCWLYDLCFAGVRNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNQ7</accession>
    <name>A0A328QNQ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016357597" evidence="2">
        <location>
            <begin position="19"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="286" mass="31293" checksum="6187EF2B867ADD5B" modified="2018-10-10" version="1">MKKIILIMVVIITVPLIAQTTTTTTTTTTTTTSSAPAATPAATSAAVPEKKGSTEQVTNKKANKFRVSLYGGSSFPSNFETSYEMKLPGGGYYQQQNSTVDLNLIANKDNAPYNYGIEFFIPANERFGFSLGYKGFSEFKYDDIDLSMGGYPQPVTLVHGNYISNEVSLFYTNLQLNMSEAFHIYGGVNFPTAKLTLANDYSAQTVSMDLEGLMGFQFGAGFNLTDNLALYVQYDQVHLSPDSENDLVKSLLKDALSQGGYNTDLELDKDYIMSVLQAGVRLDIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNR8</accession>
    <name>A0A328QNR8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DID73_02060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="9">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="193"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="335" mass="36370" checksum="AA25929BCA25C3C5" modified="2018-10-10" version="1">MILSIEILLLILVVILAFVSLWIRDLISAVIVFGAYSFLMCLIWTGMGAVDVAFTEAAVGAGVSTVFFIAVLYNTTRRIRFNPLDLSSKIFATFLCTAVGYLLFLGISDLPEWGDANSPVNTNVAGYYVESAYKDTKVPNLVTAVLADYRGFDTMFETCVVFIAVLGIFMLLKKEDDEVTDSSIESQTNDSLIIRVASRFMVPFIQLFGLYVVAHGHHSPGGGFQGGVILGASLILLAMAYDMKYVQNLLSMRKMIVFSALGVFIFAGWGLVPVFLGSNFLDYSAWAALLPGTDAIMARSHSMLAVEVGVALTVMCGMYGIYMSLVSDGGFKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QP37</accession>
    <name>A0A328QP37_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="133" mass="14481" checksum="A5E22D37E296F8D0" modified="2018-10-10" version="1">MLINILVVVLFALLASTFHHPVVSLILDGLIIGSMVTGLLFFFATSVGVLRFPDFFTRLHAAGKGDTLSTILILFSCSLFALKSAHHLDKATLLTAIKILLIINFIFIGSPTATHALIEAGYNSEVDPWENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QPC9</accession>
    <name>A0A328QPC9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002322">
        <property type="entry name" value="Cyt_c_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00609">
        <property type="entry name" value="CYTOCHROMEC3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="127"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="215" mass="24855" checksum="17A836E6B516F5A0" modified="2018-10-10" version="1">MSPQIFPKWANFLPVIALVTIVAILGTVVHLFWYWFSPKHLNVGYQPKQPIPFSHAVHVETVGLDCRYCHSNVDKAAHSNIPATETCMNCHKQIKTESKHIKKLTKYYESGEPIEWVKVHMLPDYAYFNHSAHVNVGVSCVQCHGQVNKMDVVYQAKPLSMGWCLECHREPEKYLWPKEKITDLDWRPKDQVQLGLELKEKYNVNPGEDCSVCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QPD5</accession>
    <name>A0A328QPD5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="194"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="242" mass="27515" checksum="74FD1716AFC2D89E" modified="2018-10-10" version="1" fragment="single">MSNTDKSKSKDVQDPHLEDVEITPSMETIGVVSDKEKEMINEYSYIIDAVASIITSKKKLPASIDYNDLISVGFDGLLKAIRGFDETKDAQFKTYANIRVRGSMLDLIRKEWRAKSSSKHNDLLDQIKQRVAQVIDNTIENEKAPVNVKNLLSITTTSYMVSLENVMEAYGDNVEDKGSSVDSEFELDDEYQTLNKIILDLPKEDVKFIELFYRRGLSQKEISVQLNMSEATVSRLHHRVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQ37</accession>
    <name>A0A328QQ37_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">recA</name>
        <name evidence="11" type="ORF">DID73_01810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="339" mass="36772" checksum="24EEFA2F51772B9C" modified="2018-10-10" version="1">MDENKKKALTIALSQIEKNFGKGSIMRLGDNAQLFSIDTVSTGALSLNLALGGGGYPKGRITEVYGPESSGKTTLTLHAIAEAQKNGGTCAFIDVEHALDPVYAQNLGVDTDALLLSQPDYGEQALEIAETLVRSGAVDMIVVDSVAALVPKNEIEGDMGDSHVGLQARLMSQALRKLTGIVKKSNCVVIFVNQVREKIGVMFGNPEVTPGGRALKFYSSVRMEIRRIESIKTGVDVIGNRVRVKVVKNKIAPPFKFTEFDIVFGKGISKEGDLLDLGCNFGVIEKSGTWFSCKKEKMGQGRESAKQYLRESKKLSTEVEKEIKEKVAQLKSGQEKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQ74</accession>
    <name>A0A328QQ74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000017">
        <property type="protein sequence ID" value="RAP22839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP22839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="561" mass="63294" checksum="DF54C1C993E756A3" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-06-17" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQB1</accession>
    <name>A0A328QQB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000015">
        <property type="protein sequence ID" value="RAP22879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP22879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="257" mass="28936" checksum="DE0368ACDDA2E815" modified="2018-10-10" version="1">MISLNGLITEKKSFDWLADSGFRYGYGCFETMLFTKEHIPLINHHTHRLTQSLDALCIDYTPNGLHDRIIKLAKHLQLNTPHVCHVFITGGNVLPQPSLKRTSTEIISFSPMPSPDFSKKCEFKTVQPSDYYRFKSLSYAHHIQALAASHHWPIYIDTNDQVIDSSIFSIGIIQNNTITFAQHAVQLPSVSKKVIIEKLTTISKPLQKNDLLNADTLFGCNAIRGAFPISLESNSPTTHQQIDAMNDVLDFNGRDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQD8</accession>
    <name>A0A328QQD8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_01865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016428113" evidence="3">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="5">
        <location>
            <begin position="286"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="4">
        <location>
            <begin position="369"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="479" mass="51756" checksum="778FD1FCE87C1EA7" modified="2018-10-10" version="1">MKKVIFGCLFVLMASFLAQANYLEKTSLEENIQIKAQHILDTMYGPHNFSVSVTVDMGRESWAVSYTERAKVEFEETQNTPGEKYKILPGYSAIKNLSPNEAVQMPFNSKITKLAAPVIKITLDVVTSKKISKQDVKAADKVMTKILMLNTERGDAINFVFEDFPVNKNVDEVKVGLPIEAKLMIFVLIITSLFLIVYILLKIKQLNINKEAVKAQQETAKATAAAAAAGGGGSSGPDPTPEAAPVPQAAGGGSDDVGGYFSFVGPHNANQFVDVIKKNELPVEKLAIVLSYLNPSYSKMVMDTLEEAQQVEIITALTEEKIADKAELDELEGALKSQLECSVGGASKLGAVIATFNDASKKTFLSSVESNAEIYKKIRPDIFMFEDIEKLEDGDVKKLIGAVNIEVLAASIATDDSAASGKLKSNLTGAAEAMVTQFIDLKKESLSENDVANAQSQVVQQMKVLSNQGAIDLVSKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQJ7</accession>
    <name>A0A328QQJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016253154" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="204" mass="22690" checksum="0AD7A632036EB14D" modified="2018-10-10" version="1">MKNLSIFILLFMSVFSFSQTVTKKVVTTTVEETIVFEPPRTLLSFGVMSGELETEVSSSKHTQGHGAMIAIKRYLNTPKNVSIGLMASTFSFSTFAGTVQTTWFDLPVLYHLNFKYFDLFLGTSFGWHSSSTLQKANDGFSSGSTYFEPESSINSFVFGGTLKTEIGYFLFQANIGAERLANFDEENGPKIKRNYFLAAYSVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQU7</accession>
    <name>A0A328QQU7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mraY</name>
        <name evidence="8" type="ORF">DID73_01770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="310" mass="34903" checksum="0B403BA89592B416" modified="2018-10-10" version="1">METSSRCFKHIGVYEMIWTIWSMGCILSYRWGIKGLRQLSFNQRIYEDSPESHQKKQGTPTMGGCIIFSCFLIGALILNQWNMSTMWVVATTTLFCVIGAVDDGLSLKRKSNKGLSARAKFMCQIIVSSIMVGVLYQWIKPIHWAEALLYVFLLTGTSNATNLTDGVDGLLGSTMLVSLIGMVVVLQSQWMFEEMRLTYIMMASIGFFLLFNWQPAKLFMGDVGSLMLGAFLAAMAISSGVWWMLIGFGAIYIIETLSVIIQVVSYKLRKKRVFLMTPLHHHFELLGMNDRSVVALFATLQAGFTFIQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-06-17" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRB2</accession>
    <name>A0A328QRB2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidinol-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="255" mass="27757" checksum="C2B45260420F8A67" modified="2018-10-10" version="1">MSSWIPFLTKISDVADEIALHYFNSASLEVEIKDNMTPVSAGDLAIENEIRSLVKNEHPELSIIGEEYGETTANSKLKLIIDPIDGTKNFIRGLPFFGSLFAIEDDGEIVAGMVSAPALKARWWASKGNGAFYNGAPIHTSNVASLAEANGFYGSLFGSEASSTPEPVINLLKDTYRQRGFGDFYPHMLVAMGCGEYAIDFKLSVWDIAPLKIIVEEAGGQFSNTQGENTIYSGNIISSNQKLHSTVLDYIQGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRP0</accession>
    <name>A0A328QRP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="358" mass="41291" checksum="034EB74387A1A3C5" modified="2018-10-10" version="1">MLNNKPCILIADDEPNICRIAKLIISPDEFDVITAENGLDAYEKAIKFQPALVFSDILMPKCDGFELCHKIKSNDRTQHIPFIFLTGLDEKQFKSRLNEVNADDYLTKPFSSQDMKNMINRWVEKPIIHSEDAVVPIEKQANNKPNTFQFGNETLDDQLFGEIYPQTFTLINGPIGSGKSSLTRQFIMDGIQKEQLSMLLSFETPKEKLDPIFSLNDSQKKYLQFCDASRWTTIDSEPWRNIDYIFDYISSECASRSFQRIVIDSFSHGFAFWPLVDILKFIDLCRALPNYQNQCMLWTINSHPQIESIEYHLQHVMDIGIRMKQTDGEFLTEIEYSKWQSYSKDAPTTTPSLDSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRX8</accession>
    <name>A0A328QRX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="169" mass="18836" checksum="91A03EA34AA5E88A" modified="2018-10-10" version="1">MKSILWIMIFPILLFSNNFPTISGKTLQGKKIEVPNKTSSQLLIIGFDMKSADPMEAWVRGLKLIPSANISWVQIPVIGPVPPFVDGFIKGGMRKSMPEEVQVTFFPYFGSKKFDILKSLQNSETLTDNVTPFIVLLSAEGAIEFSKQIRVSTDNIQLIQSKVSSINDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS02</accession>
    <name>A0A328QS02_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_02300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP23436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="147" mass="17012" checksum="E057157D3BC59BC9" modified="2018-10-10" version="1">MHERLFSIQHMDDLIDMCQVISPHLNAPMIIGLSGDMGSGKTTFVRTMCEVLKSSDWVNSPTYSIMQHYSSPQFDILHVDLYRLSNDIEIDQLDIPTYMKPNTIAFIEWIDKTNRLNPDALIHITTIDESRRDIRITSNQSWITTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS52</accession>
    <name>A0A328QS52_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="395" mass="44379" checksum="78B6AFC59FE083CD" modified="2018-10-10" version="1">MVVQLLTAFVALTNPGNTVSGKKNQFSSQTRRETEELKTLSYTAKGEAPPYLKTTSADVSGSGTQNPTLKLALTGDCRKLDPKGLRGLIDSITADPYPPTVGSTKRKSVGLATYRNYVVGVKGCKVSFEFYEDKSKTCDSPTSKETRIIPVENPGSYISLTLKETTIKKLYEKFKNKSNKRIFPMPPIKEAIETFKAKLREENYICAPTMPCPSSSTPNKKNCPPTPIDELLGEIRDVVKLVSNVEKQVGFFLSLDRATDFMVNKAEPFNSHMCHNCSEDFIKAANIINKIHLLKGHNKKYIFNAFKKDVSNFKTESKLNDLEKDINKELEENNIKLTAYDSGKGGFWDNVEKFIENETPLEQIADPLIQKVIKVIYLRQEIPYTSHLKQLLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS90</accession>
    <name>A0A328QS90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Manganese transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="263" mass="29205" checksum="2E79C67652C5ED27" modified="2018-10-10" version="1" fragment="single">EEIAGDKITAIGLMGPGVDPHLYKASAGDIQTLSSADLILYNGLHLESKLIDIFQKMGKKKPTKAVTTSIPKQQLTQPPEYEGFYDPHVWFDVTLWQLAAKEVFNALVSLDPKNKNTYQKNHITYQKKLSELNTWVQSELNKIPTKNRLLVTAHDAFGYFGKKYNIRVVGLQGISTASEAGTKDIQNVANIIIQNKIPTIFIESSVPIRQIKALKAAVAAKGWQVEIGEELFTDAMGDENTEKGTYIGMIKHNINSIVHGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSA3</accession>
    <name>A0A328QSA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="68" mass="7831" checksum="9CBD7825E9A59754" modified="2018-10-10" version="1">MAIEFYNVKKRKKVSINESEIKKVEYKRETAKGVQVRYAFRAQDDDGTNLTKFVSKVDYDKVDAPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSA5</accession>
    <name>A0A328QSA5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase PdxA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxA</name>
        <name evidence="3" type="ORF">DID73_00665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="313" mass="33489" checksum="9B3C2CF4D513161F" modified="2018-10-10" version="1">MPPICITVGDTAGIGPEVTFKALTNIQNHPGIILFMHESMINHQNNDLQLSIFDGQISPGEIKMVPVANNHTPNQNPNDPINATIAYDALTEAINHCKKTQSSLVTAPISKAGFLAANIPFTGHTTLLKKSFNCPNASMAFHSNQLNIVLSTIHIPLNEVEQSLTPTIIKTTIMNAKTFGQTLGIEKPRIAIAGLNPHASENGQFGTFENTVLTPLLEKLSITDASLQGPISPDIVFRQASEGMHDIVIALYHDQGLIPVKLLAFDSAVNVTVGLPICRTSPDHGTAYDIAGKNIANPSAMTAAINYAIQYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSA8</accession>
    <name>A0A328QSA8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_02075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP23556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="163" mass="18792" checksum="0FD49CF28BC29D83" modified="2018-10-10" version="1">MNRLVTFLVIFTFWLFWSGMFDAFHIILGLISSAIVVKWTGHLFVESKQSFSRRIREWLRFEVYSLWLLWQIIMANIQVFKLAFHPNLFNVLNPKLVTFNTSLEGDVAKFIFAQSITLTPGTVTVSIQGNEFRVHAINNEAASGVPGDMEKRVQAIYKGRQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSB5</accession>
    <name>A0A328QSB5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="90" mass="10682" checksum="41C271D7C5BA5025" modified="2018-10-10" version="1">MKNNYIDLFKALANEDRLKIIQLLIKNEEMCAQDVEKHFFLEQSTTSHHLNTLRRAGITKARKKGRNVYYSINYQSFIHSMDEFKSELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSE6</accession>
    <name>A0A328QSE6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_00615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="250" mass="27852" checksum="FBBF4E79171EA7A4" modified="2018-10-10" version="1">MTQDPTNIAVSIKDLTVAFDKKPVLWDIDLNIPKGALTAIVGPNGAGKTTLLKSALGILKPTAGRVDVFGQPLNRQLSQIAYVPQRNTVDWDFPTNVLDVVLMGTYGDLGWIKRPGKAEKERAMTALEKVGMQTFADRQISQLSGGQQQRVFLARALVQNAAIYIMDEPFVGVDAVTEKAIVTLLKDLRDKQKTVIVVHHDLQTIEEYYDWVFLLNVRQIAFGKVQDTFTEDNLRLTYGGRHSFIAQTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSE9</accession>
    <name>A0A328QSE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">DID73_00890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="622" mass="71886" checksum="76B5AE03705AA182" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSH6</accession>
    <name>A0A328QSH6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">DID73_00775</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="55"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="171"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAP24834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="315" mass="33422" checksum="603BC7F9640DA905" modified="2018-10-10" version="1">MDYASSGVNIDAGNDAVERIKPMVQSTFTPQVLTGLGQFASFVELPSGYLEPVLVSCTDGVGTKLKLAIDSNTFDTVGIDLVAMCVNDLICCGAKPLYFLDYIAVHALDPNQIESIMTGMVNGCKQAMCSLVGGEMAEMNDMYKKGDFDLAGFSVGVVEKSRIIDGTKVSAGDTIYALPSSGVHSNGYSLVRKICTTEAMEAHGISTPDLLTPTAIYVEDVLSIIDQHSVHGIAHITGGGLVENIERILPEGVALDIDYGAIKTPDIFSKLQQAGDVADSEMWRVFNMGVGMVVITPDELPADGNAYPIGQIINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSI4</accession>
    <name>A0A328QSI4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">proC</name>
        <name evidence="5" type="ORF">DID73_00830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="167"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="274" mass="30227" checksum="F1C828E1DD283929" modified="2018-10-10" version="1">MELLLSDSLSVGFVGFGQMGAAIAQSIHSSFPSYTLVAVESNMDRQSWIQNECAYITLASYEDLFRQCHVVFLAIKPQHVHELSKDIHPFVTPEHCLISMLAGVSYGTCSELFQPAKMVRVMPNTPAKLSKGVTGIYFSDELDKVMVQQVMALCDCFGTTIQVKNDHDMDVITAISGSGPAFFYRMVDAFINFGVASGLNESLVKDAVIQTMIGAGHMLLDDPNPMEQIQRVASPNGTTQAGLEVMDQKEFDTLMSDVLHRAYNRAVELSKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSK2</accession>
    <name>A0A328QSK2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ORF">DID73_00945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="205" mass="23652" checksum="FDFCB55AF175211D" modified="2018-10-10" version="1">MFITFEGIEGSGKSTQRKRLLDWLDQEGITYISTREPGGTDVGQTLRDLLLSNSSSIASNRTELFLFAADRCEHLTQVVQPALDRGDWVVCDRYIDSTFAYQCGGREHPEQDILDIIRLTDAIEPDMTFLLDMSPEEGLRRARERADLDRFENEQMAFHERVRNAYLICAEKNAHRFCVIPSDDRSIDDIFDMIITKIKERRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSU4</accession>
    <name>A0A328QSU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016267429" evidence="1">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="297" mass="33143" checksum="35461D9C0081B365" modified="2018-10-10" version="1">MSLLSKWVIIILTSIKLCGLSTAETPLFDPSLSARDVGLAKASFTDNNFNNMLKNPAGMVNTKGISIHANEFLGIDYSSILFVNQTLDITYGFHYIGSSVNDIPRSVAEGDLLKEVVGYAPYEYHALSFATAKEINDISFGVGFRYKTLVLDDTSNQSLEGFAGVGIKLFKDFKLGFSVKNFNIQETPTNALQTTAPILSSSFHYNVTKKTKLFLAIIENKNEIITSSTFHYSIEHYMNDYIPLRVGLDHNRYTFGVGLFIDPFEIDIGWAQSRSPVVNDQVTIGFSYGFEEKNHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT09</accession>
    <name>A0A328QT09_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1491" mass="163532" checksum="0D9771209D88A5D4" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT48</accession>
    <name>A0A328QT48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">purU</name>
        <name evidence="4" type="ORF">DID73_00725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="279" mass="31782" checksum="6A9FDEE61CE2CB4D" modified="2018-10-10" version="1">MSPVNHYVLLLTCQDRPGIVNEITGALLDLNANIVDADQHSTDDQQGVFFIRIEFVLEDGVDQLPEMVNDLKISLNADIEWHDLTEPLHCSVLVSKEDHCLQELLYQWKSNELNITIDSIISNHDDYKSLADWYGLPFHYVPSESKHVSEEQIISVTQSTNMLVMARYMQILSSEFLSTYNRPVINIHHSFLPSFAGAKPYHQAFARGVKLIGATAHYATEDLDEGPIIVQKVSPVTHRDHINDLKRLGRHLEKQCLIDAIRAIAEHRVIIHENKTIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT58</accession>
    <name>A0A328QT58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="113" mass="13177" checksum="D0C19DF591514E4F" modified="2018-10-10" version="1">MYRIISTSTKSEFEKKKAIYMQLFSHLCETKNFPFELGDTSSKGIILLLSIIKDQDTYSIEYTHQYKPFQVLTIDKITEKSTLENNRFSSITVLDLIPPKLRKKVLKLPDRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTE9</accession>
    <name>A0A328QTE9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="71" mass="8412" checksum="DCB1D0350DC554ED" modified="2018-10-10" version="1">MERLKQELTMSIKKQINELESTIENLKSNDLDFEKQIEVYQKTIKKISNLNTKIDELSDILKKTEITKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTH3</accession>
    <name>A0A328QTH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="168" mass="19310" checksum="4BCE3CE51D98C5E9" modified="2018-10-10" version="1">MHKTIAGKTTIERTNHFSGLHIDCVPKKKIIFKLNSKELLAISFKDERWSFDSDSQVSRDDDGAFFYHIWKKDLLVKSCGEFHPNEQTLPQDLALKVHIDSFGQLKYVCGLCCIFSKEVTFISSQLENNDKFPFLLFKDGALNEAFILNKEFNFFSIPTKASDCCQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTH8</accession>
    <name>A0A328QTH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">30S ribosomal protein S12 methylthiotransferase RimO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rimO</name>
        <name evidence="10" type="ORF">DID73_01925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="135"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="428" mass="48814" checksum="134D50CE70449C89" modified="2018-10-10" version="1">MTSNFSLISLGCARTLVDSEELVQSIQSVGFSMVPEGTKEEVTVLNTCSFIQAAIEETEDNIQLLIDRKNNNDIKYVCVVGCYPSRFKEAELKQKYPDVDLWCSTKDEKTLHKRMAEMVFHRKFTPETQKKYTKISPSHFAYLKISEGCDNWCTFCTIPKIRGTHTSKSIDAIRQDAKLQMAMGAKELVIIAEDTTAWGEDIYGEPCLEKLIEGLADLDVWIRLMYIFPSRVNDKLIHAIANTKNVIPYIDMPIQHVNSTLLDKMNRRHDKAFLEDIIRKMKAAIPNLAIRTTFICGFPGETDEHVTEVCDFLDEFQIDHIGCFTYSPERETRANKFDGQVPLDIAQQRLDRIMTHHHQQRGDRQLKRLGETLTVLYEGNNRCRSVYEAPDVDNLIILDQAPDTKPGDFLSIKLTGVSGIDFTAKETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTJ8</accession>
    <name>A0A328QTJ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biphenyl 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_02035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP23969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="228" mass="25422" checksum="C59F98BBBC1FF254" modified="2018-10-10" version="1">MNIFLQVGDLTGFSFFLASMALLAATVFFLLERGSVSSKWKLSLTLTTLITGIAAVHYHYMTHAWILSSASPTEIRYLDWLLTVPLMCIGFYVILQAIGHASRHILYRLFGYSVGMLVFGYLGETLLLDPMIAFGIGIILYGLILYEIFKGDTAKAMELSSHFKLKSSFKILRLFVLIGFAIYPLGYYISVLSGVEITTVVYNLTDVINKIGFSLVIYLLARSDSHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTN1</accession>
    <name>A0A328QTN1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="116" mass="12073" checksum="06409436D18B175B" modified="2018-10-10" version="1">MAVTNRAPSPGSLYLYGEISPGQGQGPQGVQTPDAHNTIEAQGIQTPAAHNTIEAQGILTPQGQTPQNLVGSPSEQEITTQQSQLGITPINPESGSRTGTPEQRAKIGDTAKKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTV1</accession>
    <name>A0A328QTV1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">DID73_01745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="203"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="282" mass="31301" checksum="191641A5B23596D7" modified="2018-10-10" version="1">MSCHILFIGTPEFSVPTLESLISEFNDGEISVISMPDKVRGRGQSTSPSSVKSLAQTHQLPVYTPLTKSDLTQKIHDLSPDLIIVVAYGMIIEKQITDHYFCVNIHSSLLPQYRGASPIHTALLNGDDTTGITLIKMNEAMDEGDILVQVELSIDPLDNLGTLTDKLSQLGAQTMIEFIHNCFLPKNITLTPQNNNMASYTKKIDKADLLLDTNENSKLLHNKIRAYSPKPGAYVIHNNKRIKIIASELINDQLQLVKVQPEGKPIMNYHDFLQGSPEGIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QV40</accession>
    <name>A0A328QV40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="178"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="357" mass="40282" checksum="895597C8CAC0606F" modified="2018-10-10" version="1">MIVIDCRSLQDDSKFRGIGTVIRNLIEFIPNKDRYCLLIEKGKGDIESYGMTVLAFKAPVNKKKYGQELAAFLLSHQIRQCHFMAQYNIPDSFDFPYSVTVHDLFNEHLLSNEKKYQQQLAPLLSKLAAANHIIAISEYTKGTVKEQLPNARVSVIYNGFNSSIARDAETEINLSVELNIQDPFILYMGNFEKRKNLIGALRGFLEFSERYPQYQLVACTGHQPLILPPDILWLRLKHRKKIKILSYIKSVQLANLYKKATALLFASHAEGFGLPVLEAMAVDTPAVISNTTSLPEVGKDAAVYVDPKDPKDIGRGLELLISDSNYRQLVSSNMTKVLNDFDIKTQAAQYDQAFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QV46</accession>
    <name>A0A328QV46_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoU_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="244" mass="27417" checksum="C599DA0898FCDA93" modified="2018-10-10" version="1">MISERDIERWFESAHYRKKCDWICVDQPKVIREWGKQGLIGQVICSDAIEKPKWTEDMPCLDVSHTWLTTISKKPSHMGMMVIIERPAYKVSKLMRATRTLVIDGIQDPGNLGNMIRTMVAFGCKTLCLTNDCVDPFHPKSVSASCGAIANIDIYYETHWGDWIKTTKHPVYILDPLALHSIWDVEKSDGYVLVCGSEGQGMKSKLIQSVQLSPISIPMADEMESLNAAMSVGIGLHQLSHPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QV83</accession>
    <name>A0A328QV83_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CaMKII_AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000015">
        <property type="protein sequence ID" value="RAP22881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CaMKII_AD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP22881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="138" mass="16113" checksum="C6A1C02BB3B9CAFD" modified="2018-10-10" version="1">MFFFVICLCYYTKMMMTQEVAFQCLESWGQSVARKDKAAVLNHYVETGTLWPTLSNELRQGPERIGDYFDHFLPKIDGDVEWNQCLFQAISDTHCVWSGIYTFNLTSGVTRARFTYTLVKQDDDWKILHHHSSLMPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVF4</accession>
    <name>A0A328QVF4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="40"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="345" mass="38214" checksum="E934F29EA6AEACF0" modified="2018-10-10" version="1">MSKLENIHISDITPIISPDDLKTSIKISEETSNFVINSRKEISNILNNNDQRLLVIVGPCSIHDPEAAIEYAKKLAPLIQKYNDRMMIVMRVYFEKPRTNIGWKGLINDPDLNGINNIEKGLKTARQLMLDILNLGIPTGSELLDPILPQYYADLICWASIGARTSESQTHREMASGLSMPIGFKNATDGNIDVAIHAIQAAQHPHAFIGVTQNGTIARVASNGNPDAHLIIRGGSNGPNYSSVQMEEHKEKVDQSKVETRILVDCSHGNSRKKAENQHKVLNSVLNQVKNGNKDILGVMIESFLSHGNQSIQSNPLNYGQSITDECISWDETNELLESIYTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVN0</accession>
    <name>A0A328QVN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="329" mass="36612" checksum="B43A0509B44C6AE7" modified="2018-10-10" version="1">MKVYSFSCNKPDSTKVYKKPFGFFGNVGDNCGFSKNGNKFDNTDNNCKADVLTRDGAHYIYPMVEGENKPPSSLLPDTEKGRLELKGRVPIHGGPGHMQLNPLKITSFILSTNHELGILALSNVEDSEGISDFLSVPKDSVHFHTFDPNSKTKKMVKLDHDGRLMETTGNRQTQVIMFFPGLDIRQFNISNPTDPTELFFALPNNTIPNVEDYAHTSLVNHFVETHKLQKFLCDDYDGGSNEIPNQIRGTVIENSDIPSTGTSIPEVILIFILMKMLYEGIRYGLKFIKCSPKGGGSDVHNVSDVDNVEMSEFDLNPLISDEEQGNNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVP9</accession>
    <name>A0A328QVP9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="808" mass="90388" checksum="61CB9FA9DCFF0407" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVZ8</accession>
    <name>A0A328QVZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="380" mass="43205" checksum="7FDB1D54ED559137" modified="2018-10-10" version="1">MNILFITNYFPKKNNKQDGIFLYWRAKEILKAGHNITVLKWNQDMGDYFMKPYNILDFNDPLFDLDITVVPVHSIQLMNPINQKKRHQWIEGNFDIVHFHWLWSMSVFPTINKWNIPFVVTCHGSDIYRMGESLNQLALGRWINKKVMKQQMARLNSADHIVFVSKDIQKVAGKKGAMPVRESVITNGVHDVFNSKDRQNSAKVTIGYVGNLEPIKRADKLIEIFHKTLQLMHVDEFLIIGDGGLKNDMKKDVIKFGMEDKVTFTGKVSFHKVAEYMRSMDVLVLPSRMEAFGCVIKEAQACGTPVVGSSNGGIPEVIGDGGVVVQEGDNFELRFAKAIAELMENPIDESVVKASAELFTWEETVKQELDIYTSLMGQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW28</accession>
    <name>A0A328QW28_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="317" mass="36947" checksum="87BBB2A67017569C" modified="2018-10-10" version="1">MKKNIVKITCIIFILIILFALYFQIRNKEVINVGKSSWPSWDLFELSQKNNNPLSNFKLQFNHYENYDGILDAFINNKIDIATVTLLEALTIQNNINEQIKIILLLDYTIGSDAILSHSNIEHLHELEGKTIGFEKNTISYYTLLRSLEKANINPNNLTLKNLSLEALITEFKQKKIDAISLYDPYIYELKKFDENFNIIFSSKEIPREICDVVIIRSKLIDKYPGIVQSIQNNWFNKIKKDISFKGAVDPLYRNNEYLSHIKENIYFANKNENMYAFGTKKVPGYLNNSISKTNEFLEKKSKTTTEETKLLKLIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-12-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW60</accession>
    <name>A0A328QW60_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="301" mass="33570" checksum="D824A6D73E5669D8" modified="2018-10-10" version="1">MNFKYLQETYLPKFEIELNKAIQFNLDDQRGILEEAISYSVKSPGKRIRPLICMATEKCLTGNVGVSIPIGVAIELIHCYSLIHDDLPAMDNDDFRRGKPTCHKVFGEDIAILSGDVLNTYVFEYLASELPKYTDESTTIKIIIDFAKACGIYGMAGGQVLDLKSNINNESSLTHLQKIHNLKTGAILKACFTLVSTIVSTDKNLKNTMENIGNHFGLLFQIIDDILDETANLEELGKSPGKDAEQNKLTYVSLLGLNNAKNEALTQKNKGIECIQTLTQSTDELITIFNYIFEKGVQYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWA2</accession>
    <name>A0A328QWA2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OstA-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="2">
        <location>
            <begin position="232"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="406" mass="46765" checksum="D34443794DD87E85" modified="2018-10-10" version="1">MTRFHILTIIGLCLLIFGIYIYKDANLMLEKSHDSPYVEQKNNQTTGYENGKKVFDIEIRSVRQNNYQHVLFAKKITNGTVYNHSGKKVINQLQGDSGRINTNIKSIIVTNNIEANIDPTTSTKSIQVKANKFKYSHQKKTAEFYDSSTLTIDDIEINSNNFTYLNHDETLIFESGFQLRDTHSQTTVNRAVININESLIIATNNIISHYKKPISKNDSDQIKALLKHPTTISAKKLMIDFSDNDHSIVTYNQKVIVNQTGKSLASDYLILDFKSDHYVAKNDLKFSFNNLQWLLNKTRTIKNKDIQKILKKQTTIRAELAQFNPKKNTFMLEKNVQLKQKNFKLTCDHLIYDINDEKITMTGNVIIKKYGIEHLNSSKLIVDIKNETFRSDSNKELSEIILELDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWD4</accession>
    <name>A0A328QWD4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP25026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="234" mass="26860" checksum="03AF44F05D43C50E" modified="2018-10-10" version="1">MHLLKKHDEIRTLTEDPIINNTNLFRESMDQVLTTHHQQFLGDPSAPIVMLGNSFSWQGHVIDYFSKHPPHTNWRKTRAIIVPYSSSFLEEDNSGTHPYKRRPHPKGHVNEATKDWVLSHLPNHPFSLIDMVKTGAGLASFLQLTSKKPNIIVFEPNTSKENSITHNEEFKKKPVTHLTIPNNQHDTLELMCDNGVRGSLQTKIYDPIPDQKQPTLFYVKKSILIYTLIKQLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWE8</accession>
    <name>A0A328QWE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="577" mass="66414" checksum="E0BCBC7561CDDE03" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWH7</accession>
    <name>A0A328QWH7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hrcA</name>
        <name evidence="6" type="ORF">DID73_00150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="2 4" id="KW-0346">Stress response</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="5">
        <location>
            <begin position="106"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="331" mass="37385" checksum="E1BD10A3422F271D" modified="2018-10-10" version="1">MNKRQEEILTCVVDHFIGSHQPISSTMVLDMLSIQLSSATVRQVFSTLDQDGYVAKLHTSSGRVPTEKGYRVYVDKIQEEGARLELDDYVTDQSYQMKFRYLFERLLSHVASKIPYISMVSLNEQALSDIAMLKYVSISSHYGLVLLFHNVGIVSEHYVRFDMDVSSCDSDQLIQWLVKEVQRHRQLIDVHIPYSDADAHFLSSIIHVITNHASIPSVSNNVMIKNVNQCLALADYTDKESVQQLLEVLDDSRVIQRLMSDGLRADQLDVLIGQELNDPRLLHSSFISIPICLDGVHVACLGILGPSRMDYLSIIRLLSSSETLAELNQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWN3</accession>
    <name>A0A328QWN3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Quinolinate synthase</fullName>
            <ecNumber evidence="3">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DID73_00405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="337" mass="38007" checksum="08E2B6ABC988E728" modified="2018-10-10" version="1">MITADELQQKLSNISIGANTCNFNKETCEKYAPIINKINQLKKEKNAMILAHSYVSPEILYGVADHVGDSFELSKAAQNTECDIIIFAAVKFMAETAKILNPQKTVYTPSEINGCSLADSITADDVLKLKEQYPDHAFICYINTSAEVKALCDSCVTSSNVYQIIENFPNDNIYFLPDKLMGKNVEAHLKKTNSKKNFSYYSGTCYVHEEYDPDMIDYLKLNHPETAIVAHPECKPSIIEKSTFVGSTSQMVNYVKETNHQKYVMLTECGLTARLQMEDPSKQFIGSCTMCKYMKSNKLDQILAILESPNPNLEVQLDEKTIEKAKHSLLQMFKYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWU3</accession>
    <name>A0A328QWU3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_02180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="73"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP23501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="177" mass="20514" checksum="BF61F6AD28E4620C" modified="2018-10-10" version="1">MMKKILLLIVLSLFLVSCRGWRSEKPPIHPNINFDFQPKVKAQTAPLEVPLYTMQFEYSNKKSRLSQFKVDEAFLKNGQKNYNIYCAACHTKTGDGTKSIISQNGWIVSNLLEKVTASKSDNELYNIIQNGIRTMPGYRKKLDSKETWEVVLYVRALQRMTSTTSYDRRLLKRKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QX76</accession>
    <name>A0A328QX76_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="411" mass="48321" checksum="36659B6E283F96A1" modified="2018-10-10" version="1">MKTVMYSPRNTGFIFNRFHSFTKDLLKHFKLISNLNHLDSFFDTENAIYFHQDEYSEKQLSQLYENEQHDYITYIQAYFNHYFSQNIPKEATELLNYCFIDMIGRYHLVKEILSSTNVDYLFICTSEIYLIDLAHQMNTKTIFLEHSPNLFPFVVFNDSIKNHIPFKTTFPDIILSENQLTTRHWQHQCTQLNQLQTQVIETGLPLDNMIKPSRISKSKKHPFTISIFNTWLDKSSPENLIENELNLIMLFDELFSSLKDLLTITPFRILLKNHPKLDENAYQTHGFYNQLAKKYGIADFEICQDLDATINQTDLAITLGKSSLLTDLLYSKIPSIIYNLFSNPATSYSDDINNIFPMVSSTHDLHLLIKKYLVSNEYDTHQNKLSDIHNKFQLNQKTIEEKCHQIIEFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXC4</accession>
    <name>A0A328QXC4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="313" mass="35673" checksum="40F590E276810606" modified="2018-10-10" version="1">METNIFVTGATGCIGHYALKELKRAFPGAHLHIMVRDIDRFKMDIPSWSNLTIHMGGMDDIGQYKEVLKTVDYVVHIATVWGYDLDVNIRINRDRTLEMFDYCDPNRLKKIIYFSTASILTDGNQLSSAAETEGTPYVKSKLEAYKAIKESSWADKVITLFPTMVLGGADDAPYSHISQGLLDIRKHLKWAKWLHLNGAFHFLHAEDIAKMISIGMTQDVPQEMVMGNPKMTFNDAILEMAEYIGMKPSIQIYLSPLLIRVLLFIFKKRVDSWGAHCAKHPYFEYDVYAPYHFGEELSFSSLTAVLKSMEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXE7</accession>
    <name>A0A328QXE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="259" mass="29081" checksum="5A273A9B9B017F72" modified="2018-10-10" version="1">MSVQSAGGNQNIQPQGAVNVDQGAETKANVKQASQGMNDVMTSIKELSQELRNQQSQKTTGKEANSKLETQTGKTLDQLQEQAQAQQKQVQGQQQSQQAQLSGGKDAEVVAAAMAGLMEEEEMGDVNEKQKALEEKMEILMEHAEKLQDVELDNPDNNFDLQQLFKNAEKFKSLKRREGQLNKQIEDLEINLKEQESREELNKLPVDETTKKMREQVLASYDEGQRQQSGNQEENANQDDENQAEDEQTQDDTPDEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXI7</accession>
    <name>A0A328QXI7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="705" mass="79547" checksum="EF4FFAB2AFE9F129" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXK4</accession>
    <name>A0A328QXK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="104" mass="12839" checksum="80AF7D365CA12412" modified="2018-10-10" version="1">MKKQKNMYEDEISIDNYHDKQAELFREEFEQELENRNSIEDLFSDELKHIQKMALIGKLNPLHKQTLIEWREIYPERFDQFCKQMDNLNRQKLLHFLHLDNDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXS0</accession>
    <name>A0A328QXS0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="101" mass="11625" checksum="B51A844AAA768695" modified="2018-10-10" version="1">MANKKVKLNKGESENLMPIIREFNKIAGAVNALLGQRVESKERKISVMVSRIKRPDEKTSQIKVKTVEFTKGFLKKQKKKKKGDDQSEWDDGFTEKRGFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXY2</accession>
    <name>A0A328QXY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1153" mass="132135" checksum="8D11109B8ABF798D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXZ2</accession>
    <name>A0A328QXZ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="66" mass="8091" checksum="CD055A472DE54003" modified="2018-10-10" version="1">MTTPEDKKRWKKEANQLKKDLDNKQTTIKKREVNIKFPKKNPYKKQEEKKPSPNLDHYFKDQINFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY24</accession>
    <name>A0A328QY24_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="460" mass="51132" checksum="AFD6BB3515B85086" modified="2018-10-10" version="1">MTSLCESMKHMFSRAVCLRSNYKPVEGAPETDLEIGANPETVKKQHSDLDLVETPPLQIVSFGCFTFSGGVTSCKAGASRCVRRSADCSAYYFKKPLLYYVAAEAGLAFCGTSIYAAVMRSFQGVQPALTEFESLWDDLYGFYEKVVSFGLNVQDSLGVSIDDLKQSFHTIQSTLVDGFSDSDEMKTRLIKLKGLITELLDYDTGWSRREDIRAELPGLIKKLNVNSDKIASVLNNISTSLGGQKEVIHRLSVVKGNVTRFVADGQHFVPELKKIWELKPYYEAAKNAIKFREDISDDAGWGISSMFSLFLLSKIHQNLQENNRLVNHLKTASVIGTLPEGFQVESEALDSLRTTSDLWYVVPFLTLAITLYLDNLLKSYMQDYNAGILDSNNATMFSPETIDASAKQFASTVFPVLAGVIPLVTNQLLNYLPITTNLKHTKHVIGRLNTGEQVDQFINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY35</accession>
    <name>A0A328QY35_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="13" type="ORF">DID73_02330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAP23442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="346" mass="38905" checksum="259A66E3247B26A3" modified="2018-10-10" version="1">MRKTYLDMLSQSSTADHIPIWMMRQAGRYLPEYREIRKQHSFLDMVYSPEVAAEVTLQPIRRFGFDAAILFSDILVTPQALGMELRFSEGVGPEFLNPIRSGEDAKKLVENASVLNPIYDTVSLVRESLPKETTLIGFAGAPFTVASYMIEGGSSKDLKHTKKMMVSEPAVFRDVLDRVLKVTIDYLDRQVQAGAEALQIFDTWINHLDWESCHEFSASYVKQIVTKLRERGVTVPVTFFGKQTSVFYPLYATTGINIISIDWNGDMRRIDSDLDASIGLQGNLDPFTLYGPKDVIQQKVSAICQSIQTSRPFIFNLGHGLMPDIPIESVQSVIDSVRSFNKTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY73</accession>
    <name>A0A328QY73_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">DID73_01800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="114"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="234"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAP24021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="391" mass="42805" checksum="72FAC710019683FE" modified="2018-10-10" version="1">MFLFTSESVSEGHPDKLCDQLSDTLLDAFFEQDPTSRVAIECFVTTGLVVVGGEVTTTAQVDVQEIIRKKLENIGYTHPDIGLDAKSCAVLVVLNRQSPDIAQGVNENDGAFKEQGAGDQGLTFGYACDQTEALMPLPIMLSHQLVFELAQLRKKNVLTYLRPDSKAQVTVEYNEDREPVRVSAIVVSTQHHPSATHEQIQDDIKKHLIDKVIPKELLPEPPTIYINPTGRFVVGGPQGDAGLTGRKIVVDTYGGWVPHGGGAFSGKDPSKIDRSAAYMARYVAKNCVAAGLCKEMEVQIAYAIGVAEPVSIKVNTFGTSDLSNNDLLAIIKDSFGFKPKEIIETLNLLQPIYSKTAAYGHFGRSDVEFPWEALNKVQQLKECKQRILTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY75</accession>
    <name>A0A328QY75_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="10" type="ORF">DID73_00140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="513"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="647" mass="69879" checksum="FB6716E2612DA9CD" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY90</accession>
    <name>A0A328QY90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3341 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="175" mass="19534" checksum="D09CF3543CD63218" modified="2018-10-10" version="1">MVFHGFLCEVENPKELVELSKKVRDSGYTNFDTYSPFPIHGIDKAMGIPASVLPWLSLTGCLIGLTSAIILQVWTSGIDYKIALSGKPYAALPAFVPVTFELTILFTAFFTVFGMFGLNKLPTWNKPIFNNESIKRATCSGFFLSISSKDKNFDEEKTMQFLKKSGGNNIERIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY92</accession>
    <name>A0A328QY92_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="129" mass="14878" checksum="07B8FDA75482F1FA" modified="2018-10-10" version="1">MIKPKYHFFHRLFLAIEGLVIAIRRERHMKAHICLSFILLTPLYWVETSVLNIWILVILITLLFIVELINTAIETTIDLVTKRFSYRAKLAKDMSSGAVLIMAILVLIFSIFIYAPSMYNFIIGVFVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY93</accession>
    <name>A0A328QY93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">maf</name>
        <name evidence="3" type="ORF">DID73_00640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="185" mass="20618" checksum="6F0843FC6C1AF6D0" modified="2018-10-10" version="1">MAHIPLILASKSAIRQQILKDRGLTFETIPANIDERSFKALDAIGIAKEKALKISKSYPKHWVIGADQVCHLNGHVFHKPNTIKNAIKTLQQLEGKTHTLLTAACIAHNNVIIWEGIDKIELTMKPLSTKEIETYVNNDQPLQSCGAYCYEGLGKNLFSFVSHPAESIQGLPLNQLLKELLKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYB7</accession>
    <name>A0A328QYB7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="262" mass="30043" checksum="22A495A2A257B5A0" modified="2018-10-10" version="1">MKKTLTIIGSGWLGSHFLNQYHTLFDFIVTTSLHSPAPQQSSEHYHINIYDNQIPSLPSTDICLVSIPFSRTLSDPNDYFLGIKKLIHQAPTYRTLIFTSSTSIYAPKNDWVDESSPINNTDRAKALHQTESFLLEQANNVYILRISGICGFSRNSMKKITQDAVKDSNQPVNLTHASDINQIMAHLLTRENKEKDIINVTSSTHPDRETYYRYLCQKFNLTPPIFTPSNHPFKKVSNKKLLSKYNIELMYPSPLTFEFDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYN0</accession>
    <name>A0A328QYN0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">grpE</name>
        <name evidence="7" type="ORF">DID73_00145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="189" mass="21445" checksum="12D6ECF063BCD668" modified="2018-10-10" version="1">MAKKETKSKEKKSKSKSKKANDIDVQLNDFQDQVLSLTKENDELKKEMESLKDQSLRSLAELENVKRRKEQEKGDAIKFANERLIMELLPILDAFDLAMAQGDVAKNDEVSAVVSGFSMIQKQIQQFLEKSGVIRIQAIDQPFDPNLHQGISQESHPDKDVNTIVKEMQPGYTLNDRVIRPSMVVVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYS1</accession>
    <name>A0A328QYS1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="17"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="266" mass="28756" checksum="E31DB804D57EF0B7" modified="2018-10-10" version="1">MNLFKFFTFKKKQTIGLALGGGAARGIAHLGILLGLEELRVPIKAISGVSSGCLIGGLYAAGVPISVLISKLSSLNWRSFTSFHLSKRGMVSSVRIQRLVESLVGKVTLNECQIPFLGVATNIVNGQSQVFYGSDHLLSKVVRASVSFPGIYPPVKIDDGFFVDGGVFQNLPVSPLQLLGVTTTIGVDVIPEGPISDIPRNVPLIVDRSLDLMLIEQRKHMVQPDILIQPVVSPISSFDIKSYDVLIEYGYQSVMKISSKLKGFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYU0</accession>
    <name>A0A328QYU0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S74 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="2">
        <location>
            <begin position="940"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP25008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1131" mass="124222" checksum="06AF58B03B333C9A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYX4</accession>
    <name>A0A328QYX4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">DID73_00375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP25038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="366" mass="40872" checksum="E3A6A34493E033F8" modified="2018-10-10" version="1">MQARLLLEDGTEFFGRYFTEVSDVFGEVVFNTAMSGYQEVVTDPSYSNQCVVMTYPMIGNYGINDDDVESKKIYLNALLCKEYVDHPSNWQSVKSLKTYLEEHGKVGVDRLDTRALTLHVRDHGAQRMMITSDVDSSVDELLKKIQAVPKMAGLNLAQQVTTESSYSWNDQRANDKKFKLAVLDCGVKYNILRHLDERGCDCVVMPIDQAKDMLENDTYHGLFISNGPGDPEPVQAAVDVIKSQLGKLPIFGICLGHQLIAHALGAKTYKLKFGHHGINHPVKNLQTGKVEITSQNHGFCVDVSSLGSDVTVTHVNLYDGTNEGFRHNAYPLFSVQYHPEAAPGPCDSDYLFDEFVQMMETTHVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZ35</accession>
    <name>A0A328QZ35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="168" mass="19539" checksum="F3900E9BEBBE811C" modified="2018-10-10" version="1">MRVFIFLLLVATHVFSQQSSINIPKETYFTYNKFIESSVPKQSSIQAPSHWIKLQYLSPLIGKFQINDSTILSISSFSGSIGNKLSNLNRWRRQLTLSPVTSIDDFFESYEWDEMDIHVVAINNSHQYFLIYWLIVGDRHIFNKVVSNTPINKSIVQSFIESQSWKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZ48</accession>
    <name>A0A328QZ48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="194"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="377" mass="43193" checksum="F91F31E4BB6CE036" modified="2018-10-10" version="1">MNIGIFTDTYEPQINGVVTSIKTSIDYLEENHTVYVFCPNVKPKLKSTDNVWRFPSVVYPFQKEYRLVLPFNKKIDAIKKLKLDILHIHTPFTMGNIGVKIGKKLNIPIVHTYHTYFEKYLHYFPILPEAWVYKYAKKESERFCNLCDKIIVPTNEMKEQLSNYKINKEMVTIPSGINVYQPTKEEIDSFKVKYMNTKTLNCLFVGRVGLEKNIHFLIDAFQQIIQAVPNIHLTIIGDGPERKAVEKKVEQLGLAQNITFTGYLEKKDVFCAYNVADLMLFPSKTETQGLTAVESIMCGTPVIGLNEMGIKNVITNNISGILTKESSREYADAAITILNDDKKRQRLSETAKKNGEKYSYLSTGKKLESLYQDIVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZK6</accession>
    <name>A0A328QZK6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="258" mass="29639" checksum="F031B7226E075A3E" modified="2018-10-10" version="1">MTPSTMLQWPTFTALTKPVEPSQPNPFQWLTHMNRLKHDGYTIFKELLPNDIFDPLNRAFDELKSANILPVGIITHPLFWQIVHALDPIIEHILNEPYAILPETWAWDIDPNKSNKGWAPHREKLFSCVTSDGMPKSMSCWFPITPANPENSCMYVLPASDDPYYPVGKTKFDYPIQSIRALPAEPGDVIVFNHNILHWGSQSSQWGTTPRRAIAFESQINSIPPYNEPTIQPKSLPNITDCQQLYNQIIQQYDHINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZT2</accession>
    <name>A0A328QZT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_01020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="312"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="413" mass="45530" checksum="5B75CFCE16C3D395" modified="2018-10-10" version="1">MSLFKLTIKSIFSRKLTSLLLIISIGISTMLFIGVQKIKLSAKKSFSHSISGTDLIVGARSGDIQLLLYTVFRQGKPIANMSWESKKKIQALPNVKWLVPLSLGDSHRGYPVLGTNTDYFKHYKYGNKKTLTFNKGTKFNQPFDAVLGSEIAKKLNYTLNDTIVLSHGMAKGNLPIHKNRVFTIVGILKPTGTPVDKTVHVSLEGISAIHINWNNESKNKIENLDTMDLTPQSITGCLIGLKSKFSIFTIKQKITNWEAEPLMAIIPGLTLSTLWQSISTIDTAFLIITIAVTLIAFLGLLLGLFMSLKERKNELSILRIMGAHPSQLSIMLILESIIITASGVIFGGLLMIIIGHIIKPILETRMGLILSFNTISTSDIYFGFGIIIFGIITSLIPAILAYKKGQHKGFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZU1</accession>
    <name>A0A328QZU1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="27"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="187" mass="20459" checksum="987770777FEDC008" modified="2018-10-10" version="1">MQAKNINERVSFDNYLDKEMDVSSDYMSELATLLSAKKLTVSVIESMTGGGIARKLVEAPGCSNYFLGGVIAYHSRLKVQYGLVSPKTIIDHGVVSASVTEEMAAGIRKVTKSDIAIASNGIAGPKNDAYSADQSGTVFLSWNIHDKIIKTKRYNLEGGRNNVIDSSIFIALSMCLRYLKNELRKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZV3</accession>
    <name>A0A328QZV3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosyl pyrophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_01180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="314" mass="34749" checksum="A7F2043F41A3C9E0" modified="2018-10-10" version="1">MLQDKIKLFSGSSHPELAKDIAANLGITLGDIKHAKFQCNESYVKIDETIRGMDTYIVQTASSAVNDDLIELFLIMDTLKRASAASINIIMPHFAYARQDKKSSPREPISARLVADLLQAVKIDRLITMDLHADQIQGFFDVPVDHLTAMPLFVDYFSKKQLEDLVVVAPDTGRAKFAKKLGDKLGADLAIMHKTRPDHNVAEIVHLVGDVKDKTVLLVDDMVDTAGSITSGLDKLRLFGCKEDIYLATTHAIFSGPAIERLKKANIKEIIATDTVPIPEHKQLDNLIILSTANLLAEVIKRNIQHESISTLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZX0</accession>
    <name>A0A328QZX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="8" type="ORF">DID73_01280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="253" mass="26780" checksum="A0D50C85708DA8F5" modified="2018-10-10" version="1">MSELFIAGQSFSSRLLLGTGKFSSDEVMAGAIRASGAEIITAALRRVDLENPNDVFLNVINPKEYVFLTNTSGARIADEAIRLARLGKTQSNWVKLELTPEPNHLLPDPIETLKAAEVLVNEGMIVLPYINADPIVCKRLEDVGCQAVMPLGAPIGTNKGLTTRDQLQIIIENSNVPVIIDAGLGAPSHASEAMEMGADAVLVNTAIATANDPIAMATAFKMAVESGRLAFESGLPQKKQDAVASSPLTGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0D2</accession>
    <name>A0A328R0D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">DID73_01445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
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    </dbReference>
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        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="289"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <begin position="403"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="417" mass="46153" checksum="CA68236E1E221F21" modified="2018-10-10" version="1">MSVKVIVGTQWGDEGKGKITDILAEKMDYVVRYQGGNNAGHTVVVGENTFKLHLIPSGILYDSVTSVIGNGVVIDPGVLIKEMDTLAEQGIHIDDNRLKISSIAHVILPVHRSIDSKQESMRREEKIGTTGRGIGPCYTDKVSRVGVRMMDLLSKDRLVSRLKKHPHLEDAEINEISDLYIGYGERLRPYITDTSLRINQAISSGKRIIMEGAQGTMLDIDHGTYPFVTSSNPISGAACIGAGIGPHKIDQVIGVTKAYSTRVGEGPFPTEDFDDISEYLRTKGCEFGTTTSRPRRCGWLDLVVLRYAVRINGITEICLTKLDVLDELKSIKVCTAYETPDGKVEEFPLDLETFSEAKPIYDELPGWETDISDLTNFDDLPQNAKSYVKYISNILGVRISLVSVGSRRKQTIHLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0J1</accession>
    <name>A0A328R0J1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="135"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="265"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="526"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="755" mass="86288" checksum="2A1359C19F5402A7" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0K2</accession>
    <name>A0A328R0K2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="164" mass="19306" checksum="60B83057ED13C87A" modified="2018-10-10" version="1">MKKIIKTIKLFWPAFIPIVLLNIVALRQIYLSNVDHLDAWKGGGFGMFSRVHKRYYHIHLLNRGAFECAVAPDDYFTELHKIQYYPKYLSLEQLTKLLTKKLWVYNNIKSKNKSVVMIGKNAKLRPGDKIAHFDAIEIQVFDMKFTKKSFTLEPKLIRKISYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0L6</accession>
    <name>A0A328R0L6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="161" mass="18073" checksum="AD767DE482E85631" modified="2018-10-10" version="1">MSVHNASRYDELLQNEEYHTILIELEGTSNPEDLLVKGIAHYKLNQADEANTVFKNLHASYPSNEITAYFIITKLKLNDVMAASKLYNELCFEENKAILNDIKSNCLEQAINRCLFLQSIPVERPNLEAAATVEQDINNSNYKAAIEKLAPKAETSSCSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0M7</accession>
    <name>A0A328R0M7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ORF">DID73_00210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="151" mass="17007" checksum="09F7C8F2C7DBB57B" modified="2018-10-10" version="1">MLIKVDTYIARAIDLAVEASNNNEFPVGAILIKDEEIIGEGMNLKETLKDPTAHAEVMAIRQACQKIGDWRLNGSTLMTTLEPCPMCLGTILQARVTEIIYLAKDLRWGACGSVMDFSNNSELNHRCKLTYLPNDEVVQLMKTFFKDQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0N2</accession>
    <name>A0A328R0N2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045301">
        <property type="term" value="F:tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010386">
        <property type="entry name" value="tRNA-Hydrxlase_MiaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42637">
        <property type="entry name" value="PTHR42637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06175">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020736">
        <property type="entry name" value="MiaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="205" mass="23254" checksum="3A7FEB29C4F5E220" modified="2018-10-10" version="1">MSTYTITDLPLTVTTPLEWAVKVLADPITLLNDHAHLEKKAASNAMDMLNRWPTNPPPTSWVANMIHVAKDEVEHLHVVNKLLERRGGSMSKSHKNTYAAALNGLIRLGAGHSEHVDRLLVSALIECRSCERFALLAEASEGVDDELHHLYSELWRSEHGHYVVFLEMARLITTESIDERWAWFLAKEAKIIQKQPFLVSMHSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0P5</accession>
    <name>A0A328R0P5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="415" mass="47553" checksum="A83C00D41E553A9E" modified="2018-10-10" version="1">MACISRFYPFFCSILLLCSISIKGSQFSIDTGLLDSANSNRAIAQFNLDVMGATNDILRWTHKSSQMSRLVTKGYFIANIFLPYHIGSLVNLAYHEFGHGGRADALGYNHYYQLAFSFDDDQHSAKLHTYYDLFFAIMMNPFIEGASASYYGEMYDHISSDEQAFFSALISANGVNNEMFLASRLSDQNYDRGRGTIFDFLTYHQSKLAVYGYARSEEKGVFGDSGLGDLSYVQSYYEDQHKLSVSMSDFKSYNLVAYFFSAQTWAYFNAIPDYIYRDEFNFSMAPFNGWRLPEVDFYLNPQGPSYLVRSQYEWSSSLSIPFAIEYVFLGDQVLEYTVGVRSNWSSFLSTYTECRLGQQVGFSQTVSMALTDRWITGIGWIHYSGKNLYGARHIPSFERSDWRADDFFISTTYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0R1</accession>
    <name>A0A328R0R1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">DID73_00360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="34"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="568" mass="62962" checksum="2A01B87349DFB66E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-06-17" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R114</accession>
    <name>A0A328R114_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="209" mass="22854" checksum="D92B6D56A08C389E" modified="2018-10-10" version="1">MIIGVDATSRWIQYAALSQGGVQSHEWDGVGTIETLPMRIQSLCSDTEPLTGALIILGPGSYTGIRLSLTTLKVLTMVHEVPLMGVSLFDAYLTLNHHLLQGVTVLTSPSRKGVFNAQLFQATDDGFDAMSSLLQLTQNELKVWLGRFEAPIHWHHFGDDLLSLDASVITGHGVRLDLVGLIRHHQHHIPSLSKGSSLSPIYSYPPVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R193</accession>
    <name>A0A328R193_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ORF">DID73_00555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="131"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP25040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="288" mass="31723" checksum="4E4FB91A6091E943" modified="2018-10-10" version="1">MQPFQPELWESVGDHFEDITYHTAKGQGTVRIAINRPECRNAFRPQTVDELLEALDDARCNASVGCVLLTGNGPSPKDGGWAFSSGGDQRIRGVDGYQYNGKSSGGRLHILEVQRLIRFMPKIVIAVVPGWAVGGGHSLHVVCDLTIASKEHAQFKQTDPDVASFDSGYGSAYLAKQIGQKRAREIFFLGLDYSAQEAFEMGMVNAVIPHADIETKALEWGQLINSKSPTAMRMLKYGFNLADDGMVGQQLFAGEATRLAYGTDEAKEGRNAFVEKRDQDYSSFDWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1M8</accession>
    <name>A0A328R1M8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase RhlE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DID73_01185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="49"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="424" mass="47243" checksum="3FC5942D4CC20C3E" modified="2018-10-10" version="1">MITIFNRSKDDAKDSNGAQFKSLGLSEDILKALLEKGYETPTPIQEKAIPVVLNGDDLMAAAQTGTGKTAGFTLPILHQLSKVTTDRGKRPVRVLILTPTRELASQILDSVALYGKYLPLRSMSVFGGVNINPQKQRLKKGVDILVATPGRLLDLFQQRAVSFNQIETLVLDEADRMLDMGFIHDIKRIINLLPKDRQTLLFSATFSNPIQKLAQQFLSNPIEISVTPKNAAAATVKQSMFSVEKKQKSQVLYHLITKNHWDQVLVFSRTKHGANKLTKFLDKNGINASAIHGNKSQSARTKALADFKLGTIQVLVATDIASRGLDINELPQVVNFELPHVPEDYVHRIGRTGRAGSEGQAVSLVSSDESKQLRDIERLIKKKLPQESLSGFEPVAIEHKENKASRPFRRRRPKQQQRKYKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1N6</accession>
    <name>A0A328R1N6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translational GTPase TypA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">typA</name>
        <name evidence="3" type="ORF">DID73_01235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="589" mass="65543" checksum="538D0ACEB5D37671" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1Y5</accession>
    <name>A0A328R1Y5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsaD</name>
        <name evidence="8" type="ORF">DID73_00820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="131"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="328" mass="35182" checksum="D94EE4E7BAB30DBF" modified="2018-10-10" version="1">MILAIETSCDETSVAILNGNQILSNVLYSQIKHHRKHGGVVPELASRLHAEKIDHILKQALIEADVQLSELTHIAVTVGPGLEGALLVGITAANMLAQSLQIPLVPVNHLHGHIYAAASDSALIYPSLICLASGGHTMIIYMKKNLQFEVVANTMDDACGECFDKVARMLDLGYPGGPKIEALAKEGSPTIQFPHPIKQKANAFSFSGLKTAVLTKVKDSDSNESADIAASIQHRIATVLSHKLNLSLESYDAKQLVLCGGVFANKYIRSHILSEVPLKNVLIPAPILCTDNAAMIGLAAVQYIEEGMVCDVITKCTPQLGLNFPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R269</accession>
    <name>A0A328R269_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_00110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="449" mass="49782" checksum="B7A7F83D846A2B82" modified="2018-10-10" version="1">MIFWYSMGVLEKNSILLGTVTDQGKKGEGLLWQNDVPVYIPNCIPGDEIEFKLIKVDKRRAFGKLLRVMAPSSDRVDAKCSVALQCGGCQLQHQSQMSQVSFKSNLLVSRLSRFVDLSNVLVKPMLSGDRQWATRNKMQFAFGQGDNGLEIGLYAPRSHRVVNMDYCDIMSNSMNQVLVAIRSWHSQAQVPVFNEITGEGTLRHVTLRHSYVSGELMVILTVSTSFEMDSFIDAVRQVDGVTSVYVSYQADPQNDQVLGEKMTLVWGESVIHDVVCGTTCHVSPKTFMQANAMLVNTLYQTLMKSLDVQGTLVDLYCGAGVLTCALARHYDQVIGVDNNESAIEDAKLNAQKNGLSVDFVCNDAGDFLRAYSDEKMTIIVDPPRQGLAIVADMLAKCPNQIIYVSCYPDTLGRDLRQFVEGGYVIDSIQGVDMFCHTPHIECIAVLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R283</accession>
    <name>A0A328R283_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3467 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021857">
        <property type="entry name" value="DUF3467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11950">
        <property type="entry name" value="DUF3467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="103" mass="11753" checksum="402E0DF066D55307" modified="2018-10-10" version="1">MNPQENDRIPIQCPSELANGVYANLGVANFNHEEFVLDFIFLHPNTKTGEVRSRVVLHPDHVRRLVNMLKKNLDNYDEQFHGDGSDGDDMGDDDFPPITLNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R2F2</accession>
    <name>A0A328R2F2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TSPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSPc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="202" mass="22492" checksum="7E68D142CC8C5C4E" modified="2018-10-10" version="1">MNLFKQLIFLLYCIPIIASVSVTPISDSISISVKNFNSGTITTETLKKLSNYHPEKAPNIIIDLRNNHGGTLHDAIGFGALFVTKNELIQLVKMDNTPLLITRPKNHPLVTANRLIILINEETASAAEAAVHILSQHKNSIRIGTHTYGKTIINTEKTPSPYKEMSIKTIHPDIQYEWENSDQEAIILKALAIANHHQINAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QMJ2</accession>
    <name>A0A328QMJ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ORF">DID73_02500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP23103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="596" mass="66756" checksum="426F980E9178C2D9" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QML6</accession>
    <name>A0A328QML6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flg_bb_rod domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000016">
        <property type="protein sequence ID" value="RAP22845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="1">
        <location>
            <begin position="4"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP22845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="85" mass="9477" checksum="08C2C38A515CDCDA" modified="2018-10-10" version="1">MNDRQNAAAYNIANASTPGFKPIRYEDEIQHAVRLYGNTKMLNVVNVDDEMVKSTKIRLKHSAYVRLLTTKIGITKKVVTLGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QMP4</accession>
    <name>A0A328QMP4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="263" mass="29966" checksum="13F0EF3E6F106CD1" modified="2018-10-10" version="1">MHDIKRKFKDSTVIFIVVHYEYECVELTLLNILSIIEAMEDTYLVIINSKASPRIEALLNRIHSDKVDMVHLPINFGYNHGINYYIRDFISDENLPQCIVSLGADILFNQADFGTLVDAIMNLEKYGTISLSYENNQCNPERNVLKAKDVVGKNGKKYPIRHTFLCPVAGGIMGIRGEILRDTLNYKLFHPKYFPKQYLDISPVGGADSALYNAIKRKYKVGYIANTTALHMKSRDGLIVDISDAWDGYIKDIREKSTHLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNS2</accession>
    <name>A0A328QNS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxygen-dependent coproporphyrinogen oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_02340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="PTHR10755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="SSF102886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP23444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="312" mass="35421" checksum="AFB8132F8F947D28" modified="2018-10-10" version="1">MASDQAQQFATLVKTRQNDICDALSAIDDVPFHVDEWTRPGGGGGNTRILTSSTFEKAGVNTSQVFGTISTKEAPMFSTLIDKVNPKFTLTDDSHFFATGVSLVIHPKNPFVPTVHANYRFFECTNNTSTIWWMGGGADLTPYYLDEDDATHFHTTHHQVCEAFIPGCYNDYKKACDDYFFLPHRGETRGIGGIFFDYLSNDYNAQFSFISNISKAFIDAYLPIVKKQKDTPYSDEHREWQAVRRGRYAEFNLLYDRGTLFGLKTNGRIESILMSMPPKAQWTYDHSPLPNSPEYALLNVLKHPQPWVKTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNU0</accession>
    <name>A0A328QNU0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-glycero-beta-D-manno-heptose-7-phosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_02165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="12"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="321" mass="34546" checksum="E506E169560CD462" modified="2018-10-10" version="1">MSIKEAVQKSPKILVVGDVILDQYLWTSVNRISPEAPVPVCHIQETTHCLGGAGNVANNLSAFGAKVSVAGIIGNDVNADIMKTYFNKANINIDQLVQVNNYPTICKSRIIAKGQQLLRLDDEKLALNMDQNVQVCLDGLLSGEFDYDGVIISDYNKGVVSEHMAQQIIQLANKNSVPVVVDPKGHKASKYSGATYITPNTNEFKELTGLKSLENDDEVIAKGQTLIKENNINYLILTRSEKGMVVISTDGAQYYPTKAIEVSDVTGAGDTVVGAIAFGAALQLDQKTIINFANYAAGVVVSKVGTATASIEEIDAYESNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QP71</accession>
    <name>A0A328QP71_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="568" mass="63229" checksum="70D5A965D3DB360A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QPH2</accession>
    <name>A0A328QPH2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="10" type="ORF">DID73_02125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="165"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="254"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="417" mass="47533" checksum="CA889CF8AC41D360" modified="2018-10-10" version="1">MINPKLLRESPDVVKTSLHNRGCQPDVFSTLQALDIEWREKQQALEQLQALRNESVPKGKPSEEERQKLSELSQKLKLHQQDVVEIKEKLDAFSFEVPNILQSDTPVGEDESKNIVVRKEGTPRSFDFEAKTHDELATNLNLIDFDRATKVTGSRFATFTGLGAKLERALAHFMLDVHTQSHGYTEVSPPVIVNSAAMRGTGQLPKFEDDLYKVSEDYWLSPTAEVQLTNLHFDEIIPTEDLPIKYCAFTQCFRKEAGSYGKDMKGIIRLHQFNKVELVQLVSPEKSNDCLMELLEHAEQILKLLELPYRVVQLCSGDMGFSSSKTYDLEVWFPSQNQYREISSCSNFLDFQARRSKIRYRDSNQSVNYLHTLNGSGLAVGRTFAALLENYQTESGIIQIPNKLKDYLGIQEIGYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QPX4</accession>
    <name>A0A328QPX4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_02005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="PTHR23289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP23963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="335" mass="37548" checksum="B8B37DEE6B0902C6" modified="2018-10-10" version="1">MKQVKTWLLICLGLIAGIVMVGGATRLTGSGLSMVDWRPIMGSIPPITAAAWDATFSAYQQSPEFQKINFNMTLGEFKSIFFWEYLHRMLGRLIGLVAIIPFIYFSIKKALPRGFSRRWLGIIALIGCQGLMGWYMVKSGLVDNPHVSHFRLAAHLSLAFIIFLLIFVELLKLQFPSKRIKGTFLSKLSKLVFGLIGCQVVYGAFTAGLKAGHYYNTYPKMGPDWLPDSALMYGGGLINNMLNNPIMIQWVHRWFGVAVVIGVLILWLKCKDHKNLYLQYSGLLLVAVVGFQFILGVITLLTRVWLPVALAHQLGALLLLSASTLFNYFSTRTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQ61</accession>
    <name>A0A328QQ61_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DID73_01950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="11"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="407" mass="42781" checksum="D2FC34716C52ED78" modified="2018-10-10" version="1">MSEIQLTISNLWILIATAMVFIMHLGFAALEAGFTRSKNTVNILFKNIGVISIGLLSFALIGYSLMYPGDAFSGGVFGFSGFGLPFSGDAANSTNANYTFYTDFIFQAMFAATAATIVSGAIAERMKLSAFLIFSLLLVGVSYPITGMWKWGGGFLDSLTVPFYDFAGSTLVHSVGGWAALVAAIMIGPRLGRYDGSNSIRPHSFALSTIGVLLLWFGWFGFNGGSVLSADPFTLSLVFVTTALGGAAGVAFAMGTSWLINKRPDLANTLNGSLAGLVGVTASADIITPLEAVLIGSVAGVLVVFSAKIFDSLRVDDPVGAISVHLVCGVWGTLAVGLFGAQASGAQFISQLIGVLSVGAFTVTFSLAILKLIKIFIGLRVSADHEEEGLDKAEHKDMSYFYSHVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQA2</accession>
    <name>A0A328QQA2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="100" mass="11769" checksum="81B41C6A99027D09" modified="2018-10-10" version="1">MALAYSTDTITKDEKKELIDKMTRIEGRVRGITKMIEDDRQVEDIMMQVTATYESLRVAMKTLVKKHMEEFVTKGLISTNQQKRDEAYTQLINDIFKYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQE6</accession>
    <name>A0A328QQE6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">miaA</name>
        <name evidence="9" type="ORF">DID73_01915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="284" mass="33013" checksum="D8B25E290A5914F4" modified="2018-10-10" version="1">MYSLILFIMMQKTRVIIGPTASGKSDFSIDMALKDSSEIISADAYQIYKEFNIGTGKLPASEMQGIQHHLIDTLHPETPYSVQMFLDDVHEILSQKNASFIICGGSAMYIKALLYGYQPLKRLPVDERPTGDPKTLWEELNQVDPALAEKTPFQNASRVQRYLELYKIYDVPPSTLFTSEPFDPSKYQVIGLSIEKETLKDRIHYRVNDMINKGLVDEVNYLMKKYDIKSPAFQAIGYKEVIHYFQKKFDKETMIQTIKKNTYQYAKRQMTWFRAFDHVQWITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQH8</accession>
    <name>A0A328QQH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="150" mass="16964" checksum="8961950360074074" modified="2018-10-10" version="1">MTNIKKLYQQVLLDHNKKPRNFNVIENPTNYAHGVNPLCGDDYHLFLKVTDNKIEEIGFTGTGCAISKSVSSMMTQEIKGKEINEVLKIKDTFIEMLTENLNANDAKHIIGHLTLFENVKDFPIRVKCATLIWRALEAALSNNESKVSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQI7</accession>
    <name>A0A328QQI7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2779" evidence="1">
        <location>
            <begin position="291"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="482" mass="55434" checksum="D0E9925C3F8FF6DD" modified="2018-10-10" version="1">MGLLTKSKYIQALQCKKLLWLTLNQPSALSINDNKQAVYDQGTMVGIDAQSLFPSGIMVDSDLSFPEKISTTRDYISKSQSMFEGAFKWDQCFCMVDVLVFNDGAWDLIEVKSSTSVKPIHYHDVGFQTFVLTQLGIEIRDMFICHIDTSYKRQGMLDRTALFHCDKVTNDVLDLLPTIKKNIHEFLPILKSANSDIPIGPHCFSPYECSAMDHCWKGVPDDSIFEITEMSIQHKFSLYYKNQFLISELDPNSFSRFKQKQQIACHLEGLDFINTEKLTTYLSQIHAPFSFLDFECFQTAIPPFDGLHPYDQIPFQFSLHIDNEKELLHHGYIAPYGEDPRPLILDELKKHIPSSGSILVFNRQYEALILNQLKTRFPSEAPFIDGVLERLIDLEIPFKNNYIYLRQMKGKTSIKSVLPALCPTFSYDQLTISSGRSINSMYQKLSDDNDKDDAYQFLFEYGRLDTYAMVMILKRLMFLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QR04</accession>
    <name>A0A328QR04_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mur_ligase_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="53"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="300" mass="33130" checksum="90A97A619293C49F" modified="2018-10-10" version="1" fragment="single">MPHSLNTQSFSDTLTKLQDKVARRGINYSLDRLSNALTKLNNPHQSLPSTVHIAGTNGKGSVAHYLTHALIQQNRQVITYTSPHIQCYTERFLINGRPIDQSQFSDLFDAVAHADTNNELSEYELLTLMAFTLVQQESPEVFLMETGLGGRLDATNVVPSSMAIITDIGLDHTSILGPSISDIAKEKAGIIKEHSTLITHLDHEPNVLEIIKEHAKQQCATIHWSGPKPNMHNRNKGLATIAINELLSIDHGEEIITSIAPPFGRLTPSTYHGTPCWMDVGHNLHAAKAIHQTLPNADQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRY7</accession>
    <name>A0A328QRY7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="463" mass="52789" checksum="569D4E8F7B4FDDA8" modified="2018-10-10" version="1">MHHLCEKFFEGNGRLPCGYLLIPEGNHDEIVNSLYCPKFLVVNGVLVNHLALMAIIRNLLTPGEAQGDSSDYIVPLQILSGVIILFTIPLLNSSSTFSRAEKLVEERLDVSVGFLEGGLDDGSKLNQNPDVGSLLNVADTITATVPNFSVNPVFLTYIVILLPLALQFIPELLSHMIKKDDSIFPQYAFCSMNASIAFTMKGNTTIPTSEVRFECSKDQQENLLRWWTQILIAIFLVTFNRVNSSQISQFLKKTRFCPSGQFKEFHGDIYSKPQILLSIYIMLTGVLAFYYNGMIFDAEFARGDYDNERSQTLFNDVGLFRVSLSLIYLLFFIPLNVNKISPRKSSWQVLEPTPSFPEEKRLIFKRIGVVPKRSRWILFPSIQSRCFHWFLNEDTKLVIPVAFLLYCLNLIMDNLLFKGRDGEKPLVEAKNINLTAFSFLLTYQFIFSVLYIYLKKKQKSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS15</accession>
    <name>A0A328QS15_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">pckA</name>
        <name evidence="9" type="ORF">DID73_01190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="248"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="453"/>
            <end position="454"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="545" mass="60406" checksum="22AC52C9E75E319B" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS39</accession>
    <name>A0A328QS39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome C551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_01290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="78" mass="8721" checksum="2694A278F3A56F8E" modified="2018-10-10" version="1">MNKPHIYKKKSITKNLDPGHHAICSCGLSKSQPFCDGNHKGTNFEPKIITLRAPKTVSLCLCKYSKSFPYCDGSHKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS69</accession>
    <name>A0A328QS69_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_01145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="247"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1408"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1960" mass="214833" checksum="D85D826F11E18A35" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS74</accession>
    <name>A0A328QS74_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="108" mass="12181" checksum="4F9463CDE2E44929" modified="2018-10-10" version="1">MDQLSSKDKENLQAIAIKYDKDSKKAPTVVASGRGKIAKKIVELAEENKIPMVEDPKLSKLLSSLKIKSEIPANLFKVVAEILAFIFYLEKMASKRSSLRSKFKRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSB2</accession>
    <name>A0A328QSB2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="19" type="ORF">DID73_00715</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="439"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="18">
        <location>
            <begin position="604"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="628"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RAP24823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="665" mass="75329" checksum="D6138EA2891DCF62" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSC2</accession>
    <name>A0A328QSC2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ORF">DID73_00770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="190" mass="20723" checksum="6ECF90D15D31C4C2" modified="2018-10-10" version="1">MHKLGILISGRGSNMTAIHQNTQSGQLNAQIAVVISNKPDAEGLVFARENGIPTHVFEPKNYTDRDAYEHDVVSCLQSLDVDLVVLAGYMKLVGDPMLKAYEGRMVNIHPSLLPSFKGLNAQQQALEYGVKITGCTAHYVIRDVDAGPIILQSAVPVLDDDTDDSLSARILDKEHEVFSKAIQVALNQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSG0</accession>
    <name>A0A328QSG0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">DID73_00940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="111"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP24863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="247" mass="26741" checksum="028592013A36093E" modified="2018-10-10" version="1">MSKVKVIVNGAKGNMGKASVQAIENDVDLECVSQCDVGSDLNEEIKSKSPDVILDFTHPNVVFSNAKTIIESGKRAVVGTTGLTETQLQELDALSKSNNTGILVCPNFAIGAVLMMQFAAQASKYLNEVEIIEYHHPYKADAPSGTAIKTADMIHEVSPNVNDHFGDFKQTELIEGAKGGYYKNVPIHSVRLDSYIASQEVLMGSPGQRLTIRHDSIDRLSFMPGVCLAIKKSVDVTGLVYGLEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSG6</accession>
    <name>A0A328QSG6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="469"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="744"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="905" mass="104916" checksum="7FF65EF3567FD234" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSH8</accession>
    <name>A0A328QSH8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="345" mass="40717" checksum="832E841F7D72FB24" modified="2018-10-10" version="1">MTNNSKDINHLYTIYDRYCETHPDDDKAHFILGTILFLLNKVEDAIRTFEKCMRINPTFNSLNFNLGLCNITLEKFIESEKYFRIELENTNYKHLNSALSLANLYLNKMSLFDIEAMVEIEDIIKQSMIHFNENETLKRDFDLIKYINRRNKKWGKFKIFNSREEILTYLSVGGIAAEIGVQEGNFSEKILTRQPKHLHLIDCWDFQPSEKYIDHHANISQQYHDQLFEEVIKKFEKEINNQQVIIHKDYSANVFKTFSPNTFDWVYIDANHAYEFVKEDLNLAYLKTKPGGFICGHDYVSEEFIKGYGVERAVDEFIEEKNMIPIGLTNEFYSSFILQKPKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSJ9</accession>
    <name>A0A328QSJ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">DID73_01510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="158" mass="16801" checksum="F8C7137DAA4EE591" modified="2018-10-10" version="1">MIRIGTGYDVHQLASDRPLIIGGVTIPHDKGLLGHSDADVLTHAITDAILGALAMGSIGDWFPDTDPKYKDADSIELLKDIYQKVKDKGFHIANIDSVIIAQNPKFKPHISAIQECLAAALGCAVDVVGVKATTTEKLGFEGREEGIAAQASVLLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSN0</accession>
    <name>A0A328QSN0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="273" mass="32144" checksum="E0D58407281EFC6A" modified="2018-10-10" version="1">MQIFSAFDIPPPYTTSNTPASTAPTDDADLSDPDSMYEIWIKPHVDIFEAFTKDNWKNELDNIFNIYLELKKNAPKITSHSLLKEMSIQVSVYEALIFRDMLLDSKSNHWTLSKCDKTDNPNEFQFKNQKTQIKSTIKKNKVYFKNNQLPIGHLTIDMENIILEKLHGTLFDKPFILDPIWLKKQRKVDAVKIQIDQFKTEIVHKKNHMNTLWTGGNEVSQMTISKNESLSINKQLLLNFKKIHWKSFTLYTFQWITPWYRLPIQGQYKLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QST1</accession>
    <name>A0A328QST1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argF</name>
        <name evidence="5" type="ORF">DID73_00270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="147"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="289" mass="32095" checksum="D835D3C3804550EC" modified="2018-10-10" version="1">MTHFIDILEHSKSDISDVLTRSIEIQSVPSNALSGKSVGLIFEKPSNRTRLSFEVGIQRLGGHAVYIKGEDIQMGDREPISHVSRVMSRYFDLIVYRTTDHARLLEFAKHSTVPVINGLSNESHPCQAVADALTIQQNFGSFESVFLTYIGDGNNVCQSLMNISQACGFDMAVVSPSAYAPKNAPNSIHVTDDISTVIGKTNVIYTDVWVSMGDEHEANQRLTAFQQYQVTSDLMRSAKDDCIFLHCLPANLGQEVTNEVFESSQSKVFDQAENRMHAQNGIMDWLMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QST4</accession>
    <name>A0A328QST4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="312" mass="34468" checksum="001ABC4884FFCAE8" modified="2018-10-10" version="1">MVKKIIIIGLIWCSGLLGSKITDSIYWMGSASSSAIGLATTAKTNSQDALYFNPAGLNTNKKSSINASYTSTYNTDFSNIGYIASSDLLSFGIGIHTSQSPDIEKTAFDESSNKISTSGHYQYTYSSLFLSSAIKIPYISFGHIGSSIHFHRMSISENILSGKSINLGIILEPISFISIGYTHHNVIPLYLTWVSKNKINTPPNTTIHKVESYGTLGIELNAIQMKSFKWSILADLDMDTIKATSTNGYSPLKIGTEIGFHPITIKAGYNHRFMSFGVTTSLNHIQFNYSFMLPKEKEMLDNRHAFGINYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QST5</accession>
    <name>A0A328QST5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ORF">DID73_00175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="321"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="474" mass="51307" checksum="82EBEE247F186B03" modified="2018-10-10" version="1">MIKVSSKLNQKNHVVVFVHDKTSGKKVQSAVSNDLANLYQSYKKAKKIKENAFHVIQTGPDPSSPHFVVVNLGKKASVVQFRSLAANVVRHFSDESHVQWVNVESISDWELHLAQVIPMSSYQMPNQKSDKKKASQTQHVILSKEKTSVNEGDIVGEAVNKARTFANSPANVLTTSNFVKEIKSLFKSDKRYSVTVLDESQLKKKKMNALLGVGQGSKYPSYLVDITYKGGSGDAIALVGKGVMFDTGGISIKPSRNMKEMKGDMGGAAAVVGAAWAAGQLNLKRSVSFIVPIVENMVSSEAQRPGDVVVASNGKSIEITNTDAEGRLILADALVYAAKKKVSCILDIATLTGASIIALGPYAISVMGNHQSLVDQLLQSSLGYNERCWQLPLFDEYKDLLKSDVADLLNANEGREAGTITAAKFLEQFVDDVPWAHLDIASTMSSSSTKGDQVKGMTGAGTRALISFMKQYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSU5</accession>
    <name>A0A328QSU5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="275" mass="31557" checksum="091BF1418E0ACB78" modified="2018-10-10" version="1">MHIGPHKGPYTPPSTPKRKLSKKESSTPQSKKRKKPLKSNQAVSNKIFTDGVLESLKIGRKKFSSTLAHFFKPGESLKHRAIRRAIFQNLYDLDLNAQFLTPKEWGEVNKLVGSTIYKEITLRHKKHLNAYTTGAHETHSERLIKGKDHTNHVIQGSNSIMGFLEKNKGKISDKLKALLHLLLECTFILEEDENTPPKKQNHTADESKHKSKKPKEAKKSKYWAKYLKKFDSNRLVSDSDFKLLKPLTEEINLDNYITKAEKGVQRKLSLPEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSV7</accession>
    <name>A0A328QSV7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="233" mass="26869" checksum="84C631C78CDBDEF0" modified="2018-10-10" version="1">MKLQHVLSKQGIFSRRVAETMIKDGYVLVNDDIQTNHLFQVSDQDQVSFADKIHDYAKQLGVLLVHKPRGVWTNCKIGVQEKEVVDLLPRKYQGYSSIGRLDKDSEGLILFTNDGVFANQFLNSDEIHERVYHVWTKQPLTAAHQRTLRSGVLLKDGMTQPCRLTEIKRNCYEIRLVEGKNRQIRRMVEICGTHVTRLKRLSFGDYTLGGIVAGQYRFQSLSELFLKRLNAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSW5</accession>
    <name>A0A328QSW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="93" mass="11077" checksum="617B5E00E9A78C4D" modified="2018-10-10" version="1">MSILTSLFLGTFLVLYSIFYPIFKRPVFATYVVILLIIGFCSVKLFRYLRQQTFAKTNVKQKLRLGFLWAFQGYLALMVIWYVVVHFKTYKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT20</accession>
    <name>A0A328QT20_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000017">
        <property type="protein sequence ID" value="RAP22838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP22838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="183" mass="19805" checksum="6C4769DCF4841EA4" modified="2018-10-10" version="1">MANGIIKTFDEPITLKSGKKSTLYVNWRTVAEDAYLMDQLTDFVLAFAQDNNIEPDTFYGVPEGATKLGILTQFKYAMNSNASKGSHTLAMGRAKPKEHGDPKDRYFVGSPQGSICILEDVTTTGGSLIECIKSLQAMGHSITAAIGLTNRNETLDEHASVAAAINELNVPYLEMSSAKALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT89</accession>
    <name>A0A328QT89_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">DID73_00955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="88"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="206" mass="23304" checksum="6D8085ED8A5D73BE" modified="2018-10-10" version="1">MHDDSFHQTKATFPLDDLIQHFSFYKGIGQKTAQRLALETIMLSPEKVQMFASSLVESKKNIKFCSDCYYLTWETKCHICLDQSRRRDTVCVVSEPKDVLSIEQSKSYRGLFHVLGGVISPLDGMYPELLRFKELQERISNGGITDVILALNPTVEGDTTSLYLQELFSHSPVTIYKLAQGIPIGSDLAYLDEVTIDKAFEGKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTI6</accession>
    <name>A0A328QTI6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="282" mass="31957" checksum="B879C7980F3B406B" modified="2018-10-10" version="1">MGLLRTIQTIQPLLRQFLVQSFSTLPPSGVSISKLNLSIPGTVLTRKDLKDLKETSPPPMILSGIYQNLDIRDVTFSRTDNLTDQHCDIGLCFVRNYAVSLAGLIHQIRFSKEFPNGSIPSSLCTPVTIVLVPTMGSGLKDFPTTVHQDENLAVHRTLYQSDVLGDVQTYFYAVLLRNLNLYAIEIAKRVNGEDAIYDNGAVIDPKQIHYDWGARILYREYFNQSWKTIDSDHLEYEGYFHACQKAMLESSGLLLYHQVLYPPQLYLPSTELCRVVMEVHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTI7</accession>
    <name>A0A328QTI7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="375"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="467" mass="54067" checksum="DE8FF782CE3B3D50" modified="2018-10-10" version="1">MMYSLSYKTHLLTLSSIFFLIITLSITIGSFFGVKSIQLINKKIDNTTNILLLSNAVLNYEEFLKSLDKSNNYRFLLKEHKHLYNTSFNLVNHLIIQFELFNIESNNKERAIITTLYNIQTKLSRISFQTDQFIYRKIKKSTKNPEPFILFLKEEKKLLNKELILLSNVNQDGIKRQITDIANKFIKYLSIICIFGFLLFIHFKLRIMKDLNAIKRNQDSNEGNELKGIMKKINEIQHKLTKSNLSENEQKIIINEKSKQIQQVTEQLIQSQEAERQNISQFIHNDIGQHLTALQLETAILEPKVKKSNDLNHTKELIQLCLKKIKTISKYIHPPQLNTQPLHYILNNHANETLPNTIECNIHTKDLNEEKLSNHQKLALFRTFQEGITNIIRHAEATIIKINLSSNNKEHILTIEDNGIGIKTNKDSTGLNTLKHRITMNNGTFLVENKDAALGTLLKITLPFEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTK8</accession>
    <name>A0A328QTK8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="82" mass="9230" checksum="E6A1BD3384589899" modified="2018-10-10" version="1">MQFLGLALGECESQLLILRPLANRLVSLLRRSSSPTGISDPVNQLNDEQINDEQIQQLNQLRETLAQLPDPCAHVHKKSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTS9</accession>
    <name>A0A328QTS9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="74"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="272" mass="30763" checksum="281684E904CF2B91" modified="2018-10-10" version="1">MTYSNKSISFILVSSDQGTMIVNRHDYNMSNGEAYGVGHQLLNHSSYDYPEVEFTKMLLNYKRKYNGDGVIAIDCGANIGVHTIQWGNLMHNWGTIYSFEAQEKIFYALAGNIVMNNCFNIHAFHKAVSFENGHLMIPKLDYTKSSSFGSFEIKKKESTEFIGQPIDYENDLISVPTITLDSLELDRLDLVKIDVEGMEIDVLTGAKQSIEQFKPILVIEFIKSDLTLLNEFLNSMDYKIIPMNSNIIALHSSDPLNDHIKVDNNVLSLDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTY4</accession>
    <name>A0A328QTY4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cyoE</name>
        <name evidence="7" type="synonym">ctaB</name>
        <name evidence="8" type="ORF">DID73_02210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="7"/>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP23507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="285" mass="32606" checksum="7E29CEEDC0966183" modified="2018-10-10" version="1">MFQKIKNYISFTKPGISRAQILTVSIGYFLAKQSIKIDWNYIYLIVATYCYSASACGANNLIEKNHDRKMNRTKGRELVTGEMNSLEAIIIIVLMFFIATIYMLKINMATLVISLITVVTYVAIYTPLKRHSWINTHVGAIPGALPLLGGWVATGTPFHMAVISLFFTLFCWQIPHFYALSMMYFDEYKEAGFRMLPNQHGGIQATKRQIIFFSTLMVLSSIYPFFIGFLSKIYLIGVLILSAIFWRFALQAVNDLKKNAKKLFILSIIYLPLWFTLIIIDIILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTZ7</accession>
    <name>A0A328QTZ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="259" mass="29336" checksum="737F3FA2EEC1FDEA" modified="2018-10-10" version="1">MGQLIRKTLILMVILFFTPSVVYPSFNDGLYLSTMMGCSKSGRSPLTIKYDDRQHESISARYNNRCLDDSHWWSIRVENWTNQTGWGLELIHHKIYLANTTDNLTSFSISDGYNLLLFNFVKQVNDINYRIGFGGVLGHMDAHVSGRDRYIRKGFKGHYLTGPAFQINVEKIIWQSDTHFISFDSKFTAAYAEVPISSNNNELAIAPDHAVHFSLALGSKPEALTSAKKNYHKAWYFAPLVYPAIVGRLIGTGVLPDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QU07</accession>
    <name>A0A328QU07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="82" mass="9615" checksum="5D0FB45AA59C1AA3" modified="2018-10-10" version="1" fragment="single">LTQASLTNTYEAMSDIPILMYTNWNNTVSMGGYITIIVLSIPIYYFYKVSIQKYRDKVLPKLKNSKIIHILKLPNWLTLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QV45</accession>
    <name>A0A328QV45_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="436" mass="49980" checksum="E7C65D4276DA4051" modified="2018-10-10" version="1">MYCKESVKSFDIPQKKMSNYGSSRCQPTPQSSKALREVEKMIGLLNQVIDPYLYDPFCPHLFTSINEKITDIRRQVNNDPDQIASRLKDNLFNYFLTPIDDMVKVNKKDMRPSLFLADILTLIVEIEEHKNKHNKAMEQFATLPDDMSATDILINGERVTVTNTYDDGKSSYESFILGDGSYKADAPMMLLMDKSKKTNTLVSLDMFKGIYKSSQKNHPITLRSLLDGNMACMVVSPINDVRTCIAFAIPERLFAHVTMALADHLRRTPWLEVPKKPVDGVYLKNGKTAQDVCNEWMNDVTDAMEIRGLGTTELIDETPFNEDEKIREAFNNEGKYLVSLTNKTIQIARVFLRARLEVAALKNKMEIKHQIIFTEREFKDQLERGELDPLKEILAAYLEIIQIKTALHGQFNQPLPNQPLHLWELFQSLKNEASYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QV48</accession>
    <name>A0A328QV48_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000016">
        <property type="protein sequence ID" value="RAP22841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP22841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="172" mass="19268" checksum="84873F2251524AD8" modified="2018-10-10" version="1">MDNLVKAKVIIELLDDRKYSVLSSFSSQELNKLNGIDLDVLNNLSNADINKTIGEFLENIEKRKDIEPEPDAPSEPSQEKSVELKGASKEKGGDSQQPVEEKKVLTIAEKIQLQPPQLLACILNRVDEEKKAVLLSHLDEDKKQLIESIEVENTPIAEQVIQVLLKELELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QV98</accession>
    <name>A0A328QV98_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutaminase</fullName>
            <ecNumber evidence="3 7">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glsA</name>
        <name evidence="10" type="ORF">DID73_01965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 7"/>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand_14" evidence="9">
        <location>
            <begin position="33"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="536" mass="59534" checksum="7D4C7FC62D5017B6" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVE3</accession>
    <name>A0A328QVE3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="330" mass="38162" checksum="145400CE613579EA" modified="2018-10-10" version="1">MLRTVQRSPSDRLKPMGKVPQQGVDALAERYKSGDAQDPANGESKISDAKSGVATVYPADLKLSIQHSAGESKSNDNKERYFDICREMERLLDNVDSEDTVQRLIDNLDEISNTVQRLIDNFDELSKPDKRTLHDLGSFTLRYRFMNGVLAKVTEKLESEDGITNGRCIFRLLYKVDEMHKKTWFKEILYPPMFTLPDTEVTYLHKLRKVKNIVYTNLDQSERIVADAYARRSCLLSCFGSSQNRRALTQADLDKLNVQKLFQRIKLLQNKELELISKINDIYDGNMESLNLGYRIWHSSKKQEAELKNVRQQLKPYYRELRALVSNKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVR3</accession>
    <name>A0A328QVR3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="411"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="585" mass="66951" checksum="F8E02EAB68DBF36E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVV0</accession>
    <name>A0A328QVV0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="158" mass="18172" checksum="11A846F744A8FB30" modified="2018-10-10" version="1">MNKTIAIGKLCNYLKWLFCHCCPSNDSNLKNSKRPLLADPNIHTYTTEHPDSRPKIPDHSIKIKLIEGTRKDIKRALKECHFFQISHYDGIQLEKGEPDTFIASADIKNAKINLKYNQTNIEKGAYFRIKITEDFENEAFFVIFKILVVNRGSKSIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVZ1</accession>
    <name>A0A328QVZ1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ispH</name>
        <name evidence="6" type="ORF">DID73_01220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="316" mass="34971" checksum="91F027EF38272C8B" modified="2018-10-10" version="1">MSVKELHLAHTQGFCAGVVNAIDIVELSIQKFGVPLYVRHAIVHNTSVIKDFESRGVIFIETLSDVPNDQVVVFSAHGTAPDVYTEAQERNLTIVDATCPLVTKVHRQARRYSERGIHIILIGHRGHQELIGTSGYIDKDLLHIVEDQHDIDALSIPSNVEVGVLTQTTLSVDDTSQLIDQLRLKFPNLITGGKEDICYATQNRQDAVKALAKKCELIIVIGSSNSSNSNRLVETSKLMGVESFIIDLPEEIDYSVLNQFESVGVTSGASVPSYLIDRLVKAIKKRHPDVVIFQEDTIEKDILFPLPKEVADMRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW04</accession>
    <name>A0A328QW04_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoid-associated protein, YbaB/EbfC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="110" mass="11935" checksum="5AABE21AE3554431" modified="2018-10-10" version="1">MLEKFKNMGKALKEAQNMKGMMEEVQKELEKSIIPISELDGKIKIEITGELQVVKFEIDPSLLTQDQKQAVENAVQQGFSKAIKQAKDLATNKLQSVTGGLFSGGAAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW07</accession>
    <name>A0A328QW07_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="109" mass="12794" checksum="35DEF90CDAD261B9" modified="2018-10-10" version="1">MGKHEPNKIKKEILKSGKFHPGKISLQYTVCNKPNCACKDKINPKKHGPYYQLSYSVKGKSRTRFIKAKDIQKVNEYIDEYNRIKDLLSDLSEAYVHNFKEHGWDYDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW73</accession>
    <name>A0A328QW73_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016323832" evidence="1">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="300" mass="32789" checksum="0F1242ADE74C2936" modified="2018-10-10" version="1">MKKHIALLLTILIMGCSNSGSDGVQKIDFTVAELDALKSLKNIKAAPSSGDGSSDTDGLGIRLSSGNLSSIGSQGSGSETTLHVAKFHEDIHPFKYEQKVVSSNSGLKALRFYSSSFEGEVEKYNALTAVDHNFPVSSDDIHGYIWYQSFIIDETSNNNNQYASHIVSYGFLSDHKLHFESDTFHIVDEIKISRFEVGSSSERCNYSVSFVSNTVSVAFSDCDLKITAYDESQTAHQFIGSLKNKSLEFPLEDIDEGIDVSSASIVTNALFNTSGQQVGYFNLNLVDGSFTILDNNKQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWB7</accession>
    <name>A0A328QWB7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="52"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="200" mass="22999" checksum="5AEE381FB218885B" modified="2018-10-10" version="1">MTLLRPNIKETSLYYDDCASFIDDDAKAMGWSSQFNQMLRFDVMTYLVDMRNSSILDVGCGDGAFFHYLSDQNINAEYKGIDVSKKMVQRAQNRYPGINVRQIDFFDVQEPYDVVACSGALSMSADEPMQYLSSAIDHLFSISRSHLVFNLLSHHAPSKSSKFNRYYPQEVLNLCFSKTQYVTMHHGYLPNDFTIYMVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWB9</accession>
    <name>A0A328QWB9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="123" mass="13509" checksum="BF95C03CFDEC8CEE" modified="2018-10-10" version="1">MKKTIIKLIIFTVMQLTIDVAGSDSLLKGRIQHAPNPFKLSQGTTFVYELSQPAAVQLLIYNQFGQRIMMENYAAGAPGGQQNKNLVSISKRNFSGLDLPKGVYFYIVTSNGRVLGKGKMAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWC9</accession>
    <name>A0A328QWC9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">sfsA</name>
        <name evidence="4" type="ORF">DID73_00495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="2">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP25016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="228" mass="25289" checksum="6BA304A8CD49F4FE" modified="2018-10-10" version="1">MILSLHQPRVYGTLIKRYKRFLADVELASGEIITAHCPNPGRMLTCSDPGSKVRLSVFDDGKRKYPHRLDLVHNGDCWIGVNPNLANDIVGAAIDQGLLFSELDPAGWQREVPYAEKHRIDFMHGSGKQKCFVEVKSVTYAEAGVGYFPDAVSKRATLHLHALSQMVKDGYQANMVYCIQRPDVNSVEPAAHIDSKYAEAVDEAVLNGVTCIPFSIRFDESGDAVFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWH3</accession>
    <name>A0A328QWH3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026444">
        <property type="entry name" value="Secre_tail"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04183">
        <property type="entry name" value="Por_Secre_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1093" mass="116634" checksum="80BA11AB978E4F22" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWJ1</accession>
    <name>A0A328QWJ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoheptose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="39"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="193" mass="20716" checksum="7AF45DA3F04B2504" modified="2018-10-10" version="1">MMYNEKMIQTILKEAADTHQLLIDDQPLQKNIQSLASACTTAIQNGHKIILCGNGGSFGDAQHICAEFVGRFLQDRHALPAICLGCNSSSTTAIGNDYSFNDIFSRELSALGQTGDVLIGITTSGNSSNVLTAIDVALEKNIQVFGLTSNKKGAITEKCPCIEVPSDHTPRVQECHILIGHIICEMVDAAILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWJ4</accession>
    <name>A0A328QWJ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bro-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000015">
        <property type="protein sequence ID" value="RAP22882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018873">
        <property type="entry name" value="KilA-N_DNA-bd_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10543">
        <property type="entry name" value="ORF6N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51750">
        <property type="entry name" value="BRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="1">
        <location>
            <begin position="127"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP22882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="354" mass="40897" checksum="EEA728408D63F1FE" modified="2018-10-10" version="1">MISILSKKPLLSIRHQTVILDRDLAPLLGLETKRLMEKYKRANLDHNETDCFQLTDSEFLNWRSQNASSNDIKIGLRRPPYAFTKTGLKSLIPMMKKNNQQRGLADTIHLFESTPNATKELNKNEPKNKLITYTSNDGNLQFDVEFDGDTVWLSQQQMADLLGTTQQNISRHLDNIFSDEELKKSSVHKESLYTANDGKQYKTTLYNLDAILSVGYRVRSTVAVHFRHWATAILKQHLMHGFSIKDRISTQQLQQAQTVIHNQINIGDIHIHVKNRDINIASNNLNKDEFLPLFHLLQQQLKGTMIAPFLDETKEKNRWDEFIELLKPDSWLRQSISHATDAKDTLQQIIELIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWM2</accession>
    <name>A0A328QWM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="247"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="332"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="417" mass="46619" checksum="AA0D1274EFD1A8D5" modified="2018-10-10" version="1">MSDIQLESDNPIDSSSQITETPQETAGTKIGEVSDFEKDLIQSEVIEEQAPRVDLISDDNKDEQVENMFASHLSQDFSDYVEGEIVKARVRMVKKSGVLVDFSYKSDGFIPSNELSDSLVGDLEEGFELHAMIQKLETKEGYSLLSETNARAEMIWDDLYDIMNRKEVLDIQIKKVNPKGYLVDYEGASGFLHAEEGDDFSEGDVVQALIINVDKRRRKVLFSTRNIQNVLFKKEEVGKFLETVAVGDTLKGTISGIKKFGVFVNLGQAEGLVHISEISWRRISHPSDVVELGQEVDVEVLSLDKEQGKLSLGMKQLSQDPWETIDANYEVGQVVTGKVVRIIDFGAFILIDKDLEGLVHISEVSVKRINSLDDVLLVGDSVNVKIIKLTKHDQKIGLSIKNVPQDNEELAQRIESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWN0</accession>
    <name>A0A328QWN0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ORF">DID73_02325</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RAP23441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="566" mass="59380" checksum="806F04BF08979CA4" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWQ5</accession>
    <name>A0A328QWQ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lysine 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_00510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP25019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="487" mass="56319" checksum="6C9723A20FBDDF6D" modified="2018-10-10" version="1">MQSTIEETTNDIFNLTDTSVIFKKPQHWTTPNGVEMKHQPFKKFLRTDIRPLFEAKGINDPDLDAREVVAQVFPFKINQHIINRINWNAYEDDPIFQLTFPQKEMLHPEEIETILSLKNSGASRDAIADKISEIRSKKNPAPANQSANRPFIDDDNEPEFIDGLQHKYKKIVLMFHKNAQTCHAYCTYCFRFNQFVGKDKFLEEDHVRLHKYLKAHPEVSDVLMTGGDPATMKTDTWKEVLLPLLSPEYEHVQTIRMGTKALTYHPYRFLTEPDADELIALFRKLRDHGKHVSIMAHFSHFQEMGPVTLEAVRRLREEAGATIRTQSPVMKHINDSSYVWSKMWDLQVRHGMIPYYMFVARDTGARHYFEIPLAQALDIYQGARKQVSGLGHTARGPSMSSGPGKICVLGRESVAGEDVFVLKFLQGRNEDWCDRVFFAKYDEKAAWIDQLQPAFGEKKFFFEDEYAHILNEKQKKYDAMIEKGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWR2</accession>
    <name>A0A328QWR2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peripla_BP_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="3">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP25029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="356" mass="39851" checksum="28301174E9DA4DD3" modified="2018-10-10" version="1">MKLFSPNSYLILGLIGVLSSALYANPIKIGMSAPLTGPSSHLGISLLEGIRPSIININKNGGIQGRLVELIVLDDQYNPKKTIQNTITLIKEKKVDLLFSYVGTPTTLQASPLLIKYNKPLFFPFTGAHVLHHGNIGNMIYHWRPNYWEESTAIVNHFIKNNQKNIAIYYQKDAFGQSGLLGIKNALSRHKKSPVSITSYPRGKSFSDDFSDEATRLLEKKPDAIICISSYEASAGLIKAIRQKNTVPIATISFSDPIGVSEKLNNQPALMTNIIYSQVVPDKTQILDLDNYKKITKKPFNPIRYEGYKNTIKLIEILSKHSLKEIRLAHKSIQQQLNEEHTVTLLKSTKNGWTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWZ8</accession>
    <name>A0A328QWZ8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_02105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP23561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="346" mass="38783" checksum="B6299AD1E6DE3A10" modified="2018-10-10" version="1">MNSYIICILMSAISMYFMTKLAIRLSKKTAFYAMPKNRNMHTKPTPVLGGLALLMSILVNVLMFTQWDWGPVMIGGVGAILIFFIGLYDDKYEIQPWLKIGLQSMVITWLFMNGIRIDFITWPTSASPMFFTPIVSFIITQCWMIIIINMFNIIDGIDGLAVGISCLTSIMLFFVSLSASPLIITYLLCSIIGSTGMFLKFNFYPAKIFLGDSGALLLGYLFALCSILGVLKSTVSFLILLFVFAIPIMDLVLSVLRRGLKRRNIFYPDLEHIHHQLVRRGLSVRKTAIILYVISGVFGLIAITSALDSNIIKITIGGALFFGVLIYFSFLQMSNKRFKALKKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXC1</accession>
    <name>A0A328QXC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_02420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="105"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP23172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="219" mass="25772" checksum="C5C79E800969FA56" modified="2018-10-10" version="1" fragment="single">MNLQTLIHNFCQYLTVQKQRSHHTISNYRRDIEQFFSIINTQDPSIINDHHIHLYLNDLNSSQMSQRSIHRKMSAIDQFWRYLIQENMVQNNPWSTIRRPKINQHLPVYLEEHAMLELLNNYPTSSPLFQRNKAILELLFSSGIRVNELIHISLDSIDLPSQECRVLGKGDKERIVLFGARAKQAIQFYLDHARHQWAPTIQTLFISSKGTPLTTRTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXM0</accession>
    <name>A0A328QXM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="141" mass="16766" checksum="6FD5B7AB220D4AB0" modified="2018-10-10" version="1">MTDLHEKFTEYLLSQKQRYTTQRKDIVTAILEKKDHFEIDEFISEVHLQGKRLARATVYRTVKQLLDANLIQKIDAGNGRIYYEYNEELEHHDHMICNQCGKILEIKNNTIEKAIKSECRKLDFQPEYRSLHIYGTCKNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXM9</accession>
    <name>A0A328QXM9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AlbA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="337" mass="38527" checksum="342253AE316CC87F" modified="2018-10-10" version="1">MNWQSFITLIQEQSENTFFLSNTRQERLIGQTLSALLNTLGGKLIVGYDKVNVHLTGYEQTDQWIDQFLADHFKNTSITSTFLFRSNKKILILDIEKSEREMPYSGKYYKIHEKKITEYTPINSQPMPPIQPAPTPEITEQAPITQPLPATTTAIENNTDHSPYQPPSQETEKPVISSTFDAVPQESLEHSDKLNTRQKKAIDFITKQGSIKNKQYRKLFGVSHKTAHIELAELVQQEKVMIVGSGRSTCYRLPNPNQKVQKMETISQVDSVIPKSLLESFMAKHQNITESMYADEFNMDMAQAINELQHFCEEGILEKTLINNETCYTKATQLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXN7</accession>
    <name>A0A328QXN7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_01355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="272" mass="29959" checksum="9FC0B38B3AEFCF05" modified="2018-10-10" version="1">MFIYRFIRLFSCGDHKVIELIAIPFLACLVLVLIHGYFGAFVLRRGIIFIDLALAQWAALGYLIGHWLGVESPASLFLIAFTGTLLASLILVGLKPFYEKVNLQEASIGVMYIFATTVATALISSTGMEGHHLKDMLSGHLLFIQPAEIFSAIILYTLIGGILYKVHHRLLSAKSRGWDFIFYSLFGLVVTSSVKMVGVLLVFSFLVIPLLTVRLFTTNFKTQLLSGWLIGSIGSVIGIILAISIDIPLSLSIILAYMGCFFTGVLIKSYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXP1</accession>
    <name>A0A328QXP1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="320" mass="35992" checksum="712082917AD935A6" modified="2018-10-10" version="1">MEYRRLGSSGLQLSALSFGAWVTFSKQVDQDVAYQLMTHAYDHGVNFFDNAEVYEQGQAEILMGNALKKAGWGRDTYCVSSKVFWGGQKPTQRGLSKKHVHDACHGALTRLQVDYLDLYFCHRPDPDTPVHETVFAMNDLITQGKVLYWGTSEWKPNQLIEAYKVASKYGLRGPVMEQPEYNLFNRNNLEVDLKPVIDKYGLGTTIWSPLCSGMLTGKYQDGIPKGSRFDLDGYEWLKDRYHSEVGQQRIQQVAQMADIVRGLDATLSQVAIAWCLKNPDVSTVILGASTMAQLTENLGSLAVLDQLDDSVMTELDQLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXV2</accession>
    <name>A0A328QXV2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_00685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="305"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="840" mass="95269" checksum="EB5501FE14D77D01" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXX8</accession>
    <name>A0A328QXX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="162" mass="18223" checksum="84538C70B4D0B765" modified="2018-10-10" version="1">MIREATDNDFDDIWGIFNAVVKTGASYVYSPDTTKDEAYRIWMTLPIKTFVMLDGQQSIVGTYYIKENRPDLGSHICRCGYMVHPDARRQGIGEAMCKHSLSVAPDLGFRGMQLGYVVSTNTASVNLWKKMGFIDVGRVPNAFQHQDLGDVDVLIMYQSLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXZ0</accession>
    <name>A0A328QXZ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_00910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="387" mass="45655" checksum="3054F67377A4ECE9" modified="2018-10-10" version="1">MKTLMGLSKLPIYTFKLVIYWISYFTEKDKNTWIFGAWDGNLFCDNSKALFLYTIKEHTKINAFWLTKNKLVYKELKEKCLPVLYIWSLKGLITSLKAHVIFISHRSYDVAEFCISKKNTIIQLWHGSPIKKICQDNKFEKKNWNMPTWKKIIYTILLPYDKTHATLTIASSKKVKEIFKNSFLINDEQIAVLGYPRNDQLKKSQHKTKKIIYLPTMRPYNKNLNYLDNIYSPELENVLKKHSASLHIKLHPIDSSKSMIENIHIINDPDIHQQLGEYDILITDYSSIIFDYLLLNQPIIHYLFDHTKYIANERELYENIDTVACGPIAKNVTELIQHLDEILEGNDNHKEKRQVVKKTYNEFDDQKNSKRVCDYVLNLINHSQTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYA1</accession>
    <name>A0A328QYA1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_02240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FlgH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009427">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, L ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000527">
        <property type="entry name" value="Flag_Lring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34933">
        <property type="entry name" value="PTHR34933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02107">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01008">
        <property type="entry name" value="FLGLRINGFLGH"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016460707" evidence="6">
        <location>
            <begin position="23"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP23512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="204" mass="22607" checksum="4A2A94F2FF1D723E" modified="2018-10-10" version="1">MIKKQLLFLVCNLVMIVTPLTADSLWSQSKESSMFDNQRVFKVGDLVTVMISAESTAVQEAGTTTRKRSDIGAKFFDTFDQYSLDANQNNSLRKMQDYRIGGDDNYSGVGQTTRKSKVEAIVSCIVTKVLTNGHLVISGERLVDVNNDSEIIQISGIVRPADINAKNTIESHQIAQFNISLKGKGVVNSKQTPGFLSNFFNWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYA5</accession>
    <name>A0A328QYA5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsP</name>
        <name evidence="5" type="ORF">DID73_00340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="98" mass="11025" checksum="D77B907B33D61AB3" modified="2018-10-10" version="1">MRKGRKKKPLYRIVVIEDSNQRDGKTIEDIGTYNPHTEPASITVKEDRAKHWISVGAQPSNTVNRLLSTVGLTEHTPLQSSSQKVAKKDRQSSKKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYC8</accession>
    <name>A0A328QYC8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ResB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_01610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="362" mass="42193" checksum="2D943E742B990B7D" modified="2018-10-10" version="1">MEKYLKQFLRLFGDIRLTIFLLFKLFFLILFATFSQVDLGIFEANKRYFTSWFVFMGAIPIYLGGYFIGLLLLINLMASHATKFRFSKSYMGIFLIHFGLILLIIGSGITSFLGEEMQISIQEGESRNYLEYPSEFELVIIDTSDTTFDRIHSFELSDLESAVPFNQVTLQYLTYAPNAIINQRGIENPKFNQLGQSFKLISMPKTYKMSERNIPGLTLMVQFKNQTDYYLLWGGSAIYQTLMIDNQQFLIKIRPKRRYLDFSIYLHDFIRNTYEKSDTARQFMSKVSLITPNGTVPFDIQMNEPLRYNGYTFFQSSFTDDEQTSVFQVVKNPSWLVPYISSIIIIIGLFVQMMTSMRKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYD2</accession>
    <name>A0A328QYD2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_02055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP23552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="122" mass="13649" checksum="D72D12F1CD4A5B2E" modified="2018-10-10" version="1">MMYLNYSAVILLMMMGLWAMIAKKNIIKKLIGMAIFQTGIILFYISMGAKSGSTIPIIDHHHLNDPIIMAQYANPLTQILMLTAIVVGVATLGLGLTLARKIYDEYSTFNEDEILIKVKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYD3</accession>
    <name>A0A328QYD3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="137" mass="16189" checksum="F05557155CB398A7" modified="2018-10-10" version="1">MLKKTCRFALQLIRDIDGLFTWATTFWHPKQPIYGQCKQRGVCCQNVAVGISKRINNSVPLLKIINWWYTFVYNFSLKGWYKNNQIMIYSCNYLKNGKCSIYWRRPLICREYPRSKRIGQSTMPGCGYSLQPKDTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYD9</accession>
    <name>A0A328QYD9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_00560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="937"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP25027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1226" mass="136928" checksum="46E0D7371E0182D2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYE0</accession>
    <name>A0A328QYE0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="409" mass="45152" checksum="5124D70C20B56153" modified="2018-10-10" version="1">MSIAIINGKLLDEDKKINVRNLLIQGSKVTGVGYIPDEDEDALNVCDVSQSMILPSTFDFFYLPELSDILSYTQEIQSKGMMNIAYIPNDASSTLDRPEDIEKMTSLLGDFSQNVSFVACASKANGADELSELSLLVNAGAKAIYFGRIIENEILFKQALTYVEMIGVPIVFGPMTKMEKNGAHLNAGATSFEIGIRGEAEEDELNTVQYVLSMLQSHVSVPVHFQCISSIDALRTIHEFKKQRQNLTVGVSPFHLVFSDEYLREYNQKLKFNPPLRSQNTMRDLRQCLSSGMVDHLTALHHPQLGDSQAQSFFDHPFGAQTLASFFQVASHCLVSEGLSLDQYDALLSCPSSLNLFDSIVLGLNTTASFIVLKAVSDDQTSQMLFDDIEIPLQGGVQVIMTNGELVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYJ9</accession>
    <name>A0A328QYJ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">dxs</name>
        <name evidence="12" type="ORF">DID73_00040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP24928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="637" mass="70691" checksum="8E13032A0EC4F01E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYR2</accession>
    <name>A0A328QYR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="446" mass="49746" checksum="A0AF9B76A1B62170" modified="2018-10-10" version="1">MMRFEGGLVNQKINALYPKKSSLKRSSARTKKHVAPQILSRKIPFPLVPKNKGHAVSTKLSSDFNQMRRLLKLLQSESLIQPLYRVGVYSIEDLQDITPTILEKKYQLKLTKLLAFVQSGWLNDYKTNESSPQVVFNFQRKVSGQFKQALMYVQHGCDLPTLDLDRRDDAVPVTGCEGRGAVRSVKLPRLPKKVCYGRKWFMSFGIDDYLHWPSLHNAVSDSTELTSYFTQQHGFQSFGEPLNGPVTKDSMARFFQKTAPMMCGPDDVLVVSFHGHGHTMSFQGKDYGFLVPSDAPQNPSPYDLISMDHLASWLKYIPSRHVLLLLDSCFSGLMAQRGLSKAVVSTSRDLSKQSYLRYHLSKVSRIVINAGHGSQMVSDGGWGTHSIFTGAILSSDVLRNDSSASIYTFFNAIHDTVVSSGHSQQIPTMARLPGDSGSDLFLGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYV2</accession>
    <name>A0A328QYV2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP23960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="210" mass="24176" checksum="F6D23BC439344486" modified="2018-10-10" version="1">MKKNICIIDDHEIIRTGVRRLMSQSNQFNVVYEFTSNASLLNHPLTKNVDIIIQDLDLKDGCNLSQLEVLHYKCPNIPILIYTMHPESMYGLACLKYNISGYLTKDKPISDLMTAIDTICSGKKFYTPELNQLLAEHYLNKNDASINQLSQRENEVFTLIGEGFSPSEISKKLFINIKTVSTYRRRILDKLNLNSNNQLIRLYLSNKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZ30</accession>
    <name>A0A328QZ30_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisA</name>
        <name evidence="11" type="ORF">DID73_01555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="242" mass="26468" checksum="81FE9FD63A12F131" modified="2018-10-10" version="1">MTPFSLIPAIDIIDGGLVRLFKGDYDQITEYDMSPLDMAYYYVSLGFKYIHVVDLNGAKDGHLTNLEVIRSIAEIPDLMVQVGGGVRNHQHIETLLDAGVSAVIVGSLFVKDFDLACQMASDFPGHIIAGLDILDDHLAAHGWTERSDLTLETILTQLSDTPLHSIVTTDISKDGTFEGLNFDLYHRMSSLSAHHIIASGGVSTISDVIQLRDMKLPNVTGCIVGKAIIEGKIKQEDITEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZ39</accession>
    <name>A0A328QZ39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="341" mass="40185" checksum="ABF847F6F066D4E7" modified="2018-10-10" version="1">MSQTYYRDGKKSVEFVPYKGEKMDTCATIHDEYVCCNVKVLKSVSNCPFDCSYCFLQNYLTNPQLEVVEDNDRLIQEIESKIKAQPWRFFRIGTWELGDSLALENDTGQAQKLIDYFSTVDNAVLELKTKSDVVDPILTCDHNQKTVVSWSMNTDYIIRTEEHKTASLEKRLIAIKKVVDAGYLIGLHFDPMIRYDEWATDYTELLTQLADIVPAEQIAWLSIGSLRFNPEQKRLIENNFRGSKLTCQEMVKGSDNKVRYVKPHRIEMYRLMFNKMRELWGNDPFIYLCMERWDMWDKIMDIQPRSIGELDYMFADHFHRFFPVVNPQIPNLELYKKYQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZM2</accession>
    <name>A0A328QZM2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="156" mass="17915" checksum="5207768013ABFBAB" modified="2018-10-10" version="1">MNDYNEAVIIGRSTEDVKKSTHGDRIKYTFIVATNYYSGKTKQQYSEFIPVCFWKSEPFKELEKLEKGDSVIVNGRVSIHSYEKNDEKKWATEVIGRYVRVFKLSKETKDMADLVTLIKSNKPLLDEITESNQITFSDDLAAELLLDTEEEAMGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZW2</accession>
    <name>A0A328QZW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="450" mass="52180" checksum="E7CB3227F86BD560" modified="2018-10-10" version="1">MKKTIAGFSDSFFVNSDFRSDNYPDQLKAIEVDKLIAYNSRKINYFDLISSPGFVFNTGLATSDTLKVDVEKIPDFIRIATIINDDNQIQIIKDFLKHQNYTFCQVKTIIDRLKQSNIQLDEDLKCSLFSSAENRFEELCIRLYCDDPLVTEFIYGNISPSKFHTQESQYGIDFEYEKGQFDIEQFSIALENNTYLKSIIFQEFPTINSKKTTVFLESLKTTQISKLILRGVQFTAYDLKLISGIDSLTALSLLDNKLNDKNFKLLGSLLLQLNSFTIGEGNLLTHAILDYTEKLFNQRLDTPKSSDDYDYLRVNLHIFTFDLFSSLSPKQYALNECPRRNTLKYSFMPRCYSELEICGNLTNFQKSTELSYDRYLNGKTLPSMYYFDHYLTQLDKISKKKQFFNVEINAPHSFNESLLDQYRQQLTSINSIVVSRNSENGNYELKAEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R036</accession>
    <name>A0A328R036_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide peptidase SppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sppA</name>
        <name evidence="4" type="ORF">DID73_00655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016300836" evidence="2">
        <location>
            <begin position="20"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="362"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="609"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="785" mass="87164" checksum="2D64C6B3C26FEFA0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R045</accession>
    <name>A0A328R045_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016431844" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="59" mass="6774" checksum="B31305251B76C7EC" modified="2018-10-10" version="1">MKRFICCCLFIALLFIGCAKTYNNSDDSEIPKSKVVTVTEKQIEAIKMFQDFNTLNEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0C6</accession>
    <name>A0A328R0C6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">DID73_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="149" mass="16081" checksum="8F4A620318027D12" modified="2018-10-10" version="1">MKCIIQRVQEASVSVNGQVIGQINQGFLVLLGIEAADTQDDQDKVLKKMLDMRIFPNGDGKFDKSLIDIKGDLLVVSQFTLMADCKKGRRPSFTDAAEPDKAKAMCDQFIEAAKKAPIGHVASGEFGANMQVALVNDGPVTIPLDSNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0J2</accession>
    <name>A0A328R0J2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="64" mass="7250" checksum="AE724CA8CF6316EC" modified="2018-10-10" version="1" fragment="single">GNLSVLTKLDLDNNRLESLPDSIGNLSALPIALIGRNQREIKTGRLEIALSHKRSFMRQIFYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0L0</accession>
    <name>A0A328R0L0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="179" mass="19417" checksum="1C2897B75ABD2DF6" modified="2018-10-10" version="1">MIQFTLPENVLKTSPTIDPDAFVAPGAQIMGDVIIKKDASVWYNSVLRGDINQIVIGERSNIQDGCILHLENGLPCIVENDVTVGHHVNLHGCHVEECCLIGIGAIILSGARIGRGSIIGAGAVILENQEIPPFSLVVGMPGKIIKSTPNDTIEKQQQWANKYVELSKVHKKHQKDAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0R8</accession>
    <name>A0A328R0R8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_00415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP25001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="215" mass="24518" checksum="539BB92DB877E2EB" modified="2018-10-10" version="1">MSHLIENINQLKKSIPSSVTIVVATKYAGLDDIKTISDHCPNIIFGENRVQQGQEKQDAYPNIKNPWHFIGHLQRNKVKKVIRNYDLIHSVDSERLMVEIDNESKKNQQITNILLQVNPLEEDSKFGFNETTIYDAIKTAKKLSNINVKGLMSMAPFDTDTATIKKTFKKTRAIYDKLKSDELQFEHLSMGMSNDFEIAIEEGANMIRVGSKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0S4</accession>
    <name>A0A328R0S4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015097">
        <property type="term" value="F:mercury ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004891">
        <property type="entry name" value="Mercury-R_MerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03203">
        <property type="entry name" value="MerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="128" mass="14405" checksum="6E2B3302B1D8E650" modified="2018-10-10" version="1">MTESTKEKLITIASFTCVLHCIIVPFLVMGAPLLGNFFENIFVELGILLFSIACGIAIIYNGYCKHKKKHAGIIFLIGISFWGMHTLIELLTHWHLDIELLTAGTILVLIAYRINHNQTKSCCTTHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0S9</accession>
    <name>A0A328R0S9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="263" mass="29450" checksum="3C9ED93D9B9513FC" modified="2018-10-10" version="1">MRLLILFFFMIGSVCYGLDYKGSCTARDPDDLSKGYEREITNPDNYTVSSGYISDLSITPKLINVTFSDNACSSTKVIKYYVNEYDDSSIDTNINVVNREFTFSLKGGVHHRTLFRTETTRIFSSKIFIEPNRILSIDNGVSTGDPFNGNTLHQISNVDGQLSWGTEDSPCDVNFPNHPDDYSVSEFGSDLGCLIQLKANDKDGASHEFSFRLKITKCADINSPTQCMQTVPLMDSNGVTTNVVVKSNLFQYEFYNADTDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R102</accession>
    <name>A0A328R102_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_00050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="249" mass="28615" checksum="49660C439BE7B946" modified="2018-10-10" version="1">MIYLELVPNNIPDLIKESKWALNSFKDIYGINVPDILRIDNRSYDAVTHLAKEAIPCIPHIRICDFSIDNLLSLCNTLQDNNVDKILLISGDPPPNPLQPIFKHNIVNVIKTITSTMPKLTIYAGHDPYRQSFKEEFNYSKKKLEAGAKGLFTQPIFDTNLTNILLDQCLPCEWFIGISPVLTEKSFNYWVSRNNVVFPPDFKLSLDYNTKIAKEIITICKEKNQHNYIMPITCDIKPYLSNICHEKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R157</accession>
    <name>A0A328R157_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_00410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="118"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="4">
        <location>
            <begin position="331"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP25000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="490" mass="55898" checksum="DD4E3A640EF3447E" modified="2018-10-10" version="1">MTDIHNEDINEENKENKNKRSLNDITKELLDQLKDTPNELFMTLPMEEEAPISDNTIANEDVIEHIKSFKIKPKEVKDYLDRFVINQTDAKKALAIAICDHYNFIKEAFESNTPGHYTKQNIIMIGPTGVGKTYMIKRVAELIGVPFVKSDATKFTETGYQGGDVEDLVRQLYKKADNNIELAEHGIIYLDEVDKITATQSSQHKDVSGRGVQSNLLKIMEETDVTIRPPWDIQAQIKQMMGNKKSTDDEKETINTKNILFIMSGAFNNLSDIVKQRLDGANIGFERPSKKKSINDHVTYLKKLRTQDLVNFGLEPEFAGRLPVRVTLNDLSANDLYDILVKSEASILEQYILSFKRFNIELAFTDDALHSIAELAHEEHIGARALSSTLEKIFRDFKFELPSTNVHYIFATKSLIQEPEDTLKKYLKSPRKQVQCDIESSISYEKEKRALKNIDTSELLETCLKPKNKGQITTIIQSFFESTTEHVTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1K6</accession>
    <name>A0A328R1K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="180" mass="20743" checksum="42A237D86E8504C3" modified="2018-10-10" version="1">MTYLLKLFGWKLNIEAIKNTQKSIIIAAPHTSNWDFIVGICAALASGIKFHFIIKKEWNKPIIGYLLLKLGAIFIDRSKPTGLTQQLVEKYRTMSEGHLIFTPEGTRSRVEKWKSGFYIIAHESRLPISVGYINYKEKSIGIDHTFYPTGNIEDDCNKLRTFYQTISAKNPKNYNPNWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1P4</accession>
    <name>A0A328R1P4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="254" mass="27984" checksum="3A3ED7A2DEC7D622" modified="2018-10-10" version="1">MKITSPSKITSDINYNGLKPTKSLKLHPALEGFLPGIIQAGTYPLQTLAIRRLLNKTNIKNGFSGITFYGCTKVIKAMTTTWLFDTTNRVKWSENKTTQQGICGGITGAIEGIGLNPLDNIRNIKQASPQKKIPEIIKELEFSGLWRGTLLKVLRNSAFSFISMTVFSKITTPNDSWFSKVNAGGVSFLWAGILTTSLESWRVGKVFKTKPKSFSSASIAMVPAYVKVSIMGMTLGPALHKTMHNKKQVAYKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R204</accession>
    <name>A0A328R204_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="226" mass="24827" checksum="9279C20F8B6985F6" modified="2018-10-10" version="1">MNITLPPPPNWIYNSLKKIQKEPHGKTKCAIVAGILDSTFGLRSFIKKSIIQAGPNQPISKLGKSKFGLGFLISNTSGHVVSSMNLESEKSQFLIPVAASTIPLSVEFFTRNLLTNTPRTSALIVPLLARETSYWAGVSYSYNTETNWTQSLATQLLFSGIIANVFDTAAGITSSKKLTMKELCNLNNNKSFKAIYFESLPIRILTAVLIPWACINAVNYKPPNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R292</accession>
    <name>A0A328R292_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">DID73_00265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="400" mass="44786" checksum="BF0C1E33F3E4683C" modified="2018-10-10" version="1">MKNKVVLAYSGGLDTSVMIPWLKEHYDCEVIAMCANLGQADELDGLEEKALQTGASKVFIEDLRETFITDYIYPTLRAGAIYEQKYLLGTSFGRPLIAKRQVEIAQQEGANMVSHGATGKGNDQVRFELTFMALDPNLQIIAPWKDDQWDLHSREDCLAYADKHNIPVTQSKKRIYSEDRNIWHISHEGGVLEDPANEAPDDVFTLSKTIESALDRPEYVTVSYEKGIPVSVNDQALSPVELLTKLNELGAEHGIGQVDMVENRLVGIKSRGVYETPGGTILYETHRMLEQLVLDRDTTLIKQKLALEYAQMVYDGRWFCPAKEALDSFVNSTQIDMTGTVRVKLYKGNIVPAGVTAKKSLYLEDLASFSDTELYDQKDATGFIRVFGLPMKVNGMVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QMK1</accession>
    <name>A0A328QMK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="292" mass="32932" checksum="751B6ECCCD396101" modified="2018-10-10" version="1">MHFLQQRYISGETVNSFRAGAILSPQLLQDRSHLKGVFTQPGDDDIQDFKSEGIFKLIQERLPTVTYPQSSLKNKTPEQMVYENCIDAIMAPVKETLAAVHFGDEYLFKQGENVAEIIPILPLFPYRAIEYAIRTLNQLMAQSNLDAAVPLLAAIQNELAEMEGTNETLGIPIYQQGQVVQYRSYCSNYQTQINNLREIQRLRNRIKVSSLGESSGRSHRSGPDQKFLATIAELTNSVTERELSEALHTTNRRGETKSKITRTRKKAVKGGSKSFNNKSAKFGALFAKMQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QMS1</accession>
    <name>A0A328QMS1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="666" mass="76329" checksum="E8669A0197C335F3" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QN58</accession>
    <name>A0A328QN58_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">23S rRNA (Guanosine(2251)-2'-O)-methyltransferase RlmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000014">
        <property type="protein sequence ID" value="RAP23055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="199" mass="21867" checksum="DAB22E257E5B3D4F" modified="2018-10-10" version="1">MLILLKKKGIQVQWLEPYRFDQRFSGEHQGIACITHSFDQTTISDIINDQPPIVLMADHLQDPHNFGAICRTAEAFGIQHICYPKNRAVQITPSVVKASAGAIETMKLCKLTNINQALKELAKNGYWVYGASSNIGQPIDSITFNFPMVIICGSEHDGISPGLTKVIDEFVHIPLLGETSSLNVSVATGIIIHKIASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNC1</accession>
    <name>A0A328QNC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">DID73_02465</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="615"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="820"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="818"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="529"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAP23115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="885" mass="101156" checksum="E19EBF88DF7E6F5C" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNH1</accession>
    <name>A0A328QNH1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DID73_02385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="578" mass="65474" checksum="6D7D3EDA4503574A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNL6</accession>
    <name>A0A328QNL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_02190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP23503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="461" mass="52547" checksum="A7370F8C7036B29A" modified="2018-10-10" version="1">MDITNEEIQRVPLVLGDKSFKEVSDIISKPAEMKAPKWWVIGLLGSLSLASLLFALIGYLIWDGVGIWGLNNPVGWGFAIVNFVFWVGIGHAGTLISAVLFLFRQKWRTSINRFAEAMTIFAVVCAGIFPGIHIGRVWAAYYMFPIPNSMAMWPNFKSALLWDVFAVSTYATVSLLFWYVGLIPDLATFRDRATTKVKQVAYGIFALGWNGSNRHWMHYEKAYLILAAIATPLVLSVHSIVSFDFATSNLPGWHTTIFPPYFVAGAVFSGFAMVLTLLIIARKIFGLEDLVTIRHLENMNKFILATGTMVGYAYAMEFFMAWYSANQYEAFAFINRAFGPYAWAYWIMVSCNVISPQFFWFKKLRTNIPIMFIISIFVNIGMWFERFVITVTSLHRDFLPSSWDYYIPTWVDILTFVGSFGLFFTLFLLFLRYLPIVSIAEVKGVMDIADPHHYDSHKEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNN3</accession>
    <name>A0A328QNN3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar P-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Basal body P-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">flgI</name>
        <name evidence="5" type="ORF">DID73_02245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FlgI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00416">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001782">
        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
        <property type="entry name" value="PTHR30381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP23513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="358" mass="38482" checksum="A9AB3F5E2E142852" modified="2018-10-10" version="1">MLRVFLLILLMAFNGVSEEAKVRIKDISRVIESRDNQLIGYGLVVGLRNTGDTQRSVFTEKALTNLLKKMGIKPDKKDFKSRNAASVIVTMNLPPYARPGQKLDVSVSSLGDATSLSGGTLLMTPLQGADFKTYAVAQGQIVVGGISGKSSKVNFRKNQTTSGRVPNGAIVEKEVKVTRDDQLNVTLVLNKPDFTMSSKVVKALKNNGFGKVSAVDAGSIIIPIAEIADMPYVDIIEKIENTKISPESTSKVIINSKTGIVVIGENVRLLPVAITHGSISIRIAGGEGDDRIYDTDSSASSEIEIKEEKTKVHYIKPDNSLSSLVDVLNDIGVNTKDLISILQAMEEAGALLATIEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNY0</accession>
    <name>A0A328QNY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="714"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="770"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="802"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="975" mass="110945" checksum="FA1238F68FB53AE1" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QPG5</accession>
    <name>A0A328QPG5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">pH regulation protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_02070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP23555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="111" mass="12462" checksum="2F400BB1F5351495" modified="2018-10-10" version="1">MDKLFLYSSLIMIALMIMLVYRIIVGPTVIDRIVAVNVIGTKSIVLLVLMGVIFGRTGMFVDIAIGYGLLNFIASLAAAKYFKKHRKLHVTDDISQSHDSQYKKEELENVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QPI1</accession>
    <name>A0A328QPI1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_02095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP23575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="274" mass="29811" checksum="BF98C7CB0D52D422" modified="2018-10-10" version="1">MTPKIWFSIIFLGFIALIALIIPFFPFDPNGIDTQLIGSPQPPSLSHWFGTDDLGRDLLLRSIYGARISLMVGLVAVSISLSIGVLIGLISGFLGGSIDMAIMRTIDVLMALPTLFLILMVQVTLDPSIFNVMVVIGITSWMGMARIVRAEVLSYKERTFVTACRARGLSEKKVLFKHILPHTLNPVIVGAMLGMGGAILVESVLSFLGLGVQPPHASWGNMLENSLGFLRDAPWMALIPGILITLTVLSLNFLGDGLWLLLDPKAKEKYAKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QPW5</accession>
    <name>A0A328QPW5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="140" mass="15547" checksum="7D175AF2F20D5040" modified="2018-10-10" version="1">MSILKLHSAMFLRIVFIFMCPVLIQCSDFKVLTSLTNSGDFSGGIRYVKSSQEVVDFGITYDESQEDASPGYWADYYYGLFGAMISAPTNESPTYSLMFSTEGQLSSSVGVGIGVRMLDVQKDRKAKVFSTWDAYLVIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQ46</accession>
    <name>A0A328QQ46_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="317" mass="36463" checksum="9A522F7A92E8B7CE" modified="2018-10-10" version="1">MKKHSVFRIIFYSLILGILCLTSLFGYANFDDNDHELAIAEKRYADALKILNNKEESKRTIPEKELIVGLEVVMDVDSLEWPKNSMAMKEDEVDPETLKKVKKYYNASIKNYLEGRGDVSRKILIQILFVYPDYPKAQYFLTKAFKMPPGTYRVKDQVLRLVKRSDTFFYGGNYLKSAEDLEVLAILERDNPIVYEKLGSAYYMMNDKQKAVDTWTTALFFNPDNTQLEKMITQTKETLLREAEEGSPLDQASANKVVIKDPQVMGVFKRQSEAFELMKDLRGQGLTVAIQENDDGKWAVQVSRKELQEKNATKGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQ90</accession>
    <name>A0A328QQ90_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="SSF110836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nfu_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="191" mass="21435" checksum="B29996BD6D43873D" modified="2018-10-10" version="1">MTKKHVQLSASPTPNPNAVKFLPNMHFFESGTVEFLKDSDHLKESPLAKKLIDIDGIDIVMIGFNFISVTKSQEAEWETLLEIIRDTIVGHLENDESVINLDYVEEIQNKKNENASEIEIKIKQILDDEIRPAIAMDGGDVELRSYENGIVTLHLQGACSTCPSSTMTLKMGIENRLKSEIPEIVEVVQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQB8</accession>
    <name>A0A328QQB8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="63"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="1">
        <location>
            <begin position="230"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="734" mass="82682" checksum="35D9253618745AA0" modified="2018-10-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQZ5</accession>
    <name>A0A328QQZ5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="331" mass="37278" checksum="8A8A12E491C8A586" modified="2018-10-10" version="1">MILICFGTRPEYIKIQPLLNQFDGKIPYKTLFTGQHLDLVDTSVDYQLAIPNGKKRMDDTVQACLATTDDVFDGITHVLVQGDTSSAFGMALAGFHRQKTIIHLEAGLRTYDLTQPYPEEGYRQAISRLTKIHLCPTEQNAQNLRNEHTQGHILVVGNTVLDHLNHVIPSDGHNVLVTMHRRENHQNLADWFDAINSLAKSKPDLMFELPIHPNPNVIKHRERLTNVQVIEPLEYSTMIEKIASSKLIISDSGGIQEEASFLNKKVIVCRQKTERIESLNTHSFLCPTPQELASTFNSVINKPNLNTSCPYGDGHAAEKIMTYLTANLFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QR06</accession>
    <name>A0A328QR06_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiE</name>
        <name evidence="11" type="ORF">DID73_02435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041397">
        <property type="entry name" value="ThiD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17792">
        <property type="entry name" value="ThiD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiD2" evidence="10">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="TMP-TENI" evidence="9">
        <location>
            <begin position="144"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="254"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP23109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="319" mass="35577" checksum="7E1B28DFECBF2648" modified="2018-10-10" version="1">MAYLRTIDANLARLSEGLRVIEDICRFELSDDQSTQQCKAIRNKLKTANERFDRPELVNARSTGTDVRAKSNVPKREALSDLLTANIKRASEACRSLEECSNDQIFSHIRYDIYDLEQSIWRLLTRAPLNGPGIYVVSDSPEHLVACAKKDYVPIVQYRNKDANKHDIFETCAPLAKELTAMDVIFMVNDHVDIAIGVGAHGVHVGQDDIPTPLIRELLGQNKLIGRTTHSFEQGQLAADEGADYVSVGPIWETPSKPGRSGIGFDYLKRAHDLPIPFVAIGGVNLSNIDEILPYTPPLIGAIRSTIDIENLWKKFKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QR31</accession>
    <name>A0A328QR31_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xth</name>
        <name evidence="3" type="ORF">DID73_01690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="255" mass="29600" checksum="1DE85B712A671B53" modified="2018-10-10" version="1">MKIISWNVNGIRACSKKGFKEFIDEHEPDVLFLQETKVAEADLPDELRDPFGYQSVWHSAERKGYSGVALLTKLKPDNVISGFGVPEFDIEGRVIQAVFGDTYIIGVYFPNGQKDDDRLHYKLRFYEALFNYCDELRSMGKKIIVCGDYNTAHTPIDLARPKENENTSGFMTIEREWISELIRRNYVDIYRIQHPSDEVYSWWSYRAGAREKDVGWRIDYFMISDDIQPNVEDSFILTKVMGSDHCPVGIQYKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QR54</accession>
    <name>A0A328QR54_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_02355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="266"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP23159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="578" mass="63029" checksum="9639AE2142A9A9C2" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRY1</accession>
    <name>A0A328QRY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FmdB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="59" mass="6707" checksum="46F8927BB2D9BB1C" modified="2018-10-10" version="1">MPTYTYRCQTCKETTEVNQSIHDTPLTYCLKCNGEANRIITSDISIQFKGSGFYCTDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRZ2</accession>
    <name>A0A328QRZ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="230" mass="26209" checksum="FA85D3A1D095F146" modified="2018-10-10" version="1">MPLLSLGNLQLDRLLGGGIEEHKSTILVGDPGCGKTTLALQFITDPRSTKIPCAYVCIDKKPERIMEKAIEMNGTVNQQITAGTLKFVEVSIQDWSPDQSMNELLLNIQLQIDALFQNFQAERLIIDSLLPHVLCSFSKENKQYFIRELLHIIHSYNTTAICILYDTSAHHSLWLDTSMVSDQLIFNRKSDLDYVTYWLEISKNSAQNLNGKYRFTFDAQKGITLKHRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS26</accession>
    <name>A0A328QS26_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="PTHR24348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="382" mass="44904" checksum="E35CC758C6731DF7" modified="2018-10-10" version="1">MKMSQSIYSSNKKIVAHSFRPSSPIHNIERFNVSGNSIKVTIGGEITSHEISEVRHTGTEKEIRTFVFQDKEYALIQRKDNTNIIKEINKKSLFGIYLWDENKKHGIGRYATTDLATFLKKNTRCLKSKLNWMQDLLLDYYKLHNQGKIHSDIKLENVLIGKNSSNVYFVGIIDLGRSQRLNGEHPLVGSSNNTPPEVYKTCINTTKVRSNTAIDIWGIGTMFIQIITKKKLTEFLIESFKFEKFKMPICWDNRKWEQFHKYYYKSRPAYKERLMYHLLNTNYANFYYSKKFNSNEGRDNFLTQLSTAIKKECRSEDAKKVIDIIIPCLNIDPKMRPSLTTLYNGLDSLIDPNRQRKRKRPVEQQTQRKVTDYFEKKRRSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSN8</accession>
    <name>A0A328QSN8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1756"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1840" mass="198594" checksum="3B39FFECB1F19253" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSQ4</accession>
    <name>A0A328QSQ4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="31"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="553" mass="65369" checksum="0630ACD2E3742E4A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSR2</accession>
    <name>A0A328QSR2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PFK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_00170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="8">
        <location>
            <begin position="55"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="487" mass="53364" checksum="E7780816F5DF9C0E" modified="2018-10-10" version="1">MIFDLIDQFETSLGTFSMDTSQVIDCPKDVVRQELMHGHVFSKSSGVNGVDSLTLGVVFSGGPAPGGHDVLCGILSHLRSEDSLIGFCNGPGGLLRGEHKLISRNDMQLIEGLGGFDFLGTDRTKISTEDQFDQVREVIDSLGISALFVVGGDDSNTNALFLSDALYGVCSVIGVPKTIDGDLVHRPYLPITFGFHTATQHYSNLVQQLSIDTAATRKYWHIVKLMGRAASHVTLEVANQACPNACVLSEEVLDKGWGLLDIIAYFSQVISERFAHGKPYGVIIFPEGIVDVVPELRSYINGDLDPINHVLSSIGAAPLALKTVHEDAHGNKNMSTIDTERIIMDAIYAYLSHRVSDDISVQLLTHFFGYTGRAENPSSFDSAYALLLGKTAYELALSKVTGVIVGCDFSDSKIRPLGVPLLALVNFDDERSRYVIKKQLVTMDAVDYQSYLTNKPQWVQHDVGFPRKEAFEIPNRVQLDYVSKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSR3</accession>
    <name>A0A328QSR3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="230" mass="25461" checksum="17FD9E8630451423" modified="2018-10-10" version="1">MKRLGILGGMGSQASAYFVSELVRQTPAKKDQDHIPFVLLNACNVPDRTTAIKAGNTAPVFNAIRPYLDDCIQLGVDSFVMPCNTVHCVYDDVVDYFKIKQADIHCYHMVDAVMQHAKNKDIQSVTLMATEGTMYSKLFHDHHHGVMINEPDSDQQNIITNLIHAKKSGGCDSSHQAQFDALVATFLMDSDAVILGCTELPLYVKNNDPRLMCPMQVQIQTIVSDFAPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSR9</accession>
    <name>A0A328QSR9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ORF">DID73_00220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="188" mass="21379" checksum="236F8A222E776787" modified="2018-10-10" version="1">MEQVVATQIRVGMILKVDGDLYKVNKTQHVTPGKGVACMQTKLKNIFNGKNLEKRFRSADRVERVSVISKPMQYLYDDHNGFHFMDTETFDQISLEIDFVGDKKWYLVEEQTYNVAFHESTPVDIDLPSSVEFTVTSAPPEIRKATASSSLRPIEVDNGMTVQAPAFIKEGDRIKVNPETGEYMERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSS6</accession>
    <name>A0A328QSS6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="201" mass="22870" checksum="0E0E01F8B600D5DE" modified="2018-10-10" version="1">MCEIYKRIAFQGSLNNVISAYLNYAKMRTLFHIQLNPDDSFTIVRQVEVGGRLKDAKYPYQSLVSIKDNQWERYREFMSCEGKSCIGVDLFKLKNPESDNMNLVSDQPKYLCFYDSNHSQILVVEIAKQVIGSQEFCGDFLMLLSVDHSGKISCITFGQYVWRGIFPVLNKGRPYLIVDVAGLSTKIIRPTATPVPCCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSZ3</accession>
    <name>A0A328QSZ3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP25014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="167" mass="20041" checksum="283F456EE35153F0" modified="2018-10-10" version="1">MQQGQGGFSDQQKTIILSEIMFFSKEDQEKVLRYVTQWLYGPVVSQLDAFYRLSDRELSMMIKLSIYFVRFYDDLVVLLDNIYKINNHDLLLLEWESTHCKVDLFYDRVRLMLREYRPNRTVSYILNPIRMSLTCNDHSSTEYAAFFRHFLNFDRLIKEQAVTIYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT00</accession>
    <name>A0A328QT00_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP25024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="155" mass="17216" checksum="9415E1BAC17A7232" modified="2018-10-10" version="1">MLCGAVTKITRQVGALKTRLQPVVPEHRFLGIHYSPTPITKLSPDYPYRSGLCAGPGLYVVSPNNHKSAHSLVRSHLLNGRHSYHVYVPECLPVETLSGALLEDRAADFSQFGAVVQFERMPYLHLGISLEEFYVPPTFIGSVLFIPRLCLQSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT26</accession>
    <name>A0A328QT26_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_02395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="121" mass="13199" checksum="C0D10A72AD476FD4" modified="2018-10-10" version="1">MIDLAINITQDQNWQVITLKGELDDYQASKLTQTFNKLIDESNSTQIILNLDDVSFVDSVGLGTIAIAGKKLLEKSGQLHIVCSQQKISQMVNLSGIISATKETIQLFDSTEEAIAAKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT39</accession>
    <name>A0A328QT39_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016326492" evidence="1">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="208" mass="23173" checksum="70F4E1CDFB1B0487" modified="2018-10-10" version="1">MIRYLFIVFLSINCLAKPNSLMFIGDSLTAGFQLPIHDTYPAIIQKKVGTQNIHIINAGVSGDTTYSVLERLDFTLTTTPNIVFLCIGANDGLRGIAPSITHSNITTIINELRKRNISVVLAGISLPKNYSPTYINAFENTFKNVANEQNIPFMPFLLKDVAGIPTLNLTDRIHPNKKGHQIIAKNVFNFLRKENIISSKNKLIQSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT69</accession>
    <name>A0A328QT69_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="172" mass="19785" checksum="C011C3DEEF27377B" modified="2018-10-10" version="1">MQITKNHLFNILLWVVIILFMAYKSIQHTISIHDQGVSVAIHEYQIQAQARVNHVLNTSNVQGVQGVSLTYTIEFVNRIKNTMDPYEYIQLNDQLTEYIDLKTIDSLQYSTDDSAILAELQRNIKQESLIFYSHAQSFNRLIQRFPYVLLSNNYPLISLGPVPSANGVIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT80</accession>
    <name>A0A328QT80_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="296" mass="33964" checksum="0BE3F0A94DF1760F" modified="2018-10-10" version="1">MTNSNTLKWIKFFLSLNIILHLGRLITWGYPFSNATDNFRIPLISWINIPSNIHLIIFGLFSITAILFCLKKQSPTLSLLISLFLSYFIINDTYSFHHDIILAIQIFFFYGCLLLVNKKHQSLIEWCIKALTVSIYGFAGLNKLSPEFLNGTLIYELSINGILYKKLIFPIINLNDLFQASSHLISYLVACIELIIPVLLLNKRTKYVGLTIAIIMHASISLMSNVGMLFNLYLPTLLIFFFTINQSPKIFFENFFKNPKKTNLEKLGYSSIAIYFLVYTFNGLLLIAPLIINQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTH9</accession>
    <name>A0A328QTH9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA (Guanosine(46)-N7)-methyltransferase TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="1" type="ORF">DID73_00180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="201" mass="24206" checksum="8C63B79CE623AADF" modified="2018-10-10" version="1">MKKRIRTHTNPLNIRQRLDDIKINDTIRSYDYLDLEIGFGRGRFMSQYAQKHGDRFVVGVEVRKQMVEEFKRRYTIDNCLPIWGAGAICLEDVIPNNSVDRVFIFHPDPWFKKRHHKRRVVNHELLRLIQSKMVSHGTVYISTDVEELYEDMLNLCETYGNLEFIEDDPFWVNDYLTHWSMFSDKDQRSQYFLSFNFKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTT1</accession>
    <name>A0A328QTT1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">DID73_01635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="394"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAP24096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="505" mass="58623" checksum="0E9D8A93CC667D21" modified="2018-10-10" version="1">MSLKRIVQETIKSCLDDATEIKEDIEIDIPRIEHGDYALNIAFKLAKMRKRNPHQIADELSEVVNNKGTSITAESASGFINVKLDNNVLFDYFITFLNQPPKVDCKDKILLEYVSANPTGPLHIGHGRWAVIGDTLFRLLTTVGINVTNEFYINDAGNQINLFNQSIEAKRNNQKMPENGYGGHFIDYVIKENKGLSNVDFVIEHQKKTLHNLRCEFNEWFKETKLHQKDILEEVKKEYGDYIYEKEGAIWFRTTDFNDDKDRVIRKENGDLTYFAADIMYHMNKINRGFSHLVNIWGADHHGYIKRIESSIKAKNDDTKLTVILGQLVHLFKNGEPVKMSKRTGELIELSEVIEEIGVDATRYFLLDKKPEQTLDFDLNIASEKSMENPVYYIQYAHARICTIIEKTNGLDNNNDLTLNEMDRKLMLHGARYYDALYEASHHYEPYKLTQYLHELAKIFHSFYQKNHIINDSKIHQQRLQIIQTTKKIIQHCSNILGISTPEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTX8</accession>
    <name>A0A328QTX8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="220" mass="25480" checksum="233B6A76CA010C37" modified="2018-10-10" version="1" fragment="single">QTLLQSDSLEYIHLAYIDLHDVVIKTLGKNFEAMQLTCLINVPKALIKQFLLSESLEEIGFENVDFKNLKIENFGTKLNKIRLHYVRNISNEMLIALFKHPVLQELQLYEEFDFRNEEITQLGENLEEISILDPKNITKQTIQAIFQSDSLERISLSGVDLQYFTFTKLGQNIKYINLDRITNVPVPLILKLVSSTSITVNLSEITIGVYYRKGKRKRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTY8</accession>
    <name>A0A328QTY8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="303" mass="35092" checksum="0AEF23C1D92EDA03" modified="2018-10-10" version="1">MSKTAHISRFNTEYLTWRFDFDVQSISMSIKDQGILTPIICIEFNNERYIVDGLKRYNAAKACDINDIPYIVISPDITIANLVFSLQQMTIFSSAILKLRFLRAFQFSLDADQCNRLQLPYYSHIKKDVDRILDLPDKAQFFLHQKGFSLKEIVNLLHYSADVFNQLLDDDHFFQFTKRTFDEALSLVTALTKRHAMTMNELLDKTNYMSLLKKDLTPQQRQKQWLSYLKEDASPVLLATQQKIDGLLADISLPATVSYDRTLEHTGLTIQSTIQTKRDLDDFSDALSNKSTQQKIHEVMELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QUV5</accession>
    <name>A0A328QUV5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="408" mass="44865" checksum="387C8F13C7371E60" modified="2018-10-10" version="1">MSQGAGPIWPGGKPPAGQPLKPAEEAFEMHKEVSAPGTNSTGAASKVSETSAQSQAQKAQEAAPTTQITKLSVKDILQQLANIKVPVNDHNQELALLMAAHGIEISEDSFGLINKLLKGKKSKAAKESAILLVSKGLGEAADDVGILNNLLSKNSQVSDSLKNLAQMQGKMMSMLNNAIKDHPGLHSFAALFDDFNEQLKKTKKISKSNQLLVNPSELMDDAMAMQAFLKGLGEKLNLNNKALAKYLSELGRLNENLMGQIILSQDSVKQPLGLLESFHYFQIPNPLSAQAVIEMLLRKQSRTKKGKDKRNVEDNEQEKIIISMDTETMGTITVIVVVMGFKVWCTIYSDKESAISHVNSFRSELSDNLQKYQYSLEEFKTSRKKINIQKFIAPSQDISEVKRIQTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QUZ6</accession>
    <name>A0A328QUZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="75"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="531" mass="60188" checksum="01863A8AB3CA1457" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVB0</accession>
    <name>A0A328QVB0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_02025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="127" mass="14818" checksum="036AD810B243672D" modified="2018-10-10" version="1">MTYYLRPYQTRKETVFDELFNDFFNVGFHRDTSFSQPDTIDETDTSVSLKIEVPGFEKSEIGIDYKDNQLVIHAKSSDETSERRDIKRQYTIRNIDIKKSTADLKNGILTLTLEKNEASKSQQLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVE8</accession>
    <name>A0A328QVE8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016424095" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="154" mass="16641" checksum="A4C9F849380BEE6A" modified="2018-10-10" version="1">MKKILILMMLLLNVAVMASDNKYQGATSTNTVGFLQGGGGLIGVDYEQMVSDRWGVSVGIGLPSYGASIHYHIEPSIVSNSIALSYWNQGFEESESSRYLGLTYVFRSKTSGWSGQVGLGSVLFRGTTAKEDLEAIFGSDLPSVIALYSIGYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVJ7</accession>
    <name>A0A328QVJ7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="234" mass="26338" checksum="563645D1F4A3A358" modified="2018-10-10" version="1">MSLIITWPEGRHLTNMLKRSFNSLSIDWRLVVPMLMLLVIGYIMIFSTTSFKGLSEFNDAYFFIKRQSAFLLVGAGLFLLGAGVPIKKYEKWALWGYLISLGLLLMTLIPGIGIKIGGAQRWLNVFGFQFQPVEVMKFWWAIAVSLVLTKKSPKLSSFSKGMLPVFIIMLVPVLCLMMQPDLGNAILTLSVGFAMLLLSQLPAVVFLLAIIMGGGLLLIQYYLTHTNWNEYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVQ2</accession>
    <name>A0A328QVQ2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">DID73_01590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="250" mass="27954" checksum="13EF23DCBCAB3578" modified="2018-10-10" version="1">MLKINNLHATLAEENLEIVKGLNLELEKGKVHAIMGPNGSGKSTLSKIIAGDENYEITKGTITFNGTDIDELDATQRALSGLFLAFQYPVEIPGVNNAEFLRMAYNAKQKHQGKDEVDPLAFNDILKNKIKDLNIPEEFLDRELNFGFSGGEKKRNEILQLAVLNPSVAILDETDSGLDIDALKQVSESVNKLKSNDNTFLIITHYQRLLDYIEPDYVHIMIDGKIVETGNKELAKELDKKGYDHLLKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVQ9</accession>
    <name>A0A328QVQ9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EPSP_synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="81" mass="8491" checksum="73215C28630D1489" modified="2018-10-10" version="1">MVIESIPGDKSISHRAIIIGSLTKGTTIFDGFLLSDDCLCTLNIFRELGVNISIEGTTVTIEGGGVSALTNAINAIGLFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVW4</accession>
    <name>A0A328QVW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2237 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="PTHR37466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="120" mass="13441" checksum="792CF030CFF561C7" modified="2018-10-10" version="1">MNNQKNVYGTPLQPCSFSPKTGYIRDGFCTCITNDPGQHTICVVLTDNFLEFSKQAGNNLSDPVPEYNFPGLKAGDQWCLCLSRWIEAHEHDAAPHVILESTNESVLKKVPLNTLKEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVW7</accession>
    <name>A0A328QVW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="712" mass="77908" checksum="A085B09B7FE6FF89" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW13</accession>
    <name>A0A328QW13_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="156" mass="17409" checksum="F7B17AC5A664FF96" modified="2018-10-10" version="1">MSTPKKVTPKTLDMSQLKRKERDAVQGAVSSTVSSKGSQKGMMDGPKRLELYKHIDIMVNICIDAAMKAAKGGSEDGRMSVDFGTMTYIITAKRIELIHKKSKSKMAYSVGRQEIVVNNTKPLPDKQCQKFVVWIKKLIDDWAKPKAESVCTWTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW85</accession>
    <name>A0A328QW85_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="896" mass="97988" checksum="B9435672B1EC5382" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW88</accession>
    <name>A0A328QW88_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="84" mass="9532" checksum="DF02B87D7E2C7076" modified="2018-10-10" version="1">MDITPPNFKNNKQGNVNDPNQVDTISLSHLGQKVDIDPKLISEACAQAARNAYKLGETDDEEGYKEDMEELITEILKEKQKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW93</accession>
    <name>A0A328QW93_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">DID73_00750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="5"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="304"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP24829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="543" mass="61075" checksum="3AC9C5B7942C1D28" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWA3</accession>
    <name>A0A328QWA3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="298" mass="34620" checksum="DBC909B8335AE72B" modified="2018-10-10" version="1">MLQPTRFGVCPLPVELTQEKVQSYRQPLSPKDRKDVKFFREKNETGIKSSKTISSALRHFLLLRKPMIIHIETQALLLCFGCGHYLDVGLFDVDHVQSSRWIIERQRAFIDRMNHDPEFAINALKDPRARDFVHLVAKETGFVYKGTKLFYRMYHNALHNLWLLCKKCNGGSSKHDGDFMEWFHGVEFFGPSFVDSLKPLDYSGIIITSKDGVGIGEAARSWFLTHHRPFMLRERQIKMIHLLFHKDNIRVFELEIQDDGHDGESTQLQAKRLNLNTRIQLVQLLLNEGDENAKNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWC1</accession>
    <name>A0A328QWC1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1133" mass="123995" checksum="FDF2EADF821E540C" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWC5</accession>
    <name>A0A328QWC5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="PTHR14463"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="516" mass="60758" checksum="13D08F00E6DB5E85" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWE1</accession>
    <name>A0A328QWE1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="181" mass="19645" checksum="BCEE57142C97AFB2" modified="2018-10-10" version="1" fragment="single">MEAKNALHNPGHMGPQHRRPSHNELKQSDKRTVAGSEVAMGEVNGPMQSSASAGDAREISAAEKSMKQQMISKPRGESKSSEHQPENTDPVMNTCSDLPNDVATNYIIPASNSEALARLAQLSQKFKKLATDDAASRLQRLDSLISNSLIAGIQIQQGPFRNSIEELSSLERLETAIKVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWE7</accession>
    <name>A0A328QWE7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="675" mass="76643" checksum="07C2AC66BBAFF872" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWG4</accession>
    <name>A0A328QWG4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UnbV_ASPIC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011519">
        <property type="entry name" value="UnbV_ASPIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07593">
        <property type="entry name" value="UnbV_ASPIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="UnbV_ASPIC" evidence="2">
        <location>
            <begin position="884"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="957" mass="111288" checksum="B0EA2ECB89ABABAE" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWI8</accession>
    <name>A0A328QWI8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022290">
        <property type="entry name" value="CHP03858_lucif-like_mOase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03858">
        <property type="entry name" value="LLM_2I7G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="352" mass="39046" checksum="85F003097F0EED5E" modified="2018-10-10" version="1">MTHQPLPKTEIGIDSFAANNSNTTNSTVNQQAMDELLTQIEFADSKGVELYGIGEHHRKEYMDSAPTVILAAAAARTKNIRLTSAVTVLSAADPVRVFQQHATLDIISKGRAEMVVGRGSFSEAFPLFGFNFDDYDALYEEKLDLLLKIRANETISWKGQFRPELVEQSIYPRPVQNELPIWVGVGGTPESCIRAGRLGLPLMIAIIGGETHRFNYHTKIYKKAGQDTGHDPKKLKVGIHSLGYVAKTTEQALEEFYPGYEKVFNQIGKERGWSPVTKEHFLMQTGPLGALVVGSPDDVAKKIMRHSQALGGLSRFTFQMNVAALNHQQVMKSIELIGTEVMPRLHALQNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWK2</accession>
    <name>A0A328QWK2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DID73_02410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="211" mass="23863" checksum="40E0C1A3A178E537" modified="2018-10-10" version="1">MIDFNKETSFNDLTHDMLKEHANSCDQCQLADERTNVVFNSGNTNAELMLIGEGPGQQEDEEGIPFIGRAGKLLTKILESVDIHRDDIYIANTVKCRPPNNRTPLPDEMTACQDYLIRQIQLVQPKIICLLGAAAVKAILGPTNTISKIRGQWITIPVNYMSDDLYIMPMFHPSYLLRNSSKEKGAPKWLTWNDMKEVKAALSFYDIMSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWM1</accession>
    <name>A0A328QWM1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="67" mass="7149" checksum="69F41051020E223E" modified="2018-10-10" version="1">MNHGQRMFVVNAIPSLLVSSIGSSGFEKELNFSSGFEKELNFSSGFEKGGSFSVGFEKGGSFSVGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWP2</accession>
    <name>A0A328QWP2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-aspartate oxidase</fullName>
            <ecNumber evidence="4">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DID73_00460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="10">
        <location>
            <begin position="33"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="11">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP25009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="522" mass="57661" checksum="C01BDB4B827758E5" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWV0</accession>
    <name>A0A328QWV0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagella basal body P-ring formation protein FlgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flgA</name>
        <name evidence="3" type="ORF">DID73_02235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017585">
        <property type="entry name" value="Flag_basal_body_FlgA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039246">
        <property type="entry name" value="Flagellar_FlgA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36307">
        <property type="entry name" value="PTHR36307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13144">
        <property type="entry name" value="ChapFlgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03170">
        <property type="entry name" value="flgA_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016193911" description="Flagella basal body P-ring formation protein FlgA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ChapFlgA" evidence="2">
        <location>
            <begin position="112"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="232" mass="26496" checksum="B8269083486946A1" modified="2018-10-10" version="1">MMRSLFLCLLIVWGGNMHAAELACNDANDAVNTKILELLKESYSKVSFHNLKVQSMGTDLPTNCDYVSFEFPKKVDLTSDLIIKFDAFKNDKFQKRATKIFRVFGYATILRATRISHRGDAIHERSVYKEKIKINKVTQHTMSEFESGDFQFRNYVGKDQIIETWMVEKKPDVLKGELVSAIVKKEKITLTLDARILENGYVGDNVKLKLSKNNKVLLGTLHDKKTVIISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXA6</accession>
    <name>A0A328QXA6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="84" mass="9688" checksum="CE0AF6BDB85899CD" modified="2018-10-10" version="1">MFKVFNKTDFNDISFISELEENGFDVHNIGGTHQSEFSNGEVYRFKNGQYQIAGQSTTILTCNANVFFKTLIDVEKQFKYQLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXI1</accession>
    <name>A0A328QXI1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flgG</name>
        <name evidence="4" type="ORF">DID73_02230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="3">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP23510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="267" mass="29684" checksum="D63451F59C47BF75" modified="2018-10-10" version="1">MFQQFNISRSGFGVYQKMMFNITNNIANAQTPGFKQTRVELATLFPVILQEAEVKYAQDEDLNPYIKKKRGIELGTGVRMEAISTDFSEGNLQVTKNDLDVAVRGEGFFQFRKQDGNIVYSRAGNLAKDVDGNIISQSGFLLDPPIRIPQNTTQLTIDPEGRVYANVNNESLPREIGQILLARFNNPDGLKNVGNNFYKETIDSGEPIVEVPGRNATGQVVQFSIENSNVDIIKEMMDMIMTQKGLELLGKAMQSGEQMLKAGMGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXJ6</accession>
    <name>A0A328QXJ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="320"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="536" mass="60945" checksum="0B4EA4FCFF30B7F3" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXL3</accession>
    <name>A0A328QXL3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DRTGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="219"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="365" mass="40378" checksum="84388F4F54BC4A0D" modified="2018-10-10" version="1">MKKVFIAATRQNDGKTTVSLGLFNALLKKDPSIQYMKPVGQQYREVEGNKIDKDAVLFQHTFELNKKKLPLMSPIASPRGFTESYINHPTPNELKEKILTADKELSKKSTSILYEGTGHAGVGSVFDCSNAAVAKSLNSPVIIVSIGGIGKAIDEIMLNVAVFKELGVPIMGVIINKVIPEKYEKINTIVRKGLNRLGLDVLGILPLNEQLTYPTISSIVDELKPNILSMADDGKNNIIEKFMIGDMMPHNALDHISRNTLMIVPGNREGLVLTALCENLLTQGPHLVSGIVFTNGIRPHQKILDLLYTSKIPLFMVEEDAFSIATKINHMIVKIRSEDKNKIAIASTLIEQYVDIDKIYSQMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXQ9</accession>
    <name>A0A328QXQ9_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2693"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3017"/>
            <end position="3104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3360"/>
            <end position="3506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="3786" mass="428732" checksum="E45531B1879086CA" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXX2</accession>
    <name>A0A328QXX2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="11" type="ORF">DID73_00795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="211" mass="24399" checksum="213A91FE146E5B5D" modified="2018-10-10" version="1">MSGKSKVKVSKFKKQRRVGIELPGLGKPGALAKRSYPPGHHGQARRRPTEYSLRLTEKQKVLFHYNIREKQFRRFVKDAKKGHVVNWTDKLFSLLEMRLDNLVFRLGFARSLPAARQMIVHGHVLVEDRVLDRPSAIVSIGQVISFKEKFYKSVQYEILKENPTLPLPEFLERSEEKKGKEVGKLTQLPTLSDVPFELQSRFISELYANVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY25</accession>
    <name>A0A328QY25_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_02275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="99"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="369"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="540"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP23432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="669" mass="76443" checksum="72F0C4BD4B533526" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY34</accession>
    <name>A0A328QY34_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="357" mass="39623" checksum="8DD9F109C4967437" modified="2018-10-10" version="1">MAVGGAKGGAKSSFNYQVKNQTLGELRGKFKSGGLTKIFPNLRQDVLNIAIKSNDQIMTLLTAETSDLAEMGEVDNKAVKTDMSQMISITINESANNEFESVIKILDDIKPDTGSPLTQKSDAELHKSAEFRQKQKEQLSSQIESLNEQVESLKTEKESILSELKQYSDESDQVLNDLANKKLELRHDDQPTLGSLEKQLAGFKEQASDVEKTLSSIENELKLRDEEAVSIDLGENPQDSGETKAASTDGKGEIEQTAFKDNNSKLDAAFNNIKGKWDTGFTIKQGNETLGVKMDNLMNYVGDEIGPEDAKKMLQSDINKLDELSNPQGGDDELEYEVSELRQQLKDKFDEIDNTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY67</accession>
    <name>A0A328QY67_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_00085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="177"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="305" mass="33873" checksum="ED0C608253AC5A41" modified="2018-10-10" version="1">MPNLSIGLIGAGAVGSFYAGHMAKHGADVTILTRTPDAYTDPIHIESPKGDFTFHPKAIQSLSEVCDPFDVLILATKALPSIDAVSLVQPFMSKNTILMIIQNGIFIEDDLLASYDQNILRCLAFICVSRHSKTHIHHMDFGSLSVGGLNCTLNDLADHPLFQLFPQLDITVRLSPDIQQSIWEKLVWNAPFNPLSVVYNGATTAELLSNPTSLSKIRTIMQEVQLAATYANITITDEFIDEKIQQTQQMVPYKTSMCLDYESGSDIEVEAILGHLLQFGEDHSFDLPEIRSLYRDIQLLINKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY77</accession>
    <name>A0A328QY77_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="422" mass="47776" checksum="881F07B35B4719F1" modified="2018-10-10" version="1">MVYCECQTEDDVKQLIQWARVNQGIIIPIGGNTNLVEASICQPSKWLSSDDLVLVVSFKNSNITYCKESTMVTCGPMTQLGELNVFLENHNRRWDLNFSAQSATIGGIISTNAGGELAKASTQLESMNIICGDGVKRKFHSHHKQTDSVFPNDGTATQGMIGMITSITLKTKPKWAETCSAMIELPINLVTEFREFVINHSPMVACELIDANSMKSVTHKKHSGMTLLLKWASEAELDLDDFWEKLIEAYPKYMDNMMLSDSLEKEEKLWTIRHDVSDANRRWASENNMSYIGYDLGIPKKHLAEVIQKIEGHVQQHHGVLFCFGHSMQSSTHDTIHCNIAMPQASTQFLPAFIQHNLGDINIQMAVEHGGCGHKSINDSLISVTDEMMEETKQYLKQYDPYQLFRRDIKVKMDRLRLDRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYA7</accession>
    <name>A0A328QYA7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="343" mass="39506" checksum="10A43FE1B7208E29" modified="2018-10-10" version="1">MQLSRSLYIVSPRYDWLGFIGAPLIALVIGWGVSRRFIPDQYVQVGHYSGYFWDMMVLILMTQCHLFITVVRAYGNSVIFRAFKWRLLLVPPMLFAVGYFSQYFLILQLVINTWWDAYHSACQTFGFTRLYDSKAGDHSLTMRRLDRILSVLIYMGPIIGGATLIEHLGTFGHFSLVGLFFLADVPAVAGTYSFYLLMVVGGFSLIFLPYYVFRSIQHSKQHPVSILKVLMLVITAVVSLLAWGFNSFGMAFIIANFFHAWQYYAMLFWSEKKALMTRFKRFRLGPFGVFFLFSVISIGFAFFLLFVINPKEASRAGLCFLATVATCHFWFDGFIWSVRKEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYB4</accession>
    <name>A0A328QYB4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ORF">DID73_00395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="243" mass="27284" checksum="C4E0889E6E040AB6" modified="2018-10-10" version="1">MTTEMPLTHHLDELRKRIIICLGSIIIASTLAFSFYASISTIFITPFEPSFLNGATMNVNSIYEGFFVKLKLSILAGLIGSLPIILFQLCRFILPGLKKNEKKWLFVIILASSILSIGSTYLGYAIVFPYVVSFLLTNAFIPENINILLNYQQNLSYIISFLMGSIIIFQSPILLTVCLAKNIITRRYLLQHARWFIIGIIITSAMVTPPDIFSQLSLSIPMIACYFICIGFAKIMGWGKTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYM4</accession>
    <name>A0A328QYM4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016367593" description="SLH domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="655"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="755" mass="84195" checksum="83909ADC50F5190E" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYP4</accession>
    <name>A0A328QYP4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">DID73_00195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="252"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="433"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="702" mass="79422" checksum="0BEDEF7B0C0BD782" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYT1</accession>
    <name>A0A328QYT1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="66" mass="6983" checksum="8C32074EB133B0F2" modified="2018-10-10" version="1">MNKQKQLVIFNHCIACSTCNNVAPTVFGLNSDGSSATVINQPNCSLIKKKSLEAMKSCPVSAIGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYV6</accession>
    <name>A0A328QYV6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cobW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="871"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1093" mass="124037" checksum="C808240A97EE140C" modified="2018-10-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYV9</accession>
    <name>A0A328QYV9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="389" mass="44272" checksum="62709D854992F852" modified="2018-10-10" version="1">MGREIAIIGGGLAGLSCAIGLQELGIPFKLFEASNELGGRVGSYKRKQLIVDKGFQVFLPHYKTSQQLLDISKLDLCYYPSGATIITNDGPKWFGYNYPEKLKTGKKVDARWTDYIQLGIDVLRGISRPRKPGSQCIDHFKKNYSESFSSEFLEPFFRGVFLDPSCEKSVRQFQYYLHCFFRKGAAIPKLGINEIPKQLVRKIQPSAIEMDSPISKIESNKLWINNKEHKFQHIVIATDFSTCYKLLKIPEPTNPWSHVTNYILAKRADTQLSPLILNTTTSPISHINIPTLISKHLAPDNTHYMNVSTFNEDDPKAIEQEVHKLTGETDWNFVWHNTIHKALPKYHHLVPNILNDQISICGDWTNFPSIEGAIESGYRFKSKAKTLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYW7</accession>
    <name>A0A328QYW7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP25028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="294" mass="32777" checksum="A6052158768E4311" modified="2018-10-10" version="1">MLNAVDINQFLAQEQSQMQDVSIDQLIVQTMAGISGADSHLLAQKQVDRRIGLYCLGVRKESIGLFDSGSGKKYLFEFDVQSNMVSMNQRRAQSKEIKFFSHRLNQLAQIGRSVAHLIGVHSDSSDQSLAVLPDPLLKKLTGIFHFKLPLQWVDVSSNQFNQLAWLFNQVVKKFHVTIVQGDDSDKMDQLFSYVEELIASQALSDEDCVMVSNQSGVNHATNVVYSMYIYSALVVIVTEKGPDKSIIEIDIKQKKASLDKAELKANAVDWLLKKCQKISADISSGVASIYESVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYZ6</accession>
    <name>A0A328QYZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="325" mass="36167" checksum="FFFEB08EA96D1695" modified="2018-10-10" version="1">MLSRLSFATSRIQRSLQANSLTTRRFSADKKPISSYDLLNHVNDQLYPVRATGSSQRFQATTLFVNNYFNQVYFNDTSVQPVVDYLQYSKGLSETQIKQSFRDHMALRTPNIASGVSLVQGLIGSGAYEYKQYLSSNNFVRMKRAIQEIQIAGTNQVAVSLCATESGMKYGMPNYLFVSMRNCNLAEPDLYRGLDQPFETNQVPEIKDDPYWVPAQELTEKHGAGAANHFTLSINELVKLGVCTDIQDFRSQILNVNGCEENSALTVKDCPDVEQYALRGNAVYVEYLNRSDSKKTPGSQVEGFSTDTENINRIGGHVGTAAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZU4</accession>
    <name>A0A328QZU4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_01125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="152" mass="17398" checksum="D4552AD2CEA42CF8" modified="2018-10-10" version="1">MTFYILKIVSILMVILFIIILLGTIMFYATLSFMPNICCVDDNQQSCLLVDTILTESGYSVSTYQSPIEFLRAFQSNHYDLIIMDVCMPEMSGIDCLKKIRDFSNNLPVIAMTALALKEELIEIENAQFLDVIIKPINILDFIERIQRLCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZY2</accession>
    <name>A0A328QZY2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="281" mass="30810" checksum="93FEC2AA86831F44" modified="2018-10-10" version="1" fragment="single">VGISRDAIRLIESPERSTAWALFSNPGLNLAVARGSGEAVRMLGGIAQQYGIPVSLHGTGGAWMMTNASTDLDRLHDAIIGSLDRKVCNTLNTLCILKSEVEAQLPVVLNALKSAGEALGQPYKVHVETSSTSYFSEEDFNSKVSVERASGVQDESQFELIDEAHLGIEWEWEQTPEVTLVVVDSLDDAIRLFNAYSPQFVASLITQSQLELVRFFNQVNAPFVGNGMTRWVDGQYALNSPELGLSNWENGRFLARSAILSGDSVFTTRIKMNQVVSDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZZ2</accession>
    <name>A0A328QZZ2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrom_C_asm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="346"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="590" mass="68519" checksum="46DC35F9C35D9818" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R055</accession>
    <name>A0A328R055_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041451">
        <property type="entry name" value="RecD-like_SH13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18335">
        <property type="entry name" value="SH3_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="313"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="677" mass="76359" checksum="028D496C3EA3AE31" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R090</accession>
    <name>A0A328R090_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="441"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="511" mass="57788" checksum="64BCCF6E255519C6" modified="2018-10-10" version="1">MDEQIIHFEEDIERLLSILPKKIQSYLSDHSELNSLYEIVMDIGHPPSIRFDGKHERMTSFSDVSQDDLDHVVSNIGEFNSDNRAGIERTLHRISAIRNRQQKILGLSIRVGRAVIGSTQLIEDLISEGKNLLILGPPGVGKTTKLREAARYLSVESDRRVMIIDTSNEIGGEGDIPHPGIGYARRMQVLSPEIQDKVMIEAVENHTPQVIVVDEIGTELESKAARTIAERGVQLIGTAHGDDFVNVLKNPTLSDLLGGIQSVILGDEEAKMRGTQKTVLERKAHPTFDFIVEIKHRHRVAVYKDVAKVVDLYLRGEDYKPEVRELDHGEIVKEEESIHWSDEFDHGIHYSPDTLTNIFPFAINRDKLFSAIRDLNVAADISHTIAQADLLITTQSQVKSNQKVKQLLKGHRIPVHVIKSNSQKCLQEFLREYFQLDQSDEAIHDDVTNEINSICDRVVAEKRAFDAAPRNSYQRRLQHGIASERNLSSLSIGEEPNRRVRVYPQLSDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0I1</accession>
    <name>A0A328R0I1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="233" mass="26202" checksum="814E4A501363E2BC" modified="2018-10-10" version="1">MNSIQVNDLFFKYNSNDSFSIDIEKLEINQQTQLFLEGPSGCGKTTFLNLLTGLLKPKIGAIQVLGTNINALSATEADRFRADHFGIIFQLFNLIPYLSVIENIILPCTFSKIKKEKALKQSITLELEASRICKELDIHSEYFQKSVHDLSIGQQQRVAIARALIGQPDIIIADEPTSALDNISKEQFMNILLSECKKINATLIFVSHDTTLKSQFPHSYQLNQLTEMAHVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0I7</accession>
    <name>A0A328R0I7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DID73_01070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RAP24700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="322" mass="35369" checksum="A7EE8E45375C2788" modified="2018-10-10" version="1">MIRPRRFRQTKAIRDLMQEHHLMLNDLVLPVFVHDQVESVSIDALEGHQRLDEISLLKYCEQALSKGISSIAIFPSIDEHKKTSDCLEALNEDNLMCHITRRVKKAFGDDLIVIGDIALDPYSSDGHDGLVKDGKILNDETVDMLAKMALVQAAAGVDILAPSDMMDGRVMAIRSALDIEGFHDKLIMSYTAKYASSFYGPFRSALNSAPKSGDKKTYQMNMANRTEAALELDLDVGEGADILMVKPAGLYLDIISDYRNSCGLPIAAYQVSGEYAMLKSAARDGVFNFDDALMESLLGIKRAGATIILTYGALEVANILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0K6</accession>
    <name>A0A328R0K6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acs</name>
        <name evidence="8" type="ORF">DID73_01175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="86"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="523"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="638" mass="71295" checksum="45D822897424051D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0M3</accession>
    <name>A0A328R0M3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-iminoacetate synthase ThiH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012726">
        <property type="entry name" value="ThiH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="PTHR43583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF1">
        <property type="entry name" value="PTHR43583:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00301">
        <property type="entry name" value="2-iminoacetate_synthase_(ThiH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02351">
        <property type="entry name" value="thiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="62"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="364" mass="41834" checksum="3965D370ED0318A2" modified="2018-10-10" version="1">MYSEQFCFKSTEEQRLLLGDGTHLTVDELLTQPYAVFSDINDQQLEALAQRASLITRQRFGHVMRFFVPLYLSNECYNNCTYCGFSYDRDIDRYTLSDAEIVENVQILVNKGFQHILLLTGEAAKTVEMTYFERVLPLIRPYVAQLGMEVQPLEESDYRQLIELGLDAVTVYQETYHKDHYLMHHLSGKKRRFEYRLDTADRAARAGVYRINIGALLGLSDWRFDAIALVGHLRYLYKTYWQTQFSISFPRITSIFDGTQPLQTVSDRQLVQLVCAFRCLFPDLGITLSTRESQKLRDGLLHLGVTDMSAESMTSPGAYSGIDAEPQFSTTDHRSLDDIQALLTQKGVDSVVKDWDRTYTQLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0V2</accession>
    <name>A0A328R0V2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">DID73_00925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RAP24860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="334" mass="36286" checksum="6F2C15B4C793728E" modified="2018-10-10" version="1">MSKKYRVGVVGATGVVGQEIIKILEAREFPVDSLRLFASERSLGQTVEFNGEHIDVEVLSEDTLKDLDFALFSAGSSISKEYCPIAADRGIVCIDNTSHFRMEEGVPLVVPEVNKEALANHKNIIANPNCSTAQMMVVLKPILDAVGIKRVVVSTYQSVSGAGSSAIKELEDQSRANLSGQQLEPKEFSAPIAFNVIPQIDVFLDNGYTKEEMKMINETKKILGSDDIKVTATTVRVPVFVSHSEAINIETDQFLSADDARKLLEDTPGVKVVDDPSKLKYPTPRDAAGEDDVLVGRIRQDVSNDNGIELWCVGDNLRKGAALNAVQIAEALIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0V9</accession>
    <name>A0A328R0V9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">ggt</name>
        <name evidence="6" type="ORF">DID73_00745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="566" mass="62304" checksum="D5AE510665881259" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R180</accession>
    <name>A0A328R180_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="74"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="184" mass="20387" checksum="0AC628D148A146E6" modified="2018-10-10" version="1">MICKLNEQTPTDWNGPEELHSLLSTHLDDSVIKGYAGFLKNQPKLDNALTAYFGAPSNYSNITPVIIFNEQTNELVTLMANNKQLPDETGEPGSILAHVRENGYNDNFMCSDCYGQLSCSSCAIEVLEGVLENPNPRDEEFDMLDIDETKPPTEKTRLGCQAILGTNPLVIKIRAPEKKVISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1J6</accession>
    <name>A0A328R1J6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021727">
        <property type="entry name" value="DUF3299"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11736">
        <property type="entry name" value="DUF3299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="160" mass="18083" checksum="B51AD46C4D3AC636" modified="2018-10-10" version="1">MRQLSLWAMIGFISLTPLLNLSAEQTIVTWDMLSSMNYETGTMPPNLKKLNHQPIQASGFIVPLEMDEYADEVKEFLLVPDPLACIHVPPPPPNQIIHVVMNEKIPVNMDYRGVEIKGILSFSKSEDGIHGFEMVGQFAKEANIEYEDPLMEIINIDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1Q3</accession>
    <name>A0A328R1Q3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_01050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="468" mass="50353" checksum="181EB89A0AEE90AD" modified="2018-10-10" version="1">MIGIGFLSSKKVTSMVDYLVAGRRISPYLGVASLGGTELGLITVMYNAQKGFSAGLSALHMAIIAGVVTFIVGKTGFIVVPLRRLKVLTIPEFYEQRFGRSVRVVGAIVLVLAGVLNMGLFLKVAAIFVSVIFGLDPTGWPLIICMTTLLVLVLIYTLLGGMVSVILTDFIQFILLSLALLIFAGVLYVGLGWDAIVTGWQSVHGMLGFNPFHADSGFGVSYVLWMVVTAGLVSIAIWPTALSRALVLPDDAAVKKQYMLASIPMMARFVIPMVIGAMAFILLGPGDGLVALPAAALQVLPAGVLGLLVAGLLAAMMSTFDGYLLCWSSVIVRDIIMPLSKRYWTDDEQMRWIRYFIVLCGVFMLYWGLFYQGSEDVWDYLAITGAIYFTGAIPVMIGGLYWQRASKAGAMLSLLCGCFALFGLAPVQQALGIPLSSAEIGLMTVIFASVVFVVGSLIWPSKERLHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1W0</accession>
    <name>A0A328R1W0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_00710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="305"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="679" mass="77176" checksum="23A223A310829A9D" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1Z3</accession>
    <name>A0A328R1Z3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="333" mass="38704" checksum="A4BC92929C900A6E" modified="2018-10-10" version="1">MNNPEISIAMCTYNGSAFIVEQLQSIFSQTIPPAEIVIYDDCSQDDTVDVIEDFIKDSEIPVYLHVNKTNLGFSKNFFQAIKKCTCEYIALADQDDIWYPNKLEVLVNELLKSSEKKLVFSNVEIVNSNNELMNGTHWELLNFNEHEIKHFNSGNELGVLLKRNVISGMSMMFHQSLVSDETDFHSLWDGYHFDGFLGIKSALQESSVAINSTLVRYRQHGANFIGVLPPKSMIGFLFNRVESSAQYLKNIEHNKLLLDYISNQSFDPQLCIDKKCQLVQQKINFYEARLSYPRFIFFRLLFVLYRFIIGDYHRFSFQSPWKSMLKDILIRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R254</accession>
    <name>A0A328R254_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="207" mass="23672" checksum="489D4CAE503179C5" modified="2018-10-10" version="1">MYKTLAGASIEKKFNHMGTTTGHRLKTFKGHVEGGAKFEGECKEVNRIKRQRFETRDGSTFFNLHKEGDVIHADKVVKKNGVYIGYHFEKGVETYNKFTNVDGSIFFNVWAKGNVVKCERLEKCDGSTFLKWVKEGNVMTCGVLKMKNGDKLEGWRKEGAVETCNKYTVYDSGKTYKGWWKANGINNLRHLIFLNLSNETPMHISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R278</accession>
    <name>A0A328R278_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_00165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="199"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="594" mass="68113" checksum="20E3211B6E6216C3" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R2A9</accession>
    <name>A0A328R2A9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">carB</name>
        <name evidence="17" type="ORF">DID73_00365</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="670"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="927"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="927"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="820"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="834"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAP24992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117195" checksum="4649FC8A4A4D60AB" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QM01</accession>
    <name>A0A328QM01_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000016">
        <property type="protein sequence ID" value="RAP22844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP22844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="146" mass="16246" checksum="05079405A2FDFCD8" modified="2018-10-10" version="1">MKFIIAFLTFSIVCFGAKSGAIDALNVAGNGMLVQKYRLRIIAENIANVSTHMTDRGEPYRKKYVIVVPDKEGVRAAGIMESDAPFGQILDASHVFSDENGVLRTPNFELNDEMVTLSYANLLYEANTTAFKSSRQMFQNTLELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNB1</accession>
    <name>A0A328QNB1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_02515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="6">
        <location>
            <begin position="51"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="172"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP23105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1375" mass="152196" checksum="C1663BA193887B1F" modified="2018-10-10" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QNS8</accession>
    <name>A0A328QNS8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">DID73_02115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="13"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP23563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="422" mass="45924" checksum="EBB74FFC8F701B32" modified="2018-10-10" version="1">MTLTTHSPLNFVEDVDKDIYDVIQKELNRQQTSIELIASENFTSEAVMQAQGSCLTNKYAEGLPGKRYYGGCEFVDEVETLAINRVCKLFGANFANVQPHSGAQANVAVFTALLQPGDTIMGMDLSHGGHLTHGSPVNFSGKFYNVVSYGINKDTELLDYDELERLAKENQPKLIIGGASAYPRIIDFERIGQIAKSVGAYFMVDMAHIAGLVASGHHPSPVPHADVVTSTTHKSLRGPRGGIILTNNEDLAKQFNKSVFPGNQGGPLMHVIAAKAVSFKQALEPDFKIYQQQVVNNAQAMAEQFIHYGFKVLTGGSDNHLNLVDLRNKGLTGKVAEKVLDDIGITANKNAVPFDTESPFVTSGLRFGTPAATSRGFKETEFKKIVDIIELVLSNPDDSTTANKAQDMVHTLCDAFPLYTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QP78</accession>
    <name>A0A328QP78_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="3">1.8.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_02345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP23445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="90" mass="10055" checksum="EDDFC8530216776A" modified="2018-10-10" version="1" fragment="single">MTDNHLDQNPNQNSNVISVYFAGGCFWCMEPVFDVIEGVTDTTVGYMGGKEDTANYKAVSSGSTKHYEAVRVTYDPSLVSYKTLLDAFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQ54</accession>
    <name>A0A328QQ54_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="468"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="696" mass="78827" checksum="1999C2E84C14276C" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQ70</accession>
    <name>A0A328QQ70_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="172" mass="19885" checksum="BE65C06F69AA1BF6" modified="2018-10-10" version="1">MILHKEISISSINEWQKWLTKKTGNRIDFTRIATFLNTKNYRYSWAQLLTRASIIASTGLSAYAGYQKSESDSKMYTTTWYGLAGFILSHTIVILPLITKRHQLNRSISQLVLDITEQSKNMSKRKAIKKEVDTILSINRSTKTRAHATLTLKVQERELNKLLNKIISFKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQ98</accession>
    <name>A0A328QQ98_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="196"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="451" mass="50444" checksum="47D933FF2CD2611D" modified="2018-10-10" version="1">MLQSALSYLNNHFDLFTDDLKDCLKIPSISTLPDSEPAVKQCSEHVASHMRAIGLKNVQQFNDYGHPIIYADYIIDSSKPTLLCYGHYDVQPVDPLNLWDTPPFDPKVRDGYIFARGASDNKGMFYAQLKAVESYLKSAKSLPVNVKFIIEGEEEIGSHGLIKFIKDHASLLQYDVLVVSDSPMFSDTQPSICTSLRGLIYLECRIKAMNHDVHSGQLGGSVPNVIHYLSDCISSMKDPKTNRVLIPGFYDDVAQFGAFNSQLPVAQQHLSNLKSFYSLGEHANEEFFNNIWFLPTLDCNGIQSGFVSEGAKTVVPCEAMVKLSCRLVPNQSPDHMVTLVTNYIRQFFPDSFDVQIDSVGPYAKPLQVDPSDSFIQAALNAVKDTHQKDVIIQGEGGSIPVLAEFQALFSKPTVLIGLNSPNDNIHAPNERFKLDHYRKGIETYIRYFNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQD0</accession>
    <name>A0A328QQD0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rny</name>
        <name evidence="8" type="ORF">DID73_01815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="323"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="507" mass="56517" checksum="668E3E3163FC86A3" modified="2018-10-10" version="1">MEIIIGLSSLLGISLIASVVQTVRINKIKVAGIKSDTIIKEANRQADKTIRDAKFQAEKETKATVRRAEEDIAFKKRQLKEVEQDVNRSKQQVQQSKKDVERLQDQFEEKMTGVKELRKKQEDVLQQLFDKLESVASLTREEAEKSLVAHVEVVAKKRAGNLIKGIEAQARKVAKQRSVEIVLEAIQKLGVETVSSNTTSVVSLPDDEMKGRIIGKEGRNIRAFETSSGVDVVIDDTPNGVILSCFDPIRRETARIALDKLVNDGRINPARVEDALQKADEEIQQVIKQKGEKAADVLGLEFDPNIVEMLGRLNYRTSYGQNILDHSIECSKIAGIIADRLGVDVELAKRGAVLHDIGKAIDFVQEGSHDDLGAEICRKYGESAEVLNCIMAHHEDEEPDTVEAVIVKVADALSSARPGARKESVELYLKRLENLEKIAMEFDGVEKVYAIQAGREVRVLVRPEDVTDEGVYKLSQDIAERIEREMDYPGEVKVNLVRETRAVSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQK4</accession>
    <name>A0A328QQK4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-threonine dehydratase</fullName>
            <ecNumber evidence="10">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ilvA</name>
        <name evidence="12" type="ORF">DID73_01735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="10"/>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="11">
        <location>
            <begin position="330"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="11">
        <location>
            <begin position="423"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP24114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="508" mass="56073" checksum="A55246D173F5D932" modified="2018-10-10" version="1">MNLTNIHDKVLSADVSGVSIMTPLQYASRLSKKLQNNIYMKREDMQSVFSFKCRGAFNKIRQLSNHDKSLGIIAASAGNHAQGVALSAQQLNINATIVMPQTTPQIKINAVRALDAEVILHGDSYDDACSHAHAISSQKGLIFIHPYDDEEVIAGQGTLGLEILDQLSEPIDYIFVAVGGGGLLAGIIAVFKVLSPSTKVIAVEPDNSDCLSQALAKKERVILDQVGIFTDGVAVKQIGEITFPIIEPHVDDSICVSIDEICSSIKDIYEETRSIVEPAGALSLAGLKKYLEVHNIQDKNMITINCGANMNFDRLRHIAERTDIGEHKEALLSVQIPEKPGALLAFCHTIGHRTITEFNYRYQSSDQAMIFVGIEKDDDFDGLLTKLTQDGYKNTDLSEDECAKIHVRHMIGGIPTPPLVNEQIIRVQFPERPGALLEFLNALNNRWNITLFHYRNHGAAYGRVLVGLDVPKNDMNDFNQFISNLGFRSYVETNNRAITNFLMAGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQM8</accession>
    <name>A0A328QQM8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="91"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP23955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="361" mass="40342" checksum="354CAAEE67F4F5D0" modified="2018-10-10" version="1">MSKQFAEYIWLDGSEPTQQLRSKTRVIELKGDPTIGIFPEWGFDGSSTNQATGDNSDCILRPVSFVTDPIRGEGNFLVMCEVFDRHGNPHRTNSRSILRQVLQAGAAEQDPLFGFEQEYTLFDENGPLGWPKNGYPEPQGPFYCGVGANRINGRELVEEHQQACIDANLLFYGINAEVMLGQWEFQIGYRGFEEPADALLTADHLWFATWLLHRLGEDHGINVSYENKPMKGDWNGAGCHTNFSTKDMRDKNLGAEAVKRAITNLEKNHQQHVAIYGHALDERLTGAHETCSINEFKSGNSDRGASIRIPIATADKGYGYLEDRRPGANSDPYLVSARILVSVCELDEVLMNIKSEELVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQX0</accession>
    <name>A0A328QQX0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MotA_ExbB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DID73_01870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="108"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="258" mass="28456" checksum="FB628637B9006BF7" modified="2018-10-10" version="1">MNLMVMLGMGVCIICIFYGIPGLWSNIGTYVDPNSFVLVLGGTFGAAIISTSPKDFVSILKIVSGYMYMKRRNIDNYQTVQKLVEIAEEANRTGKETVLEMGKGYGDGFLDRALTLMGSGLENDFVAVALETDILEEKKRHMRIIGMVRAMGSFAPMFGMMGTVMGVMLVLQNVTDIDAVVDGMGMALLTTMYGLIISTLYFIPITNKLKYLNDQDGLTKEIIMEGTIAIMDNQIPLMVEKKLMAYLSTADKGKKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QQZ6</accession>
    <name>A0A328QQZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000013">
        <property type="protein sequence ID" value="RAP23106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="271" mass="29585" checksum="43F44FF6E2E4D81D" modified="2018-10-10" version="1">MSLTNKTVIITGSSRGIGREIALKCAEDGANIVIIGKTSNPHPILEGTIHSVANEVDTAGGNALPIELDLRDDDKYQGVIDQVLDRFGGIHALVNNASALFMSKMGNTPTKKYDLVNGVNGRATFLFTQACLPHLLKQRVSDVLTISPPLNLNTKEFGKCPAYTMSKYNMSMVTLALSQAHKRDGLRANSLWPKTTVATAAVKHMLPKPVYMASRHARIMGDAAYAILSHNDKNHTGNFYLDDDVLINSGVTNLVQYKRNRLLPTVPDLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QR21</accession>
    <name>A0A328QR21_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="201" mass="23286" checksum="CD99DF1C67A32148" modified="2018-10-10" version="1">MNKTKLILYIISFVIVSLFSGIAFAYITGGQLPERSSLGQSKSFEANQQLIWAALLDIESYPLWKPSLKSVEMLGTNEKGYTKWREFYPLGKTITYEITEYIPKSLIEIRITEAKKAAGGVWIYKLSSYQDRGVLQIKRFAIIKNHIDRFTRRWIDTKYNELDYTLMSLNVYLNQLLEDQEEILELIVPDSVENNEAPLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QR40</accession>
    <name>A0A328QR40_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="147" mass="17135" checksum="20F72BDD9072CE7F" modified="2018-10-10" version="1">MPSLGLIRTLITHHQKRFFSIPKNCTTNELIERLLDKKDFTEIQDRLAQEFKQQPQQREKWLLGANWDWETNNQLHALYKNDSKPVEWLTNSRAQLKSLTPLIPDPNLYSPDKLFSTAPFPTLQLILAIARKNPSLLVQYPALKDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRW3</accession>
    <name>A0A328QRW3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="180" mass="21735" checksum="45AF5D481535B4AB" modified="2018-10-10" version="1">MNTTAIKYIKWKRPPRNIIEFNTLRKEYETLRNELKSFVQQYLNSSQPIPWEEALTKLSHLFDILESRPEFKPIPNAKNISEEKTIYGPLFHQQLTNIHDELSKKYQEELAEIDINMKKLQTKEARQKLSQLKGWPTKQPKMHILWFQIQYSECNMKLSKLERSLKKARYTIYSRWFSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QRZ6</accession>
    <name>A0A328QRZ6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="172" mass="19809" checksum="EFE12E27B33783C6" modified="2018-10-10" version="1">MERLYSYLIDPIRTIQLYTHQKDWKLWWILIFIHAIISVIKVSSLGVFSFAAHIVFSVGWLVLTAVIIDATAQLIGQKGELPSVLYWLGFANAVLWLSPSVTIIQYSFYSIGSILVFLLNIVFLYYMWTTLKKIYNINQWQLMGIFTVPIISVIVFVIAFSVYATQMAMVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS47</accession>
    <name>A0A328QS47_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000009">
        <property type="protein sequence ID" value="RAP23509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016422810" evidence="1">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="264" mass="30160" checksum="B26ACBA9B1FE1FA3" modified="2018-10-10" version="1">MRLVIALIVLSLNLSAAEHNPLQFERYDDVVLPLLKLNSASMGGFMDAMKSYIVYTAIQHVPGAKESGVGYYYDNKTRNMKRVLFYRLSDGYPRPSNKPLDFYIEGKGFFVIEIPGGWPAYTQDGRFELDENNRLVTREENFPVLGENGYIFLERGGINVDKKGVIYQNGSIVDTFRFEWPAKNHDLKSFNHKIFYLSKEDWENKNKWAPADVEVLQGHVYESSITKGYIGLVPEWKNGHEANVKMVKAYLKSMSLAVQAANPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS77</accession>
    <name>A0A328QS77_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="126" mass="14400" checksum="A1B4BE8472CE6A8C" modified="2018-10-10" version="1">MKILQRLIVLIAILSINQACYATFFNIEKLRIGPNPLVQGKDPIIINYVATLAHSAEYYVYTVTGELILKKKFEYNIPNITHAGECQFVLLNSLAMGRVPKQLYVVIIVFKQENNTVKKKKYVIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QS88</accession>
    <name>A0A328QS88_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_02090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP23559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="326" mass="36771" checksum="EBBBD0D9FE39D1BD" modified="2018-10-10" version="1">MTYFFHRILTSIPLIFGVCFLSFLIMQLAPGDPTLMYMDPSVSAADLEQVRKNLGLDRPLLVQFFYWFKELLQGNLGYSYVTGKPVLQAILERMPATLILSISSLIIILLITFPLGIICGYKKDTWVDDSITIFSFLGLSIPTFWLGLMFILFFSIQLNLFPTSGFLDPLLHDASFFQKSLNIMHHMLLPLLTIIIGGIAGLIRYNRFSMIKILAQDYITSARARGLTERRILFKHALKNALLPIITILGLDLPALISGSFIIEYIFSWPGMGQLGVQAVFQRDYPILMATILFSSFLIIIGNLLADLSYSYADPRISKKSNESQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSD7</accession>
    <name>A0A328QSD7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YggT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="83" mass="9846" checksum="15430287D94E2839" modified="2018-10-10" version="1">MINFYQIITGIFDLLYLLLMIRILISWIPHDRYHPVLQFLYQSTDPILKPFQNIFPTSVGIDFSPIFAFMFLGILKNIILRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSF6</accession>
    <name>A0A328QSF6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">DID73_00670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6 7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="263" mass="29689" checksum="AB56C8442A3D6FAD" modified="2018-10-10" version="1">MKQHTKTLGQVFLHDQNIINKIITLSNPSPNKPIIEIGCGKGILTKALSNIGPTHVIEIDERWIKHVSDLKLKNVTFTQKDALKVDYSSLPKGAPVIANIPYQITSPLIETLSEVKHHLGPITIMIQKEMADRLLAKKNTKTYGSMTIFCNYHFTITKGFNVSRHCFTPEPNVDSSVIQLTAKNDVFSESDAALFFAMTRSFFWGRRKTMINCLLNSPHLHCKPTIKSNKQLSNILSKRGESLGLEEHQQLFNDIKPYISHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSJ4</accession>
    <name>A0A328QSJ4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="127" mass="14986" checksum="640CA51B2FB72E65" modified="2018-10-10" version="1">MAKKKLNIVTILCCIYIVTIVSLGFNGLLNSKTKTDIAAWNMYKYHVVEKITCQIDNRPFNCKKHFYHNTFANSAHSRFRKHQVKLFADYLTKHYTFKNHISVQVDITVNHQPETITYKVIRNKHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSV5</accession>
    <name>A0A328QSV5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="10" type="ORF">DID73_00370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="470" mass="51656" checksum="3602A8438563105F" modified="2018-10-10" version="1">MHDIKHKCGVFGIFGIDEAAVLTTLGLHSLQHRGQEGAGIVTYDGDQFHSVRRQGLVGDNFNDADTLSKLPGRQAIGHVRYSTTGESKQENLQPLFANLAAGGFACAHNGNLTNTISLRKQLVQTGSIFQTTSDTEVILQLVARSEKTKTLDKLMDALTNIQGAYSLIIMTNKKLIGVRDPFGIRPLVLGQKNGSYVLASETCALDIIGATYIRDVKNGEMVVITEDGLESHHLFPEHQERQCIFERIYFARPDSIVDGKTVYTYRKNLGEQLALENNIDADVIVPIPDSGVPAALGFSQASGVPFELGIIRNHYIGRTFIEPSQSIRQFGVKLKHSVNKSCIKGKKVVLIDDSLVRGTTANKVVRMIYDAGATEVHLGISSPPIKHPDFYGIDTPNYSELLASNHDLAEMTKIIGATSLFFLSLQGTYKAMGLDERDSVTPQFTDHCFTGDYPVDVHELLKVEVMNEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSW3</accession>
    <name>A0A328QSW3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DID73_00325</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="15">
        <location>
            <begin position="129"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RAP24984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="242" mass="27451" checksum="B3F55C13BA807B5B" modified="2018-10-10" version="1">MKISFLTLYQNELDGFFRRGVIDKAIQSGILSVNTIQLRDYSDPPHHKVDDYPFSNRKGMLLRFDVLQKALNDAPDDVTFIMPDPKGPKFSYKDARDLSQKSHIYFISPAYEGVDARIFDAFSIQSYSMGDFIVPNGDSSSVLMAEAVARYLPGVLGCADCLEDDSILSGLLEAPQFSSPRSIDQMHVPDVLLSGHHQEIDRWKLTQSLRQTLYARPDLMNQFSFDQTLVKMIDQIIMEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSW4</accession>
    <name>A0A328QSW4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_02425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP23107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="296" mass="34022" checksum="77136A5913187D71" modified="2018-10-10" version="1">MVRLFKWFMVVMSGLLVVWWLNVPFLDSPKDTAPIIVTSTPILADLTQQLVGPDVHVISLTERVSDPSKQQITKQKLEKIKEASLVIVNGSQIEKGMVDLKPYLSEKAHLINVGNIMTKYDKGWQSYYWMSPVSWNKLVHYIQMQFKRVFPDRRSEINYRKMAYTNDIYTLHQTLKKTMDEVRQKNKVISSNHESFAPFAKAFGFEFVTLNLTDNMDEETLSKMVDTLKKRNVKVFYPNEALPQVGIDDLVKTALAQGWQLRIGKPVISLNLDMEGSGVSSYIEMMTFNLRALSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSW6</accession>
    <name>A0A328QSW6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="253" mass="29009" checksum="0248A2C7B547C14C" modified="2018-10-10" version="1">MVSPIEKLKGIVKRLRAPDGCPWDIEQTPKTITPHIIEEAYELVEAIESDNNDSIIDELSDQLLHVVMISEMINESGGFSFDDVAKHCSDKMIRRHPHVFGEDSIKTTGEVNKKWEEIKSKEKPNESIVDGIPKHLPALLHAHKIQRKVAQVGFDWPDLNGPIEKLVEECQELVEAISNDHMDEEIGDILFTIVNICRKCNKNAEELLQQANQKFKDRFKVCETIAKTHKTPMKDLNIKELEMLWDQAKKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSX2</accession>
    <name>A0A328QSX2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="198" mass="22583" checksum="9EEB07E58D76357A" modified="2018-10-10" version="1">MVFYCVFLKLMSIFYKCISLDVGFSDVRSSIHAQKVLSNGWAHFHVNGTRINYINFSNVIYAYGSDLVLYLPKVIEKVIEQCLMYSGFVAVGGWPETLIARCEDSRLDSILQNSETVFLDSLGTDGCGTGYLWLVLFYRAFILFDKYCRAAPISGYFIDKIYIEGELLGIDSRLLSSFKGNVNRKEKDNPFFFNKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QSY1</accession>
    <name>A0A328QSY1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP25004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="147" mass="16587" checksum="59287100048D6F1C" modified="2018-10-10" version="1">MIHKAPQNTQEIFQNNLRAIGVPPAHQVNSNTAHHTNKQELNATTAPRETHPNTLSEPMSSPATQHTSPTLSNTAIDALRQDNALREQLKRLERENATLKQENAALREQLSIKDDLMNKYADAVKSYNQLSNMQKEGWEKAEKKSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT29</accession>
    <name>A0A328QT29_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_00620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="365" mass="39548" checksum="6A66D4E256797B14" modified="2018-10-10" version="1">MSLVIDYPVIISLIGASLIGITSGIISCYAVLKEQSLLGDAIAHAALPGLCLAFLFTLSKQPVILLIGAIGAGLIGTLLITTIIRKSILKEDTALGIILSVFFGFGTLLLTMIQKIPTARQSGLDSYLFGNAASMLKSDITIMAILTIIIIIITLLFWKEFKCSIFDIGHFQTQGFSPIKIELLMVCLTVITIIIGLQTVGVILMSAMIIAPATAAKLWHQQLGPMMLLSIGFALISGIGGVLLSSSIHHLPTGPTIVTVISAIVAMSLLISPNGLLWQWIRKIMNKRAIRMESILTNLYTLAKTHSDHTHPHDINTLRILGGVPPNTLLKKLENNGLIYHHENHHWGLTETGITKAIQILQRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QT61</accession>
    <name>A0A328QT61_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_02545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000015">
        <property type="protein sequence ID" value="RAP22878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP22878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="183" mass="20375" checksum="18C8F44CBFDDF2D3" modified="2018-10-10" version="1" fragment="single">VDTTIIGIFTGLTVFVMSFFRDPLRNIDRENNTVYSAADGVITQINDVEIEGRAYKQVVTFLSVFNCHVNRIPLAGKIVQSVHIPGKFLAAMRGDIDKKNERQETDIETEIGLVRVVQITGAIARRICCELEPHQTTKTGERFGLIRFGSRTDVYLPVDKVNLLVKKGDKIKGGLSKIATIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTE5</accession>
    <name>A0A328QTE5_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="98" mass="11045" checksum="5D1A178F5DF9567D" modified="2018-10-10" version="1">MKDVMALCWAAYQGDIDEVQRLVASGVNLDEADYDGRTCIHLAASEGQEAVVKFLIARNVNTNPKDRWGGTPYDDAKRHGHKQIMKILKEKTKEEKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTK1</accession>
    <name>A0A328QTK1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="114" mass="12609" checksum="00EBA0D129102B7F" modified="2018-10-10" version="1">MKVDASFKKTYILLLNRLIEDLDYKLSSYKLSLSAEGGDVSYKVFITQKVNDTILQMDQLKQKIDAVKRCNDGDLFHVSTLDGQVDVSEGDDVFSALGPVSIQSEGSKITKISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTL6</accession>
    <name>A0A328QTL6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP25005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="223" mass="25135" checksum="19E333EBDCB539FF" modified="2018-10-10" version="1">MNNEINQIKENEKRFFNIVRATKLFLPLIELSLLKIRENKSRGTDKKYDFFAISLLQDAFTYINLVKKQKEGNELKLKLSKIIRSIVTHALEIIKIDISKKNKYKKLDLLKSIWNIIKVSNIELDTDQKTLLKEINQDLSKIKKTAKKKSEKLNNIEFIKLIKQILNTSSKSKKRPRTKKSDGAGSSSAGPSSSAGPLSGASSSSSGKNSSARTPKKSKLTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-12-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTM0</accession>
    <name>A0A328QTM0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="98"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="224" mass="25494" checksum="C1EF847767F0D841" modified="2018-10-10" version="1">MGRKKKEEPPELEESDGEFAAVFSDLMSFLAGLFILLFTIVNSQKSSPQYFAEMSVKMGGKKIEQQSKATAEELLVSDVRNYIQDEQMSQYALVLVEEQRIRLIFNDPILFKSGTDILTENSKSVLKGLTNIIKQVKNPIIIEGHTDDIPVKPKPGNRIKTNWDLAYFRASSVASYLMGQGVNQSRMSITSFGDQRPISRRKTYLGRKKNRRIEINVIRVKEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTP0</accession>
    <name>A0A328QTP0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016301724" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="77"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP25025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="377" mass="41684" checksum="C3B56F1FA2DFC988" modified="2018-10-10" version="1">MKKSTIFIMIKKVIVYCLLGLAGTAANAAVNTQEHSLMNAGTKIPEFQSRDLLAVITSKANKKPPSTKTLQEAPAPPWHILFKRTPTTQTTSCSGTVIKTFEGKFAMVLTAEHCNSLRKGKKMFLKGSKEDDPLTPVEIIASETIMNKDDNSVDYEKDIRLSMISVNPGELPKHIVAFPIERVFDQKPKEKETCKISGSGTLPREKEKEDFVFTEKGTGAGNFQVTKVTNSTVTLRQYTTNETLIAVIRGDSGGGVFCSNSTEFSWENAHLVGVTSTAGIYKDPPYIVSTTTATSITPRILFDTIRQVEEDAQTTIRKNSDLNLMIIKASNMLFMIIFGTTIYYCNKKPNPTPKELENDAPPVTDRDRDIETGNPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTR2</accession>
    <name>A0A328QTR2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_01790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_28" evidence="4">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="337" mass="37486" checksum="A776EEA1BE053FE0" modified="2018-10-10" version="1">MILFVSGATGGHIYPGIAMAHALDEPSYFIVPRDHPAKKILLPYAYSYQVIGFSIKNILMFPILFFQILGVFIKKKPKAVMAMGGGICIPFAILAWILRVPVISFEQNAVPGRATRAIQFFSKKIITAFDSAKKGLILRSRVACLGNPIRLNYPDVDQLPNEWSDIQGKTLLVVGGSQGARAINEFIHGNREKIMALGVNIIHLTGDAFMKEAQIIERKADQIYMALPYINDMTIAYQKASIVLCRSGATTLAELHYQKLPSILIPYPYAMDDHQEKNAIEFSLSHHNATFINESELGMPIVKEKIVESSVIRDGVDNDSARKDTNTICELVKSYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTR6</accession>
    <name>A0A328QTR6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folK</name>
        <name evidence="9" type="ORF">DID73_02305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP23437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="169" mass="19403" checksum="975361FC1EC0A6F7" modified="2018-10-10" version="1">MSKKHNRHFRFTERFMNNVFLGLGSNVGKREKNIETALDHLQSHPEITLIQISTQYETIAVSQYQQPNYLNSVAKIATFLTPMELLDITESIEQTMGRATKGMGDPRIIDIDLLFYNDDIISTDRLTIPHALAHERLFVLNPMNDIAPDYLHPILNQTMSELRADLDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTS2</accession>
    <name>A0A328QTS2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="369" mass="42035" checksum="38EB4187A517C3D9" modified="2018-10-10" version="1">MITLEKQSIKDELGKYNLTPPSKKDEDWLYYNIDKLLDENISETENIENEQVSTPEGNHLVFNNGRLVQKKLSNQIEISNASNTTNTDKGFIELAKRSPDTIHLKLKNSNETISMMYNSTSGINSTNISIEIDGGELIIERHFSTHNNSLSNNYLNIQATNNANVIINEINNENTGSTLDFVDTTLDTNCHLVGLNQSYLSHNSRFQNRVYMNGINATARLNGLCINETEKECFYNTHVFHNKGENESHQLFKSINKDKSLFEYNGKVSVKKDAQQINSYQLNQNILLDDYATIHSRPQLFIDADDVKCSHGSTTGDLNKEELFYLMSRGLDETISKKMVLRAFVDDVFQHKKLAKYNQLIGTFLNNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTS3</accession>
    <name>A0A328QTS3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobA</name>
        <name evidence="9" type="ORF">DID73_01840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="8">
        <location>
            <begin position="260"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="484" mass="53545" checksum="54CC51DA18ED43A9" modified="2018-10-10" version="1">MLKTMVYLIGAGPGDPELLTQKAARVLASADVILYDYLVHPNIVLKATSAQKVCVGKKKGAHSTQQKDINQLLIDYAKQGKVVARLKGGDPMVFGRCGEEMQALKAEGIHYEVIPGITSAISVPTYAGIPITHRDHSHSVAFVTATRANDIENMAFPNADTLIIMMSLLRLSSIVNRLKELRPIDTPIAIIESGTYADERVVVGTISTIELLQEKAQCQPPALIVVGDVAGLHHEFNWREHLPLKKHRFVLFRAEHQQSELRDTLSMMGAEVLCLSLNSIEMNPKSLEPVNLDQITHIIFTSENGVRSFFNGLFLQKKDARLLSNKQIVAIGQHTKRTLESFGILPDILPEKSTSEGVIQLLKDQLTTKDHILIPTSSEADNNLNELTNTGATVTIIPTYNNNLPKDVDTMLNWIKETDVLIFMNSASVKRLSHIYKSIVHHRVVSIGPMTTKTLTDIGSHNIIESDKPSVESIKNTILNHFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTT2</accession>
    <name>A0A328QTT2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="737" mass="85492" checksum="9D7E1A05FA248461" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QTY0</accession>
    <name>A0A328QTY0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="249" mass="26367" checksum="4646C1511A546351" modified="2018-10-10" version="1">MKHQGKIALVTGASRGIGRAIALKLASEGAEVVLNYRRSKTECESVLQEIADMGGAGIAIRADVGNEDKTDAMFEVIEQEYGRLDILIANASFGIPGNILDSTNKYWDVTFNATSRSIFHCSLRASQLMPNGGNIVTVTSYGGQRVLKGYGVVGPAKAAVEGLTRSLAVELAPKNIVVNGVMPGITDTKSFRAIENAENIVNSVETMTPAGRLVTPEDVSQVVNFLCTPDASMIVGQFIIIDGGAFIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QU57</accession>
    <name>A0A328QU57_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="118" mass="13247" checksum="C72501C502DD4B51" modified="2018-10-10" version="1">MPDLQHHSPSEDPMLDLQNDEDIATSGLLPRKQELHQKFIQTLQQVLPHLGKDESKIVSALIILALKLEGIIGKDISEKDSKLIEVLKQLVINDDEKKDSAIKIAERLMKTNSNNSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QV33</accession>
    <name>A0A328QV33_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="321" mass="35580" checksum="D7C9554984993FDA" modified="2018-10-10" version="1" fragment="single">SVIGNMVATSTDSKKSMDVSEIEFSFQHYLYPSVKADVFVGLHKESNGQRKLELEEGYVTFLDTFGVLFPNTGLPSGLGTIVGKKLVGIGKINPLHPEQWQFTDRPLPIKQFFGQDHGLSAEGIQLSYLLPLPFFSQIEWGYWTPSAHEEVAGGAHGVEYENRLMSTRLWNSLEISSTQEIQLGLNYLQGNPSASSKDDKQTLMGTDITFNQEIGGGALTLQGEIYQAEYGEEGEAAAKQNGSYVSATYDITKDYQAGIRYDQLGKHGDEGSETSQLAYMLTRQLTETSKFRLQFNSGEDVENTLYAQFIFGMGPHSHVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVD8</accession>
    <name>A0A328QVD8_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="257"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="404" mass="46258" checksum="09EE84FA9FBAB3D0" modified="2018-10-10" version="1">MSKKLPVTVLSGFLGSGKTTLLNRILNNREDLKVAVIVNDMSEINIDAQLIQNGNASLSRTEEKLVEMSNGCICCTLREDLLIEIQRLAKEDRFDYLVIESTGISEPLPVAETFTFEDEDGNSLSDYANLDTMVTVVDVVHFFDNLDSVELLKDRGESLGEEDERSIVDLLVEQIEFANIILLNKSNEIDPSHLIKIKGVIKALNPDAKCIETNYSDVPMQNVLNTKMFDFEQASQAPGWLKELRGEHIPETEEYNISSISFKSRKPFHPKRFMDFVQSKLDGVYRMKGYFWVASRMDYVGQISSAGKLAQISPAGKWWSAVPKNEWDLTDEDMIESIRENWQEPYGDRRQELVLIGTDINKEDLNRRLEECILTDKEFKEGPEKWKEYTDPIHAWELVEEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVF9</accession>
    <name>A0A328QVF9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_01205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016131">
        <property type="entry name" value="Haemerythrin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00550">
        <property type="entry name" value="HEMERYTHRINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="124" mass="14558" checksum="CF0053C4390DB872" modified="2018-10-10" version="1">MKEKINIPSLDNHHGDVFKLTHLLDEAIGANSREAFEPIIEFLSINCVNHFKEEEQLMKKNNFPDLHDHAIEHSRFINKIKQIKKMYDENIHTTHIAYGIRQLIDSMIFHVHTIDIKMKGLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVK4</accession>
    <name>A0A328QVK4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="362" mass="40449" checksum="0646643A362D3FD6" modified="2018-10-10" version="1">MKLLDSYLVKEIIFPFIFGIAAFTSIIAGSSLIFQLVSKAVKYGFSIASTVQLFVYKLPAVISLTLPMAILLATILVIGRLSADLEMVALRSAGVSLFRILIPIISIGLVVSLVNIIFNEIVVPRANYHAEILLNNLQKTNISIRENVNLTQYDDEGLPLRIINVREVEEQTLKDITIAEYEKGRLARVIRAEYGNWDSIGGWVFNNGVMHVLLESSSQELMVINFEKEIINLALDLLDFSKRAKSYDEMNGKELMSFIQKEKLLGKDINELLIQYYLKFALPFACLIFTMIGAAVSFQPHRRSSAMGMGLSIIIILTYYIIYSFGLAFGINSVIPPILAAWTPNIIIGIVSIYLLNKVANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVL2</accession>
    <name>A0A328QVL2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">DID73_01880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="231"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="260"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="339"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="471" mass="52070" checksum="8B607D969B8EC9A9" modified="2018-10-10" version="1">MSTAVNELEYKVKDMALAEFGRKEIQLAEHEMPGLMELRQQYGSEKPLKGLKISGSLHMTIQTAVLIETLVELGATVRWASCNIFSTQDHAAAAIAKAGIPVFAWKGETLEEYWWCMERALVFPDGTGPDLIVDDGGDATLLVHKGKECEEDPSLLNEKTDSKEMAVFFDLLKSSIEKYPNRWSGIAKNIRGVSEETTTGVLRLNQLQQEGRLLFPAINVNDSVTKSKFDNLYGCLESLADGIKRATDIMIAGKTVVVCGYGDVGKGCAQSMRGFGAKVVVTEIDPICALQASMAGFEVNTVESALSRGDIFVTTTGNKDVIRLEHMKQMKNKAIVCNIGHFDNEIQVEQLEAYSGIRKENIKDQVDEYHFPEGHSIILLAEGRLVNLGCATGHSSFVMSTSFTNQVLAQIDLVKNTYETGVYVLSKKLDEEVARLHLEKCNATLTQLTKEQADYINVDVEGPYKPDAYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVM0</accession>
    <name>A0A328QVM0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="252" mass="29548" checksum="BE6CF6D1CFDD3DF1" modified="2018-10-10" version="1">MYKLLNKIKNKVAKFKNKDIFLYDYEKRYYSQHGEDGVIEKIFQEIHITNRYYVEFGVENGSECNTRFFREQHQFNGLLMDGGNENDAINLKQEFITAENINELFEKYNVPESFDLLSIDIDYNDFWVLNALSPKYKPRVIVAEVNTSTPPNEDKIVPYNPFTVWDGSRYFGASLLAMTRLAQTKGYELVYVESTGTNAFYVKKDILDNLKVKFQHQGNINKCYRYPTYGPLFFKGHPKSPKRHYVSSNIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVP3</accession>
    <name>A0A328QVP3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DID73_01540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="212" mass="22508" checksum="04283661F7577A77" modified="2018-10-10" version="1" fragment="single">NSKMITSCDVSNDDDIARVVKEYSDTYGSCDFIIHAVAFANREDLEGDFSDVSREGWNMAMDVSAYSFVTIANKFKGLLSDSASLVALTYLGGERSVPNYNVMGVAKAALEASVRYLASEFGELGARVNSISAGPVKTLAAKGITGFDILLKVNAARAPMKRNVTLDEVGNAGLYLCSDLSSGVTGETHHVDCGYHSIATSREDAKIVGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVS2</accession>
    <name>A0A328QVS2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBBH-like_N" evidence="6">
        <location>
            <begin position="357"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="451" mass="50623" checksum="212048404F1FD8C4" modified="2018-10-10" version="1">MSEKENIETFLGEIYHQKSGVFLNDPDLLHDIIVTKGSVSCTFNEPAGSQEINQLKPIIEEKLFQLDWVKELEIKLRFTDQNRKQRSEGLKNVKHIIAVSSCKGGVGKSTIALNLATAFQLNGAQVGLFDADIHGPSLPTLLTPTEIATCDTDNSIPPFINNGIKLMSYGYIQESANQPAILRGPIASNLFKQLLLKTDWGHLDALIIDCPPGTGDILLSITQEIELTTAVIITTPHELSYVDVKKGLEMFKKVKVPVTTIIENMSYFSPPDSEEKYHIFGKGRLIPTAQEYGIPNWLELPISDKIAGYNNKKTPYLINAGQDESNIYQKLVNDLVWAHYFESEIDNDIEVDINNNTQEIKIITANNNVTISYKTLRNNCQCALCVDEISREKILDESTIDPKISIRRLFNVGHYAYGIEWEEHGTTHNSMYPKEQLATFFELETTGKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVW1</accession>
    <name>A0A328QVW1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_00790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="164"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="606" mass="65434" checksum="D12292A4C85AF3DD" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVY7</accession>
    <name>A0A328QVY7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">DID73_01170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP24719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="124" mass="13936" checksum="87773EF9B46A4DE8" modified="2018-10-10" version="1">MVSRYYTEDHEWVEIDNDVVTIGISSHAVDELGEIVFVELPELGKSITKGDEFASVESVKTVSGIYSPLEGEVVETNQSAVDTPEIINQSPYESGWLIRVKTNQTDYIEDLMDEPSYQSFLQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW35</accession>
    <name>A0A328QW35_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP23968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="280" mass="30370" checksum="8C8A13572D93BFA4" modified="2018-10-10" version="1">MPINKLPADSIAAPKNVKGRRCSNRKRKPSQRAEDVINTNAAIQHDKAKSEEDKIARQQLRLMKKAACKKKRQRTTQVPVTTSVKVASTQKSSSGRSTPEEYPGTPNPLSEFNLKGTGLTPFIFKQARHGDLALSVGEKGKVKFTFTPVKSSLSPMFPGLPDALGTGYSPLRSDPNQLGLDGRLEDLDSSSSSSSPSPSLESEDVQSGLDGRLEDLDSPSSPNNIGVEGFDVDKTFKAEQTPLWMRQAYDKGDENSPNSANQDFGSASENPKAKTCLKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW91</accession>
    <name>A0A328QW91_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DID73_01785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP24018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="168" mass="18533" checksum="EFC3A8911261333C" modified="2018-10-10" version="1">MVAYSVLSHPYQLERIQSFLNPWLDPLGSNYHIIQSFTAIGSGGIFGFGIGESRLKYFYLPLHYSDFIFSILCEEGGLFLGAIVVCGFGAIFIRGIQIALKKSKYSFEQFLALALTFYLIFQAIINICVVSGLFPITGIPLTFISYGGTSLLSSMFCLGVIHRIGTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW97</accession>
    <name>A0A328QW97_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028250">
        <property type="entry name" value="DsbDN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11412">
        <property type="entry name" value="DsbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC" evidence="2">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="605" mass="67981" checksum="28E24CD2D56FDA1F" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWA5</accession>
    <name>A0A328QWA5_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="11" type="ORF">DID73_01885</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="65"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="429" mass="48344" checksum="AF321569D2F3B7A9" modified="2018-10-10" version="1">MAKKKSLFNLYLDDENRLDIVKLQKAELDDLHALALELKIEQYNQLKKNELIFKILQSNPTENGLIKAQGCLEIISEGFGFLRTNNYLPSLEDIYVSNTQIRKFQLQTGDLVSGMVRPPKDNERFFSLLRVESINSESPEDITSRTLFTNLIPVYPYEQLKLETTGDLISGRIMDILCPIGKGQRSLIVSPPKAGKTSLMKEIANAISTNHPEVLIKVLLIDERPEEVTDMERSIDGEVVYSTFDEPPEQHVKVAELVLESARRLVESGKDVLILLDSITRLSRAYNLVVPPSGRTLSGGLDPSSLHKPKRFFGGARKIENGGSLTVIATALIDTGSRMDDIIFEEFKGTGNMEIHLDRRLANRRIFPSFDILNSGTRKEELLLDEHVLKKSFLLRKNLDGENSMEELIKLLQQSDSNEDFLNSPIFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWB0</accession>
    <name>A0A328QWB0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="254" mass="29278" checksum="FAD60897CA984A24" modified="2018-10-10" version="1">MIGQILLIGAGYFISSFFFNTGWDDSHKKYNNKVSTEYSKLFINYIDDQSINNEEVKKQYLLDYNQNRIAFEFNSKNKVTHQVSYGTGLSNLLIENKNVNSYNSVKTKEVKSTHHVLMFDSSYRRFNSLYGIKPIVHFNVGILHLRKKETFYSADIEDKVTDVSNSKTMAALLDTKLRLLWKGYTLKLLPSSPIMYSEIGVTFKQNDYYICLNFGGSYQLIDQFNIQGQWGLKPLYSKSNSLVGNASIGVEYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWD6</accession>
    <name>A0A328QWD6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="458" mass="52351" checksum="C11AEE1AA6EF9B2A" modified="2018-10-10" version="1">MVIICVALEKELPNQFKKWYPKHWVRIEALQAGALHHYQDASFLIVITGVGEKSKLAIEWLIQNAKPTEIINFGTAGAASLDLHQWVMLKSTSDGHTICDCDLKTSLPIPYHQFNFSDGRTVNDPDVSITDAVVDMEAHHLATACRNANIPFCAIKYITDHNNNESQTDFNASLDQFHQSLMGLFSCLVLPEFNIAVIIPTYNRHEQTKAALESVLQQHTSPNEIIIVDDGSDVPFEYSHTKVKLLRLNKNHGVSHARNIGIQNSSSVWVAFLDSDDVWHPTHLSSLTAYLEENTLCRLLQTDETWIRNGKPFNKKAYHQKPDGWSFEPSLQRCLLSPSAVMIHRSLFDWHGNFDESLTVCEDYDLWLRFLRYVPVGLVPVISMTKFGGHDDQLSTTLPAMDNFRLTALMKQWENRWPNIDRTQLRDVIKKKCEILIQGATKRDLSVDWYEQLLEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QWL1</accession>
    <name>A0A328QWL1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="214"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="497" mass="56475" checksum="6F47787D2124C925" modified="2018-10-10" version="1">MNKTMACGSISTNYKIQRKFFHIVLEQVILCTKQKKEPSEIIGLVTKRCCEKGITIQMITSLLRQPNPYLYCIDQVGMENSGEFSLWHPIMSMVQFEKNEPGYFKSCLKALVYAQTHIHFLDTPHNRCSQKEWLSAIQKFRCQLMGHQPESLQDSQFGSYESSFELTGISVDLEGFDNLLGKIASDDDLSLKIVDNKTRCEYYISGPGLKSDPEDAPSLDVIKDSLFRNGKGTFQEDSGGGLRYLSVDSREYKVFLNSKKFQKMRRLELNQALLQLSFNLKHWKELAQKQGEDPNCPKVKFDLVSQLICKYMTSILQTHPFPDGNARFAYFLTNIILHQMDLSPSVFLHNMSIFDANSTGKAMECIMIGQETFKQQFTSYGDLLAQFTSELALVGSAAGPPVQRSLMTVTEGPTLKLGHTKLKKFKAGYFIPNLSDTEEVLYKDWIKQNISSSCPLNVTYHTQKKDGKKKLIKFVCKRTDKVRTLFDLKCSLSAKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QX79</accession>
    <name>A0A328QX79_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000012">
        <property type="protein sequence ID" value="RAP23112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="306" mass="34734" checksum="1DDE348E05F68C3C" modified="2018-10-10" version="1">MTKISTTTETQKRQISTAYPTSMKSLRTSYIEQKNILKTSLDQLNTLLEKFEEYDYINLPNSGRYTHFIRQRYMSDETMKSLKDGAILAPQLLQDDATLKSIFNQASENDIIDFKAVITDGVDLDKELTKLINELDITYPEQTEGAKETPEKLFYESCIDKILGNVRESLKKVEFGETKAWNYEGGDSVAKANSTIPYMQYLGLSIEINEINKAITSKEYLKANEKLNNAKSEIEEMKKANDVTEVPIYQARRLQEYSLQLNTLEQIITSARTSYSFKSIASVSLGSFALGATIGFCLLKNQHRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QX94</accession>
    <name>A0A328QX94_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_02260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000010">
        <property type="protein sequence ID" value="RAP23430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="251" mass="28209" checksum="3F215E217D7A1074" modified="2018-10-10" version="1" fragment="single">MSQFKIIPLNTAQIPSLEELSLKQTFDTLKKHIEYIHNTEQLTEQDKKKHSIMIITWCKQLVTTQKPAIQSALLAFQKESFFEKFLRNLDLSILDVTTPAVSADHTHEASAADQEDCVVADSGDDCAAGDIKPELLNSNFLVYLNLKDFEQKGFVKLLNHNKHSLFMLNLVGVRIVNLKFIKFLLKNTSVKQIDFEHASLTEVILQTLLQSDSLEKINLSGVDLQGVTITKLGQNIKDIDLSGAKNVSKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXB1</accession>
    <name>A0A328QXB1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_02370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000011">
        <property type="protein sequence ID" value="RAP23162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="599" mass="69513" checksum="0ED4D3938566A180" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXM4</accession>
    <name>A0A328QXM4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_02100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP23560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="273" mass="30724" checksum="CDBE01EC9167F5E8" modified="2018-10-10" version="1">MDYGYCWIQKQRRNMLNIRDLDVQFQLDDNIIHAVKGISYDVQPGQSVGIVGESGSGKSVSALAIMGLLPASASIKGTISFHNNSLLQLPDDEYRRIRGKKIGYIFQNPLAALNPVFTIANQMIETIQLHHSISKDAARSYAIELLDKVKIVDPQKRIDDYPHQFSIGMCQRIMIAMTLSMKPELLIADEPTASLDVTTQKEILELIDELKTEYNMAMIFISHDLAVVAERCDHVAVMYLGNIVEQGNPRQIFTNPQNEYTKLLIDAIPKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXN3</accession>
    <name>A0A328QXN3_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DID73_02150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP23570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="354" mass="41068" checksum="66497FA7E865F0C8" modified="2018-10-10" version="1">MPVGNKMFQGEFTEMDEMSNQSIINKRRIINGYDDGLLQASPLKHPWAREIFKGMQQNNWVAEEISFQKDKEQWESNELTEQERTCFLRALAFASNLDGLLVNSLSEVIKPHITSPEVVLAVARQIYEECLHVDSYSCMVEAVGLDPEEVYGLYRKDKDLFYKNKRVLESMYKINRADFSTKTTEGAKEFLEACTTNLIFEGVFFFSAFLVFYNFGRHNKMPGSKEMIQFINRDEDLHVRLFVNIINAIKEEQPEVWTDDLKAKMKQNIIDSIEMEIEWGVSCIGEGILGITPVMLKEYIQFIGDMRLEAIGLGKEYNSSNPFPWLDEFTQNNMIETNFFEGTVREYQSGSLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXQ0</accession>
    <name>A0A328QXQ0_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="82" mass="9668" checksum="5FE4E4DE28BD48AD" modified="2018-10-10" version="1">MTKHQLKEILIKGTLIGLGILLYSTVMVTFFADFAFSIHDMMFDISREQFNFSVYLMMGVFKLMWLVVFVIPYFAIVWSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXW2</accession>
    <name>A0A328QXW2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006008">
        <property type="entry name" value="YciB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04279">
        <property type="entry name" value="IspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="179" mass="19608" checksum="8A88B6B0774CF003" modified="2018-10-10" version="1">MNAFLLSLIPLIAFAILDTYASLNIALIATIILTIIEVIYTLISIGHLDGVSLFSIGLVVLLVGLSYIKKNRVIFKLKPAILNASMGLYMLVFVAFNKPILRDIVQKYPQMIPQETLQILNTPPGQAMLEKLSLTLGVALFIHGLVVGYSGIKHSNFWWATINVVGLIIAMILASIFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QXW8</accession>
    <name>A0A328QXW8_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="154" mass="17783" checksum="4A36DBD099E4B77B" modified="2018-10-10" version="1">MQYCCNNIRFALILLIINNKRMIERKTVISENILKIFKETDNPISAGNIIDTLSKKDIAPNKATVYRILNKLKSSQQICEFTIKNGTSFFELTKHNHHHHFICNTCSTVYCLDHCHLDTHSIKLNQLLPNKHFKVDSHEFNIYGTCEPCSTSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-12-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY03</accession>
    <name>A0A328QY03_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP24718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="310" mass="34972" checksum="10FEA382DB038A5B" modified="2018-10-10" version="1">MSTLVLLKKNIDTELKKVNQIIQQTLLSTNIPTLSKIYEHILLTKGKQIRASLIILIAKSTNKSNESIYKLAAGIELIHLASLIHDDIIDEADIRRNQDTVHKRFNTNNGIISGVHCYALALKLITSIENLDVLNTISNAVIELCEGESFQVNERHNFSLTRDDYWQIVEKKTSALFKATCISAGQLIRINESDIEHLSNFGHLIGDIFQLADDYLDIFDDKNELSKKIMQDLSTGDISLPILLASEKTINKTPEEIKMVLAKEKNHIATTIKHEIASKKEAAEKNLNELSFNPDQIHTVLKIITKRILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY13</accession>
    <name>A0A328QY13_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polA</name>
        <name evidence="15" type="ORF">DID73_01215</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="QFBO01000003">
        <property type="protein sequence ID" value="RAP24728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="311"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="665"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RAP24728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="909" mass="102830" checksum="62BA03201193AC60" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY96</accession>
    <name>A0A328QY96_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="596" mass="66754" checksum="E9B71E90CE6FBF95" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYA0</accession>
    <name>A0A328QYA0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008272">
        <property type="entry name" value="HB-CoA_thioesterase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01328">
        <property type="entry name" value="4HBCOA_THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="131" mass="15338" checksum="C74D08A1A68C5122" modified="2018-10-10" version="1">MNPFKTQPYRVYVYDTDVAGVVHHSNYLRYFEAGRIEFLRDLGLPYIDFQHDGIGFVPVNIDIHYHYPLREDDEYVVTVELIELKKASFIVKQTVVCNDKVNVSATIQLACVKEPEFKPQRLPEILMNKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYC1</accession>
    <name>A0A328QYC1_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S74 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016272870" description="Peptidase S74 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="2">
        <location>
            <begin position="946"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP25007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="1106" mass="120401" checksum="084FF002B07EEBC0" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYC7</accession>
    <name>A0A328QYC7_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="450" mass="51908" checksum="6CD38093DCEBA935" modified="2018-10-10" version="1">MSFPKTINYKIISKGYDGDDFLLTNEEIKKTENKLTFLYDSSGIEISDKIKTLIQSLAVTLHKQTHSDRNNSYVEHEGTHSIRVAEAIIKNLKFVTNHFPVIINKLKKDLEIGTNKDLHFILITMALLHDCNYFVDKSRGEIKAIHALKSAFTAYRVIDEQMKRILLNKGLSPNSIQRIMNSIYDAILCHNGDKKSMKFNHMCNTPIGDIPVIDVEQLERLIHECLDYQMAHAFIASCITGKRDCHGRPCHKHPSYGIRFQDASLTNEPLLFLLRLADDFDSTENRLLPHQKSAIEKILLFTQPYMEERFMDLDRLAIGRWPWHNIIPTGVRQGFIKFTNHESNFINKIYKKDIYTHQPNESYPGYYNPHLRYFISLWLIESIGLGVDSHQLSVKVKIKQSENTSMQSLINFFATKVAKSDNPTDNGALIPLSDFYGRRILRPGMNLHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYD1</accession>
    <name>A0A328QYD1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-asparaginase 2</fullName>
            <ecNumber evidence="8">3.5.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ansB</name>
        <name evidence="8" type="ORF">DID73_01670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00520">
        <property type="entry name" value="asnASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="7">
        <location>
            <begin position="234"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="347" mass="37430" checksum="EEA8A011145B7FC2" modified="2018-10-10" version="1">MKILLLLLIIISTQLYSTQLKNIVIISTGGGISTRTVDSVNAKVREGFLTVEGLVSLVPQINRIANVKTMELFSRSSQNINNESLLKIASKVQEMINDSSVDGVVVTHGTDTLEETAYFLNLVIRTKKPIVVTGATRSSNQISSDAALNLFNSTLVASSTKSAGQGVLVVLNNKILSARGTQKIATNGIDSVFANGLSLLGYAFNKTVEFYNATLKKHTYSSEFNLKNDTVLPNVKILYAHQNIDGTMVKAFLNKGVDGVVIAGVGNGNISDSALTILKKAVENEIVVVKSSRTGNGIILSNTEVDDKKIGFVTANNLSPQQARILLMVAMLKTKKSGRLQQFFNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYD4</accession>
    <name>A0A328QYD4_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP25017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="265" mass="31029" checksum="2BC5099DFAB744E1" modified="2018-10-10" version="1">MKDSISIRASDASHRPRRGLHQHKHYEILIIKEGAGYHIVDFEKFDVKPNQIYFMRPGQMHEFSPEPGSKFYFVAFDKDEVMMNAPTELREFEFFQSFHCDGPVHLDEVDSIIKQMIDVQYELNHPGPMQSVLISGLVTVLLIKIQRKFRQFASIEGVDFNELVMLFNQMVDDPKCYFRFVKEYAQHLHVSSTYLNDTVKNVTGKPASFWIQKKHVVHSKQLLNDRRLNFKMIASQLGFTDATHFARFFKRQTNETPSSYRASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYE7</accession>
    <name>A0A328QYE7_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfaE2</name>
        <name evidence="7" type="ORF">DID73_02160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="2"/>
    <dbReference type="EMBL" id="QFBO01000008">
        <property type="protein sequence ID" value="RAP23572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="6">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RAP23572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="153" mass="16844" checksum="B9BE2A640EB42AAA" modified="2018-10-10" version="1">MNQIFDPLSIQSYIDSVSDQKIVFTNGCFDLLHPGHIHYLTEAKALGDILIVGLNSDTSVKQIKGQDRPINNQDFRAKMLLGLKPVDVVVIFNETTPTNLISSIKPSIHVKGGDYKVTELPEYEAVISNGGEVKCLSFIEGYSSTDIIDKCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYQ1</accession>
    <name>A0A328QYQ1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="316" mass="36248" checksum="C4BD9CAD6049F11A" modified="2018-10-10" version="1">MKVLILLIVLTHHTFAMIFPIISFSEETGTMAGLFVQRPIAEKSDLQLFLLSQKKGQAGFINTTNIPFGNERVNIKVYGANTGKSFYGIGNTSKKETSNNLYFDELSTTISMEKPLYKAWDMLLGANYNYYKENLDKNNHAQLFSNLSDIGIILGVQMDTRDKEFNSTSGYFNEIKAVIYNNHQILSNDVRYFHPWMDGVLATKFYSVETYTNNDHIQYLTGIGNYYFLRGYQTNDIIDRHLTYGQLEWRRPLTSWFIISPFIEAGVIGRNISNLKKSLFSYGLGGYFPIGSGSFRVESAYTHNNSEFYFGFNHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QYU4</accession>
    <name>A0A328QYU4_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="129" mass="14236" checksum="7193BD03BF3641DA" modified="2018-10-10" version="1">MSSIFTKIINGEIPCHKIAENDQFFSFMDIRPISPGHTLVIPKVEIDRFFDLDNDVLSHFLPFAKPIAEAIEAVIPCERVGLMVAGLEVPHAHLHLVPIRNIGDLSFANATPANQDDLADIAQKIIANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZ06</accession>
    <name>A0A328QZ06_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DID73_01895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP24040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="431" mass="48884" checksum="D879B4964DECB1B2" modified="2018-10-10" version="1">MLEVSIYKILTFIVFLLLSGLFSSTETAFTAINRIRLKGQYEKEKPKQTEDVERLLEQPSKLITAILIGNNFCNVACSALATTIIIDIFRQLHITNLAIIMPTITILVTVLLLIFGEITPKTLALKEPERFAVFSSKFISPLLIILYPVIIVFDAFNRLVNKVFKSKSQFSNKSLSIDELKLMLDISHDDGIIESDKNKMLTNVFEFSDIIVREIMTPRTDAICISDQETVQNAIHLIVNEGHSRIPVYEDKMDNIIGIIYAKDLLNVTTAVNSPNVRKFMRNAVFIPEYKAVDDLLQQMKNSKLHMAIVVDEHGGMSGIVTLEDIVEEILGEIQDEYDLDEKSEWTEISPNTFDVDAKINIRDLEDILDIEFPDDEDYDTLGGLVLSINGSIPSKNEVVSYKNLSILVKEIKKRRILRLEITKHVEDNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QZU6</accession>
    <name>A0A328QZU6_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">DID73_01855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="QFBO01000006">
        <property type="protein sequence ID" value="RAP24032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="426" mass="45944" checksum="6A8DBC6FC3B62862" modified="2018-10-10" version="1">MEKTISAFDEASEVLVGGVNSPVRAYKSVGGEPVFLKSGKGAMVTSIDNQSYIDYVLSYGPLLAGHAPESMISDIHNAMIKGTTFGAPTENETQLAKSIRSFFPSCEKIRLVNSGTEATMSAIRLARGATKRDVIVKFNGCYHGHVDSLLVAMGSGGLTLGKPSSAGIPDDITKNTRVLEFNDTEALTNLFEKEGAHIAAIIMEPVCGNMGVVIPDQTFITACRQLCDDHGSLLIFDEVMTGFRVGKHGAQGVFNIEADITCLGKVIGGGLPCAAYGGKSDIMNHLAPIGDVYQAGTLSGNPLAVAAGRSMMQLIESYGVYEKAEEQAKKIVQGMDVAIKAVKAPIQVISIGTMFTVFFTDQPIKSVNDVNHCDMEMFNRYFHYMKSNNILIPPSQYEANFVSSEHNDDIISTTLKVFTHFLKTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R001</accession>
    <name>A0A328R001_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_01675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000005">
        <property type="protein sequence ID" value="RAP24102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018024">
        <property type="term" value="F:histone-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOT1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="201" mass="23119" checksum="176317093BBCA990" modified="2018-10-10" version="1">MSNLTSLIDYIESLYESYDLFSSSMNGRENFSKDQDRQLIYGEIKLHEIAKAFDFLDLDSEYRFIDYGSGAGKIVLLANHLNIFRQCVGIELVTTLYEISEEVKSVYLNSTNSINKIAYFNRNFLHLNLNQIKCCIYTNSICFSLETCDQMALKFNHMVTGSYIISTKHLTLGENFSDVVHLDSIEASWGESSLFIYQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R063</accession>
    <name>A0A328R063_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DID73_00815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="10">
        <location>
            <begin position="73"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="9">
        <location>
            <begin position="275"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RAP24841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="425" mass="49617" checksum="88AC3958237E3BCF" modified="2018-10-10" version="1">MNLHMSQSLQLKQTLKLNRVMIQRFNILQQSVQDFESLVVEESRRNPFVFYKNNRESSSYFASNDDGVSAVDFATYDESLLSVLTNQLDRQFLSEKEYNIVLSLIDHCDDQGFIKNYKDIRPEIMSEFDIDEREVFRCLKILQSFEPDGVGARSLNECLWIQIDHYDLDDDDDIQNLKDLVKYHLEDISNKDYDKILSNIPISQSMLHDYIEFISQLNPNPASSYSKGATPLIQPSLRIECDDGVLRLVNLEEERMSVSLNNDMLKKLDEKPSDELEKQLAQAKVWVEHFKKRQELLQRCGDYLMKKQRLYFIEGEDFILPCLQKDMANALGVSESTISRLVRTKYIQSPHGVVLIQSLCQRNIYGKTKEQVKSLVKYYCERYPNLSDQKLAELLKSIGLPIARRTVTKYRHEVSLKSSYDRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R074</accession>
    <name>A0A328R074_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="305" mass="35421" checksum="92793EBBA411FFB8" modified="2018-10-10" version="1">MKTHVTCIILNYNHWEMTQECITSLESSDYENLTILIIDNNSLKKIDQLTYKNNHYDLFDNNYNNEQFEHHPIKVNSLYTIKNSINGGFSNGVNIGIKFAQTYLNTDYFWFLNNDTITNNSTLSELLESTNQSTITGSTIFDMNSKPLRSKGSLTCLALSKPYSKKYTTHYIPFTSALISKTIIENVGLLNEDLFLYYEDADYCKKCIDHGYVLKVSKKSIIKHNESASQKLEINKSACPDWLPIYSKKHFMKTNQYPAIYIITSLLLSALKRLKNGEFKKYKDIIMLLINEKKLLKSHHYYQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0T2</accession>
    <name>A0A328R0T2_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="202" mass="21266" checksum="839D56955CBAB6EE" modified="2018-10-10" version="1">MTFLNNVRANISTATLILGKFAEAQAPGSLAGCIMNPQDCPPKNCSETNPSTTFISSNDKIAYCEEGFHTGQKTVSCHTEELDRILGMDATTILASIQFSTPNELNTTSLTQVASTLGIISGQTKEGCSETFSFETDNNRGLVESMLSEGTTTRCESSCTEGTTAAATSDHKKASSAYQEKLSVAITSLAVVTGVIPTLTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0U0</accession>
    <name>A0A328R0U0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ispD</name>
        <name evidence="9" type="ORF">DID73_00810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="4"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="220" mass="24251" checksum="58463DDBC2DA7E45" modified="2018-10-10" version="1">MINVIIPAGGKSERYSKTTSKLDELIHGTSILKRSIEAFINHKHIQNIVIAYPKNEQKKYESLALEAGPTVSITPGGETRAHSVYNAFKTLSDNNHILIHDAARPNPSQTLIQSIIDSLEHHPVVIPGLTITDTIKKVSNNQITETINREALVAVQTPQGFHFNALHDAYESITDFSMVTDEAKLLEMNGIYGTIVPGEKENIKITHPIDLTVLSSLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0U1</accession>
    <name>A0A328R0U1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Superoxide dismutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_00520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="4">
        <location>
            <begin position="91"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP25021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="225" mass="24354" checksum="E92372DF5A7FA9AB" modified="2018-10-10" version="1">MFPWHHLNPYVYLFPNFGLPKPDTCELFIYLDVFLHGKLNTMNPIIIAIVTFFLCVGLPIHAVTPMPKIVRHTHNYKKAIAVILPTKGNKVKGSFSFKQTPDGVHVTAVLTGLTPNQNHGVHIHQWGDISDQVTGKSAGGHYNPEGHLHALPPTPTRHAGSFGNVKADKNGEALLDMLDTTITIVGMKNPIIGRTVVVHANPDTGEQPAGNAGPRIGLGVIGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R0U9</accession>
    <name>A0A328R0U9_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DID73_00580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP25031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="100" mass="11034" checksum="F2A00CB486BB1CDA" modified="2018-10-10" version="1">MNVSIETDNTKNIISVSGRIDTLTAGELEEKILPLISETHPSIQLNCESVDYISSSGLRVFILADKKSQQFNGTVTIVGLSEFLKEIFDVSGLTHLFEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R108</accession>
    <name>A0A328R108_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein DID73_00100</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DID73_00100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP24940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="246" mass="26480" checksum="436D6D557F35DD38" modified="2018-10-10" version="1">MAGHNKWSKVKHIKARVDAKKGKAFSKVGRDITIAARQGGDNPDMNPALRLAIQKARDVNMPKDNIQRAIEKGAGTGDGNDLEEIVYEAYAPGGVAILIRSLTDNKNRTVPNVRAALSKAGGSLANSGAVSYLFEKKGVIVFDDDCDSDQVMELAIDSGADDVDVQDDGSVEVTTTPDGFESVVTAFNDQSLSYLDASIEMVPQTRILLDVEKAKGFLKLIDKLEDDDDIQDVFHNADIPDEAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R122</accession>
    <name>A0A328R122_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="200" mass="22681" checksum="1CD62F6E2F0059FF" modified="2018-10-10" version="1">MRCYFCLNESDLSICNDCQRMTIPQFQWLPSLPNICMAGYLYQYTPVIQQIIQGVKYQGNFKLGDLIRSSIQVGHIPSLYFETDGYVCVPSHWFRQLFRGRQHIPYLFDVFKNTAHDLSFQCKRHRYARASVGLSRVERLNKKGVSGFSWLGDSAIRSVTILDDVCTTGATLASVARVLKNCGIESVYALVIAHQPLTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R133</accession>
    <name>A0A328R133_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ORF">DID73_00255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RAP24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="137" mass="15545" checksum="A0AC5396D8F1FB07" modified="2018-10-10" version="1">MVEQSLVFIKPDGVKRRLMAEIIGRFETRGFEFKRLELRQLSSDEVDAHYQEHVDKEFYPRLKEFILSGPILIMILEGDRVVETVRKMVGPTDALDADPGTIRGDLALSKGENVIHASDSAESAKREIENFFGSLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R140</accession>
    <name>A0A328R140_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">DID73_00305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023298727" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023298726" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="180"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="390" mass="41477" checksum="30F409013EF7B7F0" modified="2018-10-10" version="1">MLLTDIDGVFSSGIHCGIKDTEALDLGYIYVPNCVGSAIVQSQNVIRSVTLDHNESVFKEGPVKLMVINSGNANSVTGDVGIKHVHETVEKAANCFGCSISDVGVASTGIIGVPLPIQSILNGLELFSGDEKRGDLCAEAILTTDLVSKTAFRSIEIQGQMVHLSGITKGSGMISPNMATTLGFVVTNLAMDSDMCQSVLQQAINDSYNMLSVDTDSSTNDLVSLQSSGALALSLEDHDVIAFQHALTELCIDLAKQIARDGEGAEHFIETHVSGAQSKLDAKRVAKLVVDSPLVKTAIAGEDPNWGRIVMAIGKDPSVSIFQDLLCIRINDRPIFTNGHPEPLDRAGLKAVMTAMDIVIDIVIGNGPHEATAWGCDLTHGYIDINTEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R188</accession>
    <name>A0A328R188_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_00575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="282"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP25030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="639" mass="71040" checksum="BA47B5D3BA989C3A" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1B3</accession>
    <name>A0A328R1B3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_01440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="130" mass="14851" checksum="C74F944283011238" modified="2018-10-10" version="1">MSLKKCQNKHKKKGDIFTKVSLCNADKLVKMEVRSMRQTKTKQHIDVDIEVIDGNQLVGKVLEDKDPQVEQCVDTINDLPDSHDIDRVMKIKQQVDAGEYDFDAKLGKVVDALIDESMDENTIAYPLFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1C0</accession>
    <name>A0A328R1C0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DID73_01495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000004">
        <property type="protein sequence ID" value="RAP24632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="220"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RAP24632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="492" mass="53808" checksum="153488CAD400CA79" modified="2018-10-10" version="1">MSFNTNIFEKEKINLAGTEEYIIRGGRHLLDRLPEAFNGIKTIGVIGWSSQGPAQAQNLRDSLEGTDITVKVGLRENSASIPSAEEAGFRKDNGTLGEMYDIIGESDLVVLLISDAAQVKNYKKIFAALKPNATLGLSHGFLLGHLNSAGEAFPSNVNVIAVCPKGMGPSVRQLYVQGKSVNGAGINCSFAVHQDVTGSATDIALGWAVGLGAPFTFETTMEMEYRSDIFGERGILLGAVHGICEALYRHYRADGMDQSQAFNETAETITGPISEIISKQGIKAVYDQLSDEDKQTFEVVYSETYGPAFDVLFEIYDEVQSGNEIRSVVMAGDRHSRYPMGKIDQTEMWLVGEKVRENRSGNVGVNATTAAVYIATMMAQIDLLKEKGHSYSEICNESIIESVDSLNPYIDYKGIAFMVDNCSTTARLGSRKWAPRFDYNFTQQAFPNFENGSVNNQLIESFKTHSVHEAMKVCATLRPSVDISLVATTNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-10-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1V1</accession>
    <name>A0A328R1V1_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_00660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="214" mass="23933" checksum="54D122847BC3931E" modified="2018-10-10" version="1">MEIILNELEWLVFIFKIILSIGCGFAIGIERETMGKPAGVKTHTLICMGSCLFTHFSLMASEGDPTRIAAQVVSGIGFIGAGTILQSKQRIEGLTSAALVFVNASIGMLIGGSYFMYSILSTAALLILFQFLRTNKYQTKLRSYRVYIRCKNYKDIETTLRFIHHLNCKITNKKVEKKTKSMELTVTYLTTPLANHRILSKLNGLTTIDTYTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R1X0</accession>
    <name>A0A328R1X0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">DID73_00765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RAP24832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="513" mass="56013" checksum="076133017208DE83" modified="2018-10-10" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R209</accession>
    <name>A0A328R209_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">DID73_00975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="151"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RAP24872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="302" mass="33508" checksum="D7DB92728847E850" modified="2018-10-10" version="1">MAQRINHCIGLRFLSNESILSILDEAQKIKSGDSIVNLQNQSVVHVFFEPSTRTRLSFEMATQRCQAFPMMLDVKTSSLTKGESLVDMMRNIESLGAKAVIVRHSNGGIPYFISQQLNIPVINAGDGYHEHPSQGLLDLFTLRERFGDLAGKHVLILGDIMHSRVAKSNIWGLLSLGAKVSVSGPPNLVPECVKKWGVDICFDLDECLPRVDAVNVLRIQFERQHGIALPSIREYREQFGLTKKRQQLLPDSAIVLHPGPINRGVELDSDVADGEKNVILDQVSNGVFVRMALLSLMMEGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R262</accession>
    <name>A0A328R262_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DID73_00060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RAP24932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="291" mass="34086" checksum="5CD2B37FD6C17437" modified="2018-10-10" version="1">MKPKLLNQIQSINPINLSLLLTVFFIVTHFESVIKSSPMIYTPILMLGSAGVLFEQCRKSKYFWLLTSIFYAIFILFNWQTVDNHMYLWGYWLIAITMSFYSIDKETSLKLSAKYLIAFCMGYAGIQKLNPNFLSGDFFYFKLITDPRFNFIGSLIQFNLPEVISENKYLIQKVMQESKTSLLNAGPYILHPISKILTWYTIIIETIVTLVFFLPRKRFYIWQHWLLLLFGSLYFVLPIRGFAFTLLTMGFILIKKEDIKLKVIYLLFLAYIFILSTTVLKALLKATYQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2021-02-10" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R2C0</accession>
    <name>A0A328R2C0_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="6" type="ORF">DID73_00420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RAP25002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="148" mass="16759" checksum="D2DF5E5662A22BDE" modified="2018-10-10" version="1">MTVIDSMLTFFGFSDDDEDTNDSSAVIHHVSQTKPNIHNIQQSQDPKFEIRISFPRTYEDSVNIATHLQQNRAVLVNLQYLDPSTTKRLIDFLCGTAYAMSGNMKKVTDQIFIFSPKNTLLEMAEDITDVEKATQEYEGYKIENVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R2E6</accession>
    <name>A0A328R2E6_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP25022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="375" mass="44227" checksum="AA9B7BB567DFB619" modified="2018-10-10" version="1">MDLNDAMETLNGYIRKFIRPDQVLYEVAAQTLDEYNQAILTNDSNVDLQSLAYQIHALRLLIEKPGSQPRHIRRRLSHMSYNDQHQILTRWAWMRFHYENLTQKHKSKRPFQCNLGEFHQWITEDYEYYVLLNFLPHFSSESNIEFLFEGKPEQLHFAPDFLVKHKRKTMGIEITIAPEHETFGRNQYYRSRFISHLHKTYQSHPIEISLMDVNRWHACIEEKQHICLAIDLWLILNKCNQLAQQSLTIDQTLITINPIKGGTILTVENQAKDANITFEIQPANGFILNEADIVKEQTHLDETYQVDQCCKSIISRINAKNTAQFGPNTILVIWPMNQFNAIDYGDIAKKLRKMKIKTHFKEVWIFTKTNSHKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QVT3</accession>
    <name>A0A328QVT3_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DID73_00625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000002">
        <property type="protein sequence ID" value="RAP24806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RAP24806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="369" mass="39941" checksum="7B82B5482F1F00D2" modified="2018-10-10" version="1">MSPIIEIMIIGCLVATTAAIPGCFLILRKMAMMSDAISHSVLLGIVLMFFAIQSLHSPLLIVAATITGLITVALTEALISSKKMKKDAAIGLIFPLFFAIAIILISQFASNIHLDEDSIILGEIAFAPFNRWTIDTIDLGPIAIWIMGGIGLLNTLFIGLFYKELKLATFDAPLAASLGFSPVLLHYGLMACVSITCVGAFDIVGTILIVALIITPPATAYLLTQQLSQMIKLSIIIGCTCAILGTVLALAIDGSIAGAMCTVAGALFLLAFLFSPNHGIVHKFYNQKRQKLQFSAILLTIQFLNHQGPSQNPFEYSIQNLVDHMRWSDSFAKKVISYALAKNYITYDTTNYRLTPYGIEVAKNAIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QW19</accession>
    <name>A0A328QW19_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DID73_01920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000007">
        <property type="protein sequence ID" value="RAP23948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RAP23948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="152" mass="16755" checksum="8D94F941B3B5B126" modified="2018-10-10" version="1" fragment="single">PLHIAIMNKKTELVQALLNAGADHNIRTNAGWTPLEEAIGSGHTEIVKILITAGANVNLSGSDGVTPLNVATRYANTPIKIIEALVDAGADPYAKDSEGNSPEKWAYRTANQTNKILISLTFYIRLYRQCQQPQQEGRENQRGNKEVIRHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2020-04-22" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328QY84</accession>
    <name>A0A328QY84_9BACT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DID73_00190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP24957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RAP24957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="174" mass="20443" checksum="3F768553B2947295" modified="2018-10-10" version="1">MGFFNKLDMNSIESRMHLLDNTDEQAQSVSTALNSKQSKFLKRYFKFQSYFIKKIQKDNLMKEGYLILMPKKGSGNDNMYVVLSKNVIYVVRNSVNIFKFRIVKDRLLLEYAIYPSISFSGCNINTYRKFFGLLFAMFRCVLDMPSQFVVSTKMGVTKKDFENLVRFSQIDKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A328R2D2</accession>
    <name>A0A328R2D2_9BACT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">ispG</name>
        <name evidence="5" type="synonym">gcpE</name>
        <name evidence="5" type="ORF">DID73_00475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Marinamargulisbacteria bacterium SCGC AG-343-K17</name>
        <dbReference type="NCBI Taxonomy" id="2184341"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Candidatus Margulisbacteria</taxon>
            <taxon>Candidatus Marinamargulisbacteria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-05" db="EMBL/GenBank/DDBJ databases">
            <title>Hydrogen-based metabolism : an ancestral trait in lineages sibling to the Cyanobacteria.</title>
            <authorList>
                <person name="Matheus Carnevali P.B."/>
                <person name="Schulz F."/>
                <person name="Castelle C.J."/>
                <person name="Kantor R."/>
                <person name="Shih P."/>
                <person name="Sharon I."/>
                <person name="Santini J.M."/>
                <person name="Olm M.R."/>
                <person name="Amano Y."/>
                <person name="Thomas B.C."/>
                <person name="Anantharaman K."/>
                <person name="Burstein D."/>
                <person name="Becraft E."/>
                <person name="Stepanauskas R."/>
                <person name="Woyke T."/>
                <person name="Banfield J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">AG-343-K17</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="QFBO01000001">
        <property type="protein sequence ID" value="RAP25012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000248590">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RAP25012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000248590"/>
        </source>
    </evidence>
    <sequence length="404" mass="44057" checksum="0FFEF6C2C8265DD5" modified="2018-10-10" version="1">MKLIQRRNTSSVDIGGILMGADHPIRIQSMTNTVTQDVAATVDQIKSLADAGSEYVRITVNDLNAAQAVPDIVHQLRDQGYNTPIIGDFHYNGHILLTKYPKAAEALAKYRINPGNVGKGDKRDDNFATMIQVAKDYNRPVRIGVNWGSIDQQLLDAHMEANAKRSTPKAFNDIMIDTMIESAERSVDAALNLGLGKDKIVVSVKMSEIQDMIAAYERVAPLIDVPIHLGLTEAGNGIKGITCSAAALSILLQQGIGDTIRVSLTPEPGLPRSREVDVCTNLLQTMGFRFFKPSVTSCPGCGRTDSDYFVHLAQDVNEHIAKKINEWRPKYPGVESMKIAVMGCVVNGPGESKYANIGISLPGLRENPAAPVYIDGELSTTLRGDNITQEFMAILDDYIVKTYS</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>